Daf-12

{{Infobox nonhuman protein

| Name = Nuclear hormone receptor family member daf-12

| image =

| width =

| caption =

| Organism = Caenorhabditis elegans

| TaxID = 6239

| Symbol = daf-12

| AltSymbols = NR1J1

| EntrezGene = 181263

| HomoloGene =

| PDB =

| RefSeqmRNA = NM_001029376.5

| RefSeqProtein = NP_001024547.1

| UniProt = G5EFF5

| Chromosome = X

| EntrezChromosome = NC_003284.9

| GenLoc_start = 10641038

| GenLoc_end = 10670243

}}

The DAF-12 (abnormal dauer formation protein 12) gene encodes the nuclear receptor of dafachronic acid (a steroid hormone) in the worm Caenorhabditis elegans, with the NRNC Symbol NR1J1 as the homolog of nuclear hormone receptor HR96 ([https://www.uniprot.org/uniprot/Q24143 Hr96]) in Drosophila melanogaster.{{cite journal | vauthors = Kaur S, Jobling S, Jones CS, Noble LR, Routledge EJ, Lockyer AE | title = The nuclear receptors of Biomphalaria glabrata and Lottia gigantea: implications for developing new model organisms | journal = PLOS ONE | volume = 10 | issue = 4 | pages = e0121259 | date = 7 April 2015 | pmid = 25849443 | pmc = 4388693 | doi = 10.1371/journal.pone.0121259 | doi-access = free | bibcode = 2015PLoSO..1021259K }} DAF-12 has been implicated by Cynthia Kenyon and colleagues in the formation of Dauer larva.{{cite journal |vauthors=Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R | title=A C. elegans mutant that lives twice as long as wild type | journal=Nature | volume=366 | issue=6454 | year=1993 | pages=461–464 | pmid=8247153 | doi=10.1038/366461a0| bibcode=1993Natur.366..461K | s2cid=4332206 }}

In favorable environments, a cytochrome p450 Daf-9 (Cyp22a1){{cite journal | vauthors = Jia K, Albert PS, Riddle DL| title = DAF-9, a cytochrome P450 regulating C. elegans larval development and adult longevity | journal = Development | volume = 129 | issue = 1 | pages = 221–31 | date = 2002 | doi = 10.1242/dev.129.1.221 | pmid = 11782415 }} produce dafachronic acid to binding Daf-12 to initiating downstream gene expression.{{cite journal | vauthors = Aguilaniu H, Fabrizio P, Witting M | title = The Role of Dafachronic Acid Signaling in Development and Longevity in Caenorhabditis elegans: Digging Deeper Using Cutting-Edge Analytical Chemistry | journal = Frontiers in Endocrinology | volume = 7 | pages = 12 | date = 2016 | pmid = 26903948 | pmc = 4749721 | doi = 10.3389/fendo.2016.00012 | doi-access = free }} When in unfavorable environments, like starvation, dafachronic acid decreases, Daf-12 will form a complex with co-repressor DIN-1.{{cite journal | vauthors = Bento G, Ogawa A, Sommer RJ | title = Co-option of the hormone-signalling module dafachronic acid-DAF-12 in nematode evolution | journal = Nature | volume = 466 | issue = 7305 | pages = 494–7 | date = July 2010 | pmid = 20592728 | doi = 10.1038/nature09164 | bibcode = 2010Natur.466..494B | s2cid = 4405326 }}