HLA-DR14
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| align="center" colspan="2" | Image:DR Illustration.PNG | |
| align="center" colspan="2" | major histocompatibility complex, class II, DR14 | |
| bgcolor="#e7dcc3" | Haplotypes groups
| bgcolor="#eeeeee" | DRA*01:DRB1*1401 DRA*01:DRB1*1402 DRA*01:DRB1*1403 DRA*01:DRB1*1404 .... | |
| colspan="2" bgcolor="#dddddd" | Structure (See HLA-DR) | |
| style="background:#f8f8f8"
| bgcolor="#dddddd" | Identifiers | align="center" | alpha *0101 |
| bgcolor="#e7dcc3" | Symbol(s)
| bgcolor="#eeeeee" | [http://www.gene.ucl.ac.uk/nomenclature/data/get_data.php?hgnc_id=HGNC4947 HLA-DRA]{{Dead link|date=January 2020 |bot=InternetArchiveBot |fix-attempted=yes }} | |
| bgcolor="#e7dcc3" | EBI-HLA
| bgcolor="#eeeeee" | [http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi?DRA*0101 DRA*0101] | |
| style="background:#f8f8f8"
| bgcolor="#dddddd" | Identifiers | align="center" | beta 1 *1401 to *1408 *1410 |
| bgcolor="#e7dcc3" | Symbol(s)
| bgcolor="#eeeeee" | [http://www.gene.ucl.ac.uk/nomenclature/data/get_data.php?hgnc_id=4953 HLA-DRB1]{{Dead link|date=January 2020 |bot=InternetArchiveBot |fix-attempted=yes }} | |
| bgcolor="#e7dcc3" | EBI-HLA
| bgcolor="#eeeeee" | [http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi?DRB1*1401 DRB1*1401] {{Webarchive|url=https://web.archive.org/web/20110515171141/http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi?DRB1*1401 |date=2011-05-15 }} | |
| bgcolor="#e7dcc3" | EBI-HLA
| bgcolor="#eeeeee" | [http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi?DRB1*1402 DRB1*1402] | |
| bgcolor="#e7dcc3" | EBI-HLA
| bgcolor="#eeeeee" | [http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi?DRB1*1403 DRB1*1403] | |
| bgcolor="#e7dcc3" | EBI-HLA
| bgcolor="#eeeeee" | [http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi?DRB1*1404 DRB1*1404] | |
| bgcolor="#e7dcc3" | EBI-HLA
| bgcolor="#eeeeee" | [http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi?DRB1*1405 DRB1*1405] {{Webarchive|url=https://web.archive.org/web/20110515171447/http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi?DRB1*1405 |date=2011-05-15 }} | |
| bgcolor="#e7dcc3" | EBI-HLA
| bgcolor="#eeeeee" | [http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi?DRB1*1406 DRB1*1406] | |
| colspan="2" bgcolor="#dddddd" | Shared data | |
| bgcolor="#e7dcc3" | Locus
| bgcolor="#eeeeee" | chr.6 [https://www.ncbi.nlm.nih.gov/Omim/getmap.cgi?chromosome=6p21.31 6p21.31] |
HLA-DR14(DR14) is a HLA-DR serotype that recognizes the DRB1*1401 to *1408, *1410 to *1418, and other *14 gene products. DR14 serotype is a split antigen of the older HLA-DR6 serotype group which also contains the similar HLA-DR13 antigens.
