tubular carcinoma
{{short description|Type of breast cancer}}
File:Histopathology of tubular carcinoma, low magnification.jpg
File:Histopathology of tubular carcinoma, high magnification.jpg
Tubular carcinoma is a subtype of invasive ductal carcinoma of the breast.{{cite web |last=Hudis |first=Kenneth |title=IDC Type: Tubular Carcinoma of the Breast |date=22 June 2019 |website=Breastcancer.org |url=https://www.breastcancer.org/symptoms/types/tubular |access-date=26 February 2022}}{{cite journal |last1=Limaiem |first1=Faten |last2=Mlika |first2=Mouna |title=Tubular Breast Carcinoma |journal=StatPearls |date=2022 |url=https://www.ncbi.nlm.nih.gov/books/NBK542223/ |access-date=3 March 2022 |publisher=StatPearls Publishing|pmid=31194380 }} More rarely, tubular carcinomas may arise in the pancreas{{cite journal |last1=Chelliah |first1=Adeline |last2=Kalimuthu |first2=Sangeetha |last3=Chetty |first3=Runjan |title=Intraductal tubular neoplasms of the pancreas: an overview |journal=Ann Diagn Pathol |date=October 2016 |volume=24 |number=24:68–72 |pages=68–72 |doi=10.1016/j.anndiagpath.2016.04.009 |pmid=27185640 |url=https://pubmed.ncbi.nlm.nih.gov/27185640/ }} or kidney.{{cite journal |last1=Zhao |first1=Ming |last2=He |first2=Xiang-lei |last3=Teng |first3=Xiao-dong |title=Mucinous tubular and spindle cell renal cell carcinoma: a review of clinicopathologic aspects |journal=Diagnostic Pathology |date=December 2015 |volume=10 |issue=1 |pages=168 |doi=10.1186/s13000-015-0402-1|pmid=26377921 |pmc=4573286 |doi-access=free }} Most tubular carcinomas begin in the milk duct of the breast and spread to healthy tissue around it.{{cite book |last=Musser |first=Robert |date=2009 |title=The P.I.N.K. Primer |publisher=Dog Ear Publishing |pages=20– |isbn=978-1-60844-176-1 |url=https://books.google.com/books?id=ShofrML71dsC&pg=PA20}}{{cite journal |last1=Feng |first1=Yixiao |last2=Spezia |first2=Mia |last3=Huang |first3=Shifeng |last4=Yuan |first4=Chengfu |last5=Zeng |first5=Zongyue |last6=Zhang |first6=Linghuan |last7=Ji |first7=Xiaojuan |last8=Liu |first8=Wei |last9=Huang |first9=Bo |last10=Luo |first10=Wenping |last11=Liu |first11=Bo |last12=Lei |first12=Yan |last13=Du |first13=Scott |last14=Vuppalapati |first14=Akhila |last15=Luu |first15=Hue H. |last16=Haydon |first16=Rex C. |last17=He |first17=Tong-Chuan |last18=Ren |first18=Guosheng |title=Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis |journal=Genes & Diseases |date=June 2018 |volume=5 |issue=2 |pages=77–106 |doi=10.1016/j.gendis.2018.05.001 |pmid=30258937 |pmc=6147049 |language=en}}
Pathology
Although tubular carcinoma has been considered a special-type tumor,{{efn|Special-type tumor: such as mucinous and cribriform carcinomas.{{citation |title=Understanding Your Pathology Report: Breast Cancer |date=2022 |website=Cancer.org |publisher=American Cancer Society |url=https://www.cancer.org/treatment/understanding-your-diagnosis/tests/understanding-your-pathology-report/breast-pathology/breast-cancer-pathology.html |access-date=26 February 2022}}}} recent trend has been to classify it as a low-grade, invasive NOS carcinoma because there is a continuous spectrum from pure tubular carcinomas to mixed NOS{{efn|NOS: of type "Not Otherwise Specified".{{cite web |title=Farlex Partner Medical Dictionary |date=2009 |url=https://medical-dictionary.thefreedictionary.com/Not+otherwise+specified |at=not otherwise specified |access-date=26 February 2022}}}} carcinomas with tubular features, depending on the percentage of the lesion that displays tubular features.{{rp|647}}
Histology
Tubular carcinomas are generally around 1 cm. or smaller, and are made up of tubules. They are usually low-grade. Elastosis has been noted as common but is not present in all cases.{{cite book |editor-last=Rosen |editor-first=Paul Peter |date=2001 |title=Rosen's Breast Pathology |publisher=Lippincott Williams & Wilkins |pages=373– |isbn=978-0-7817-2379-4 |oclc=1117861419 |url=https://books.google.com/books?id=_DJvdehOkzgC&pg=PA373}}
Prevalence
Prevalence has previously been controversial, with contradictory reports from studies reporting either very low prevalence, or a high prevalence.{{cite book |last=Stavros |first=A. Thomas |editor1-last=Rapp |editor1-first=Cynthia L. |editor2-last=Parker |editor2-first=Steve H. |date=2004 |title=Breast Ultrasound |publisher=Lippincott Williams & Wilkins |pages=647–649 |isbn=978-0-397-51624-7 |oclc=1065689596 |url=https://books.google.com/books?id=UkGtw5VI15sC&pg=PA649 |quote=A highly differentiated invasive carcinoma that forms well-defined tubules (containing epithelium, but no myoepithelium) and that have abundant desmoplastic fibrous stromal reaction between the tubules. |quote-page=649}} With the increasing availability of screening mammography, however, tubular carcinomas are being diagnosed earlier, and more recent studies suggest tubular carcinomas represent between 8% and 27% of all breast cancers.
