daf-7

{{Infobox nonhuman protein

| Name = abnormal dauer formation protein 7

| image =

| width =

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| Organism = Caenorhabditis elegans

| TaxID = 6239

| Symbol = daf-7

| AltSymbols =

| EntrezGene = 175237

| HomoloGene = 21183

| PDB =

| RefSeqmRNA = NM_064864.5

| RefSeqProtein = NP_497265.1

| UniProt = P92172

| Chromosome = III

| EntrezChromosome = NC_003281.10

| GenLoc_start = 811828

| GenLoc_end = 813773

}}

The DAF-7 gene encodes for the ortholog of GDF11, a ligand of TGF-beta signaling pathway, in the worm Caenorhabditis elegans.{{cite journal | vauthors = Morita K, Shimizu M, Shibuya H, Ueno N | title = A DAF-1-binding protein BRA-1 is a negative regulator of DAF-7 TGF-beta signaling | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 98 | issue = 11 | pages = 6284–8 | date = May 2001 | pmid = 11353865 | doi = 10.1073/pnas.111409798 | pmc = 33460 | bibcode = 2001PNAS...98.6284M | doi-access = free }} When binds to the complex of type II receptor Daf-4 and type I receptor Daf-1, this receptor protein serine/threonine kinase will phosphorylation activate the Smad Protein Daf-8/14.{{cite journal | vauthors = Krishna S, Maduzia LL, Padgett RW | title = Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans | journal = Development | volume = 126 | issue = 2 | pages = 251–60 | date = January 1999 | doi = 10.1242/dev.126.2.251 | pmid = 9847239 | s2cid = 2460114 }}