cephamycin

File:Cephamycin core structure.svg

Cephamycins are a group of β-lactam antibiotics. They are very similar to cephalosporins, and the cephamycins are sometimes classified as cephalosporins.

Like cephalosporins, cephamycins are based upon the cephem nucleus. Unlike most cephalosporins, cephamycins are a very efficient antibiotic against anaerobic microbes.{{cn|date=January 2023}}

Cephamycins were originally produced by Streptomyces, but synthetic ones have been produced as well.{{cn|date=January 2023}}

Cephamycins possess a methoxy group at the 7-alpha position.{{cite book |author=Oreste A. Mascaretti |title=Bacteria Versus Antibacterial Agents: An Integrated Approach |publisher=American Society Microbiology |year=2003 |pages=144 |isbn=1-55581-258-9 }}

In addition, cephamycins have been shown to be stable against extended-spectrum beta-lactamase (ESBL) producing organisms, although their use in clinical practice is lacking for this indication.{{cn|date=January 2023}}

Examples

Cephamycins include:

Cefoxitin{{cite journal |vauthors=Little PJ, Peddie BA |title=Clinical use of cefoxitin, a new semisynthetic cephamycin |journal=N. Z. Med. J. |volume=88 |issue=616 |pages=46–9 |date=July 1978 |pmid=279853 }}
Cefotetan{{cite journal |vauthors=Clarke AM, Zemcov SJ |title=Antibacterial activity of the cephamycin cefotetan: an in-vitro comparison with other beta-lactam antibiotics |journal=J. Antimicrob. Chemother. |volume=Suppl |pages=67–72 |series=11 |date=January 1983 |pmid=6404881 |doi= 10.1093/jac/11.suppl_A.67}}
Cefmetazole{{cite journal |vauthors=Benlloch M, Torres A, Soriano F |title=Cefmetazole (CS-1170): a new cephamycin with activity against gram-negative bacilli and staphylococci |journal=J. Antimicrob. Chemother. |volume=10 |issue=4 |pages=347–50 |date=October 1982 |pmid=6958672 |doi= 10.1093/jac/10.4.347|doi-access=free }}

References

Category:Cephalosporin antibiotics