pyrimidodiazepine synthase

{{infobox enzyme

| Name = pyrimidodiazepine synthase

| EC_number = 1.5.4.1

| CAS_number = 93586-06-2

| GO_code = 0004734

| image =

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| caption =

}}

In enzymology, a pyrimidodiazepine synthase ({{EC number|1.5.4.1}}) is an enzyme that catalyzes the chemical reaction

:a pyrimidodiazepine + glutathione disulfide + H₂O $\backslash rightleftharpoons$ 6-pyruvoyltetrahydropterin + 2 glutathione

The 3 substrates of this enzyme are pyrimidodiazepine, glutathione disulfide, and H₂O, whereas its two products are 6-pyruvoyltetrahydropterin and glutathione.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with a disulfide as acceptor. The systematic name of this enzyme class is pyrimidodiazepine:glutathione-disulfide oxidoreductase (ring-opening, cyclizing). Other names in common use include PDA synthase, pyrimidodiazepine:oxidized-glutathione oxidoreductase (ring-opening,, and cyclizing). This enzyme participates in glutathione metabolism.