User:Mim.cis/sandbox/Jeff Siewerdsen

Jeffrey Siewerdsen did his undergaduate studies at the University of Minnesota in Minneapolis, MN, where he received his Bachelor of Arts degree in Physics and Astrophysics with a minor in Japanese in 1992. His undergraduate research experience included construction and testing of particle detectors for the Soudan 2 proton decay project.

Siewerdsen began graduate studies at the University of Michigan in Ann Arbor, MI, in 1992, working initially in high-energy physics (D0 experiment) under supervision of Professor Homer Neal and earning his Master of Science degree in Physics in 1994.

Siewerdsen's doctoral research involved early development of amorphous silicon Flat panel detector for medical x-ray imaging under the supervision of Professor Larry E. Antonuk. Siewerdsen's work focused on the development of early flat-panel detector systems for diagnostic radiography, fluoroscopy, and mammography as well as megavoltage portal imaging for guidance of radiation therapy. His doctoral dissertation{{Cite journal|last=Siewerdsen|first=Jeffrey H.|date=1998-11-01|title=Signal, noise, and detective quantum efficiency of a-Si:H flat-panel imagers|url=http://onlinelibrary.wiley.com/doi/10.1118/1.598427/abstract|journal=Medical Physics|language=en|volume=25|issue=11|pages=2250–2250|doi=10.1118/1.598427|issn=2473-4209}} established mathematical models for the signal-to-noise properties (specifically, the modulation transfer function, noise-power spectrum, and detective quantum efficiency) of flat-panel x-ray detectors. His Ph.D. thesis was awarded the Kent M. Terwilliger Prize for Best Doctoral Dissertation in Physics, 1998.

Siewerdsen conducted post-graduate research beginning in 1998 as a Research Scientist at William Beaumont Hospital in Royal Oak, MI, with Dr. David Jaffray and Dr. John Wong on the topic of cone beam computed tomography (CBCT) for image-guided radiation therapy (IGRT).{{Cite journal|last=Jaffray|first=David A|last2=Siewerdsen|first2=Jeffrey H|last3=Wong|first3=John W|last4=Martinez|first4=Alvaro A|title=Flat-panel cone-beam computed tomography for image-guided radiation therapy|url=https://doi.org/10.1016/S0360-3016(02)02884-5|journal=International Journal of Radiation Oncology*Biology*Physics|volume=53|issue=5|pages=1337–1349|doi=10.1016/s0360-3016(02)02884-5}}{{Cite journal|last=Jaffray|first=D. A.|last2=Siewerdsen|first2=J. H.|date=2000-06-01|title=Cone-beam computed tomography with a flat-panel imager: Initial performance characterization|url=http://onlinelibrary.wiley.com/doi/10.1118/1.599009/abstract|journal=Medical Physics|language=en|volume=27|issue=6|pages=1311–1323|doi=10.1118/1.599009|issn=2473-4209}} The Beaumont team produced the first IGRT system for CBCT, beginning with laboratory studies to investigate image quality characteristics,{{Cite journal|last=Siewerdsen|first=Jeffrey H.|last2=Jaffray|first2=David A.|date=2001-02-01|title=Cone-beam computed tomography with a flat-panel imager: Magnitude and effects of x-ray scatter|url=http://onlinelibrary.wiley.com/doi/10.1118/1.1339879/abstract|journal=Medical Physics|language=en|volume=28|issue=2|pages=220–231|doi=10.1118/1.1339879|issn=2473-4209}} and translating to clinical studies for guidance of prostate cancer therapy.{{Cite journal|last=Létourneau|first=Daniel|last2=Wong|first2=John W.|last3=Oldham|first3=Mark|last4=Gulam|first4=Misbah|last5=Watt|first5=Lindsay|last6=Jaffray|first6=David A.|last7=Siewerdsen|first7=Jeffrey H.|last8=Martinez|first8=Alvaro A.|title=Cone-beam-CT guided radiation therapy: technical implementation|url=https://doi.org/10.1016/j.radonc.2005.03.001|journal=Radiotherapy and Oncology|volume=75|issue=3|pages=279–286|doi=10.1016/j.radonc.2005.03.001}}

{Insert media: photo_Siewerdsen_and_Jaffray.png}

{Caption: Jeff Siewerdsen and David Jaffray in laboratory at William Beaumont Hospital circa 2000.}

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{Caption: Jeff Siewerdsen with a prototype mobile C-arm for Cone beam computed tomography at William Beaumont Hospital in 2001.}

