COG3
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Conserved oligomeric Golgi complex subunit 3 is a protein that in humans is encoded by the COG3 gene.{{cite journal | vauthors = Ungar D, Oka T, Brittle EE, Vasile E, Lupashin VV, Chatterton JE, Heuser JE, Krieger M, Waters MG | title = Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function | journal = The Journal of Cell Biology | volume = 157 | issue = 3 | pages = 405–15 | date = April 2002 | pmid = 11980916 | pmc = 2173297 | doi = 10.1083/jcb.200202016 }}{{cite web | title = Entrez Gene: COG3 component of oligomeric golgi complex 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83548| access-date = }}
The protein encoded by this gene has similarity to a yeast protein. It seems to be part of a peripheral membrane protein complex localized on cis/medial Golgi cisternae where it may participate in tethering intra-Golgi transport vesicles.
Interactions
COG3 has been shown to interact with COG2{{cite journal | vauthors = Loh E, Hong W | title = Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp | journal = The Journal of Biological Chemistry | volume = 277 | issue = 24 | pages = 21955–61 | date = June 2002 | pmid = 11929878 | doi = 10.1074/jbc.M202326200 | doi-access = free }} and COG1.
References
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External links
- {{UCSC gene info|COG3}}
Further reading
{{refbegin | 2}}
- {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | date = January 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
- {{cite journal | vauthors = Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA | title = A "double adaptor" method for improved shotgun library construction | journal = Analytical Biochemistry | volume = 236 | issue = 1 | pages = 107–13 | date = April 1996 | pmid = 8619474 | doi = 10.1006/abio.1996.0138 }}
- {{cite journal | vauthors = Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA | title = Large-scale concatenation cDNA sequencing | journal = Genome Research | volume = 7 | issue = 4 | pages = 353–8 | date = April 1997 | pmid = 9110174 | pmc = 139146 | doi = 10.1101/gr.7.4.353 }}
- {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | date = October 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
- {{cite journal | vauthors = Kim DW, Sacher M, Scarpa A, Quinn AM, Ferro-Novick S | title = High-copy suppressor analysis reveals a physical interaction between Sec34p and Sec35p, a protein implicated in vesicle docking | journal = Molecular Biology of the Cell | volume = 10 | issue = 10 | pages = 3317–29 | date = October 1999 | pmid = 10512869 | pmc = 25597 | doi = 10.1091/mbc.10.10.3317 }}
- {{cite journal | vauthors = VanRheenen SM, Cao X, Sapperstein SK, Chiang EC, Lupashin VV, Barlowe C, Waters MG | title = Sec34p, a protein required for vesicle tethering to the yeast Golgi apparatus, is in a complex with Sec35p | journal = The Journal of Cell Biology | volume = 147 | issue = 4 | pages = 729–42 | date = November 1999 | pmid = 10562277 | pmc = 2156162 | doi = 10.1083/jcb.147.4.729 }}
- {{cite journal | vauthors = Suvorova ES, Kurten RC, Lupashin VV | title = Identification of a human orthologue of Sec34p as a component of the cis-Golgi vesicle tethering machinery | journal = The Journal of Biological Chemistry | volume = 276 | issue = 25 | pages = 22810–8 | date = June 2001 | pmid = 11292827 | doi = 10.1074/jbc.M011624200 | doi-access = free }}
- {{cite journal | vauthors = Loh E, Hong W | title = Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp | journal = The Journal of Biological Chemistry | volume = 277 | issue = 24 | pages = 21955–61 | date = June 2002 | pmid = 11929878 | doi = 10.1074/jbc.M202326200 | doi-access = free }}
- {{cite journal | vauthors = Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J | title = Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides | journal = Nature Biotechnology | volume = 21 | issue = 5 | pages = 566–9 | date = May 2003 | pmid = 12665801 | doi = 10.1038/nbt810 | s2cid = 23783563 }}
- {{cite journal | vauthors = Loh E, Hong W | title = The binary interacting network of the conserved oligomeric Golgi tethering complex | journal = The Journal of Biological Chemistry | volume = 279 | issue = 23 | pages = 24640–8 | date = June 2004 | pmid = 15047703 | doi = 10.1074/jbc.M400662200 | doi-access = free }}
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