replichore

The Escherichia coli chromosome shows two main levels of global organization, macrodomains and replichores.{{cite journal |vauthors=Lesterlin C, Mercier R, Boccard F, Barre FX, Cornet F |title=Roles for replichores and macrodomains in segregation of the Escherichia coli chromosome |journal=EMBO Rep. |volume=6 |issue=6 |pages=557–62 |date=June 2005 |pmid=15891766 |pmc=1369093 |doi=10.1038/sj.embor.7400428 |url=}} In E. coli chromosomes, the origin and terminus of replication divide the genome into oppositely replicated halves called replichores. Replichore 1, which is replicated clockwise, has the presented strand of E. coli as its leading strand; in replichore 2 the complementary strand is the leading one. Many features of E. coli are oriented with respect to replication.{{cite journal |vauthors=Blattner FR, Plunkett G, Bloch CA, etal |title=The complete genome sequence of Escherichia coli K-12 |journal=Science |volume=277 |issue=5331 |pages=1453–62 |date=September 1997 |pmid=9278503 |doi=10.1126/science.277.5331.1453 |doi-access=free }}