Xiyanping

{{Short description|Chemical compound}}

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| IUPAC_name = 9-dehydro-17-hydro-andrographolide and sodium 9-dehydro-17-hydro-andrographolide-19-yl sulfate

| image = Xiyanping_structure.png

| width = 280

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| CAS_number = 1418130-80-9 

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| CAS_number2 = 1443513-92-5

| UNII_Ref = {{fdacite|correct|FDA}}

| UNII = R4JE0B5I4U 

| UNII2_Ref = {{fdacite|correct|FDA}}

| UNII2 = Z5RVW4Z10Q

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Xiyanping (喜炎平) is an anti-inflammatory and antiviral preparation developed and licensed for use in China. It is a semi-synthetic injectable product derived from the active component of the plant Andrographis paniculata (Chuan Xin Lian, 穿心蓮),{{cite journal | vauthors = Xiao XW, Fu HZ, Luo YH, Wei XY | title = Potential anti-angiogenic sulfates of andrographolide | journal = Journal of Asian Natural Products Research | volume = 15 | issue = 8 | pages = 809–18 | date = 2013 | pmid = 23777373 | doi = 10.1080/10286020.2013.803473 | s2cid = 42522012 }} which is used in Traditional Chinese medicine.{{cite book | vauthors = Chen JK, Chen TT | title = Chinese Medical Herbology and Pharmacology | chapter = Chapter 2, Chuan Xin Lian | pages = 214–215 | publisher = Art of Medicine Press | date = 2012 | isbn = 978-0-9740635-0-8 }} Xiyanping is primarily composed of 9-dehydro-17-hydro-andrographolide and sodium 9-dehydro-17-hydro-andrographolide-19-yl sulfate.{{cite journal | vauthors = Chong L, Chen W, Luo Y, Jiang Z | title = Simultaneous determination of 9-dehydro-17-hydro-andrographolide and sodium 9-dehydro-17-hydro-andrographolide-19-yl sulfate in rat plasma by UHPLC-ESI-MS/MS after administration of xiyanping injection: application to a pharmacokinetic study | journal = Biomedical Chromatography| volume = 27 | issue = 7 | pages = 825–30 | date = July 2013 | pmid = 23355108 | doi = 10.1002/bmc.2866 }} It is used mainly in the treatment of hand, foot and mouth disease, diarrhea, upper respiratory tract infections and viral pneumonia,{{cite journal | vauthors = Zhang P, Xu H, Ling L, Wu X | title = Meta analysis of the efficacy of Xiyanping injection in the treatment of autumnal diarrhea in children. | journal = Pharmaceutical Care and Research | date = 2012 | volume = 12 | issue = 5 | pages = 349–353 | doi = 10.5428/pcar20120511 | doi-broken-date = 2024-11-02 }}{{cite journal | vauthors = Wang J, Ren JX, Xie YM, Wang WW, Hu J, Liao X | title = [Systematic review of xiyanping injection for hand foot mouth disease] | language = zh | journal = Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica | volume = 38 | issue = 18 | pages = 3215–22 | date = September 2013 | pmid = 24471354 }}{{cite journal | vauthors = Wang ZF, Chen X, Zhang W, Xie YM | title = [Literature review on premarketing and postmarketing evidence of xiyanping injection] | language = zh | journal = Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica | volume = 39 | issue = 18 | pages = 3637–40 | date = September 2014 | pmid = 25532411 }}Sun SG, Shi YF, Yan H, Li Y, Wang R, Wang SH, Sun XD. Xiyanping Injection in Treatment of Viral Pneumonia in Children: A Meta-analysis of Random Control Trials. Chinese Herbal Medicines. 2015 May; 7(2):173-178. doi: 10.1016/S1674-6384(15)60035-1 though one case report suggested it may also be useful in the treatment of Zika fever.{{cite journal | vauthors = Deng Y, Zeng L, Bao W, Xu P, Zhong G | title = [Experience of integrated traditional Chinese and Western medicine in first case of imported Zika virus disease in China] | language = zh | journal = Zhonghua Wei Zhong Bing Ji Jiu Yi Xue | volume = 28 | issue = 2 | pages = 106–9 | date = February 2016 | pmid = 26911940 | doi = 10.3760/cma.j.issn.2095-4352.2016.02.005 }}