Login
Login

UHRF2

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{cs1 config|name-list-style=vanc}}

{{Infobox_gene}}

E3 ubiquitin-protein ligase UHRF2 is an enzyme that in humans is encoded by the UHRF2 gene.{{cite journal | vauthors = Mori T, Li Y, Hata H, Ono K, Kochi H | title = NIRF, a novel RING finger protein, is involved in cell-cycle regulation | journal = Biochem Biophys Res Commun | volume = 296 | issue = 3 | pages = 530–6 |date=Aug 2002 | pmid = 12176013 | doi =10.1016/S0006-291X(02)00890-2 }}{{cite web | title = Entrez Gene: UHRF2 ubiquitin-like, containing PHD and RING finger domains, 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=115426}}

This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis.{{cite web | title = Entrez Gene: UHRF2 ubiquitin-like, containing PHD and RING finger domains, 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=115426}}

References

{{reflist}}

Further reading

{{refbegin | 2}}

  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
  • {{cite journal | vauthors=Unoki M, Nishidate T, Nakamura Y |title=ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain. |journal=Oncogene |volume=23 |issue= 46 |pages= 7601–10 |year= 2004 |pmid= 15361834 |doi= 10.1038/sj.onc.1208053 |doi-access= |s2cid=21948278 }}
  • {{cite journal |vauthors=Colland F, Jacq X, Trouplin V, etal |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 | pmc=442148 }}
  • {{cite journal |vauthors=Li Y, Mori T, Hata H, etal |title=NIRF induces G1 arrest and associates with Cdk2. |journal=Biochem. Biophys. Res. Commun. |volume=319 |issue= 2 |pages= 464–8 |year= 2004 |pmid= 15178429 |doi= 10.1016/j.bbrc.2004.04.190 }}
  • {{cite journal |vauthors=Humphray SJ, Oliver K, Hunt AR, etal |title=DNA sequence and analysis of human chromosome 9. |journal=Nature |volume=429 |issue= 6990 |pages= 369–74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465 | pmc=2734081 |bibcode=2004Natur.429..369H }}
  • {{cite journal | vauthors=Mori T, Li Y, Hata H, Kochi H |title=NIRF is a ubiquitin ligase that is capable of ubiquitinating PCNP, a PEST-containing nuclear protein. |journal=FEBS Lett. |volume=557 |issue= 1–3 |pages= 209–14 |year= 2004 |pmid= 14741369 |doi=10.1016/S0014-5793(03)01495-9 |s2cid=10006213 |doi-access= }}
  • {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}

{{refend}}

{{PDB Gallery|geneid=115426}}

{{gene-9-stub}}