Alleles
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|+ DR14, DR6 and other serotype recognition of some DRB1*14 alleles[http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA] | ||||
| style="background:#f0f0ff"
| style="width:60px" | DRB1* | style="width:60px" | DR14
| style="width:60px" | DR6 | style="width:60px" | DR13 | style="width:60px" | Sample | |
| style="background:#f0f0ff"
| allele | % | % | % | size (N) |
| style = "background:#e8e8f8" | 1401 | 74 | 14 | 3 | 1942 |
| style = "background:#e8e8f8" | 1402 | 61 | 13 | 9 | 204 |
| style = "background:#e8e8f8" | 1403 | 72 | 12 | 2 | 37 |
| style = "background:#e8e8f8" | 1404 | 79 | 8 | 80DR1404 - 3% | |
| style = "background:#e8e8f8" | 1405 | 86 | 10 | 58 | |
| style = "background:#e8e8f8" | 1406 | 37 | 15 | 22 | 117 |
| style = "background:#e8e8f8" | 1407 | 90 | 10 | ||
| style = "background:#e8e8f8" | 1408 | 25 | 4 | ||
| style = "background:#e8e8f8" | 1410 | >75 | 4 |
Serotypes are unknown the following alleles: DRB1**1409, *1419 to *1462
Disease associations
DRB1*1402: juvenile rheumatoid arthritis,{{cite journal |vauthors=Garavito G, Yunis E, Egea E, Ramirez L, Malagón C, Iglesias A, De La Cruz O, Uribe O, Navarro E, Martinez P, Jaraquemada D | title = HLA-DRB1 alleles and HLA-DRB1 shared epitopes are markers for juvenile rheumatoid arthritis subgroups in Colombian mestizos. | journal = Hum Immunol | volume = 65 | issue = 4 | pages = 359–65 | year = 2004 | pmid = 15120191 | doi = 10.1016/j.humimm.2004.01.016}} increased longevity in Okinawans.
=Extended linkage=
DR*14:DQ5 haplotype: increased risk for non-AChR autoantibodies in myasthenia gravis.{{cite journal |vauthors=Niks EH, Kuks JB, Roep BO, etal | title = Strong association of MuSK antibody-positive myasthenia gravis and HLA-DR14-DQ5 | journal = Neurology | volume = 66 | issue = 11 | pages = 1772–4 | year = 2006 | pmid = 16769963 | doi = 10.1212/01.wnl.0000218159.79769.5c| s2cid = 41206495 }}
Genetic Linkage
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|align="center" colspan="4" | DR14 Haplotypes | ||
| style="background:#f8f8f8"
| bgcolor="#dddddd"| ! bgcolor="#dddddd"| DRA !! bgcolor="#dddddd"| DRB1 !! bgcolor="#dddddd" | DRB3 | ||
| style="background:#f8f8f8"
| rowspan = "3" bgcolor="#e7dcc3" | DR14(6)-DR52 | bgcolor="#eeeeee"| *0101 | bgcolor="#eeeeee"| *1401 | bgcolor="#eeeeee" | *0201 |
| style="background:#f8f8f8"
| bgcolor="#eeeeee"| *0101 | bgcolor="#eeeeee"| *1402 | bgcolor="#eeeeee" | *0201 |
| style="background:#f8f8f8"
| bgcolor="#eeeeee"| *0101 | bgcolor="#eeeeee"| *1403 | bgcolor="#eeeeee" | *0101 |
| style="background:#f8f8f8"
| bgcolor="#dddddd"| ! bgcolor="#dddddd"| DQA1 !! bgcolor="#dddddd"| DQB1 !! bgcolor="#dddddd" | DRB1 | ||
| bgcolor="#e7dcc3" | DR14-DQ5(5.3, 1)
| bgcolor="#eeeeee"| *0104 | bgcolor="#eeeeee"| *0503 | bgcolor="#eeeeee" | *1401 |
| style="background:#f8f8f8"
| bgcolor="#dddddd"| ! bgcolor="#dddddd"| HLA-A !! bgcolor="#dddddd"| HLA-B !! bgcolor="#dddddd" | DRB1 | ||
| bgcolor="#e7dcc3" | A11-B35-DR14(6)
| bgcolor="#eeeeee"| *1101 | bgcolor="#eeeeee"| *3501 | bgcolor="#eeeeee" | *1401 |
| bgcolor="#e7dcc3" | A2-B51(5)-DR14(6)
| bgcolor="#eeeeee"| *0201 | bgcolor="#eeeeee"| *5101 | bgcolor="#eeeeee" | *1401 |
HLA-DR13 is genetically linked to HLA-DR52{{cite journal |vauthors=Song EY, Park H, Roh EY, Park MH |title=HLA-DRB1 and -DRB3 allele frequencies and haplotypic associations in Koreans |journal=Hum. Immunol. |volume=65 |issue=3 |pages=270–6 |year=2004 |pmid=15041167 |doi=10.1016/j.humimm.2003.12.005}} and HLA-DQ5 (HLA-DQ1) serotypes.