mBOAT

{{Short description|Family of various acyltransferase enzymes}}

{{Infobox protein family

| Symbol = MBOAT

| Name = MBOAT

| image =

| width =

| caption =

| Pfam = PF03062

| Pfam_clan = CL0517

| InterPro = IPR004299

| SMART =

| PROSITE =

| MEROPS =

| SCOP =

| TCDB =

| OPM family =

| OPM protein =

| CAZy =

| CDD =

}}

{{Infobox protein family

| Symbol = MBOAT_2

| Name = MBOAT_2

| image =

| width =

| caption =

| Pfam = PF13813

| Pfam_clan = CL0517

| InterPro =

| SMART =

| PROSITE =

| MEROPS =

| SCOP =

| TCDB =

| OPM family =

| OPM protein =

| CAZy =

| CDD =

}}

The MBOAT (membrane bound O-acyl transferase) family of membrane proteins is a family of various acyltransferase enzymes. All family members contain multiple transmembrane domains and most carry two conserved residues, a conserved histidine (His) embedded in a hydrophobic stretch of residues and an asparagine (Asn) or histidine within a more hydrophilic region some 30-50 residues upstream.{{cite journal | author = Hofmann K | title = A superfamily of membrane-bound O-acyltransferases with implications for wnt signaling | journal = Trends Biochem. Sci. | volume = 25 | issue = 3 | pages = 111–2 |date=March 2000 | pmid = 10694878 | doi = 10.1016/s0968-0004(99)01539-x}}

MBOAT enzymes catalyze the transfer of an acyl group from an acyl-coenzyme or accessory protein to one of several different substrates. The family is found from bacteria to eukaryotes.{{Cite journal|last=Chang, C.C.Y., Sun, J. & Chang, TY.|date=2011|title=Membrane-bound O-acyltransferases (MBOATs)|journal=Front. Biol.|volume=6|issue=3|pages=177|doi=10.1007/s11515-011-1149-z|s2cid=41626991}}

The family may be grouped into three categories, according to function:

1. enzymes involved in neutral lipid biosynthesis;
2. enzymes involved in protein/peptide acylation;
3. enzymes involved in phospholipid re-modelling.{{cite journal| vauthors =Wang P, Wang Z, Dou Y, Zhang X, Wang M, Tian X| title=Genome-wide identification and analysis of membrane-bound O-acyltransferase (MBOAT) gene family in plants. | journal=Planta | year= 2013 | volume= 238 | issue= 5 | pages= 907–22 | pmid=23928653 | doi=10.1007/s00425-013-1939-4 | bibcode=2013Plant.238..907W | s2cid=1328304 }}