:Antonio Vidal-Puig

Vidal-Puig studied medicine at University of Valencia Medical School, and trained in endocrinology at the University of Granada Medical School. He held post-doctoral positions in Boston at the Massachusetts General Hospital and Beth Israel Hospital, Harvard Medical School, from 1992–1999, where his mentors included Jeff Flier, Brad Lowell, David Moller, and Leo Krall.{{cite web |title=Meet the Endocrinologist: Interview with Prof Antonio Vidal-Puig |url=https://endocrinologyblog.org/2017/09/14/meet-the-endocrinologist-interview-with-prof-antonio-vidal-puig/ |website=endocrinologyblog.org |access-date=Feb 9, 2020|date=2017-09-14 }} In 2015 he completed the Executive Master of Business Administration at the Cambridge Judge Business School.{{cite web |title=Clinicians and the EMBA |url=https://www.jbs.cam.ac.uk/programmes/executivemba/people/clinicians-and-the-emba/ |website=jbs.cam.ac.uk |access-date=Feb 11, 2020 |archive-date=February 28, 2021 |archive-url=https://web.archive.org/web/20210228223008/https://www.jbs.cam.ac.uk/programmes/executivemba/people/clinicians-and-the-emba/ |url-status=dead }}

Vidal-Puig established his research laboratory (TVP Lab){{Cite web|title=Metabolic Research {{!}} Toni Vidal-Puig TVP Lab {{!}} University of Cambridge|url=https://www.tvplab-cambridge.com/|access-date=2021-04-03|website=TVP Lab|language=en}} at the Institute of Metabolic Science, of the University of Cambridge in 2000, and became a Professor of Molecular Nutrition and Metabolism, as well as an Honorary Consultant in Metabolic Medicine.{{Cite web|url=https://www.mrl.ims.cam.ac.uk/research/principal-investigators/antonio-vidal-puig/|title=Antonio Vidal-Puig|website=Wellcome-MRC Institute of Metabolic Science|language=en-GB|access-date=2020-02-09}} He is also an Associate Faculty of the Wellcome Sanger Institute.{{Cite web|title=Vidal-Puig, Antonio - Wellcome Sanger Institute|url=https://www.sanger.ac.uk/person/vidal-puig-antonio/|access-date=2021-04-13|website=www.sanger.ac.uk|language=en-US}} In 2014 he was elected a Fellow of the Academy of Medical Sciences (UK).{{cite web |title=Professor Antonio Vidal-Puig FMedSci |url=https://acmedsci.ac.uk/fellows/fellows-directory/ordinary-fellows/fellow/Professor-Antonio-Vidal-Puig-0018003 |website=acmedsci.ac.uk |access-date=Feb 11, 2020}}

Together with Matej Orešič, in 2014 he edited an essay volume "A Systems Biology Approach to Study Metabolic Syndrome".{{Cite book|url=https://www.springer.com/gp/book/9783319010076|title=A Systems Biology Approach to Study Metabolic Syndrome|date=2014|publisher=Springer International Publishing|isbn=978-3-319-01007-6|editor-last=Oresic|editor-first=Matej|language=en|editor-last2=Vidal-Puig|editor-first2=Antonio}}

His academic engagements outside the UK include his affiliation with the Centre on Artificial Intelligence for Humankind at the National University of Singapore Business School.{{Cite web|title=International Research Affiliates|url=https://bschool.nus.edu.sg/aith/people/international-research-affiliate/|access-date=2020-12-25|website=bschool.nus.edu.sg}} Since 2019 he has been associated with the newly launched Cambridge University Nanjing Centre for Technology. As a visiting professor at Nanjing University, he is engaged in studies concerning aspects of the epidemic of obesity and diabetes occurring in China.{{Cite web|url=http://kyanizing20.rssing.com/chan-11037865/all_p151.html|title=University of Cambridge - Latest news|website=kyanizing20.rssing.com|access-date=2020-02-16}} He is also a Chair of the Life Sciences Panel and a recipient of a Principal Investigator award of the European Research Council.{{cite web|url=https://erc.europa.eu/sites/default/files/document/file/erc_2019_stg_panel_chairs.pdf|title=Panel Chairs of the ERC Peer Review Panels ERC Starting Grant Panel 2019|website=erc.europa.eu|access-date=Feb 11, 2020}}{{cite web|url=https://erc.europa.eu/sites/default/files/document/file/erc_2014_adg_results_ls.pdf|title=List of principal investigators – Life sciences|website=erc.europa.eu|access-date=Feb 11, 2020}} In 2024 he was named the Toh Chin Chye Visiting Professor at the National University of Singapore.{{Cite web |title=Cardiovascular-Metabolic Disease Translational Research Programme, NUS Yong Loo Lin school of Medicine |url=https://medicine.nus.edu.sg/trp/cardiovascular-disease/about-us/our-people/ |access-date=2024-07-11 |website=medicine.nus.edu.sg}}

Vidal-Puig's research laboratory in Cambridge is devoted to exploring "the molecular mechanisms involved in controlling energy expenditure, fat deposition, and the mechanisms controlling the partition of energy towards oxidation or storage". More specifically it works on lipotoxic effects on insulin sensitivity, activation of thermogenesis in adipose tissue, molecular mechanisms controlling energy expenditure and brown fat activation, and modulation of fatty acid oxidation in skeletal muscle.

