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UQCRC1

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Cytochrome b-c1 complex subunit 1, mitochondrial is a protein that in humans is encoded by the UQCRC1 gene.{{cite journal |vauthors=Hoffman GG, Lee S, Christiano AM, Chung-Honet LC, Cheng W, Katchman S, Uitto J, Greenspan DS | title = Complete coding sequence, intron/exon organization, and chromosomal location of the gene for the core I protein of human ubiquinol-cytochrome c reductase | journal = J Biol Chem | volume = 268 | issue = 28 | pages = 21113–9 |date=Nov 1993 | doi = 10.1016/S0021-9258(19)36900-5 | pmid = 8407948 | doi-access = free }}{{cite web | title = Entrez Gene: UQCRC1 ubiquinol-cytochrome c reductase core protein I| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7384}}

Its gene product is a subunit of the respiratory chain protein Ubiquinol Cytochrome c Reductase (UQCR, Complex III or Cytochrome bc1 complex), which consists of the products of one mitochondrially encoded gene, MTCYTB (mitochondrial cytochrome b) and ten nuclear genes: UQCRC1, UQCRC2, Cytochrome c1, UQCRFS1 (Rieske protein), UQCRB, "11kDa protein", UQCRH (cyt c1 Hinge protein), Rieske Protein presequence, "cyt. c1 associated protein", and Rieske-associated protein.

