HLA-DR13
| id="drugInfoBox" style="float: right; clear: right; margin: 0 0 0.5em 1em; background: #ffffff;" class="toccolours" border=0 cellpadding=0 align=right width="240px" | |
| align="center" colspan="2" | Image:DR Illustration.PNG | |
| align="center" colspan="2" | major histocompatibility complex, class II, DR13 | |
| bgcolor="#e7dcc3" | Haplotypes groups
| bgcolor="#eeeeee" | DQA*01:DRB1*1301 to DQA*01:DRB1*1309 DQA*01:DRB1*1310 DQA*01:DRB1*1312 .... | |
| colspan="2" bgcolor="#dddddd" | Structure (See HLA-DR) | |
| style="background:#f8f8f8"
| bgcolor="#dddddd" | Identifiers | align="center" | alpha *0101 |
| bgcolor="#e7dcc3" | Symbol(s)
| bgcolor="#eeeeee" | [http://www.gene.ucl.ac.uk/nomenclature/data/get_data.php?hgnc_id=HGNC4947 HLA-DRA]{{Dead link|date=January 2020 |bot=InternetArchiveBot |fix-attempted=yes }} | |
| bgcolor="#e7dcc3" | EBI-HLA
| bgcolor="#eeeeee" | [http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi?DRA*0101 DRA*0101] | |
| style="background:#f8f8f8"
| bgcolor="#dddddd" | Identifiers | align="center" | beta 1 *1301 to *1308 *1310 |
| bgcolor="#e7dcc3" | Symbol(s)
| bgcolor="#eeeeee" | [http://www.gene.ucl.ac.uk/nomenclature/data/get_data.php?hgnc_id=4953 HLA-DRB1]{{Dead link|date=January 2020 |bot=InternetArchiveBot |fix-attempted=yes }} | |
| bgcolor="#e7dcc3" | EBI-HLA
| bgcolor="#eeeeee" | [http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi?DRB1*1301 DRB1*1301] | |
| bgcolor="#e7dcc3" | EBI-HLA
| bgcolor="#eeeeee" | [http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi?DRB1*1302 DRB1*1302] {{Webarchive|url=https://web.archive.org/web/20110515170809/http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi?DRB1*1302 |date=2011-05-15 }} | |
| bgcolor="#e7dcc3" | EBI-HLA
| bgcolor="#eeeeee" | [http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi?DRB1*1304 DRB1*1304] {{Webarchive|url=https://web.archive.org/web/20110515170846/http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi?DRB1*1304 |date=2011-05-15 }} | |
| bgcolor="#e7dcc3" | EBI-HLA
| bgcolor="#eeeeee" | [http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi?DRB1*1306 DRB1*1306] | |
| bgcolor="#e7dcc3" | EBI-HLA
| bgcolor="#eeeeee" | [http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi?DRB1*1307 DRB1*1307] {{Webarchive|url=https://web.archive.org/web/20070926223620/http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi?DRB1*1307 |date=2007-09-26 }} | |
| bgcolor="#e7dcc3" | EBI-HLA
| bgcolor="#eeeeee" | [http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi?DRB1*1310 DRB1*1310] | |
| colspan="2" bgcolor="#dddddd" | Shared data | |
| bgcolor="#e7dcc3" | Locus
| bgcolor="#eeeeee" | chr.6 [https://www.ncbi.nlm.nih.gov/Omim/getmap.cgi?chromosome=6p21.31 6p21.31] |
HLA-DR13(DR13) is a HLA-DR serotype that recognizes the DRB1*1301 to *13082, *1310 and some other *13 gene products. DR13 serotype is a split antigen of the older HLA-DR6 serotype group which also contains the similar HLA-DR14 antigens.