Siewerdsen joined the Ontario Cancer Institute and University of Toronto Department of Medical Biophysics as a Scientist and Assistant Professor, respectively, in 2002, and subsequently as Senior Scientist and Associate Professor in 2007. Research in his laboratory focused on image-guided surgery, new imaging methods such as dual-energy imaging, and image registration. His work involved the development of early systems for cone beam computed tomography (CBCT) with a flat-panel detector on mobile C-arms for image-guided surgery{{Cite journal|last=Siewerdsen|first=J. H.|last2=Moseley|first2=D. J.|last3=Burch|first3=S.|last4=Bisland|first4=S. K.|last5=Bogaards|first5=A.|last6=Wilson|first6=B. C.|last7=Jaffray|first7=D. A.|date=2005-01-01|title=Volume CT with a flat-panel detector on a mobile, isocentric C-arm: Pre-clinical investigation in guidance of minimally invasive surgery|url=http://onlinelibrary.wiley.com/doi/10.1118/1.1836331/abstract|journal=Medical Physics|language=en|volume=32|issue=1|pages=241–254|doi=10.1118/1.1836331|issn=2473-4209}} and translated the first such systems to clinical studies in image-guided otolaryngology-head and neck surgery{{Cite journal|last=Daly|first=M. J.|last2=Siewerdsen|first2=J. H.|last3=Moseley|first3=D. J.|last4=Jaffray|first4=D. A.|last5=Irish|first5=J. C.|date=2006-10-01|title=Intraoperative cone-beam CT for guidance of head and neck surgery: Assessment of dose and image quality using a C-arm prototype|url=http://onlinelibrary.wiley.com/doi/10.1118/1.2349687/abstract|journal=Medical Physics|language=en|volume=33|issue=10|pages=3767–3780|doi=10.1118/1.2349687|issn=2473-4209}}{{Cite journal|last=Rafferty|first=M A.|last2=Siewerdsen|first2=J H.|last3=Chan|first3=Y|last4=Moseley|first4=D J.|last5=Daly|first5=M J.|last6=Jaffray|first6=D A.|last7=Irish|first7=J C.|date=2005-12-01|title=Investigation of C-Arm Cone-Beam CT-Guided Surgery of the Frontal Recess|url=http://onlinelibrary.wiley.com/doi/10.1097/01.mlg.0000180759.52082.45/abstract|journal=The Laryngoscope|language=en|volume=115|issue=12|pages=2138–2143|doi=10.1097/01.mlg.0000180759.52082.45|issn=1531-4995}}{{Cite journal|last=Rafferty|first=Mark A.|last2=Siewerdsen|first2=Jeffrey H.|last3=Chan|first3=Yvonne|last4=Daly|first4=Michael J.|last5=Moseley|first5=Douglas J.|last6=Jaffray|first6=David A.|last7=Irish|first7=Jonathan C.|date=2016-05-17|title=Intraoperative Cone-beam CT for Guidance of Temporal Bone Surgery|url=http://journals.sagepub.com/doi/10.1016/j.otohns.2005.12.007|journal=Otolaryngology-Head and Neck Surgery|language=en|volume=134|issue=5|pages=801–808|doi=10.1016/j.otohns.2005.12.007}} with Dr. Jonathan Irish. He also collaborated closely with Dr. Kristy Brock on deformable image registration using the Demons algorithm{{Cite journal|last=Nithiananthan|first=S.|last2=Brock|first2=K. K.|last3=Daly|first3=M. J.|last4=Chan|first4=H.|last5=Irish|first5=J. C.|last6=Siewerdsen|first6=J. H.|date=2009-10-01|title=Demons deformable registration for CBCT-guided procedures in the head and neck: Convergence and accuracy|url=http://onlinelibrary.wiley.com/doi/10.1118/1.3223631/abstract|journal=Medical Physics|language=en|volume=36|issue=10|pages=4755–4764|doi=10.1118/1.3223631|issn=2473-4209}}{{Cite journal|last=Nithiananthan|first=Sajendra|last2=Schafer|first2=Sebastian|last3=Mirota|first3=Daniel J.|last4=Stayman|first4=J. Webster|last5=Zbijewski|first5=Wojciech|last6=Reh|first6=Douglas D.|last7=Gallia|first7=Gary L.|last8=Siewerdsen|first8=Jeffrey H.|date=2012-09-01|title=Extra-dimensional Demons: A method for incorporating missing tissue in deformable image registration|url=http://onlinelibrary.wiley.com/doi/10.1118/1.4747270/abstract|journal=Medical Physics|language=en|volume=39|issue=9|pages=5718–5731|doi=10.1118/1.4747270|issn=2473-4209}} and with Dr. Narinder Paul on development of dual-energy chest radiography systems for detection of early stage lung cancer.{{Cite journal|last=Shkumat|first=N. A.|last2=Siewerdsen|first2=J. H.|last3=Dhanantwari|first3=A. C.|last4=Williams|first4=D. B.|last5=Richard|first5=S.|last6=Paul|first6=N. S.|last7=Yorkston|first7=J.|last8=Van Metter|first8=R.|date=2007-10-01|title=Optimization of image acquisition techniques for dual-energy imaging of the chest|url=http://onlinelibrary.wiley.com/doi/10.1118/1.2777278/abstract|journal=Medical Physics|language=en|volume=34|issue=10|pages=3904–3915|doi=10.1118/1.2777278|issn=2473-4209}}{{Cite journal|last=Kashani|first=Hany|last2=Varon|first2=Carlos A.|last3=Paul|first3=Narinder S.|last4=Gang|first4=Grace J.|last5=Metter|first5=Rich Van|last6=Yorkston|first6=John|last7=Siewerdsen|first7=Jeffrey H.|title=Diagnostic Performance of a Prototype Dual-Energy Chest Imaging System|url=http://linkinghub.elsevier.com/retrieve/pii/S1076633209005844|journal=Academic Radiology|volume=17|issue=3|pages=298–308|doi=10.1016/j.acra.2009.10.012}} His research also extended cascaded systems models{{Cite journal|last=Siewerdsen|first=J. H.|last2=Antonuk|first2=L. E.|last3=El-Mohri|first3=Y.|last4=Yorkston|first4=J.|last5=Huang|first5=W.|last6=Boudry|first6=J. M.|last7=Cunningham|first7=I. A.|date=1997-01-01|title=Empirical and theoretical investigation of the noise performance of indirect detection, active matrix flat-panel imagers (AMFPIs) for diagnostic radiology|url=http://onlinelibrary.wiley.com/doi/10.1118/1.597919/abstract|journal=Medical Physics|language=en|volume=24|issue=1|pages=71–89|doi=10.1118/1.597919|issn=2473-4209}} for x-ray imaging performance to describe 3D imaging performance in CBCT{{Cite journal|last=Tward|first=Daniel J.|last2=Siewerdsen|first2=Jeffrey H.|date=2008-12-01|title=Cascaded systems analysis of the 3D noise transfer characteristics of flat-panel cone-beam CT|url=http://onlinelibrary.wiley.com/doi/10.1118/1.3002414/abstract|journal=Medical Physics|language=en|volume=35|issue=12|pages=5510–5529|doi=10.1118/1.3002414|issn=2473-4209}}{{Cite journal|last=Tward|first=Daniel J.|last2=Siewerdsen|first2=Jeffrey H.|date=2009-08-01|title=Noise aliasing and the 3D NEQ of flat-panel cone-beam CT: Effect of 2D/3D apertures and sampling|url=http://onlinelibrary.wiley.com/doi/10.1118/1.3166933/abstract|journal=Medical Physics|language=en|volume=36|issue=8|pages=3830–3843|doi=10.1118/1.3166933|issn=2473-4209}} and helped to establish mathematical methods for imaging system optimization according to the imaging task.{{Cite journal|last=Gang|first=Grace J.|last2=Lee|first2=Junghoon|last3=Stayman|first3=J. Webster|last4=Tward|first4=Daniel J.|last5=Zbijewski|first5=W.|last6=Prince|first6=Jerry L.|last7=Siewerdsen|first7=Jeffrey H.|date=2011-04-01|title=Analysis of Fourier-domain task-based detectability index in tomosynthesis and cone-beam CT in relation to human observer performance|url=http://onlinelibrary.wiley.com/doi/10.1118/1.3560428/abstract|journal=Medical Physics|language=en|volume=38|issue=4|pages=1754–1768|doi=10.1118/1.3560428|issn=2473-4209}}

