phenylbutynamine

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| class = Norepinephrine–dopamine releasing agent

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| PubChem = 15728382

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| ChemSpiderID = 28566744

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| synonyms = 4-Phenylbut-3-yn-2-amine; PAL-874; PAL874

| IUPAC_name = 4-phenylbut-3-yn-2-amine

| C=10 | H=11 | N=1

| SMILES = CC(C#CC1=CC=CC=C1)N

| StdInChI = 1S/C10H11N/c1-9(11)7-8-10-5-3-2-4-6-10/h2-6,9H,11H2,1H3

| StdInChIKey = CBRPSVDSBGTOKK-UHFFFAOYSA-N

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Phenylbutynamine (4-phenylbut-3-yn-2-amine; development code PAL-874) is a monoamine releasing agent (MRA) of the arylalkylamine family related to β-phenethylamine and amphetamine.{{cite journal | vauthors = Rothman RB, Partilla JS, Baumann MH, Lightfoot-Siordia C, Blough BE | title = Studies of the biogenic amine transporters. 14. Identification of low-efficacy "partial" substrates for the biogenic amine transporters | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 341 | issue = 1 | pages = 251–262 | date = April 2012 | pmid = 22271821 | pmc = 3364510 | doi = 10.1124/jpet.111.188946 }} It acts as a norepinephrine–dopamine releasing agent (NDRA), albeit with far lower potency than β-phenethylamine or amphetamine.{{cite book | vauthors = Blough B | chapter = Dopamine-releasing agents | veditors = Trudell ML, Izenwasser S | title = Dopamine Transporters: Chemistry, Biology and Pharmacology | pages = 305–320 | date = July 2008 | isbn = 978-0-470-11790-3 | oclc = 181862653 | ol = OL18589888W | publisher = Wiley | location = Hoboken [NJ] | doi = | url = https://books.google.com/books?id=QCagLAAACAAJ | chapter-url = https://bitnest.netfirms.com/external/Books/Dopamine-releasing-agents_c11.pdf }}