ETS2

ETS2 has been shown to interact with:

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• C-jun,
• Cyclin-dependent kinase 10,{{cite journal | vauthors = Kasten M, Giordano A | title = Cdk10, a Cdc2-related kinase, associates with the Ets2 transcription factor and modulates its transactivation activity | journal = Oncogene | volume = 20 | issue = 15 | pages = 1832–1838 | date = April 2001 | pmid = 11313931 | doi = 10.1038/sj.onc.1204295 | doi-access = free }}
• ERG,{{cite journal | vauthors = Basuyaux JP, Ferreira E, Stéhelin D, Butticè G | title = The Ets transcription factors interact with each other and with the c-Fos/c-Jun complex via distinct protein domains in a DNA-dependent and -independent manner | journal = The Journal of Biological Chemistry | volume = 272 | issue = 42 | pages = 26188–26195 | date = October 1997 | pmid = 9334186 | doi = 10.1074/jbc.272.42.26188 | doi-access = free }}
• myb,{{cite journal | vauthors = Dudek H, Tantravahi RV, Rao VN, Reddy ES, Reddy EP | title = Myb and Ets proteins cooperate in transcriptional activation of the mim-1 promoter | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 89 | issue = 4 | pages = 1291–1295 | date = February 1992 | pmid = 1741383 | pmc = 48435 | doi = 10.1073/pnas.89.4.1291 | doi-access = free | bibcode = 1992PNAS...89.1291D }} and
• ZMYND11.{{cite journal | vauthors = Wei G, Schaffner AE, Baker KM, Mansky KC, Ostrowski MC | title = Ets-2 interacts with co-repressor BS69 to repress target gene expression | journal = Anticancer Research | volume = 23 | issue = 3A | pages = 2173–2178 | year = 2003 | pmid = 12894593 }}

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ETS2 has been linked to a variety of diseases, including Takayasu's arteritis, inflammatory bowel disease, primary sclerosing cholangitis, and ankylosing spondylitis, all associated with a region on chromosome 21 at 21q22.{{cite journal | vauthors = Stankey CT, Bourges C, Haag LM, Turner-Stokes T, Piedade AP, Palmer-Jones C, Papa I, Silva Dos Santos M, Zhang Q, Cameron AJ, Legrini A, Zhang T, Wood CS, New FN, Randzavola LO, Speidel L, Brown AC, Hall A, Saffioti F, Parkes EC, Edwards W, Direskeneli H, Grayson PC, Jiang L, Merkel PA, Saruhan-Direskeneli G, Sawalha AH, Tombetti E, Quaglia A, Thorburn D, Knight JC, Rochford AP, Murray CD, Divakar P, Green M, Nye E, MacRae JI, Jamieson NB, Skoglund P, Cader MZ, Wallace C, Thomas DC, Lee JC | title = A disease-associated gene desert directs macrophage inflammation through ETS2 | journal = Nature | volume = 630 | issue = 8016 | pages = 447–456 | date = June 2024 | pmid = 38839969 | doi = 10.1038/s41586-024-07501-1 | pmc = 11168933 | bibcode = 2024Natur.630..447S }}

