UQCRH
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Cytochrome b-c1 complex subunit 6, mitochondrial is a protein that in humans is encoded by the UQCRH gene.{{cite journal | vauthors = Ohta S, Goto K, Arai H, Kagawa Y | title = An extremely acidic amino-terminal presequence of the precursor for the human mitochondrial hinge protein | journal = FEBS Lett | volume = 226 | issue = 1 | pages = 171–5 | date = Jan 1988 | pmid = 2826252 | doi =10.1016/0014-5793(87)80573-2 | doi-access = free }}{{cite web| title = Entrez Gene: UQCRH ubiquinol-cytochrome c reductase hinge protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7388| access-date = 2017-09-17| archive-date = 2024-04-28| archive-url = https://web.archive.org/web/20240428045823/https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=7388| url-status = live}}
Its gene product is a subunit of the respiratory chain protein Ubiquinol Cytochrome c Reductase (UQCR, Complex III or Cytochrome bc1 complex; E.C. 1.10.2.2), which consists of the products of one mitochondrially encoded gene, MTCYTB (mitochondrial cytochrome b) and ten nuclear genes: UQCRC1, UQCRC2, Cytochrome c1, UQCRFS1 (Rieske protein), UQCRB, "11kDa protein", UQCRH (cyt c1 Hinge protein), Rieske Protein presequence, "cyt. c1 associated protein", and "Rieske-associated protein".
References
{{reflist}}
Further reading
{{refbegin | 2}}
- {{cite journal | vauthors=Liu AY, Bradner RC |title=Elevated expression of the human mitochondrial hinge protein gene in cancer. |journal=Cancer Res. |volume=53 |issue= 11 |pages= 2460–5 |year= 1993 |pmid= 7684318 }}
- {{cite journal |vauthors=Kato S, Sekine S, Oh SW, etal |title=Construction of a human full-length cDNA bank. |journal=Gene |volume=150 |issue= 2 |pages= 243–50 |year= 1995 |pmid= 7821789 |doi=10.1016/0378-1119(94)90433-2 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Modena P, Testi MA, Facchinetti F, etal |title=UQCRH gene encoding mitochondrial Hinge protein is interrupted by a translocation in a soft-tissue sarcoma and epigenetically inactivated in some cancer cell lines |journal=Oncogene |volume=22 |issue= 29 |pages= 4586–93 |year= 2003 |pmid= 12881716 |doi= 10.1038/sj.onc.1206472 |doi-access= free }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal | vauthors=Wen JJ, Garg N |title=Oxidative modification of mitochondrial respiratory complexes in response to the stress of Trypanosoma cruzi infection |journal=Free Radic. Biol. Med. |volume=37 |issue= 12 |pages= 2072–81 |year= 2005 |pmid= 15544925 |doi= 10.1016/j.freeradbiomed.2004.09.011 }}
- {{cite journal |vauthors=Gregory SG, Barlow KF, McLay KE, etal |title=The DNA sequence and biological annotation of human chromosome 1 |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 |bibcode=2006Natur.441..315G |doi-access= free }}
- {{cite journal |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |s2cid=7827573 |doi-access=free }}
{{refend}}
{{PDB Gallery|geneid=7388}}
{{protein-stub}}