Daf-14

{{More citations needed|date=July 2020}}

{{Infobox nonhuman protein

| Name = MH2 domain-containing protein

| image =

| width =

| caption =

| Organism = Caenorhabditis elegans

| TaxID = 6239

| Symbol = daf-14

| AltSymbols =

| EntrezGene = 177908

| HomoloGene =

| PDB =

| RefSeqmRNA = NM_001268546.3

| RefSeqProtein = NP_001255475.1

| UniProt = G5EEP2

| Chromosome = IV

| EntrezChromosome = NC_003282.8

| GenLoc_start = 10250646

| GenLoc_end = 10255844

}}

The DAF-14 is a gene of the nematode Caenorhabditis elegans encoding a R-SMAD protein of TGF-beta signaling pathway, which will be phosphorylated and forms a heterodimer with phosphorylated daf-8 when the TGF-β ligand daf-7 binds to the TGF-β receptors daf-1/daf-4, then the heterodimer enter to the nucleus to inhibit transcription regulated by daf-3/daf-5.{{cite journal | vauthors = Gumienny TL, Savage-Dunn C | title = TGF-β signaling in C. elegans | journal = WormBook | pages = 1–34 | date = July 2013 | pmid = 23908056 | doi = 10.1895/wormbook.1.22.2 | pmc = 5081272 }}