ARHGAP8

This gene encodes a member of the RHOGAP family. GAP (GTPase-activating) family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. GAP proteins alternate between an active (GTP-bound) and inactive (GDP-bound) state based on the GTP:GDP ratio in the cell. Rare read-through transcripts, containing exons from the PRR5 gene which is located immediately upstream, led to the original description of this gene as encoding a RHOGAP protein containing the proline-rich domains characteristic of PRR5 proteins. Alternatively spliced variants encoding different isoforms have been described.

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• {{UCSC gene info|ARHGAP8}}

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• {{cite journal | vauthors = Peck J, Douglas G, Wu CH, Burbelo PD | title = Human RhoGAP domain-containing proteins: structure, function and evolutionary relationships | journal = FEBS Lett. | volume = 528 | issue = 1–3 | pages = 27–34 | year = 2002 | pmid = 12297274 | doi = 10.1016/S0014-5793(02)03331-8 | bibcode = 2002FEBSL.528...27P | s2cid = 30443852 }}
• {{cite journal | vauthors = Shan Z, Haaf T, Popescu NC | title = Identification and characterization of a gene encoding a putative mouse Rho GTPase activating protein gene 8, Arhgap8 | journal = Gene | volume = 303 | pages = 55–61 | year = 2003 | pmid = 12559566 | doi = 10.1016/S0378-1119(02)01143-5 }}
• {{cite journal | vauthors = Shang X, Zhou YT, Low BC | title = Concerted regulation of cell dynamics by BNIP-2 and Cdc42GAP homology/Sec14p-like, proline-rich, and GTPase-activating protein domains of a novel Rho GTPase-activating protein, BPGAP1 | journal = J. Biol. Chem. | volume = 278 | issue = 46 | pages = 45903–45914 | year = 2003 | pmid = 12944407 | doi = 10.1074/jbc.M304514200 | doi-access = free }}
• {{cite journal | vauthors = Lua BL, Low BC | title = BPGAP1 interacts with cortactin and facilitates its translocation to cell periphery for enhanced cell migration | journal = Mol. Biol. Cell | volume = 15 | issue = 6 | pages = 2873–2883 | year = 2004 | pmid = 15064355 | pmc = 420110 | doi = 10.1091/mbc.E04-02-0141 }}
• {{cite journal | vauthors = Johnstone CN, Castellví-Bel S, Chang LM, Bessa X, Nakagawa H, Harada H, Sung RK, Piqué JM, Castells A, Rustgi AK | title = ARHGAP8 is a novel member of the RHOGAP family related to ARHGAP1/CDC42GAP/p50RHOGAP: mutation and expression analyses in colorectal and breast cancers | journal = Gene | volume = 336 | issue = 1 | pages = 59–71 | year = 2004 | pmid = 15225876 | doi = 10.1016/j.gene.2004.01.025 }}
• {{cite journal | vauthors = Lua BL, Low BC | title = Filling the GAPs in cell dynamics control: BPGAP1 promotes cortactin translocation to the cell periphery for enhanced cell migration | journal = Biochem. Soc. Trans. | volume = 32 | issue = Pt 6 | pages = 1110–2 | year = 2005 | pmid = 15506981 | doi = 10.1042/BST0321110 }}
• {{cite journal | vauthors = Lua BL, Low BC | title = Activation of EGF receptor endocytosis and ERK1/2 signaling by BPGAP1 requires direct interaction with EEN/endophilin II and a functional RhoGAP domain | journal = J. Cell Sci. | volume = 118 | issue = Pt 12 | pages = 2707–2721 | year = 2005 | pmid = 15944398 | doi = 10.1242/jcs.02383 | doi-access = free }}

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