Brendan P. Lucey

{{Infobox scientist

| name = Brendan P. Lucey

| image = Brendan Lucey-cropped.jpg

| caption = Lucey in 2012

| birth_date = {{Birth year and age|1977}}

| birth_place = {{no wrap|Burlington, Vermont, U.S.}}

| workplaces = Washington University School of Medicine

| alma_mater = {{no wrap|University of Vermont (B.A.)}}
Johns Hopkins University (M.D.)
Washington University in St. Louis (M.S.)

| known_for =

}}

Brendan P. Lucey (born 1977) is an American neurologist who is a current Professor of Neurology and Sleep Medicine Section Head at Washington University School of Medicine in St. Louis, where he is also the director of Washington University’s Sleep Medicine Center.

Lucey is also known for his research on sleep and its effect on Alzheimer’s disease, and his lab is currently studying the potential for sleep interventions to prevent the onset of Alzheimer's.{{Cite web |date=2024-01-08 |title=Our Team |url=https://sleep.wustl.edu/our-team/ |access-date=2025-04-08 |website=Section of Sleep Medicine |language=en-US}}

Early life and education

Brendan Lucey was born and raised in Burlington, Vermont.

Lucey went on to receive his bachelor’s (B.A.) degree from the University of Vermont in 1999, and received his M.D. at the Johns Hopkins School of Medicine in 2003.{{Cite web |title=Brendan P. Lucey, MD |url=https://physicians.wustl.edu/people/brendan-p-lucey-md/ |access-date=2025-04-08 |website=WashU Medicine Physicians |language=en-US}}

Academic career

After receiving his M.D., Lucey pursued his residency in Neurology at Washington University School of Medicine in St. Louis from 2003-2007, and went on to complete his fellowship in Clinical neurophysiology/Electroencephalography at Harvard Medical School in 2008.

Lucey also served as an active duty member of the United States Air Force from 2008 to 2012, and continued to pursue his Masters of Science in Clinical Investigation from Washington University in St. Louis in 2018.{{Cite web |title=People of the School of Medicine < Washington University in St.Louis |url=https://bulletin.wustl.edu/medicine/people/#l1415411 |access-date=2025-04-08 |website=bulletin.wustl.edu}}

Currently, Lucey is a board certified physician in Neurology, Sleep Medicine, and Clinical Neurophysiology, and serves as a Professor of Neurology at Washington University School of Medicine in St. Louis and the chief of the WashU Medicine Section of Sleep Medicine.

Research

= Seizure and sleep =

Lucey has also contributed literature regarding the relationship between sleep in Drosophila melanogaster and seizure susceptibility.{{Cite journal |last1=Mituzaite |first1=Jurga |last2=Petersen |first2=Rasmus |last3=Claridge-Chang |first3=Adam |last4=Baines |first4=Richard A. |date=2021 |title=Characterization of Seizure Induction Methods in Drosophila |journal=eNeuro |volume=8 |issue=4 |pages=ENEURO.0079–21.2021 |doi=10.1523/ENEURO.0079-21.2021 |issn=2373-2822 |pmc=8387149 |pmid=34330816}} Lucey’s work demonstrated that when comparing seizure prone BS flies ses^B and heat-sensitive sei^TS, there was a discrepancy of sleep pattern between the two sets of flies. Lucey's team found that while there were no alterations to sleep pattern, sleep deprivation led to increased seizure severity. Notably, administering the anti-seizure drug valproic acid mitigated this effect in sesB mutants. Furthermore, sleep deprivation during early development led to a persistent increase in seizure susceptibility into adulthood.{{Cite journal |last1=Lucey |first1=Brendan P. |last2=Leahy |first2=Averi |last3=Rosas |first3=Regine |last4=Shaw |first4=Paul J. |date=2015-05-01 |title=A new model to study sleep deprivation-induced seizure |journal=Sleep |volume=38 |issue=5 |pages=777–785 |doi=10.5665/sleep.4674 |issn=1550-9109 |pmc=4402675 |pmid=25515102}} This, along with a separate study, which indicated decreased seizure likelihood but increased seizure threshold with sleep deprivation in a different set of GEFS+ flies, indicated distinct mutational differences in the relationship between sleep and seizures.

Due to these results indicating sleep loss contributes to increased seizure frequency, Lucey’s work has also been noted as a potential link between the recent research into sleep deprivation, the associated breakdown of the blood brain barrier, and seizure burden.{{Cite journal |last1=Cuddapah |first1=Vishnu Anand |last2=Zhang |first2=Shirley L. |last3=Sehgal |first3=Amita |date=July 2019 |title=Regulation of the Blood-Brain Barrier by Circadian Rhythms and Sleep |journal=Trends in Neurosciences |volume=42 |issue=7 |pages=500–510 |doi=10.1016/j.tins.2019.05.001 |issn=1878-108X |pmc=6602072 |pmid=31253251}}

