Estradiol butyrylacetate/testosterone ketolaurate/reserpine

{{Short description|Combination drug}}

{{Drugbox

| image = Estradiol butyrylacetate.svg

| image_class = skin-invert-image

| width = 250px

| caption =

| image2 = Testosterone ketolaurate.svg

| image_class2 = skin-invert-image

| width2 = 235px

| caption2 = Estradiol butyrylacetate (top) and
testosterone ketolaurate (bottom)

| type = combo

| drug_name = Estradiol butyrylacetate /
testosterone ketolaurate

| component1 = Estradiol butyrylacetate

| class1 = Estrogen

| component2 = Testosterone ketolaurate

| class2 = Androgen; Anabolic steroid

| component3 = Reserpine

| class3 = Antipsychotic

| tradename = Klimanosid R-Depot

| Drugs.com =

| MedlinePlus =

| pregnancy_AU =

| pregnancy_US =

| pregnancy_category =

| legal_AU =

| legal_CA =

| legal_UK =

| legal_US =

| legal_status =

| routes_of_administration = Intramuscular injection

| CAS_number =

| ATC_prefix =

| ATC_suffix =

| PubChem =

| DrugBank =

| synonyms = EBA/TKL; EBA/TCA

}}

Estradiol butyrylacetate/testosterone ketolaurate/reserpine (EBA/TKL/R), sold under the brand name Klimanosid R-Depot, is an injectable combination medication of estradiol butyrylacetate (EBA), an estrogen, testosterone ketolaurate (TKL; testosterone caprinoylacetate), an androgen/anabolic steroid, and reserpine, an antipsychotic, which was previously used in menopausal hormone therapy for women, particularly in those with pronounced neurovegetative symptoms.{{cite journal|title=Neue Spezialitäten|journal=Klinische Wochenschrift|volume=35|issue=13|year=1957|pages=692|issn=0023-2173|doi=10.1007/BF01481278|quote=Klimanosid "R"-Depot enthält je Ampulle: Testosteron als Caprinoytacetat 50,0 mg, Oestradiol als Butyrylacetat 2,0 mg und Reserpin "Boehringer" 0,4 mg (Klimakterische und präklimaterische Ausfallserscheinungen einsehließlich ausgeprägter emotioneller Störungen). Hersteller: C.F. Boehringer & Soehne GmbH, Mannheim.|s2cid=40387087}}{{cite book | vauthors = Schirren C | chapter = Die Sexualhormone | veditors = Kimmig J |title=Therapie der Haut- und Geschlechtskrankheiten|chapter-url=https://books.google.com/books?id=txrUBgAAQBAJ&pg=PA508|date=14 March 2013|publisher=Springer-Verlag|isbn=978-3-642-94850-3|pages=508–}}{{cite book| vauthors = Kaiser R |title=Die hormonale Behandlung von Zyklusstörungen: ein Leitfaden für die Praxis|url=https://books.google.com/books?id=Sd1sAAAAMAAJ|year=1962|publisher=Thieme|page=86}}{{cite book|author=Gehe & Co|title=Gehes Codex der pharmazeutischen u. Organotherapeutischen Spezialpräparate(einschl. Der Sera, Impfstoffe, Kosmetica, Reinigungs-, Desinfektions- u. Schädlingsbekämpfungsmittel) umfassend deutsche und zahlreiche ausländische Erzeugnisse|url=https://books.google.com/books?id=wskrAQAAMAAJ|year=1969|publisher=Schwarzeck-Verlag G.m.b.H.|quote=KlimanosidDepot-Ampullen (f üher Klimanosid-„R“-Depot-Ampullen) Z : 1 Ampulle zu 1 ml zur i.m. Injektion enthält: 50 mg Testosteron (in Form des Caprinoylacetatsä sowie 2 mg Oestradiol (in Form des Butyrylacetats). I: Klimakterische und [...]}}{{cite journal | vauthors = Wenner R, Hauser GA | title = [Neurovegetative studies and results of therapy in climacteric women] | journal = Archiv für Gynäkologie | volume = 193 | issue = 1 | pages = 58–69 | year = 1959 | pmid = 13843987 | doi = 10.1007/BF00837146 | s2cid = 42511052 }}{{cite book| vauthors = Knörr K, Lauritzen C, Beller FK |title=Lehrbuch der Gynäkologie|chapter=Empfängnisregelung — Empfängnisverhütung|year=1972|pages=227–257|publisher=Springer |doi=10.1007/978-3-662-00942-0_20|isbn=978-3-540-05593-8}} It contains 2 mg EBA, 50 mg TKL, and 0.4 mg reserpine in oil solution in each 1 mL ampoule and is administered by intramuscular injection at regular intervals. The medication was marketed in 1957.

EBA/TKL reportedly has a duration of about 21 days.{{cite book | vauthors = Ufer J | title = Hormontherapie in der Frauenheilkunde: Grundlagen und Praxis | trans-title = Hormone Therapy in Gynecology: Principles and Practice | edition = 5th | language = German | date = 1 January 1978 | isbn = 978-3110066647 | oclc = 924728827 | publisher = de Gruyter | page = 276}}

Oral tablet products with the same brand names of Klimanosid and Klimanosid R, containing methylestradiol and methyltestosterone, with and without reserpine, were marketed around the same time as Klimanosid-R Depot, and should not be confused with the injectable formulation.{{cite book | vauthors = Hager HH, Kern W, List PH, Roth HJ |title=Hagers Handbuch der Pharmazeutischen Praxis: Für Apotheker, Arzneimittelhersteller, Ärzte und Medizinalbeamte: Wirkstoffgruppen II Chemikalien und Drogen (A-AL)|url=https://books.google.com/books?id=a2a0BgAAQBAJ&pg=PA185|date=29 July 2013|publisher=Springer-Verlag|isbn=978-3-662-25655-8|pages=157, 160, 185}}{{cite book| vauthors = Kahr H, Müller HA |title=Konservative Therapie der Frauenkrankheiten|chapter=Behandlung der Menstruationsstörungen|year=1956|pages=1–85|publisher=Springer |doi=10.1007/978-3-7091-5694-0_1|isbn=978-3-7091-5696-4|quote=[Not to be confused with the oral tablet version:] Klimanosid: Tabl. 0,005 mg Methyloestradiol + 3,0 mg Methyltestosteron.}}

{{Androgen replacement therapy formulations and dosages used in women}}