References

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Further reading

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  • {{cite journal |vauthors=Suzuki H, Hosokawa Y, Nishikimi M, Ozawa T |title=Existence of common homologous elements in the transcriptional regulatory regions of human nuclear genes and mitochondrial gene for the oxidative phosphorylation system. |journal=J. Biol. Chem. |volume=266 |issue= 4 |pages= 2333–8 |year= 1991 |doi=10.1016/S0021-9258(18)52248-1 |pmid= 1846623 |doi-access=free }}
  • {{cite journal |vauthors=Broger C, Nałecz MJ, Azzi A |title=Interaction of cytochrome c with cytochrome bc1 complex of the mitochondrial respiratory chain. |journal=Biochim. Biophys. Acta |volume=592 |issue= 3 |pages= 519–27 |year= 1980 |pmid= 6251869 |doi=10.1016/0005-2728(80)90096-1 }}
  • {{cite journal | author=Islam MM |title=A complete cDNA sequence for core I protein subunit of human ubiquinol-cytochrome c reductase |journal=Biochem. Mol. Biol. Int. |volume=33 |issue= 2 |pages= 410 |year= 1994 |pmid= 7951059 |name-list-style=vanc| author2=Tanaka M | author3=Suzuki H | display-authors=3 | last4=Torii | first4=K | last5=Hattori | first5=N | last6=Ozawa | first6=T }}
  • {{cite journal | author=Islam MM |title=A complete cDNA sequence for core I protein subunit of human ubiquinol-cytochrome c reductase |journal=Biochem. Mol. Biol. Int. |volume=33 |issue= 4 |pages= 815 |year= 1995 |pmid= 7981668 |name-list-style=vanc| author2=Tanaka M | author3=Suzuki H | display-authors=3 | last4=Torii | first4=K | last5=Hattori | first5=N | last6=Ozawa | first6=T }}
  • {{cite journal | author=Islam MM |title=A complete cDNA sequence for core I protein subunit of human ubiquinol-cytochrome c reductase |journal=Biochem. Mol. Biol. Int. |volume=32 |issue= 5 |pages= 797–805 |year= 1994 |pmid= 8069229 |name-list-style=vanc| author2=Tanaka M | author3=Suzuki H | display-authors=3 | last4=Torii | first4=K | last5=Hattori | first5=N | last6=Ozawa | first6=T }}
  • {{cite journal | author=Hughes GJ |title=Human liver protein map: update 1993 |journal=Electrophoresis |volume=14 |issue= 11 |pages= 1216–22 |year= 1994 |pmid= 8313870 |doi=10.1002/elps.11501401181 |name-list-style=vanc| author2=Frutiger S | author3=Paquet N | display-authors=3 | last4=Pasquali | first4=Christian | last5=Sanchez | first5=Jean-Charles | last6=Tissot | first6=Jean-Daniel | last7=Bairoch | first7=Amos | last8=Appel | first8=Ron D. | last9=Hochstrasser | first9=Denis F. |s2cid=33424554 }}
  • {{cite journal | author=Hillier LD |title=Generation and analysis of 280,000 human expressed sequence tags |journal=Genome Res. |volume=6 |issue= 9 |pages= 807–28 |year= 1997 |pmid= 8889549 |doi=10.1101/gr.6.9.807 |name-list-style=vanc| author2=Lennon G | author3=Becker M | display-authors=3 | last4=Bonaldo | first4=M F | last5=Chiapelli | first5=B | last6=Chissoe | first6=S | last7=Dietrich | first7=N | last8=Dubuque | first8=T | last9=Favello | first9=A | doi-access=free }}
  • {{cite journal | author=Valnot I |title=A mitochondrial cytochrome b mutation but no mutations of nuclearly encoded subunits in ubiquinol cytochrome c reductase (complex III) deficiency |journal=Hum. Genet. |volume=104 |issue= 6 |pages= 460–6 |year= 1999 |pmid= 10453733 |doi=10.1007/s004390050988 |name-list-style=vanc| author2=Kassis J | author3=Chretien D | display-authors=3 | last4=De Lonlay | first4=Pascale | last5=Parfait | first5=Béatrice | last6=Munnich | first6=Arnold | last7=Kachaner | first7=Jean | last8=Rustin | first8=Pierre | last9=Rötig | first9=Agnès |s2cid=30584267 }}
  • {{cite journal | author=Hu WH |title=Identification and characterization of a novel Nogo-interacting mitochondrial protein (NIMP) |journal=J. Neurochem. |volume=81 |issue= 1 |pages= 36–45 |year= 2002 |pmid= 12067236 |doi=10.1046/j.1471-4159.2002.00788.x |name-list-style=vanc| author2=Hausmann ON | author3=Yan MS | display-authors=3 | last4=Walters | first4=Winston M. | last5=Wong | first5=Paul K. Y. | last6=Bethea | first6=John R. |s2cid=38794348 }}
  • {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |vauthors=Aboulaich N, Vainonen JP, Strålfors P, Vener AV |title=Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes |journal=Biochem. J. |volume=383 |issue= Pt 2 |pages= 237–48 |year= 2005 |pmid= 15242332 |doi= 10.1042/BJ20040647 | pmc=1134064 }}
  • {{cite journal | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-style=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
  • {{cite journal |vauthors=Wen JJ, Garg N |title=Oxidative modification of mitochondrial respiratory complexes in response to the stress of Trypanosoma cruzi infection |journal=Free Radic. Biol. Med. |volume=37 |issue= 12 |pages= 2072–81 |year= 2005 |pmid= 15544925 |doi= 10.1016/j.freeradbiomed.2004.09.011 }}
  • {{cite journal | author=Rual JF |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |name-list-style=vanc| author2=Venkatesan K | author3=Hao T | display-authors=3 | last4=Hirozane-Kishikawa | first4=Tomoko | last5=Dricot | first5=Amélie | last6=Li | first6=Ning | last7=Berriz | first7=Gabriel F. | last8=Gibbons | first8=Francis D. | last9=Dreze | first9=Matija |bibcode=2005Natur.437.1173R |s2cid=4427026 }}
  • {{cite journal | author=Kulawiec M |title=Proteomic analysis of mitochondria-to-nucleus retrograde response in human cancer |journal=Cancer Biol. Ther. |volume=5 |issue= 8 |pages= 967–75 |year= 2007 |pmid= 16775426 |doi= 10.4161/cbt.5.8.2880|name-list-style=vanc| author2=Arnouk H | author3=Desouki MM | display-authors=3 | last4=Kazim | first4=L | last5=Still | first5=I | last6=Singh | first6=KK |s2cid=84608368 }}
  • {{cite journal | author=Ewing RM |title=Large-scale mapping of human protein-protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue= 1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 |name-list-style=vanc| author2=Chu P | author3=Elisma F | display-authors=3 | last4=Li | first4=Hongyan | last5=Taylor | first5=Paul | last6=Climie | first6=Shane | last7=McBroom-Cerajewski | first7=Linda | last8=Robinson | first8=Mark D | last9=O'Connor | first9=Liam }}

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