Siewerdsen joined Johns Hopkins Biomedical Engineering as an Associate Professor in 2009 and subsequently as a Professor in 2012, with cross-appointment in Computer Science, Radiology, and Neurosurgery. He founded the I-STAR Lab (Imaging for Surgery, Therapy, and Radiology) {{Cite web|url=http://istar.jhu.edu/|title=I-STAR Lab {{!}} Imaging for Surgery, Therapy, and Radiology|website=istar.jhu.edu|language=en-US|access-date=2017-11-13}}as a collaborative research endeavor bridging biomedical engineering with clinical collaborators at Johns Hopkins Hospital. In 2015, he established the Carnegie Center for Surgical Innovation in the Johns Hopkins School of Medicine. He is also a John C. Malone Professor in Computer Science and Member of the Malone Center for Engineering in Healthcare. Research in Siewerdsen's laboratory includes: mathematical modeling / imaging science of digital x-ray,{{Cite journal|last=Siewerdsen|first=Jeffrey H.|title=Cone-beam CT with a flat-panel detector: From image science to image-guided surgery|url=http://linkinghub.elsevier.com/retrieve/pii/S0168900210026239|journal=Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment|volume=648|pages=S241–S250|doi=10.1016/j.nima.2010.11.088}} dual-energy imaging,{{Cite journal|last=Richard|first=S.|last2=Siewerdsen|first2=J. H.|date=2007-01-01|title=Optimization of dual-energy imaging systems using generalized NEQ and imaging task|url=http://onlinelibrary.wiley.com/doi/10.1118/1.2400620/abstract|journal=Medical Physics|language=en|volume=34|issue=1|pages=127–139|doi=10.1118/1.2400620|issn=2473-4209}} cone beam computed tomography (CBCT),{{Cite journal|last=Siewerdsen|first=Jeffrey H.|last2=Jaffray|first2=David A.|date=2000-08-01|title=Optimization of x-ray imaging geometry (with specific application to flat-panel cone-beam computed tomography)|url=http://onlinelibrary.wiley.com/doi/10.1118/1.1286590/abstract|journal=Medical Physics|language=en|volume=27|issue=8|pages=1903–1914|doi=10.1118/1.1286590|issn=2473-4209}} and computed tomography (CT) systems;{{Cite journal|last=Bian|first=Junguo|last2=Siewerdsen|first2=Jeffrey H.|last3=Han|first3=Xiao|last4=Sidky|first4=Emil Y.|last5=Prince|first5=Jerry L.|last6=Pelizzari|first6=Charles A.|last7=Xiaochuan Pan|date=2010|title=Evaluation of sparse-view reconstruction from flat-panel-detector cone-beam CT|url=http://stacks.iop.org/0031-9155/55/i=22/a=001|journal=Physics in Medicine & Biology|language=en|volume=55|issue=22|pages=6575|doi=10.1088/0031-9155/55/22/001|issn=0031-9155}} image-guided surgery;{{Cite journal|last=Schafer|first=S.|last2=Nithiananthan|first2=S.|last3=Mirota|first3=D. J.|last4=Uneri|first4=A.|last5=Stayman|first5=J. W.|last6=Zbijewski|first6=W.|last7=Schmidgunst|first7=C.|last8=Kleinszig|first8=G.|last9=Khanna|first9=A. J.|date=2011-08-01|title=Mobile C-arm cone-beam CT for guidance of spine surgery: Image quality, radiation dose, and integration with interventional guidance|url=http://onlinelibrary.wiley.com/doi/10.1118/1.3597566/abstract|journal=Medical Physics|language=en|volume=38|issue=8|pages=4563–4574|doi=10.1118/1.3597566|issn=2473-4209}}{{Cite journal|last=Wang|first=Adam S|last2=Stayman|first2=J Webster|last3=Otake|first3=Yoshito|last4=Kleinszig|first4=Gerhard|last5=Vogt|first5=Sebastian|last6=Gallia|first6=Gary L|last7=Khanna|first7=A Jay|last8=Siewerdsen|first8=Jeffrey H|title=Soft-tissue imaging with C-arm cone-beam CT using statistical reconstruction|url=http://stacks.iop.org/0031-9155/59/i=4/a=1005?key=crossref.a57fdd600f4403e76d37fb25998fc364|journal=Physics in Medicine and Biology|volume=59|issue=4|pages=1005–1026|doi=10.1088/0031-9155/59/4/1005}} multi-modality medical image registration;{{Cite journal|last=Nithiananthan|first=Sajendra|last2=Schafer|first2=Sebastian|last3=Uneri|first3=Ali|last4=Mirota|first4=Daniel J.