normustine

{{Short description|Nitrogen mustard used as a chemotherapy agent}}

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| IUPAC_name = Bis(2-chloroethyl)carbamic acid

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| CAS_number = 78619-95-1

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| PubChem = 18377863

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| UNII = Q2KPX8TH4K

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| C=5 | H=9 | Cl=2 | N=1 | O=2

| SMILES = C(CCl)N(CCCl)C(=O)O

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| StdInChI = 1S/C5H9Cl2NO2/c6-1-3-8(4-2-7)5(9)10/h1-4H2,(H,9,10)

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| StdInChIKey = TTYAKTJQJVVKED-UHFFFAOYSA-N

| synonyms = Bis(2-chloroethyl)carbamic acid

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Normustine, also known as bis(2-chloroethyl)carbamic acid, is a nitrogen mustard and alkylating antineoplastic agent (i.e., chemotherapy agent).{{cite book| vauthors = Brunton L, Chabner B, Knollman B |title=Goodman and Gilman's The Pharmacological Basis of Therapeutics, Twelfth Edition|url=https://books.google.com/books?id=e_yAOpyyaowC|date=14 January 2011|publisher=McGraw Hill Professional|isbn=978-0-07-176939-6|page=1709}}{{cite book| vauthors = Fox BW, Fox M |title=Antitumor Drug Resistance|url=https://books.google.com/books?id=m-TrCAAAQBAJ&pg=PA199|date=6 December 2012|publisher=Springer Science & Business Media|isbn=978-3-642-69490-5|pages=199–}}{{cite book| vauthors = Decker M |title=Design of Hybrid Molecules for Drug Development|url=https://books.google.com/books?id=gfEbDQAAQBAJ&pg=PA201|date=5 April 2017|publisher=Elsevier Science|isbn=978-0-08-101118-8|pages=201–}} It is a metabolite of a number of antineoplastic agents that have been developed for the treatment of tumors, including estramustine phosphate, alestramustine, cytestrol acetate, and ICI-85966 (stilbostat), but only the former of which has actually been marketed.