1454

• February 4 – Thirteen Years' War: The Secret Council of the Prussian Confederation sends a formal act of disobedience to the Grand Master, and the citizens of Toruń rebel against the Teutonic Knights, beginning the conflict.
• March 6 – Casimir IV of Poland renounces allegiance to the Teutonic Knights.
• March 27 – Richard Plantagenet, Duke of York, becomes Protector for King Henry VI of England, who is in a catatonic state.
• April 9 – Treaty of Lodi: Francesco Sforza forms a triple alliance between the Duchy of Milan, the Republic of Florence and Kingdom of Naples.{{cite book|author=Christina J. Moose|title=Great Events from History: The Renaissance & early modern era, 1454-1600|url=https://books.google.com/books?id=oKXxAAAAMAAJ|year=2005|publisher=Salem Press|isbn=978-1-58765-215-8|page=15}}
• August – In Moldavia, Petru Aron retakes the throne from Alexăndrel.
• September 18 – Thirteen Years' War – Battle of Chojnice: The Polish army is defeated by a smaller but more professional Teutonic army.
• October 9 – Thirteen Years' War: Malbork treaty between the authorities of the Teutonic Order and the mercenary forces fighting for the Teutonic Order.
• December – King Henry VI of England having regained his sanity dismisses the Duke of York as Protector.

• The press of Johannes Gutenberg (at Mainz on the Rhine) produces the first printed documents bearing a date.
• Isaac Zarfati sends a circular letter to Rhineland, Swabia, Moravia and Hungary, praising the happy conditions of the Jews under the crescent, in contrast to the "great torture chamber" under the cross, and urging them to come to the Ottoman Empire.{{cite web|url=http://www.turkishjews.com/history/letter.asp |title=Letter of Rabbi Isaac Zarfati |website=Turkishjews.com |access-date=2016-07-09}}
• The Statutes of Nieszawa are enacted in Poland.
• The Drought of One Rabbit is recorded in Aztec history.

• June 3 – Bogislaw X, Duke of Pomerania (1474–1523) (d. 1523)
• June 16 – Joanna of Aragon, Queen of Naples (d. 1517)
• July 14 – Poliziano, Italian humanist (d. 1494)
• September 4 – Henry Stafford, 2nd Duke of Buckingham, English politician (d. 1483)
• September 24 – Gerold Edlibach, Swiss historian (d. 1530)
• November 25 – Catherine Cornaro, Queen of Cyprus (d. 1510)
• date unknown
• Domenico Maria Novara da Ferrara, Italian astronomer (d. 1504)
• Pinturicchio, Italian painter (d. 1513)
• Choe Bu, Korean official and venturer to China (d. 1504)
• Alexander Stewart, Duke of Albany (d. 1485)

• March 22 – John Kemp, Archbishop of Canterbury
• July 20 – King John II of Castile (b. 1405)
• December 10 – Ignatius Behnam Hadloyo, Syriac Orthodox Patriarch of Antioch.{{cite book | last1 =Barsoum| first=Ephrem |date=2003|title=The Scattered Pearls: A History of Syriac Literature and Sciences|edition=2nd|publisher=Gorgias Press|translator=Matti Moosa|author-link=Ignatius Aphrem I Barsoum|page=497}}
• date unknown
• Chiara Zorzi, regent of Athens
• William Turnbull, Bishop of Glasgow
• Robert Wingfield, English politician (b. 1403)

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