glomerulopathy

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Glomerulopathy is a disease that impacts the glomeruli in the nephron, either inflammatory or noninflammatory.{{cite web | title=Monarch Initiative | website=monarchinitiative.org |url=https://monarchinitiative.org/HP:0100820 | access-date=January 7, 2024}} Glomerulopathy includes collapsing glomerulopathy, glomerulocystic kidney disease, glomerulomegaly, membranous nephropathy, and tip lesion glomerulopathy.{{cite web | title=Glomerulopathy (Concept Id: C0268731) | website=NCBI | date=October 31, 2023 |url=https://www.ncbi.nlm.nih.gov/medgen/451033 | access-date=January 7, 2024}}

Collapsing glomerulopathy (CG) is a clinicopathologic entity that involves hypertrophy and hyperplasia of podocytes and segmentar or global collapse of the glomerulus.{{cite journal | last1=Cutrim | first1=Érico Murilo Monteiro | last2=Neves | first2=Precil Diego Miranda de Meneses | last3=Campos | first3=Marcos Adriano Garcia | last4=Wanderley | first4=Davi Campos | last5=Teixeira-Júnior | first5=Antonio Augusto Lima | last6=Muniz | first6=Monique Pereira Rêgo | last7=Ladchumananandasivam | first7=Francisco Rasiah | last8=Gomes | first8=Orlando Vieira | last9=Vasco | first9=Rafael Fernandes Vanderlei | last10=Brito | first10=Dyego José de Araújo | last11=Lages | first11=Joyce Santos | last12=Salgado-Filho | first12=Natalino | last13=Guedes | first13=Felipe Leite | last14=de Almeida | first14=José Bruno | last15=Magalhães | first15=Marcelo | last16=Araújo | first16=Stanley de Almeida | last17=Silva | first17=Gyl Eanes Barros | title=Collapsing Glomerulopathy: A Review by the Collapsing Brazilian Consortium | journal=Frontiers in Medicine | publisher=Frontiers Media SA | volume=9 | date=March 3, 2022 | issn=2296-858X | doi=10.3389/fmed.2022.846173 | doi-access=free | page=| pmid=35308512 | pmc=8927620 }}

Glomerulocystic kidney disease is a rare form of renal cyst disease. Cortical microcysts, which are portrayed by cystic dilatation of Bowman's spaces, are its defining feature.{{cite journal | last1=Sahay | first1=M. | last2=Gowrishankar | first2=S. | title=Glomerulocystic disease | journal=Clinical Kidney Journal | publisher=Oxford University Press (OUP) | volume=3 | issue=4 | date=April 13, 2010 | issn=2048-8505 | doi=10.1093/ndtplus/sfq048 | pages=349–350 | doi-access=free| pmid=25949428 }}

Glomerulomegaly is defined by unusually large glomeruli.{{cite journal | last1=Hughson | first1=M. D. | last2=Hoy | first2=W. E. | last3=Douglas-Denton | first3=R. N. | last4=Zimanyi | first4=M. A. | last5=Bertram | first5=J. F. | title=Towards a definition of glomerulomegaly: clinical-pathological and methodological considerations | journal=Nephrology Dialysis Transplantation | publisher=Oxford University Press (OUP) | volume=26 | issue=7 | date=November 29, 2010 | issn=0931-0509 | doi=10.1093/ndt/gfq688 | pages=2202–2208 | doi-access=free| pmid=21115671 | pmc=3164445 }}

Membranous nephropathy (MN) is an uncommon autoimmune condition in which autoantibodies directed primarily against podocyte antigens target the glomerulus, causing electron-dense immune complexes to form, complement activation to occur, and severe proteinuria.{{cite journal | last1=Ronco | first1=Pierre | last2=Plaisier | first2=Emmanuelle | last3=Debiec | first3=Hanna | title=Advances in Membranous Nephropathy | journal=Journal of Clinical Medicine | publisher=MDPI AG | volume=10 | issue=4 | date=February 5, 2021 | issn=2077-0383 | doi=10.3390/jcm10040607 | doi-access=free | page=607| pmc=7915386 }}

The glomerular tip lesion (GTL) is a unique histopathologic lesion that appears in idiopathic nephrotic syndrome patients.{{cite journal | last1=Stokes | first1=M. Barry | last2=Markowitz | first2=Glen S. | last3=Lin | first3=Julie | last4=Valeri | first4=Anthony M. | last5=D'Agati | first5=Vivette D. | title=Glomerular tip lesion: A distinct entity within the minimal change disease/focal segmental glomerulosclerosis spectrum | journal=Kidney International | publisher=Elsevier BV | volume=65 | issue=5 | year=2004 | issn=0085-2538 | doi=10.1111/j.1523-1755.2004.00563.x | pages=1690–1702| pmid=15086908 | doi-access=free }}