Alleles
| border="0" cellspacing="0" cellpadding="0" align="center" style="text-align:center; background:#ffffff; margin-right: 1em; border:2px #e0e0ff solid;"
|+ DR13, DR6 and other serotype recognition of some DRB1*13 alleles[http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA] | ||||
| style="background:#f0f0ff"
| style="width:60px" | DRB1* | style="width:60px" | DR13
| style="width:60px" | DR6 | style="width:60px" | DR14 | style="width:60px" | Sample | |
| style="background:#f0f0ff"
| allele | % | % | % | size (N) |
| style = "background:#e8e8f8" | 1301 | 81 | 14 | 1 | 3788 |
| style = "background:#e8e8f8" | 1302 | 74 | 17 | 2 | 3081 |
| style = "background:#e8e8f8" | 1303 | 69 | 10 | 2 | 948DR12 - 3%, DR11 - 3% DR5-2% |
| style = "background:#e8e8f8" | 1304 | 87 | 127 | ||
| style = "background:#e8e8f8" | 1305 | 54 | 12 | 305DR12 - 6%, DR11 - 7% DR5-4% | |
| style = "background:#e8e8f8" | 1306 | 78 | 9 | ||
| style = "background:#e8e8f8" | 1307 | >50 | 1 | ||
| style = "background:#e8e8f8" | 1308 | 45 | 55 | 9 | |
| style = "background:#e8e8f8" | 1310 | >75 | 5 |
Serotypes are unknown the following alleles: DRB1*1309, *1315 to *1379
DRB1*13 allele group
- 81 Alleles: 74 proteins
- DR13 (weak or no DR6) Serotype: *1301, *1302, *1304, *1306, *1307, *1310, *1312 to *1314
- DR6 (weak DR13) Serotype: *1308
- DR13&Other serotypes: *1303, *1305, *1311,
- Serotype unknown: *1309, *1315 to *1374
Disease associations
DRB1*1302 is linked to early childhood myastenia gravis.{{cite journal |vauthors=Shinomiya N, Nomura Y, Segawa M | title = A variant of childhood-onset myasthenia gravis: HLA typing and clinical characteristics in Japan. | journal = Clin Immunol | volume = 110 | issue = 2 | pages = 154–8 | year = 2004 | pmid = 15003812 | doi = 10.1016/j.clim.2003.10.004}} Alleles of DR13 along with immunization for hepatitis B and C are most protective against the disease.
=Extended linkage=
Genetic Linkage
| id="drugInfoBox" style="float: right; clear: right; margin: 0 0 0.5em 1em; background: #ffffff;" class="toccolours" border=0 cellpadding=0 align=left width="300px" | ||
| style="background:#f8f8f8"
|align="center" colspan="4" | DR13 Haplotypes | ||
| style="background:#f8f8f8"
| bgcolor="#dddddd"| ! bgcolor="#dddddd"| DRA !! bgcolor="#dddddd"| DRB1 !! bgcolor="#dddddd" | DRB3 | ||
| style="background:#f8f8f8"
| rowspan = "3" bgcolor="#e7dcc3" | DR13(6)-DR52 |bgcolor="#eeeeee"| *0101 | bgcolor="#eeeeee"| *1301 | bgcolor="#eeeeee" | *0101 |
| style="background:#f8f8f8"
|bgcolor="#eeeeee"| *0101 | bgcolor="#eeeeee"| *1301 | bgcolor="#eeeeee" | *0201 |
| style="background:#f8f8f8"
| bgcolor="#eeeeee"| *0101 | bgcolor="#eeeeee"| *1302 | bgcolor="#eeeeee" | *0301 |
| style="background:#f8f8f8"
| bgcolor="#dddddd"| ! bgcolor="#dddddd"| DQA1 !! bgcolor="#dddddd"| DQB1 !! bgcolor="#dddddd" | DRB1 | ||
| bgcolor="#e7dcc3" | DR13(6)-DQ6(6.3, 1)
| bgcolor="#eeeeee"| *0103 | bgcolor="#eeeeee"| *0603 | bgcolor="#eeeeee" | *1301 |
| bgcolor="#e7dcc3" | DR13(6)-DQ6(6.4, 1)
| bgcolor="#eeeeee"| *0102 | bgcolor="#eeeeee"| *0604 | bgcolor="#eeeeee" | *1302 |
| style="background:#f8f8f8"
| bgcolor="#e7dcc3" | DR13(6)-DQ6(6.5, 1) | bgcolor="#eeeeee"| *0102 | bgcolor="#eeeeee"| *0605 | bgcolor="#eeeeee" | *1302 |
| style="background:#f8f8f8"
| bgcolor="#e7dcc3" | DR13(6)-DQ6(6.9, 1) | bgcolor="#eeeeee"| *0102 | bgcolor="#eeeeee"| *0609 | bgcolor="#eeeeee" | *1302 |
| style="background:#f8f8f8"
| bgcolor="#dddddd"| ! bgcolor="#dddddd"| HLA-A !! bgcolor="#dddddd"| HLA-B !! bgcolor="#dddddd" | DRB1 | ||
| bgcolor="#e7dcc3" | A2-Cw5-B44(16)-DR13
| bgcolor="#eeeeee"| *02 | bgcolor="#eeeeee"| *4402 | bgcolor="#eeeeee" | *1301 |
HLA-DR13 is genetically linked to DR52{{cite journal |vauthors=Song EY, Park H, Roh EY, Park MH |title=HLA-DRB1 and -DRB3 allele frequencies and haplotypic associations in Koreans |journal=Hum. Immunol. |volume=65 |issue=3 |pages=270–6 |year=2004 |pmid=15041167 |doi=10.1016/j.humimm.2003.12.005}} and HLA-DQ6 (HLA-DQ1) serotypes.