|last5=Stayman|first5=J. Webster|last6=Zbijewski|first6=Wojciech|last7=Brock|first7=Kristy K.|last8=Daly|first8=Michael J.|last9=Chan|first9=Harley|date=2011-04-01|title=Demons deformable registration of CT and cone-beam CT using an iterative intensity matching approach|url=http://onlinelibrary.wiley.com/doi/10.1118/1.3555037/abstract|journal=Medical Physics|language=en|volume=38|issue=4|pages=1785–1798|doi=10.1118/1.3555037|issn=2473-4209}}{{Cite journal|last=Reaungamornrat|first=S|last2=Wang|first2=A S|last3=Uneri|first3=A|last4=Otake|first4=Y|last5=Khanna|first5=A J|last6=Siewerdsen|first6=J H|title=Deformable image registration with local rigidity constraints for cone-beam CT-guided spine surgery|url=http://stacks.iop.org/0031-9155/59/i=14/a=3761?key=crossref.a44eb94f62273b05ea02dc049ce125be|journal=Physics in Medicine and Biology|volume=59|issue=14|pages=3761–3787|doi=10.1088/0031-9155/59/14/3761}}{{Cite journal|last=Reaungamornrat|first=S|last2=Silva|first2=T De|last3=Uneri|first3=A|last4=Goerres|first4=J|last5=Jacobson|first5=M|last6=Ketcha|first6=M|last7=Vogt|first7=S|last8=Kleinszig|first8=G|last9=Khanna|first9=A J|title=Performance evaluation of MIND demons deformable registration of MR and CT images in spinal interventions|url=http://stacks.iop.org/0031-9155/61/i=23/a=8276?key=crossref.4ef27154670afb10de1c82143093ebed|journal=Physics in Medicine and Biology|volume=61|issue=23|pages=8276–8297|doi=10.1088/0031-9155/61/23/8276}}{{Cite journal|last=Uneri|first=Ali|last2=Nithiananthan|first2=Sajendra|last3=Schafer|first3=Sebastian|last4=Otake|first4=Yoshito|last5=Stayman|first5=J. Webster|last6=Kleinszig|first6=Gerhard|last7=Sussman|first7=Marc S.|last8=Prince|first8=Jerry L.|last9=Siewerdsen|first9=Jeffrey H.|date=2013-01-01|title=Deformable registration of the inflated and deflated lung in cone-beam CT-guided thoracic surgery: Initial investigation of a combined model- and image-driven approach|url=http://onlinelibrary.wiley.com/doi/10.1118/1.4767757/abstract|journal=Medical Physics|language=en|volume=40|issue=1|pages=n/a–n/a|doi=10.1118/1.4767757|issn=2473-4209}} new imaging systems for musculoskeletal radiology and orthopedic surgery;{{Cite journal|last=Prakash|first=P.|last2=Zbijewski|first2=W.|last3=Gang|first3=G. J.|last4=Ding|first4=Y.|last5=Stayman|first5=J. W.|last6=Yorkston|first6=J.|last7=Carrino|first7=J. A.|last8=Siewerdsen|first8=J. H.|date=2011-10-01|title=Task-based modeling and optimization of a cone-beam CT scanner for musculoskeletal imaging|url=http://onlinelibrary.wiley.com/doi/10.1118/1.3633937/abstract|journal=Medical Physics|language=en|volume=38|issue=10|pages=5612–5629|doi=10.1118/1.3633937|issn=2473-4209}}{{Cite journal|last=Carrino|first=John A.|last2=Al Muhit|first2=Abdullah|last3=Zbijewski|first3=Wojciech|last4=Thawait|first4=Gaurav K.|last5=Stayman|first5=J. Webster|last6=Packard|first6=Nathan|last7=Senn|first7=Robert|last8=Yang|first8=Dong|last9=Foos|first9=David H.|date=2013-11-18|title=Dedicated Cone-Beam CT System for Extremity Imaging|url=http://pubs.rsna.org/doi/10.1148/radiol.13130225|journal=Radiology|volume=270|issue=3|pages=816–824|doi=10.1148/radiol.13130225|issn=0033-8419}} and clinical research collaborations in robot-assisted surgery and data science related to medical imaging.

