Insulin-like growth factor 1 receptor

File:Structure of IGF-1R.jpg

Two alpha subunits and two beta subunits make up the IGF-1 receptor. Both the α and β subunits are synthesized from a single mRNA precursor. The precursor is then glycosylated, proteolytically cleaved, and crosslinked by cysteine bonds to form a functional transmembrane αβ chain.{{cite journal | vauthors = Gregory CW, DeGeorges A, Sikes RA | title = The IGF axis in the development and progression of prostate cancer | journal = Recent Research Developments in Cancer | pages = 437–462 | year = 2001 | isbn = 81-7895-002-2}} The α chains are located extracellularly, while the β subunit spans the membrane and is responsible for intracellular signal transduction upon ligand stimulation. The mature IGF-1R has a molecular weight of approximately 320 kDa.^{[https://www.uniprot.org/uniprot/P08069 citation?]} The receptor is a member of a family which consists of the insulin receptor and the IGF-2R (and their respective ligands IGF-1 and IGF-2), along with several IGF-binding proteins.

IGF-1R and the insulin receptor both have a binding site for ATP, which is used to provide the phosphates for autophosphorylation. There is a 60% homology between IGF-1R and the insulin receptor. The structures of the autophosphorylation complexes of tyrosine residues 1165 and 1166 have been identified within crystals of the IGF1R kinase domain.{{cite journal | vauthors = Xu Q, Malecka KL, Fink L, Jordan EJ, Duffy E, Kolander S, Peterson JR, Dunbrack RL | title = Identifying three-dimensional structures of autophosphorylation complexes in crystals of protein kinases | journal = Science Signaling | volume = 8 | issue = 405 | pages = rs13 | date = December 2015 | pmid = 26628682 | pmc = 4766099 | doi = 10.1126/scisignal.aaa6711 }}

In response to ligand binding, the α chains induce the tyrosine autophosphorylation of the β chains. This event triggers a cascade of intracellular signaling that, while cell type-specific, often promotes cell survival and cell proliferation.{{cite journal | vauthors = Jones JI, Clemmons DR | title = Insulin-like growth factors and their binding proteins: biological actions | journal = Endocrine Reviews | volume = 16 | issue = 1 | pages = 3–34 | date = February 1995 | pmid = 7758431 | doi = 10.1210/edrv-16-1-3 }}{{cite journal | vauthors = LeRoith D, Werner H, Beitner-Johnson D, Roberts CT | title = Molecular and cellular aspects of the insulin-like growth factor I receptor | journal = Endocrine Reviews | volume = 16 | issue = 2 | pages = 143–63 | date = April 1995 | pmid = 7540132 | doi = 10.1210/edrv-16-2-143 }}

Tyrosine kinase receptors, including the IGF-1 receptor, mediate their activity by causing the addition of a phosphate groups to particular tyrosines on certain proteins within a cell. This addition of phosphate induces what are called "cell signaling" cascades - and the usual result of activation of the IGF-1 receptor is survival and proliferation in mitosis-competent cells, and growth (hypertrophy) in tissues such as skeletal muscle and cardiac muscle.

During embryonic development, the IGF-1R pathway is involved with the developing limb buds.

The IGFR signalling pathway is of critical importance during normal development of mammary gland tissue during pregnancy and lactation. During pregnancy, there is intense proliferation of epithelial cells which form the duct and gland tissue. Following weaning, the cells undergo apoptosis and all the tissue is destroyed. Several growth factors and hormones are involved in this overall process, and IGF-1R is believed to have roles in the differentiation of the cells and a key role in inhibiting apoptosis until weaning is complete.

