macrodomain

The Escherichia coli chromosome shows two main levels of global organization: macrodomains and replichores. Macrodomains were discovered by cytological studies. They contain loci showing the same intracellular positioning and choreography during the cell cycle.{{cite journal |vauthors=Niki H, Yamaichi Y, Hiraga S |title=Dynamic organization of chromosomal DNA in Escherichia coli |journal=Genes Dev. |volume=14 |issue=2 |pages=212–23 |date=January 2000 |doi=10.1101/gad.14.2.212 |pmid=10652275 |pmc=316355 |url=http://www.genesdev.org/cgi/pmidlookup?view=long&pmid=10652275}}