:Cinitapride

{{Short description|Chemical compound}}

{{Drugbox

| Verifiedfields = changed

| Watchedfields = changed

| verifiedrevid = 451552541

| IUPAC_name = 4-amino-N-[1-(cyclohex-3-en-1-ylmethyl)piperidin-4-yl]-2-ethoxy-5-nitrobenzamide

| image = Cinitapride.svg

| width = 222

| image2 = 3D Cinitapride.png

| chirality = Racemic mixture

| drug_name =

| tradename = Cintapro, Pemix, Gapulsid

| pregnancy_category =

| legal_status = Rx-only

| routes_of_administration = Oral

| bioavailability =

| metabolism =

| elimination_half-life =

| excretion =

| CAS_number_Ref = {{cascite|correct|??}}

| CAS_number = 66564-14-5

| ATC_prefix = A03

| ATC_suffix = FA08

| PubChem = 68867

| DrugBank_Ref = {{drugbankcite|correct|drugbank}}

| DrugBank = DB08810

| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}

| ChemSpiderID = 62099

| ChEMBL_Ref = {{ebicite|changed|EBI}}

| ChEMBL = 2104523

| UNII_Ref = {{fdacite|correct|FDA}}

| UNII = R8I97I2L24

| KEGG_Ref = {{keggcite|correct|kegg}}

| KEGG = D07700

| C=21 | H=30 | N=4 | O=4

| StdInChI_Ref = {{stdinchicite|correct|chemspider}}

| StdInChI = 1S/C21H30N4O4/c1-2-29-20-13-18(22)19(25(27)28)12-17(20)21(26)23-16-8-10-24(11-9-16)14-15-6-4-3-5-7-15/h3-4,12-13,15-16H,2,5-11,14,22H2,1H3,(H,23,26)

| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}

| StdInChIKey = ZDLBNXXKDMLZMF-UHFFFAOYSA-N

}}

Cinitapride (trade names Cintapro, Pemix, Gapulsid) is a gastroprokinetic agent and antiemetic agent of the benzamide class which is marketed in India, Mexico, Pakistan, Spain,{{cite journal | vauthors = Robert M, Salvà M, Segarra R | title = The prokinetic cinitapride has no clinically relevant pharmacokinetic interaction and effect on QT during coadministration with ketoconazole | journal = Drug Metabolism and Disposition | volume = 35 | issue = 7 | pages = 1149–56 |date=July 2007 | pmid = 17437965 | doi = 10.1124/dmd.106.010835 | s2cid = 1284844 | url = http://dmd.aspetjournals.org/cgi/pmidlookup?view=long&pmid=17437965|display-authors=etal| url-access = subscription }}{{cite journal | vauthors = Fernández AG, Massingham R | title = Peripheral receptor populations involved in the regulation of gastrointestinal motility and the pharmacological actions of metoclopramide-like drugs | journal = Life Sciences | volume = 36 | issue = 1 | pages = 1–14 |date=January 1985 | pmid = 2981378 | doi = 10.1016/0024-3205(85)90280-2}} Croatia and the Czech Republic. It acts as an agonist of the 5-HT₁ and 5-HT₄ receptors and as an antagonist of the 5-HT₂ receptors.{{cite journal | vauthors = Alarcón-de-la-Lastra Romero C, López A, Martín MJ, la Casa C, Motilva V | title = Cinitapride protects against ethanol-induced gastric mucosal injury in rats: role of 5-hydroxytryptamine, prostaglandins and sulfhydryl compounds | journal = Pharmacology | volume = 54 | issue = 4 | pages = 193–202 |date=April 1997 | pmid = 9211565 | doi = 10.1159/000139487}}{{cite journal | vauthors = Alarcón de la Lastra C, La Casa C, Martin MJ, Motilva V | title = Effects of cinitapride on gastric ulceration and secretion in rats | journal = Inflammation Research | volume = 47 | issue = 3 | pages = 131–6 | date = March 1998 | pmid = 9562338 | doi = 10.1007/s000110050301 | s2cid = 25620004 | url = http://link.springer-ny.com/link/service/journals/00011/bibs/8047003/80470131.htm | access-date = 2010-02-27 | archive-url = https://web.archive.org/web/19990827033745/http://link.springer-ny.com/link/service/journals/00011/bibs/8047003/80470131.htm | archive-date = 1999-08-27 | url-status = dead | url-access = subscription }}