Novel concepts worked on by Vidal-Puig include:

• Adipose tissue expandability hypothesis. The concept was advanced by him in 2006.{{cite journal|last1=Slawik|first1=M|last2=Vidal-Puig|first2=AJ|date=May 2006|title=Lipotoxicity, overnutrition and energy metabolism in aging.|journal=Ageing Research Reviews|volume=5|issue=2|pages=144–64|doi=10.1016/j.arr.2006.03.004|pmid=16630750}} According to the hypothesis, the expansion of adipose tissue (AT) is a normal phenomenon when an individual undergoes sustained positive energy balance, providing strategic fuel storage. However, it may reach a threshold beyond which toxic effects ensue: abnormal accumulation of lipids in organs such as muscle, liver, heart, kidney; accumulation of macrophages in AT, and spillover of proinflammatory molecules from metabolically stressed AT (lipotoxicity). These eventually lead to disease states typically accompanying obesity, such as metabolic syndrome, diabetes, atherosclerosis, hypertension, and heart attacks.{{cite journal|last1=Virtue|first1=S|last2=Vidal-Puig|first2=A|date=Jan 6, 2010|title=Adipose tissue expandability, lipotoxicity and the Metabolic Syndrome--an allostatic perspective.|journal=Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids|volume=1801|issue=3|pages=338–49|doi=10.1016/j.bbalip.2009.12.006|pmid=20056169}} This expandability concept has gained considerable acceptance among experts.{{cite journal|last1=Caprio|first1=S|last2=Pierpont|first2=B|last3=Kursawe|first3=R|date=29 March 2018|title=The "adipose tissue expandability" hypothesis: a potential mechanism for insulin resistance in obese youth.|journal=Hormone Molecular Biology and Clinical Investigation|volume=33|issue=2|doi=10.1515/hmbci-2018-0005|pmid=29596053}}
• Brown fat targeting to treat obesity. Since brown fat burns lipids to produce heat through the uncoupling of its mitochondria (thermogenesis), this phenomenon has been historically suggested as a method to fight obesity.{{Cite journal|last=Garrow|first=J. S.|date=1983-05-28|title=Luxuskonsumption, brown fat, and human obesity|journal=British Medical Journal (Clinical Research Ed.)|volume=286|issue=6379|pages=1684–1686|doi=10.1136/bmj.286.6379.1684-a|issn=0267-0623|pmc=1548238|pmid=6405934}}{{cite journal |last1=Himms-Hagen |first1=J |title=Impaired thermogenesis and brown fat in obesity. |journal=Canadian Journal of Surgery |date=March 1, 984 |volume=27 |issue=2 |pages=125 |pmid=6704806 }} Vidal-Puig's contributions have included studies of the neural, metabolic, and genetic control of the thermogenic uncoupling of adipocyte mitochondria, and the therapeutically oriented testing of possible synthetic activators of such uncoupling. In reports attracting media coverage, his team unveiled the existence of naturally occurring, pro-thermogenic biochemical mechanisms controlling mitochondrial uncoupling in fat cells, a finding with potential use to treat overweight.{{cite journal |last1=Whittle |first1=AJ |last2=Carobbio |first2=S |last3=Martins |first3=L |last4=Slawik |first4=M |last5=Hondares |first5=E |last6=Vázquez |first6=MJ |last7=Morgan |first7=D |last8=Csikasz |first8=RI |last9=Gallego |first9=R |last10=Rodriguez-Cuenca |first10=S |last11=Dale |first11=M |last12=Virtue |first12=S |last13=Villarroya |first13=F |last14=Cannon |first14=B |last15=Rahmouni |first15=K |last16=López |first16=M |last17=Vidal-Puig |first17=A |title=BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions. |journal=Cell |date=11 May 2012 |volume=149 |issue=4 |pages=871–85 |doi=10.1016/j.cell.2012.02.066 |pmid=22579288 |pmc=3383997 }} and control thermogenesis{{cite journal |last1=Whittle |first1=AJ |last2=Jiang |first2=M |last3=Peirce |first3=V |last4=Relat |first4=J |last5=Virtue |first5=S |last6=Ebinuma |first6=H |last7=Fukamachi |first7=I |last8=Yamaguchi |first8=T |last9=Takahashi |first9=M |last10=Murano |first10=T |last11=Tatsuno |first11=I |last12=Takeuchi |first12=M |last13=Nakaseko |first13=C |last14=Jin |first14=W |last15=Jin |first15=Z |last16=Campbell |first16=M |last17=Schneider |first17=WJ |last18=Vidal-Puig |first18=A |last19=Bujo |first19=H |title=Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans. |journal=Nature Communications |date=20 November 2015 |volume=6 |pages=8951 |doi=10.1038/ncomms9951 |pmid=26584636 |pmc=4673879 |bibcode=2015NatCo...6.8951W }}{{Cite journal|last1=Carobbio|first1=Stefania|last2=Guénantin|first2=Anne-Claire|last3=Samuelson|first3=Isabella|last4=Bahri|first4=Myriam|last5=Vidal-Puig|first5=Antonio|title=Brown and beige fat: From molecules to physiology and pathophysiology|journal= Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids|volume=1864|issue=1|pages=37–50|doi=10.1016/j.bbalip.2018.05.013|issn=1879-2618|pmid=29852279|year=2019}}

