1953 Challenge Desgrange-Colombo

{{Short description|Cycling season 6}}{{ Infobox cycling season

| name = 1953 Challenge Desgrange-Colombo

| edition = 6

| competition = Challenge Desgrange-Colombo

| image =

| image_caption =

| image_alt =

| image_size =

| dates = 18 March – 25 October

| location = Europe

| rounds = 11

| individual_champion = {{flagathlete|Loretto Petrucci|ITA}}

| individual_champion_team = Bianchi–Pirelli

| nations_champion = {{ITA}}

| previous = 1952

| next = 1954

}}

The 1953 Challenge Desgrange-Colombo was the sixth edition of the Challenge Desgrange-Colombo. It included eleven races: all the races form the 1952 edition were retained with no additions. Loretto Petrucci won the individual championship while Italy retained the nations championship.