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{Caption: Siewerdsen in the laboratory for image-guided surgery at Johns Hopkins University circa 2011.}

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{Caption: Siewerdsen with a prototype Cone beam computed tomography scanner for extremity imaging at Johns Hopkins University in 2017.}

Notable achievements, scientific awards, and honors associated with Siewerdsen's work include:

• (2016) Frost & Sullivan Award for New Product Innovation (OnSight 3D Extremity System, collaboration with Carestream Health, Rochester NY
• (2016) Best New Radiology Device awarded by Aunt Minnie Radiology News (OnSight 3D Extremity System, collaboration with Carestream Health, Rochester NY
• (2016) Fellow, AIMBE
• (2013) Spine Technology of the Year awarded by Orthopedics This Week (LevelCheck algorithm for vertebral localization in spine surgery){{Cite journal|last=Otake|first=Y.|last2=Schafer|first2=S.|last3=Stayman|first3=J. W.|last4=Zbijewski|first4=W.|last5=Kleinszig|first5=G.|last6=Graumann|first6=R.|last7=Khanna|first7=A. J.|last8=Siewerdsen|first8=J. H.|date=2012-09-07|title=Automatic localization of vertebral levels in x-ray fluoroscopy using 3D-2D registration: a tool to reduce wrong-site surgery|url=https://www.ncbi.nlm.nih.gov/pubmed/22864366|journal=Physics in Medicine and Biology|volume=57|issue=17|pages=5485–5508|doi=10.1088/0031-9155/57/17/5485|issn=1361-6560|pmc=PMC3429949|pmid=22864366}}{{Cite news|url=https://www.bme.jhu.edu/news-events/news/jeff-siewerdsen-and-the-i-star-lab-win-the-2013-spine-technology-award/|title=Jeff Siewerdsen and the I-STAR Lab win the 2013 Spine Technology Award {{!}} Johns Hopkins Department of Biomedical Engineering|work=Johns Hopkins Department of Biomedical Engineering|access-date=2017-11-12|language=en-US}}
• (2012) Fellow, AAPM{{Cite news|url=https://www.bme.jhu.edu/news-events/news/jeffrey-siewerdsen-elected-to-the-aapm-board-of-directors/|title=Jeffrey Siewerdsen elected to the AAPM Board of Directors {{!}} Johns Hopkins Department of Biomedical Engineering|work=Johns Hopkins Department of Biomedical Engineering|access-date=2017-11-12|language=en-US}}
• (1999) Terwilliger Prize for best doctoral dissertation in Physics