Research articles where Vidal-Puig is an author will be found in current entries on Adipogenesis, Gene expression profiling, Lipidomics, Lipotoxicity, Macrophages, Metabolic syndrome, Metabolomics, Mitophagy, Nicotinamide phosphoribosyltransferase, Non-alcoholic fatty liver disease, Pyruvate carboxylase, Resistin, Senotherapy, Stearoyl-CoA desaturase-1, Uncoupling protein, UCP2, and UCP3.{{cn|date=July 2024}}

Notable Cambridge scientists with whom Vidal-Puig has shared paper authorship include Krishna Chatterjee, Sadaf Farooqi, Nita Forouhi, Giles Yeo, Stephen O'Rahilly, and Nick Wareham.{{cn|date=July 2024}}

Vidal-Puig gave the 2015 FEBS National Lecture,{{Cite web|url=https://www.metabolism.cam.ac.uk/prof-toni-vidal-puig-awarded-febs-national-lecturer-2015/|title=Prof Toni Vidal-Puig has been awarded the FEBS National Lecturer 2015|date=2015-09-10|website=Cambridge Metabolic Network|language=en-GB|access-date=2020-02-09}} the 2016 Maimonides Lecture Award by the University of Córdoba,{{Cite web|url=https://www.mrl.ims.cam.ac.uk/blog/congratulations-prof-toni-vidal-puig-gave-vi-maimonides-lecture-cordoba-13th-december/|title=Congratulations to Prof Toni Vidal-Puig who gave the VI Maimónides Lecture in Cordoba on 13th December|date=2016-12-19|website=Wellcome-MRC Institute of Metabolic Science|language=en-GB|access-date=2020-02-09}} and the 2019 Sir Philip Randle Lecture sponsored by the British Biochemical Society.{{cite web|url=https://biochemistry.org/2018/04/04/biochemical-society-announces-2020-award-recipients-2019/|title=Biochemical Society announces 2019 award recipients|website=biochemistry.org|access-date=Feb 9, 2020}}

He has been awarded the Lilly Foundation Distinguished Career Award (2015),{{Cite web|url=https://www.fundacionlilly.com/es/noticias/2015_fotonoticia_151201_awardobesidad2015.aspx|title=La Fundación Lilly reconoce la trayectoria científica del Prof. Antonio Vidal Puig con el Premio a una Carrera Distinguida en Endocrinología, Nutrición y Obesidad|website=www.fundacionlilly.com|access-date=2020-02-09}} the Hippocrates International Award for Medical Research on Human Nutrition given by the Real Academia de Medicina y Cirugía of the Principality of Asturias (2015),{{Cite web|url=https://www.mrl.ims.cam.ac.uk/blog/prof-toni-vidal-puig-has-been-awarded-the-2015-hippocrates-international-award/|title=Prof. Toni Vidal Puig has been awarded the 2015 Hippocrates International Award|date=2015-07-30|website=Wellcome-MRC Institute of Metabolic Science|language=en-GB|access-date=2020-02-09}} and the Society for Endocrinology Medal (2017).{{Cite web|url=https://www.endocrinology.org/grants-and-awards/prizes-and-awards/medals/|title=Medals {{!}} Society for Endocrinology|website=www.endocrinology.org|access-date=2020-02-09}}

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Category:Living people

Category:Spanish scientists

Category:People from Valencia

Category:1962 births