oxalate decarboxylase

{{infobox enzyme

| Name = oxalate decarboxylase

| EC_number = 4.1.1.2

| CAS_number = 9024-97-9

| GO_code = 0046564

| image = 5hi0.jpg

| width = 270

| caption = Oxalate decarboxylase hexamer, Bacillus subtilis

}}

In enzymology, an oxalate decarboxylase ({{EnzExplorer|4.1.1.2}}) is an oxalate degrading enzyme that catalyzes the chemical reaction

:oxalate + H⁺ $\rightleftharpoons$ formate + CO₂

Thus, the two substrates of this enzyme are oxalate and H⁺, whereas its two products are formate and CO₂.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is oxalate carboxy-lyase (formate-forming). This enzyme is also called oxalate carboxy-lyase. This enzyme participates in glyoxylate and dicarboxylate metabolism.

Structural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1UW8}}, {{PDB link|2UY8}}, {{PDB link|2UY9}}, {{PDB link|2UYA}}, and {{PDB link|2UYB}}.

References

{{cite journal | vauthors = HAYAISHI O, JAKOBY WB, OHMURA E | date = 1956 | title = Enzymatic decarboxylation of oxalic acid | journal = J. Biol. Chem. | volume = 222 | pages = 435–46 | pmid = 13367015 | issue = 1 | doi = 10.1016/S0021-9258(19)50807-9 | doi-access = free }}
{{cite journal | vauthors = Tanner A, Bornemann S | date = 2000 | title = Bacillus subtilis YvrK is an acid-induced oxalate decarboxylase | journal = J. Bacteriol. | volume = 182 | pages = 5271–3 | pmid = 10960116 | doi = 10.1128/JB.182.18.5271-5273.2000 | issue = 18 | pmc = 94680 }}
{{cite journal | vauthors = Tanner A, Bowater L, Fairhurst SA, Bornemann S | date = 2001 | title = Oxalate decarboxylase requires manganese and dioxygen for activity Overexpression and characterization of Bacillus subtilis YvrK and YoaN | journal = J. Biol. Chem. | volume = 276 | pages = 43627–34 | pmid = 11546787 | doi = 10.1074/jbc.M107202200 | issue = 47 | doi-access = free }}

Category:EC 4.1.1

Category:Enzymes of known structure