Notable scientific contributions from Siewerdsen's work include:

• Cone beam computed tomography (CBCT) systems on mobile C-arms for image-guided surgery.{{Cite journal|last=Siewerdsen|first=Jeffrey H.|date=2011-08-21|title=Cone-Beam CT with a Flat-Panel Detector: From Image Science to Image-Guided Surgery|url=http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429946/|journal=Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment|volume=648|issue=Suppl 1|pages=S241–S250|doi=10.1016/j.nima.2010.11.088|issn=0168-9002|pmc=PMC3429946|pmid=22942510}}{{Cite journal|last=Mirota|first=Daniel J.|last2=Uneri|first2=Ali|last3=Schafer|first3=Sebastian|last4=Nithiananthan|first4=Sajendra|last5=Reh|first5=Douglas D.|last6=Gallia|first6=Gary L.|last7=Taylor|first7=Russell H.|last8=Hager|first8=Gregory D.|last9=Siewerdsen|first9=Jeffrey H.|date=2011-03-02|title=High-accuracy 3D image-based registration of endoscopic video to C-arm cone-beam CT for image-guided skull base surgery|url=https://www.spiedigitallibrary.org/conference-proceedings-of-spie/7964/79640J/High-accuracy-3D-image-based-registration-of-endoscopic-video-to/10.1117/12.877803.short|publisher=International Society for Optics and Photonics|volume=7964|pages=79640J|doi=10.1117/12.877803}}
• Cone beam computed tomography (CBCT) systems for imaging of the weight-bearing foot, ankle, and knee with high spatial resolution and low radiation dose.{{Cite news|url=https://hub.jhu.edu/2016/10/27/jeff-siewerdsen-standing-ct-machine/|title=A stand-up CT machine: Weight-bearing scanner developed at Johns Hopkins wins industry accolade|date=2016-10-27|work=The Hub|access-date=2017-11-12|language=en}}
• Cone beam computed tomography (CBCT) systems for image-guided radiation therapy (IGRT).{{Cite journal|last=Jaffray|first=David A.|last2=Siewerdsen|first2=Jeffrey H.|last3=Wong|first3=John W.|last4=Martinez|first4=Alvaro A.|date=2002-08-01|title=Flat-panel cone-beam computed tomography for image-guided radiation therapy|url=https://www.ncbi.nlm.nih.gov/pubmed/12128137|journal=International Journal of Radiation Oncology, Biology, Physics|volume=53|issue=5|pages=1337–1349|issn=0360-3016|pmid=12128137}}
• Cone beam computed tomography (CBCT) systems for high-quality, low-dose imaging of intracranial hemorrhage.{{Cite journal|last=Xu|first=Jennifer|last2=Sisniega|first2=Alejandro|last3=Zbijewski|first3=Wojciech|last4=Dang|first4=Hao|last5=Stayman|first5=J. Webster|last6=Mow|first6=Michael|last7=Wang|first7=Xiaohui|last8=Foos|first8=David H.|last9=Koliatsos|first9=Vassillis E.|date=October 2016|title=Technical assessment of a prototype cone-beam CT system for imaging of acute intracranial hemorrhage|url=https://www.ncbi.nlm.nih.gov/pubmed/27782694|journal=Medical Physics|volume=43|issue=10|pages=5745|doi=10.1118/1.4963220|issn=2473-4209|pmid=27782694}}
• Influence of x-ray Compton scattering in cone beam computed tomography (CBCT).{{Cite journal|last=Siewerdsen|first=Jeffrey H.|last2=Jaffray|first2=David A.|date=2001-02-01|title=Cone-beam computed tomography with a flat-panel imager: Magnitude and effects of x-ray scatter|url=http://onlinelibrary.wiley.com/doi/10.1118/1.1339879/abstract|journal=Medical Physics|language=en|volume=28|issue=2|pages=220–231|doi=10.1118/1.1339879|issn=2473-4209}}
• Image registration methods for minimally invasive spine surgery.{{Cite journal|last=Reaungamornrat|first=S.|last2=Silva|first2=T. De|last3=Uneri|first3=A.|last4=Vogt|first4=S.|last5=Kleinszig|first5=G.|last6=Khanna|first6=A. J.|last7=Wolinsky|first7=J. P.|last8=Prince|first8=J. L.|last9=Siewerdsen|first9=J. H.|date=November 2016|title=MIND Demons: Symmetric Diffeomorphic Deformable Registration of MR and CT for Image-Guided Spine Surgery|url=http://ieeexplore.ieee.org:80/document/7484313/?reload=true|journal=IEEE Transactions on Medical Imaging|volume=35|issue=11|pages=2413–2424|doi=10.1109/TMI.2016.2576360|issn=0278-0062}}{{Cite journal|last=Otake|first=Yoshito|last2=Wang|first2=Adam S|last3=Stayman|first3=J Webster|last4=Uneri|first4=Ali|last5=Kleinszig|first5=Gerhard|last6=Vogt|first6=Sebastian|last7=Khanna|first7=A Jay|last8=Gokaslan|first8=Ziya L|last9=Siewerdsen|first9=Jeffrey H|title=Robust 3D–2D image registration: application to spine interventions and vertebral labeling in the presence of anatomical deformation|url=http://stacks.iop.org/0031-9155/58/i=23/a=8535?key=crossref.f24fda6a69c24e7692a06ab547672ff2|journal=Physics in Medicine and Biology|volume=58|issue=23|pages=8535–8553|doi=10.1088/0031-9155/58/23/8535}}{{Cite journal|last=Uneri|first=A|last2=Silva|first2=T De|last3=Stayman|first3=J W|last4=Kleinszig|first4=G|last5=Vogt|first5=S|last6=Khanna|first6=A J|last7=Gokaslan|first7=Z L|last8=Wolinsky|first8=J-P|last9=Siewerdsen|first9=J H|title=Known-component 3D–2D registration for quality assurance of spine surgery pedicle screw placement|url=http://stacks.iop.org/0031-9155/60/i=20/a=8007?key=crossref.39a5f0888f103ba99184b436508cab39|journal=Physics in Medicine and Biology|volume=60|issue=20|pages=8007–8024|doi=10.1088/0031-9155/60/20/8007}}
