narnatumab
{{Short description|Monoclonal antibody}}
{{cs1 config|name-list-style=vanc}}
{{Drugbox
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 458283354
| type = mab
| image =
| alt =
| mab_type = mab
| source = o
| target = MST1R (aka RON)
| tradename =
| Drugs.com =
| MedlinePlus =
| pregnancy_AU =
| pregnancy_US =
| pregnancy_category=
| legal_AU =
| legal_CA =
| legal_UK =
| legal_US =
| legal_status =
| routes_of_administration =
| bioavailability =
| protein_bound =
| metabolism =
| elimination_half-life =
| excretion =
| CAS_number_Ref = {{cascite|changed|??}}
| CAS_number = 1188275-92-4
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = R42YK40U9M
| ATC_prefix = none
| ATC_suffix =
| PubChem =
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank =
| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}
| ChemSpiderID = none
| KEGG = D10074
| C=6454 | H=10026 | N=1754 | O=2020 | S=44
|drug_name=|caption=|licence_EU=|licence_US=}}
Narnatumab is a human monoclonal antibody designed for the treatment of cancer.{{cite web|title=Statement On A Nonproprietary Name Adopted By The USAN Council: Narnatumab|publisher=American Medical Association|url=http://www.ama-assn.org/resources/doc/usan/narnatumab.pdf | archive-url = https://web.archive.org/web/20120928203005/http://www.ama-assn.org/resources/doc/usan/narnatumab.pdf | archive-date = 28 September 2012 }} Clinical development was abandoned after phase I trials.{{cite web |title= Narnatumumab|url=http://adisinsight.springer.com/drugs/800032136 | work = AdisInsight | publisher = Springer Nature Switzerland AG |access-date=31 January 2017}}{{cite journal | vauthors = LoRusso PM, Gounder M, Jalal SI, André V, Kambhampati SR, Loizos N, Hall J, Holzer TR, Nasir A, Cosaert J, Kauh J, Chiorean EG | display-authors = 6 | title = Phase 1 study of narnatumab, an anti-RON receptor monoclonal antibody, in patients with advanced solid tumors | journal = Investigational New Drugs | volume = 35 | issue = 4 | pages = 442–450 | date = August 2017 | pmid = 28161886 | pmc = 5502198 | doi = 10.1007/s10637-016-0413-0 }}
Narnatumab was developed by ImClone Systems.
References
{{reflist}}
{{monoclonals for tumors}}
Category:Monoclonal antibodies
{{monoclonal-antibody-stub}}
{{antineoplastic-drug-stub}}