COG2
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}Conserved oligomeric Golgi complex subunit 2 is a protein that in humans is encoded by the COG2 gene.{{cite journal | vauthors = Podos SD, Reddy P, Ashkenas J, Krieger M | title = LDLC encodes a brefeldin A-sensitive, peripheral Golgi protein required for normal Golgi function | journal = J Cell Biol | volume = 127 | issue = 3 | pages = 679–91 |date=Dec 1994 | pmid = 7962052 | pmc = 2120235 | doi =10.1083/jcb.127.3.679 }}{{cite web | title = Entrez Gene: COG2 component of oligomeric golgi complex 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22796}}
Multiprotein complexes are key determinants of Golgi apparatus structure and its capacity for intracellular transport and glycoprotein modification. Several complexes have been identified, including the Golgi transport complex (GTC), the LDLC complex, which is involved in glycosylation reactions, and the SEC34 complex, which is involved in vesicular transport. These 3 complexes are identical and have been termed the conserved oligomeric Golgi (COG) complex, which includes COG2 (Ungar et al., 2002).{{cite web | title = Entrez Gene: COG2 component of oligomeric golgi complex 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22796}}
Interactions
COG2 has been shown to interact with COG4{{cite journal |last=Loh |first=Eva |author2=Hong Wanjin |date=Jun 2004 |title=The binary interacting network of the conserved oligomeric Golgi tethering complex |journal=J. Biol. Chem. |volume=279 |issue=23 |pages=24640–8 | issn = 0021-9258| pmid = 15047703 |doi = 10.1074/jbc.M400662200 |doi-access=free }} and COG3.{{cite journal |last=Loh |first=Eva |author2=Hong Wanjin |date=Jun 2002 |title=Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp |journal=J. Biol. Chem. |volume=277 |issue=24 |pages=21955–61 | issn = 0021-9258| pmid = 11929878 |doi = 10.1074/jbc.M202326200 |doi-access=free }}
References
{{reflist}}
External links
- {{UCSC gene info|COG2}}
Further reading
{{refbegin | 2}}
- {{cite journal | vauthors=Salesiotis AN, Wang CK, Wang CD |title=Identification of novel genes from stomach cancer cell lines by differential display. |journal=Cancer Lett. |volume=91 |issue= 1 |pages= 47–54 |year= 1995 |pmid= 7750094 |doi=10.1016/0304-3835(95)03717-B |display-authors=etal}}
- {{cite journal | vauthors=Loh E, Hong W |title=Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp. |journal=J. Biol. Chem. |volume=277 |issue= 24 |pages= 21955–61 |year= 2002 |pmid= 11929878 |doi= 10.1074/jbc.M202326200 |doi-access= free }}
- {{cite journal | vauthors=Ungar D, Oka T, Brittle EE |title=Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function. |journal=J. Cell Biol. |volume=157 |issue= 3 |pages= 405–15 |year= 2002 |pmid= 11980916 |doi= 10.1083/jcb.200202016 | pmc=2173297 |display-authors=etal}}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal|bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal | vauthors=Loh E, Hong W |title=The binary interacting network of the conserved oligomeric Golgi tethering complex. |journal=J. Biol. Chem. |volume=279 |issue= 23 |pages= 24640–8 |year= 2004 |pmid= 15047703 |doi= 10.1074/jbc.M400662200 |doi-access= free }}
- {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal|bibcode=2005Natur.437.1173R |s2cid=4427026 }}
- {{cite journal | vauthors=Sohda M, Misumi Y, Yoshimura S |title=The interaction of two tethering factors, p115 and COG complex, is required for Golgi integrity. |journal=Traffic |volume=8 |issue= 3 |pages= 270–84 |year= 2007 |pmid= 17274799 |doi= 10.1111/j.1600-0854.2006.00530.x |display-authors=etal|doi-access=free }}
{{refend}}