• Image registration methods for otolaryngology-head and neck surgery.{{Cite journal|last=Nithiananthan|first=Sajendra|last2=Schafer|first2=Sebastian|last3=Uneri|first3=Ali|last4=Mirota|first4=Daniel J.|last5=Stayman|first5=J. Webster|last6=Zbijewski|first6=Wojciech|last7=Brock|first7=Kristy K.|last8=Daly|first8=Michael J.|last9=Chan|first9=Harley|date=2011-04-01|title=Demons deformable registration of CT and cone-beam CT using an iterative intensity matching approach|url=http://onlinelibrary.wiley.com/doi/10.1118/1.3555037/abstract|journal=Medical Physics|language=en|volume=38|issue=4|pages=1785–1798|doi=10.1118/1.3555037|issn=2473-4209}}{{Cite journal|last=Nithiananthan|first=Sajendra|last2=Schafer|first2=Sebastian|last3=Mirota|first3=Daniel J.|last4=Stayman|first4=J. Webster|last5=Zbijewski|first5=Wojciech|last6=Reh|first6=Douglas D.|last7=Gallia|first7=Gary L.|last8=Siewerdsen|first8=Jeffrey H.|date=2012-09-01|title=Extra-dimensional Demons: A method for incorporating missing tissue in deformable image registration|url=http://onlinelibrary.wiley.com/doi/10.1118/1.4747270/abstract|journal=Medical Physics|language=en|volume=39|issue=9|pages=5718–5731|doi=10.1118/1.4747270|issn=2473-4209}}
• Mathematical models of 3D imaging performance in cone beam computed tomography (CBCT).{{Cite journal|last=Gang|first=G. J.|last2=Tward|first2=D. J.|last3=Lee|first3=J.|last4=Siewerdsen|first4=J. H.|date=2010-05-01|title=Anatomical background and generalized detectability in tomosynthesis and cone-beam CT|url=http://onlinelibrary.wiley.com/doi/10.1118/1.3352586/abstract|journal=Medical Physics|language=en|volume=37|issue=5|pages=1948–1965|doi=10.1118/1.3352586|issn=2473-4209}}{{Cite journal|last=Tward|first=Daniel J.|last2=Siewerdsen|first2=Jeffrey H.|date=2008-12-01|title=Cascaded systems analysis of the 3D noise transfer characteristics of flat-panel cone-beam CT|url=http://onlinelibrary.wiley.com/doi/10.1118/1.3002414/abstract|journal=Medical Physics|language=en|volume=35|issue=12|pages=5510–5529|doi=10.1118/1.3002414|issn=2473-4209}}
• Mathematical models of spectral imaging performance for photon counting x-ray detectors.{{Cite journal|last=Xu|first=J.|last2=Zbijewski|first2=W.|last3=Gang|first3=G.|last4=Stayman|first4=J. W.|last5=Taguchi|first5=K.|last6=Lundqvist|first6=M.|last7=Fredenberg|first7=E.|last8=Carrino|first8=J. A.|last9=Siewerdsen|first9=J. H.|date=2014-10-01|title=Cascaded systems analysis of photon counting detectors|url=http://onlinelibrary.wiley.com/doi/10.1118/1.4894733/abstract|journal=Medical Physics|language=en|volume=41|issue=10|pages=n/a–n/a|doi=10.1118/1.4894733|issn=2473-4209}}
• Mathematical models of 2D imaging performance for flat-panel detectors.{{Cite journal|last=Siewerdsen|first=Jeffrey H.|date=1998-11-01|title=Signal, noise, and detective quantum efficiency of a-Si:H flat-panel imagers|url=http://onlinelibrary.wiley.com/doi/10.1118/1.598427/abstract|journal=Medical Physics|language=en|volume=25|issue=11|pages=2250–2250|doi=10.1118/1.598427|issn=2473-4209}}{{Cite journal|last=Siewerdsen|first=J. H.|last2=Cunningham|first2=I. A.|last3=Jaffray|first3=D. A.|date=2002-11-01|title=A framework for noise-power spectrum analysis of multidimensional images|url=http://onlinelibrary.wiley.com/doi/10.1118/1.1513158/abstract|journal=Medical Physics|language=en|volume=29|issue=11|pages=2655–2671|doi=10.1118/1.1513158|issn=2473-4209}}
• Software tools for x-ray spectrum modeling (spektr).{{Cite journal|last=Siewerdsen|first=J. H.|last2=Waese|first2=A. M.|last3=Moseley|first3=D. J.|last4=Richard|first4=S.|last5=Jaffray|first5=D. A.|date=November 2004|title=Spektr: a computational tool for x-ray spectral analysis and imaging system optimization|url=https://www.ncbi.nlm.nih.gov/pubmed/15587659|journal=Medical Physics|volume=31|issue=11|pages=3057–3067|doi=10.1118/1.1758350|issn=0094-2405|pmid=15587659}}{{Cite journal|last=Punnoose|first=J.|last2=Xu|first2=J.|last3=Sisniega|first3=A.|last4=Zbijewski|first4=W.|last5=Siewerdsen|first5=J. H.|date=2016-08-01|title=Technical Note: spektr 3.0—A computational tool for x-ray spectrum modeling and analysis|url=http://onlinelibrary.wiley.com/doi/10.1118/1.4955438/abstract|journal=Medical Physics|language=en|volume=43|issue=8Part1|pages=4711–4717|doi=10.1118/1.4955438|issn=2473-4209}}