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• {{cite journal | vauthors = Boulukos KE, Pognonec P, Sariban E, Bailly M, Lagrou C, Ghysdael J | title = Rapid and transient expression of Ets2 in mature macrophages following stimulation with cMGF, LPS, and PKC activators | journal = Genes & Development | volume = 4 | issue = 3 | pages = 401–409 | date = March 1990 | pmid = 2186967 | doi = 10.1101/gad.4.3.401 | doi-access = free }}
• {{cite journal | vauthors = Watson DK, Mavrothalassitis GJ, Jorcyk CL, Smyth FE, Papas TS | title = Molecular organization and differential polyadenylation sites of the human ETS2 gene | journal = Oncogene | volume = 5 | issue = 10 | pages = 1521–1527 | date = October 1990 | pmid = 2250910 }}
• {{cite journal | vauthors = Watson DK, McWilliams MJ, Lapis P, Lautenberger JA, Schweinfest CW, Papas TS | title = Mammalian ets-1 and ets-2 genes encode highly conserved proteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 85 | issue = 21 | pages = 7862–7866 | date = November 1988 | pmid = 2847145 | pmc = 282297 | doi = 10.1073/pnas.85.21.7862 | doi-access = free | bibcode = 1988PNAS...85.7862W }}
• {{cite journal | vauthors = Watson DK, McWilliams-Smith MJ, Nunn MF, Duesberg PH, O'Brien SJ, Papas TS | title = The ets sequence from the transforming gene of avian erythroblastosis virus, E26, has unique domains on human chromosomes 11 and 21: both loci are transcriptionally active | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 82 | issue = 21 | pages = 7294–7298 | date = November 1985 | pmid = 2997781 | pmc = 391330 | doi = 10.1073/pnas.82.21.7294 | doi-access = free | bibcode = 1985PNAS...82.7294W }}
• {{cite journal | vauthors = Le Beau MM, Rowley JD, Sacchi N, Watson DK, Papas TS, Diaz MO | title = Hu-ets-2 is translocated to chromosome 8 in the t(8;21) in acute myelogenous leukemia | journal = Cancer Genetics and Cytogenetics | volume = 23 | issue = 3 | pages = 269–274 | date = November 1986 | pmid = 3021321 | doi = 10.1016/0165-4608(86)90189-5 }}
• {{cite journal | vauthors = Fujiwara S, Fisher RJ, Seth A, Bhat NK, Showalter SD, Zweig M, Papas TS | title = Characterization and localization of the products of the human homologs of the v-ets oncogene | journal = Oncogene | volume = 2 | issue = 2 | pages = 99–103 | date = February 1988 | pmid = 3285299 }}
• {{cite journal | vauthors = Sumarsono SH, Wilson TJ, Tymms MJ, Venter DJ, Corrick CM, Kola R, Lahoud MH, Papas TS, Seth A, Kola I | title = Down's syndrome-like skeletal abnormalities in Ets2 transgenic mice | journal = Nature | volume = 379 | issue = 6565 | pages = 534–537 | date = February 1996 | pmid = 8596630 | doi = 10.1038/379534a0 | s2cid = 4365956 | bibcode = 1996Natur.379..534H }}
• {{cite journal | vauthors = Basuyaux JP, Ferreira E, Stéhelin D, Butticè G | title = The Ets transcription factors interact with each other and with the c-Fos/c-Jun complex via distinct protein domains in a DNA-dependent and -independent manner | journal = The Journal of Biological Chemistry | volume = 272 | issue = 42 | pages = 26188–26195 | date = October 1997 | pmid = 9334186 | doi = 10.1074/jbc.272.42.26188 | doi-access = free }}
• {{cite journal | vauthors = Blumenthal SG, Aichele G, Wirth T, Czernilofsky AP, Nordheim A, Dittmer J | title = Regulation of the human interleukin-5 promoter by Ets transcription factors. Ets1 and Ets2, but not Elf-1, cooperate with GATA3 and HTLV-I Tax1 | journal = The Journal of Biological Chemistry | volume = 274 | issue = 18 | pages = 12910–12916 | date = April 1999 | pmid = 10212281 | doi = 10.1074/jbc.274.18.12910 | doi-access = free }}
• {{cite journal | vauthors = Jayaraman G, Srinivas R, Duggan C, Ferreira E, Swaminathan S, Somasundaram K, Williams J, Hauser C, Kurkinen M, Dhar R, Weitzman S, Buttice G, Thimmapaya B | title = p300/cAMP-responsive element-binding protein interactions with ets-1 and ets-2 in the transcriptional activation of the human stromelysin promoter | journal = The Journal of Biological Chemistry | volume = 274 | issue = 24 | pages = 17342–17352 | date = June 1999 | pmid = 10358095 | doi = 10.1074/jbc.274.24.17342 | doi-access = free }}
