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EIF2C2

{{Short description|Protein-coding gene in the species Homo sapiens}}

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{{Infobox_gene}}

Protein argonaute-2 is a protein that in humans is encoded by the EIF2C2 gene.{{cite journal | vauthors = Koesters R, Adams V, Betts D, Moos R, Schmid M, Siermann A, Hassam S, Weitz S, Lichter P, Heitz PU, von Knebel Doeberitz M, Briner J | title = Human eukaryotic initiation factor EIF2C1 gene: cDNA sequence, genomic organization, localization to chromosomal bands 1p34-p35, and expression | journal = Genomics | volume = 61 | issue = 2 | pages = 210–8 |date=Dec 1999 | pmid = 10534406 | doi = 10.1006/geno.1999.5951 | s2cid = 24461432 }}{{cite journal | vauthors = Sasaki T, Shiohama A, Minoshima S, Shimizu N | title = Identification of eight members of the Argonaute family in the human genome small star, filled | journal = Genomics | volume = 82 | issue = 3 | pages = 323–30 |date=Aug 2003 | pmid = 12906857 | doi =10.1016/S0888-7543(03)00129-0 }}{{cite web | title = Entrez Gene: EIF2C2 eukaryotic translation initiation factor 2C, 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27161}}

This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with Dicer1 and play a role in short-interfering-RNA-mediated gene silencing.{{cite web | title = Entrez Gene: EIF2C2 eukaryotic translation initiation factor 2C, 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27161}}

Interactions

EIF2C2 has been shown to interact with

  • DDX20,{{cite journal | vauthors = Nelson PT, Hatzigeorgiou AG, Mourelatos Z | title = miRNP:mRNA association in polyribosomes in a human neuronal cell line | journal = RNA | volume = 10 | issue = 3 | pages = 387–94 |date=March 2004 | pmid = 14970384 | pmc = 1370934 | doi = 10.1261/rna.5181104}}{{cite journal | vauthors = Mourelatos Z, Dostie J, Paushkin S, Sharma A, Charroux B, Abel L, Rappsilber J, Mann M, Dreyfuss G | title = miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs | journal = Genes Dev. | volume = 16 | issue = 6 | pages = 720–8 |date=March 2002 | pmid = 11914277 | pmc = 155365 | doi = 10.1101/gad.974702 }}
  • DICER1,{{cite journal | vauthors = Doi N, Zenno S, Ueda R, Ohki-Hamazaki H, Ui-Tei K, Saigo K | title = Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors | journal = Curr. Biol. | volume = 13 | issue = 1 | pages = 41–6 |date=January 2003 | pmid = 12526743 | doi = 10.1016/S0960-9822(02)01394-5| s2cid = 14650075 | doi-access = free | bibcode = 2003CBio...13...41D }}
  • FMRP, FXR1P, FXR2P,{{cite journal | vauthors = Jin P, Zarnescu DC, Ceman S, Nakamoto M, Mowrey J, Jongens TA, Nelson DL, Moses K, Warren ST | title = Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway | journal = Nat. Neurosci. | volume = 7 | issue = 2 | pages = 113–7 |date=February 2004 | pmid = 14703574 | doi = 10.1038/nn1174 | s2cid = 1146182 }} and
  • TNRC6B.{{cite journal | vauthors = Till S, Lejeune E, Thermann R, Bortfeld M, Hothorn M, Enderle D, Heinrich C, Hentze MW, Ladurner AG | title = A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain | journal = Nat. Struct. Mol. Biol. | volume = 14 | issue = 10 | pages = 897–903 |date=October 2007 | pmid = 17891150 | doi = 10.1038/nsmb1302 | s2cid = 8136380 }}