Membership and volunteerism in the biomedical engineering], [[physics, and medical physics communities include:

• AAPM - Member, Science Council Chair, Scientific Program Director.
• AIMBE{{Cite web|url=http://aimbe.org/college-of-fellows/about/|title=About the College - AIMBE|website=aimbe.org|language=en|access-date=2017-11-12}} - Member, College of Fellows.
• SPIE - Medical Imaging Symposium: Program Committees.
• RSNA - Liaison to the Scientific Program Committee.
• North American Spine Society (NASS) - Member, Section on Radiology, Section on Robotics and Navigation.
• American Physical Society (APS) - Member and Program Chair for the Topic Group of Medical Physics (GMED).

Board Member and other Advisory appointments include:

• (2013 - 2017) - AAPM Board Member
• (2016 - ) - Carestream Health Advisory Board
• (2010 - 2016) - Carestream Health Medical Advisory Board
• (2014 - 2016) - Siemens Advisory Group on Surgery
• (2011 - 2012) - Siemens Advisory Group on Image-Guided Surgery

{{Reflist}}

• Johns Hopkins Biomedical Engineering: Pioneering in Medical Imaging.
• [https://www.youtube.com/watch?v=QGJ2dVmIaXE] DASER Seminar: Images are Numbers.
• [https://www.aapm.org/education/VL/vl.asp?id=2052] AAPM Lecture: C-Arm Cone-Beam CT.
• [https://www.aapm.org/education/VL/vl.asp?id=208] AAPM Lecture: C-arm Computed Tomography.
• [https://vimeo.com/88174889] AAPM Lecture: Image-Guided Therapies.
• [https://www.aapm.org/education/VL/vl.asp?id=3750] AAPM President's Symposium: Innovation in Medical Physics.
• [https://www.aapm.org/education/VL/vl.asp?id=11340] AAPM Lecture: Image-Guided Surgery