== Epilepsy and sleep ==

Lucey has also researched the intersections between epilepsy, treatment methods, monitoring technologies, and other neurological conditions. His research encompasses the relationship between epileptic associations and sleep stages,{{Cite journal |last1=Lucey |first1=Brendan P. |last2=Noetzel |first2=Michael J. |last3=Duntley |first3=Stephen P. |date=June 2011 |title=Paroxysmal arousals and myoclonic movements associated with interictal epileptiform discharges in NREM and REM sleep |url=https://pubmed.ncbi.nlm.nih.gov/21334137 |journal=Clinical Neurology and Neurosurgery |volume=113 |issue=5 |pages=419–422 |doi=10.1016/j.clineuro.2010.12.018 |issn=1872-6968 |pmid=21334137}} as well as additional explorations into how abnormal sleep and epileptiform discharges can impact cognitive function.{{Cite journal |last1=Lucey |first1=Brendan P. |last2=Duntley |first2=Stephen P. |date=March 2008 |title=Electrical status epilepticus during sleep in an adult |url=https://pubmed.ncbi.nlm.nih.gov/17644477 |journal=Sleep Medicine |volume=9 |issue=3 |pages=332–334 |doi=10.1016/j.sleep.2007.02.011 |issn=1389-9457 |pmid=17644477}}

His team has additionally explored how electrical status epilepticus during sleep (ESES) can occur in adults despite being usually observed in children. He has also researched differences in seizure activity between NREM and REM sleep, finding that NREM sleep is more susceptible to epileptiform discharges while REM sleep instead suppresses seizures.

Lucey has also contributed to research investigating the association between antiepileptic drugs (AEDs) and fracture risk in patients with epilepsy. His work highlighted that long term AED use, with calcium and vitamin D supplementation could increase fracture risk.{{Cite web |title=ASSOCIATION-OF-ANTIEPILEPTIC-DRUGS--VITAMIN-D--AND-CALCIUM-SUPPLEMENTATION-WITH-OCCURRENCE-OF-FRACTURES-IN-PATIENTS-WITH-EPILEPSY |url=https://aesnet.org/abstractslisting/association-of-antiepileptic-drugs--vitamin-d--and-calcium-supplementation-with-occurrence-of-fractures-in-patients-with-epilepsy |access-date=2025-04-08 |website=Default}} He has also been involved in research evaluating the efficiency of the use of a seven-electrode montage EEG for screening in emergency scenarios.{{Cite web |title=A-SEVEN-ELECTRODE-MONTAGE-EEG-AS-A-POTENTIAL-SCREENING-TOOL-FOR-EMERGENCY-SITUATIONS |url=https://aesnet.org/abstractslisting/a-seven-electrode-montage-eeg-as-a-potential-screening-tool-for-emergency-situations |access-date=2025-04-08 |website=Default}}

= Alzheimer's Disease and sleep =

In collaboration with the Washington University Knight Alzheimer Disease Research Center (ADRC),{{Cite web |date=2020-02-26 |title=Brendan Lucey, MD |url=https://hopecenter.wustl.edu/people/brendan-lucey-md/ |access-date=2025-04-08 |website=Hope Center for Neurological Disorders |language=en-US}} Lucey and colleagues investigate how sleep affects different markers of Alzheimer’s disease such as cognitive performance and levels of amyloid-beta and tau. Despite the low risk associated with undergoing a spinal tap, many, due to the popular belief of it being painful and invasive, many try to avoid this option. Dr. Lucey’s work in non-invasive methods can alleviate concerns in AD testing.{{Cite journal |last1=Hampel |first1=Harald |last2=Elhage |first2=Aya |last3=Shaw |first3=Leslie |last4=Aisen |first4=Paul |last5=Chen |first5=Christopher |last6=Lleó |first6=Alberto |last7=Iwatsubo |first7=Takeshi |last8=Iwata |first8=Atsushi |last9=Yamada |first9=Masahito |last10=Ikeuchi |first10=Takeshi |last11=Jia |first11=Jianping |last12=Wang |first12=Huali |last13=Teunissen |first13=Charlotte |last14=Peskind |first14=Elaine |last15=Blennow |first15=Kaj |date=2022-10-01 |title=The Use of Lumbar Puncture and Safety Recommendations in Alzheimer's Disease: A Plain Language Summary |url=https://www.tandfonline.com/doi/epdf/10.2217/nmt-2022-0012 |journal=Neurodegenerative Disease Management |volume=12 |issue=5 |pages=221–229 |doi=10.2217/nmt-2022-0012 |issn=1758-2024 |pmid=35866715}} Further research interests include whether sleep quality may serve as a non-invasive marker for Alzheimer’s disease progression.{{Cite journal |last1=Lucey |first1=Brendan P |last2=Wisch |first2=Julie |last3=Boerwinkle |first3=Anna H |last4=Landsness |first4=Eric C |last5=Toedebusch |first5=Cristina D |last6=McLeland |first6=Jennifer S |last7=Butt |first7=Omar H |last8=Hassenstab |first8=Jason |last9=Morris |first9=John C |last10=Ances |first10=Beau M |last11=Holtzman |first11=David M |date=2021-09-01 |title=Sleep and longitudinal cognitive performance in preclinical and early symptomatic Alzheimer's disease |url=https://academic.oup.com/brain/article/144/9/2852/6401973?guestAccessKey=0bcf0a9e-de1b-4ad1-960b-26646dfd5746#307777715 |journal=Brain |volume=144 |issue=9 |pages=2852–2862 |doi=10.1093/brain/awab272 |pmid=34668959 |issn=0006-8950|pmc=8536939 }}