References

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Further reading

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  • {{cite journal | vauthors=Carmell MA, Xuan Z, Zhang MQ, Hannon GJ |title=The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis. |journal=Genes Dev. |volume=16 |issue= 21 |pages= 2733–42 |year= 2002 |pmid= 12414724 |doi= 10.1101/gad.1026102 |doi-access= free }}
  • {{cite journal | vauthors=Mourelatos Z, Dostie J, Paushkin S |title=miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs. |journal=Genes Dev. |volume=16 |issue= 6 |pages= 720–8 |year= 2002 |pmid= 11914277 |doi= 10.1101/gad.974702 | pmc=155365 |display-authors=etal}}
  • {{cite journal | vauthors=Martinez J, Patkaniowska A, Urlaub H |title=Single-stranded antisense siRNAs guide target RNA cleavage in RNAi. |journal=Cell |volume=110 |issue= 5 |pages= 563–74 |year= 2003 |pmid= 12230974 |doi=10.1016/S0092-8674(02)00908-X |display-authors=etal|hdl=11858/00-001M-0000-0012-F2FD-2 |s2cid=10616773 |hdl-access=free }}
  • {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Doi N, Zenno S, Ueda R |title=Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors. |journal=Curr. Biol. |volume=13 |issue= 1 |pages= 41–6 |year= 2003 |pmid= 12526743 |doi=10.1016/S0960-9822(02)01394-5 |s2cid=14650075 |display-authors=etal|doi-access=free |bibcode=2003CBio...13...41D }}
  • {{cite journal | vauthors=Tahbaz N, Kolb FA, Zhang H |title=Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer. |journal=EMBO Rep. |volume=5 |issue= 2 |pages= 189–94 |year= 2004 |pmid= 14749716 |doi= 10.1038/sj.embor.7400070 | pmc=1298981 |display-authors=etal}}
  • {{cite journal | vauthors=Nelson PT, Hatzigeorgiou AG, Mourelatos Z |title=miRNP:mRNA association in polyribosomes in a human neuronal cell line. |journal=RNA |volume=10 |issue= 3 |pages= 387–94 |year= 2004 |pmid= 14970384 |doi=10.1261/rna.5181104 | pmc=1370934 }}
  • {{cite journal | vauthors=Liu J, Carmell MA, Rivas FV |title=Argonaute2 is the catalytic engine of mammalian RNAi. |journal=Science |volume=305 |issue= 5689 |pages= 1437–41 |year= 2004 |pmid= 15284456 |doi= 10.1126/science.1102513 |bibcode=2004Sci...305.1437L |s2cid=2778088 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
  • {{cite journal | vauthors=Rivas FV, Tolia NH, Song JJ |title=Purified Argonaute2 and an siRNA form recombinant human RISC. |journal=Nat. Struct. Mol. Biol. |volume=12 |issue= 4 |pages= 340–9 |year= 2005 |pmid= 15800637 |doi= 10.1038/nsmb918 |s2cid=2021813 |display-authors=etal}}
  • {{cite journal | vauthors=Sen GL, Blau HM |title=Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies. |journal=Nat. Cell Biol. |volume=7 |issue= 6 |pages= 633–6 |year= 2005 |pmid= 15908945 |doi= 10.1038/ncb1265 |s2cid=6085169 }}
  • {{cite journal | vauthors=Liu J, Valencia-Sanchez MA, Hannon GJ, Parker R |title=MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies. |journal=Nat. Cell Biol. |volume=7 |issue= 7 |pages= 719–23 |year= 2005 |pmid= 15937477 |doi= 10.1038/ncb1274 | pmc=1855297 }}
  • {{cite journal | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 |display-authors=etal}}
  • {{cite journal | vauthors=Kraynack BA, Baker BF |title=Small interfering RNAs containing full 2'-O-methylribonucleotide-modified sense strands display Argonaute2/eIF2C2-dependent activity. |journal=RNA |volume=12 |issue= 1 |pages= 163–76 |year= 2006 |pmid= 16301602 |doi= 10.1261/rna.2150806 | pmc=1370895 }}
  • {{cite journal | vauthors=Maniataki E, Mourelatos Z |title=A human, ATP-independent, RISC assembly machine fueled by pre-miRNA. |journal=Genes Dev. |volume=19 |issue= 24 |pages= 2979–90 |year= 2006 |pmid= 16357216 |doi= 10.1101/gad.1384005 | pmc=1315402 }}
  • {{cite journal | vauthors=Shi H, Tschudi C, Ullu E |title=Functional replacement of Trypanosoma brucei Argonaute by the human slicer Argonaute2. |journal=RNA |volume=12 |issue= 6 |pages= 943–7 |year= 2006 |pmid= 16611939 |doi= 10.1261/rna.20806 | pmc=1464859 }}
  • {{cite journal | vauthors=Wichroski MJ, Robb GB, Rana TM |title=Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies. |journal=PLOS Pathog. |volume=2 |issue= 5 |pages= e41 |year= 2006 |pmid= 16699599 |doi= 10.1371/journal.ppat.0020041 | pmc=1458959 |doi-access=free }}

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Category:RNA interference

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