Prognosis
Tubular carcinoma is one of the histologic types of breast cancer with a more favorable outcome.{{cite web |title=Breast Cancer Treatment (Adult) (PDQ®)–Health Professional Version |date=20 January 2022 |url=https://www.cancer.gov/types/breast/hp/breast-treatment-pdq |publisher=National Cancer Institute |access-date=26 February 2022}}
See also
- Breast cancer classification
- Ductal carcinoma in situ – a common precancerous or Stage 0 breast cancer
- Invasive cribriform carcinoma of the breast – a rare breast cancer that consists of >50% cribriform histopathology but commonly has small or large areas (<50%) closely resembling tubular carcinoma histopathology.{{cite journal | vauthors = Demir S, Sezgin G, Sari AA, Kucukzeybek BB, Yigit S, Etit D, Yazici A, Kucukzeybek Y | title = Clinicopathological analysis of invasive cribriform carcinoma of the breast, with review of the literature | journal = Annals of Diagnostic Pathology | volume = 54 | issue = | pages = 151794 | date = October 2021 | pmid = 34325338 | doi = 10.1016/j.anndiagpath.2021.151794 | url = }}
- Intraductal papillary mucinous neoplasm
- Invasive carcinoma of no special type
- Invasive lobular carcinoma
- Invasion (cancer)
Notes and references
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;References
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Further reading
- {{cite journal |last=Cserni |first=Gábor |title=Histological type and typing of breast carcinomas and the WHO classification changes over time |journal=Pathologica |url= |date=March 2020 |volume=112 |issue=1 |pages=25–41 |doi=10.32074/1591-951X-1-20 |pmid=32202537 |pmc=8138497}}
- {{cite journal |last1=Erber |first1=Ramona |last2=Hartmann |first2=Arndt |title=Histology of Luminal Breast Cancer |journal=Breast Care |location=Basel |url= |date=August 2020 |volume=15 |issue=4 |pages=327–336 |doi=10.1159/000509025 |pmid=32982642|pmc=7490665 }}
- {{cite book |last1=Sanders |first1=Melinda A. |last2=Mayer |first2=Ingrid A. |last3=Chakravarthy |first3=Bapsi |editor1-first=Derek |editor1-last=Raghavan |editor2-first=Manmeet S. |editor2-last=Ahluwalia |editor3-first=Charles D. |editor3-last=Blanke |editor4-first=Jubilee |editor4-last=Brown |editor5-first=Edward S. |editor5-last=Kim |editor6-first=Gregory H. |editor6-last=Reaman |editor7-first=Mikkael A. |editor7-last=Sekeres |display-editors=3 |date=3 March 2017 |title=Textbook of Uncommon Cancer |edition=5 |publisher=John Wiley & Sons |chapter=22 Tubular Carcinoma of the Breast |pages=338–344 |isbn=978-1-119-19621-1 |oclc=1069570078 |chapter-url=https://books.google.com/books?id=19lGDgAAQBAJ&pg=PA338 |ref={{harvid|Raghavan|2017}} }}
- {{cite journal |last1=Zhang |first1=Hanwen |last2=Zhang |first2=Ning |title=Special subtypes with favorable prognosis in breast cancer: A registry-based cohort study and network meta-analysis |journal=Cancer Treatment Reviews |url= |date=December 2020 |volume=91 |issue= |pages=102–108 |doi=10.1016/j.ctrv.2020.102108 |pmid=33075683 |pmc= }}
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