• {{cite journal | vauthors = Kilpatrick LM, Kola I, Salamonsen LA | title = Transcription factors Ets1, Ets2, and Elf1 exhibit differential localization in human endometrium across the menstrual cycle and alternate isoforms in cultured endometrial cells | journal = Biology of Reproduction | volume = 61 | issue = 1 | pages = 120–126 | date = July 1999 | pmid = 10377039 | doi = 10.1095/biolreprod61.1.120 | doi-access = free }}
• {{cite journal | vauthors = Rameil P, Lécine P, Ghysdael J, Gouilleux F, Kahn-Perlès B, Imbert J | title = IL-2 and long-term T cell activation induce physical and functional interaction between STAT5 and ETS transcription factors in human T cells | journal = Oncogene | volume = 19 | issue = 17 | pages = 2086–2097 | date = April 2000 | pmid = 10815800 | doi = 10.1038/sj.onc.1203542 | doi-access = free }}
• {{cite journal | vauthors = Park US, Park SK, Lee YI, Park JG, Lee YI | title = Hepatitis B virus-X protein upregulates the expression of p21waf1/cip1 and prolongs G1-->S transition via a p53-independent pathway in human hepatoma cells | journal = Oncogene | volume = 19 | issue = 30 | pages = 3384–3394 | date = July 2000 | pmid = 10918595 | doi = 10.1038/sj.onc.1203674 | doi-access = free }}
• {{cite journal | vauthors = Pastorcic M, Das HK | title = Regulation of transcription of the human presenilin-1 gene by ets transcription factors and the p53 protooncogene | journal = The Journal of Biological Chemistry | volume = 275 | issue = 45 | pages = 34938–34945 | date = November 2000 | pmid = 10942770 | doi = 10.1074/jbc.M005411200 | doi-access = free }}
• {{cite journal | vauthors = Smith JL, Schaffner AE, Hofmeister JK, Hartman M, Wei G, Forsthoefel D, Hume DA, Ostrowski MC | title = ets-2 is a target for an akt (Protein kinase B)/jun N-terminal kinase signaling pathway in macrophages of motheaten-viable mutant mice | journal = Molecular and Cellular Biology | volume = 20 | issue = 21 | pages = 8026–8034 | date = November 2000 | pmid = 11027273 | pmc = 86413 | doi = 10.1128/MCB.20.21.8026-8034.2000 }}
• {{cite journal | vauthors = Mullick J, Anandatheerthavarada HK, Amuthan G, Bhagwat SV, Biswas G, Camasamudram V, Bhat NK, Reddy SE, Rao V, Avadhani NG | title = Physical interaction and functional synergy between glucocorticoid receptor and Ets2 proteins for transcription activation of the rat cytochrome P-450c27 promoter | journal = The Journal of Biological Chemistry | volume = 276 | issue = 21 | pages = 18007–18017 | date = May 2001 | pmid = 11279115 | doi = 10.1074/jbc.M100671200 | doi-access = free }}
• {{cite journal | vauthors = Kasten M, Giordano A | title = Cdk10, a Cdc2-related kinase, associates with the Ets2 transcription factor and modulates its transactivation activity | journal = Oncogene | volume = 20 | issue = 15 | pages = 1832–1838 | date = April 2001 | pmid = 11313931 | doi = 10.1038/sj.onc.1204295 | doi-access = free }}
• {{cite journal | vauthors = Ezashi T, Ghosh D, Roberts RM | title = Repression of Ets-2-induced transactivation of the tau interferon promoter by Oct-4 | journal = Molecular and Cellular Biology | volume = 21 | issue = 23 | pages = 7883–7891 | date = December 2001 | pmid = 11689681 | pmc = 99954 | doi = 10.1128/MCB.21.23.7883-7891.2001 }}
• {{cite journal | vauthors = Xu XR, Huang J, Xu ZG, Qian BZ, Zhu ZD, Yan Q, Cai T, Zhang X, Xiao HS, Qu J, Liu F, Huang QH, Cheng ZH, Li NG, Du JJ, Hu W, Shen KT, Lu G, Fu G, Zhong M, Xu SH, Gu WY, Huang W, Zhao XT, Hu GX, Gu JR, Chen Z, Han ZG | title = Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 98 | issue = 26 | pages = 15089–15094 | date = December 2001 | pmid = 11752456 | pmc = 64988 | doi = 10.1073/pnas.241522398 | doi-access = free | bibcode = 2001PNAS...9815089X }}
• {{cite journal | vauthors = Islas JF, Liu Y, Weng KC, Robertson MJ, Zhang S, Prejusa A, Harger J, Tikhomirova D, Chopra M, Iyer D, Mercola M, Oshima RG, Willerson JT, Potaman VN, Schwartz RJ | title = Transcription factors ETS2 and MESP1 transdifferentiate human dermal fibroblasts into cardiac progenitors | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 109 | issue = 32 | pages = 13016–13021 | date = August 2012 | pmid = 22826236 | pmc = 3420197 | doi = 10.1073/pnas.1120299109 | doi-access = free | bibcode = 2012PNAS..10913016I }}

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• [http://www.sdbonline.org/fly/neural/pointed.htm Drosophila pointed - The Interactive Fly]

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{{Transcription factors|g3}}

Category:Transcription factors