Wellcome Centre for Human Genetics
{{Short description|Research Institute at the University of Oxford}}
{{Use dmy dates|date=March 2021}}
{{Infobox institute
| image = Logo of the Wellcome Center for Human Genetics.png
| established = {{start date and age|1994}}
| head_label = Director
| head = Holm Uhlig https://www.chg.ox.ac.uk/about-us
| key_people = Yvonne Jones (deputy director)
| parent = University of Oxford
Wellcome Trust
| affiliations =
| budget =
| remarks =
| name = Centre for Human Genetics
| location = Henry Wellcome Building of Genomic Medicine, Oxford
| staff = 470
| num_volunteers =
| website = {{URL|https://www.chg.ox.ac.uk/}}
| former_name = Wellcome Trust Center for Human Genetics
| coordinates = {{coord|51.752248|-1.215255|region:GB-OXF|display=inline,title}}
}}
The Centre for Human Genetics (CHG) is a human genetics research centre of the Nuffield Department of Medicine in the Medical Sciences Division, University of Oxford, funded by the Wellcome Trust among others.{{cite web|url=http://www.well.ox.ac.uk/about-us/|title=Welcome to the WHG|publisher=well.ox.ac.uk|access-date=21 November 2018}}
Facilities & resources
The centre is located at the Henry Wellcome Building of Genomic Medicine, which cost £20 million and was officially opened in June 2000 with Anthony Monaco as the director.{{cite news|url=http://www.timeshighereducation.co.uk/story.asp?storyCode=152220|title=Vanguard digs deep into data at Oxford|last=Farrar|first=Steve|access-date=19 December 2011|publisher=Times Higher Education|year=2000}} {{dead link|date=July 2017}}{{Cite journal|last1=Ramagopalan|first1=S. V.|year=2008|title=Life on top—working@ the Wellcome Trust Centre for Human Genetics: Scotland Yard for DNA detectives|journal=New Biotechnology|volume=25|issue=1|pages=39–45|doi=10.1016/j.nbt.2008.04.007|pmid=18504015}}
Within the CHG a number of 'cores' provide services to the researchers:
= Oxford Genomics Centre =
The Oxford Genomics Centre provides high throughput sequencing services, using Illumina HiSeq4000 2500 and NextSeq500 and MiSeq.{{Cite news|url=http://www.well.ox.ac.uk/ogc/expertise/sequencing/|title=Sequencing - Oxford Genomics Centre|work=Oxford Genomics Centre|access-date=2017-12-01|language=en-GB}} They also offer Oxford Nanopore MinION and PromethION sequencing. There are also Array platforms for genotyping, gene expression, and methylation including Illuminia Infinium, Affymetrix and Fluidigm.{{Cite news|url=http://www.well.ox.ac.uk/ogc/expertise/arrays/|title=Arrays - Oxford Genomics Centre|work=Oxford Genomics Centre|access-date=2017-12-01|language=en-GB}}
= Research Computing Core =
The Research Computing Core provides access to computer resources including 4120 cores and 4.2 PB of storage.{{Citation|last=DDN Storage|title=Making high-performance compute appropriate to population-scale biomedical data|date=2016-11-02|url=https://www.youtube.com/watch?v=_3GGSvcr2D0|access-date=2017-12-01}}
= Transgenics =
The Transgenics Core provides access to genetically modified mice and cell lines.{{Cite web|url=http://www.well.ox.ac.uk/transgenics|title=Transgenics Core|access-date=2017-12-01}}
= Cellular Imaging =
Cellular Imaging Core provides microscopy facilities including fluorescence microscopy (including Fluorescence Correlation Spectroscopy (FCS), Fluorescence Lifetime Correlation Spectroscopy (FLCS), Fluorescence Lifetime Imaging Microscopy (FLIM), Total Internal Reflection Fluorescence Microscopy (TIRF), Photoactivated Localisation Microscopy (PALM), Spectral Imaging (SI) and Single Particle Tracking (SPT).{{Cite web|url=http://www.well.ox.ac.uk/cellular-imaging|title=Cellular Imaging - Wellcome Trust Centre for Human Genetics|website=www.well.ox.ac.uk|access-date=2017-12-01}}
Research
= Statistical and population genetics =
The CHG has been involved in many international statistical genetics advances including the Wellcome Trust Case Control Consortia (WTCCC, WTCCC2), the 1000 Genomes Project and the International HapMap Project.{{Cite web|url=http://www.well.ox.ac.uk/research-areas|title=Research areas - Wellcome Trust Centre for Human Genetics|website=www.well.ox.ac.uk|access-date=2017-12-01}}
References
{{reflist}}
{{Wellcome Trust|state=expanded}}
{{University of Oxford}}
{{authority control}}
Category:1994 establishments in England
Category:Biotechnology in the United Kingdom
Category:Departments of the University of Oxford
Category:Educational institutions established in 1994
Category:Genetics in the United Kingdom
Category:Genetics or genomics research institutions
Category:Research institutes in Oxford