oxalate oxidase
{{infobox enzyme
| Name = oxalate oxidase
| EC_number = 1.2.3.4
| CAS_number = 9031-79-2
| GO_code = 0050162
| image = 2ete.jpg
| width = 270
| caption = Oxalate oxidase 1 dimer, Barley
}}
In enzymology, an oxalate oxidase ({{EC number|1.2.3.4}}) is an oxalate degrading enzyme that catalyzes the chemical reaction:
:oxalate + O2 + 2 H+ 2 CO2 + H2O2
The 3 substrates of this enzyme are oxalate, O2, and H+, whereas its two products are CO2 and H2O2.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with oxygen as acceptor. The systematic name of this enzyme class is oxalate:oxygen oxidoreductase. Other names in common use include aero-oxalo dehydrogenase, and oxalic acid oxidase. This enzyme participates in glyoxylate and dicarboxylate metabolism. It uses Manganese as a cofactor.
Structural studies
As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1FI2}}, {{PDB link|2ET1}}, {{PDB link|2ET7}}, and {{PDB link|2ETE}}.
References
{{reflist|1}}
- {{cite journal | vauthors = DATTA PK, MEEUSE BJ | date = 1955 | title = Moss oxalic acid oxidase-a flavoprotein | journal = Biochim. Biophys. Acta | volume = 17 | pages = 602–3 | pmid = 13250021 | doi = 10.1016/0006-3002(55)90436-4 | issue = 4 | doi-access = free }}
- {{cite journal | vauthors = Kotsira VP, Clonis YD | date = 1997 | title = Oxalate oxidase from barley roots: purification to homogeneity and study of some molecular, catalytic, and binding properties | journal = Arch. Biochem. Biophys. | volume = 340 | pages = 239–49 | pmid = 9143327 | doi = 10.1006/abbi.1997.9896 | issue = 2 }}
- {{cite journal | vauthors = Requena L, Bornemann S | date = 1999 | title = Barley (Hordeum vulgare) oxalate oxidase is a manganese-containing enzyme | journal = Biochem. J. | volume = 343 |issue=Pt 1 | pages = 185–90 | doi = 10.1042/bj3430185 | pmid = 10493928 | pmc = 1220540}}
{{Aldehyde/Oxo oxidoreductases}}
{{Enzymes}}
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Category:Enzymes of known structure
{{1.2-enzyme-stub}}