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COG1

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Conserved oligomeric Golgi complex subunit 1 is a protein that in humans is encoded by the COG1 gene.{{cite journal | vauthors = Chatterton JE, Hirsch D, Schwartz JJ, Bickel PE, Rosenberg RD, Lodish HF, Krieger M | title = Expression cloning of LDLB, a gene essential for normal Golgi function and assembly of the ldlCp complex | journal = Proc Natl Acad Sci U S A | volume = 96 | issue = 3 | pages = 915–20 |date=Mar 1999 | pmid = 9927668 | pmc = 15325 | doi =10.1073/pnas.96.3.915 | bibcode = 1999PNAS...96..915C | doi-access = free }}{{cite web | title = Entrez Gene: COG1 component of oligomeric golgi complex 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9382| accessdate = }}

The protein encoded by this gene is one of eight proteins (Cog1-8) which form a Golgi-localized complex (COG) required for normal Golgi morphology and function. It is thought that this protein is required for steps in the normal medial and trans-Golgi-associated processing of glycoconjugates and plays a role in the organization of the Golgi-localized complex.

Interactions

COG1 has been shown to interact with COG4{{cite journal |last=Loh |first=Eva |author2=Hong Wanjin |date=Jun 2004 |title=The binary interacting network of the conserved oligomeric Golgi tethering complex |journal=J. Biol. Chem. |volume=279 |issue=23 |pages=24640–8 |location = United States| issn = 0021-9258| pmid = 15047703 |doi = 10.1074/jbc.M400662200 |doi-access=free }} and COG3.{{cite journal |last=Loh |first=Eva |author2=Hong Wanjin |date=Jun 2002 |title=Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp |journal=J. Biol. Chem. |volume=277 |issue=24 |pages=21955–61 |location = United States| issn = 0021-9258| pmid = 11929878 |doi = 10.1074/jbc.M202326200 |doi-access=free }}

References

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Further reading

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  • {{cite journal | vauthors=Nagase T, Kikuno R, Ishikawa KI |title=Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 1 |pages= 65–73 |year= 2000 |pmid= 10718198 |doi=10.1093/dnares/7.1.65 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Loh E, Hong W |title=Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp. |journal=J. Biol. Chem. |volume=277 |issue= 24 |pages= 21955–61 |year= 2002 |pmid= 11929878 |doi= 10.1074/jbc.M202326200 |doi-access= free }}
  • {{cite journal | vauthors=Ungar D, Oka T, Brittle EE |title=Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function. |journal=J. Cell Biol. |volume=157 |issue= 3 |pages= 405–15 |year= 2002 |pmid= 11980916 |doi= 10.1083/jcb.200202016 | pmc=2173297 |display-authors=etal}}
  • {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal|bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Loh E, Hong W |title=The binary interacting network of the conserved oligomeric Golgi tethering complex. |journal=J. Biol. Chem. |volume=279 |issue= 23 |pages= 24640–8 |year= 2004 |pmid= 15047703 |doi= 10.1074/jbc.M400662200 |doi-access= free }}
  • {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
  • {{cite journal | vauthors=Ungar D, Oka T, Vasile E |title=Subunit architecture of the conserved oligomeric Golgi complex. |journal=J. Biol. Chem. |volume=280 |issue= 38 |pages= 32729–35 |year= 2005 |pmid= 16020545 |doi= 10.1074/jbc.M504590200 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Vasile E, Oka T, Ericsson M |title=IntraGolgi distribution of the Conserved Oligomeric Golgi (COG) complex. |journal=Exp. Cell Res. |volume=312 |issue= 16 |pages= 3132–41 |year= 2006 |pmid= 16857184 |doi= 10.1016/j.yexcr.2006.06.005 |display-authors=etal}}

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External links

  • [https://www.ncbi.nlm.nih.gov/books/NBK1332/ GeneReviews/NCBI/NIH/UW entry on Congenital Disorders of Glycosylation Overview]
  • {{UCSC gene info|COG1}}

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