Notably, Lucey’s group has demonstrated that poor sleep hygiene and sleep loss are tied to an increase in amyloid-beta and tau accumulation in the brain. These proteins are detrimental for Alzheimer’s patients given that amyloid-beta forms plaques while tau forms tangles inside neurons—both of these lead to cell death.{{Cite journal |last=Bloom |first=George S. |date=April 2014 |title=Amyloid-β and tau: the trigger and bullet in Alzheimer disease pathogenesis |url=https://pubmed.ncbi.nlm.nih.gov/24493463 |journal=JAMA Neurology |volume=71 |issue=4 |pages=505–508 |doi=10.1001/jamaneurol.2013.5847 |issn=2168-6157 |pmid=24493463}} Lucey and colleagues seek to further investigate medical applications of these findings through ongoing clinical trials on the insomnia medication Suvorexant,{{Cite journal |last1=Lucey |first1=Brendan P. |last2=Liu |first2=Haiyan |last3=Toedebusch |first3=Cristina D. |last4=Freund |first4=David |last5=Redrick |first5=Tiara |last6=Chahin |first6=Samir L. |last7=Mawuenyega |first7=Kwasi G. |last8=Bollinger |first8=James G. |last9=Ovod |first9=Vitaliy |last10=Barthélemy |first10=Nicolas R. |last11=Bateman |first11=Randall J. |date=July 2023 |title=Suvorexant Acutely Decreases Tau Phosphorylation and Aβ in the Human CNS |journal=Annals of Neurology |volume=94 |issue=1 |pages=27–40 |doi=10.1002/ana.26641 |issn=1531-8249 |pmc=10330114 |pmid=36897120}} which has been found to be associated with a decrease in tau phosphorylation and amyloid-beta concentrations in the central nervous system in preliminary evaluations. These studies have been recognized through the 2024 Sleep Science Award from the American Academy of Neurology, awarded to Lucey in June 2024.{{Cite web |last=Wheeler |first=Brittney |date=2024-06-14 |title=Lucey receives sleep science award |url=https://source.washu.edu/2024/06/lucey-receives-sleep-science-award/ |access-date=2025-04-08 |website=The Source |language=en-US}}

= Schizophrenia and sleep =

Lucey's work in the area of sleep and schizophrenia centers on NPTX2, a protein that enhances inhibitory signaling through interneurons and that is responsible for resetting synaptic connections. In patients with schizophrenia, Lucey observed a decrease of both cerebrospinal fluid and NPTX2.{{Cite journal |last1=Xiao |first1=Mei-Fang |last2=Roh |first2=Seung-Eon |last3=Zhou |first3=Jiechao |last4=Chien |first4=Chun-Che |last5=Lucey |first5=Brendan P. |last6=Craig |first6=Michael T. |last7=Hayes |first7=Lindsay N. |last8=Coughlin |first8=Jennifer M. |last9=Leweke |first9=F. Markus |last10=Jia |first10=Min |last11=Xu |first11=Desheng |last12=Zhou |first12=Weiqiang |last13=Conover Talbot |first13=C. |last14=Arnold |first14=Don B. |last15=Staley |first15=Melissa |date=2021-11-26 |title=A biomarker-authenticated model of schizophrenia implicating NPTX2 loss of function |journal=Science Advances |volume=7 |issue=48 |pages=eabf6935 |doi=10.1126/sciadv.abf6935 |issn=2375-2548 |pmc=8612534 |pmid=34818031|bibcode=2021SciA....7.6935X }}

His group further demonstrated how NPTX2 levels decrease during sleep activity and conversely increase during wake. The back and forth of these protein expressions create a circadian rhythm responsible for homeostasis in both humans and mice. Such insights led to the hypothesis that NPTX2 protein is a biomarker for circadian rhythmicity and could have a potential role in psychiatric symptoms observed in patients with schizophrenia.

Awards and honors

2013: Physician Scientist Training Award from the American Academy of Sleep Medicine{{Cite web |last=clederhouse |date=2013-06-06 |title=Brendan P. Lucey, MD |url=https://foundation.aasm.org/brendan-p-lucey-md/ |access-date=2025-04-08 |website=AASM Foundation |language=en-US}}

2016: K76 Paul B. Beeson Emerging Leaders Career Development Award in Aging in 2016{{Cite web |title=Archived Beeson Reports |url=https://www.afar.org/archived-beeson-reports?token=8LdRkCaDvRoOP13lQIMsTv4ZfglJoTSx |access-date=2025-04-08 |website=American Federation for Aging Research |language=en-US}}

2024: Sleep Science Award from the American Academy of Neurology