RhoGAP domain
{{Short description|Evolutionary conserved protein domain}}
{{Pfam_box
| Symbol = RhoGAP
| Name = RhoGAP domain
| image = PDB 1rgb EBI.jpg
| width =
| caption = Structure of Phospholipase A2.{{cite journal |vauthors=Georgieva DN, Rypniewski W, Gabdoulkhakov A, Genov N, Betzel C |title=Asp49 phospholipase A(2)-elaidoylamide complex: a new mode of inhibition |journal=Biochem. Biophys. Res. Commun. |volume=319 |issue=4 |pages=1314–21 |date=July 2004 |pmid=15194511 |doi=10.1016/j.bbrc.2004.05.106 }}
| Pfam= PF00620
| InterPro= IPR000198
| SMART= RhoGAP
| PROSITE= PDOC50238
| SCOP = 1rgb
| TCDB =
| OPM family=
| OPM protein= 1xa6
| CDD = cd00159
| PDB=
{{PDB3|1xa6}}A:291-444 {{PDB3|1f7c}}A:199-355 {{PDB3|1am4}}B:260-408
{{PDB3|1grn}}B:260-408 {{PDB3|1ow3}}A:260-408 {{PDB3|1rgp}} :260-402
{{PDB3|1tx4}}A:260-408 {{PDB3|2ngr}}B:260-408 {{PDB3|1pbw}}B:129-281
}}
RhoGAP domain is an evolutionary conserved protein domain of
GTPase activating proteins towards Rho/Rac/Cdc42-like small GTPases.
Human proteins containing this domain
ABR; ARHGAP1; ARHGAP10; ARHGAP11A; ARHGAP11B; ARHGAP12; ARHGAP15; ARHGAP17;
ARHGAP18; ARHGAP19; ARHGAP20; ARHGAP21; ARHGAP22; ARHGAP23; ARHGAP24; ARHGAP25;
ARHGAP26; ARHGAP27; ARHGAP28; ARHGAP29; ARHGAP30; ARHGAP4; ARHGAP5; ARHGAP6;
ARHGAP8; ARHGAP9; BCR; BPGAP1; C1; C5orf5; CDGAP; CENTD1;
CENTD2; CENTD3; CHN1; CHN2; DEPDC1; DEPDC1A; DEPDC1B; DLC1;
FAM13A1; FKSG42; GMIP; GRLF1; HMHA1; INPP5B; KIAA1688; LOC553158;
MYO9A; MYO9B; OCRL; OPHN1; PIK3R1; PIK3R2; PRR5; RACGAP1;
RACGAP1P; RALBP1; RICH2; RICS; SH3BP1; SLIT1; SNX26; SRGAP1;
Notes
{{reflist}}
References
- {{Cite journal
| last1 = Musacchio | first1 = A.
| last2 = Cantley | first2 = L. C.
| last3 = Harrison | first3 = S. C.
| title = Crystal structure of the breakpoint cluster region-homology domain from phosphoinositide 3-kinase p85 alpha subunit
| journal = Proceedings of the National Academy of Sciences of the United States of America
| volume = 93
| issue = 25
| pages = 14373–14378
| year = 1996
| pmid = 8962058
| pmc = 26139
| doi=10.1073/pnas.93.25.14373
| doi-access = free
}}
- {{Cite journal
| last1 = Barrett | first1 = T.
| last2 = Xiao | first2 = B.
| last3 = Dodson | first3 = E. J.
| last4 = Dodson | first4 = G.
| last5 = Ludbrook | first5 = S. B.
| last6 = Nurmahomed | first6 = K.
| last7 = Gamblin | first7 = S. J.
| last8 = Musacchio | first8 = A.
| last9 = Smerdon | first9 = S. J.
| doi = 10.1038/385458a0
| last10 = Eccleston | first10 = J. F.
| title = The structure of the GTPase-activating domain from p50rhoGAP
| journal = Nature
| volume = 385
| issue = 6615
| pages = 458–461
| year = 1997
| pmid = 9009196
| s2cid = 4235645
}}
- {{Cite journal
| last1 = Gamblin | first1 = S. J.
| last2 = Rittinger | first2 = K.
| last3 = Walker | first3 = P. A.
| last4 = Eccleston | first4 = J. F.
| last5 = Nurmahomed | first5 = K.
| last6 = Owen | first6 = D.
| last7 = Laue | first7 = E.
| last8 = Smerdon | first8 = S. J.
| title = Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP
| journal = Nature
| volume = 388
| issue = 6643
| pages = 693–697
| doi = 10.1038/41805
| year = 1997
| pmid = 9262406
| s2cid = 4415826
| doi-access = free
}}
- {{Cite journal
| last1 = Boguski | first1 = M. S.
| last2 = McCormick | first2 = F.
| doi = 10.1038/366643a0
| title = Proteins regulating Ras and its relatives
| journal = Nature
| volume = 366
| issue = 6456
| pages = 643–654
| year = 1993
| pmid = 8259209
| s2cid = 4338237
}}
Category:Peripheral membrane proteins
{{membrane-protein-stub}}