IGF-1 binds to at least two cell surface receptors: the IGF1 Receptor (IGFR), and the insulin receptor. The IGF-1 receptor seems to be the "physiologic" receptor—it binds IGF-1 at significantly higher affinity than it binds insulin.{{cite journal|vauthors=Hawsawi Y, El-Gendy R, Twelves C, Speirs V, Beattie J|date=December 2013|title=Insulin-like growth factor - oestradiol crosstalk and mammary gland tumourigenesis|journal=Biochimica et Biophysica Acta (BBA) - Reviews on Cancer|volume=1836|issue=2|pages=345–53|doi=10.1016/j.bbcan.2013.10.005|pmid=24189571|url=http://eprints.whiterose.ac.uk/80781/1/Insulin%20like%20growth%20factor%20Oestradiol%20crosstalk%20and%20mammary%20gland%20tumourigenesis.pdf}} Like the insulin receptor, the IGF-1 receptor is a receptor tyrosine kinase—meaning it signals by causing the addition of a phosphate molecule on particular tyrosines. IGF-1 activates the insulin receptor at approximately 10% the potency of insulin. Part of this signaling may be via IGF1R/insulin receptor heterodimers (the reason for the confusion is that binding studies show that IGF-1 binds the insulin receptor 100-fold less well than insulin, yet that does not correlate with the actual potency of IGF-1 in vivo at inducing phosphorylation of the insulin receptor, and hypoglycemia).

Studies in female mice have shown that both supraoptic nucleus (SON) and paraventricular nucleus (PVN) lose approximately one-third of IGF-1R immunoreactive cells with normal aging. Also, old calorically restricted (CR) mice lost higher numbers of IGF-1R non-immunoreactive cells while maintaining similar counts of IGF-1R immunoreactive cells in comparison to old-Al mice. Consequently, old-CR mice show a higher percentage of IGF-1R immunoreactive cells, reflecting increased hypothalamic sensitivity to IGF-1 in comparison to normally aging mice.{{cite journal | vauthors = Saeed O, Yaghmaie F, Garan SA, Gouw AM, Voelker MA, Sternberg H, Timiras PS | title = Insulin-like growth factor-1 receptor immunoreactive cells are selectively maintained in the paraventricular hypothalamus of calorically restricted mice | journal = International Journal of Developmental Neuroscience | volume = 25 | issue = 1 | pages = 23–8 | date = February 2007 | pmid = 17194562 | doi = 10.1016/j.ijdevneu.2006.11.004 | s2cid = 5828689 | doi-access = free }}{{cite journal | vauthors = Yaghmaie F, Saeed O, Garan SA, Voelker MA, Gouw AM, Freitag W, Sternberg H, Timiras PS | title = Age-dependent loss of insulin-like growth factor-1 receptor immunoreactive cells in the supraoptic hypothalamus is reduced in calorically restricted mice | journal = International Journal of Developmental Neuroscience | volume = 24 | issue = 7 | pages = 431–6 | date = November 2006 | pmid = 17034982 | doi = 10.1016/j.ijdevneu.2006.08.008 | s2cid = 22533403 }}

Mutations in IGF1R have been associated with craniosynostosis.{{cite journal | vauthors = Cunningham ML, Horst JA, Rieder MJ, Hing AV, Stanaway IB, Park SS, Samudrala R, Speltz ML | title = IGF1R variants associated with isolated single suture craniosynostosis | journal = American Journal of Medical Genetics. Part A | volume = 155A | issue = 1 | pages = 91–7 | date = January 2011 | pmid = 21204214 | pmc = 3059230 | doi = 10.1002/ajmg.a.33781 }}

IGF-1R has been shown to have a significant effect on body size in small dog breeds. A "nonsynonymous SNP at chr3:44,706,389 that changes a highly conserved arginine at amino acid 204 to histidine" is associated with particularly tiny body size. "This mutation is predicted to prevent formation of several hydrogen bonds within the cysteine-rich domain of the receptor’s ligand-binding extracellular subunit. Nine of 13 tiny dog breeds carry the mutation and many dogs are homozygous for it." Smaller individuals within several small and medium-sized breeds were shown to carry this mutation as well.

Mice carrying only one functional copy of IGF-1R are normal, but exhibit a ~15% decrease in body mass. IGF-1R has also been shown to regulate body size in dogs. A mutated version of this gene is found in a number of small dog breeds.{{cite journal | vauthors = Hoopes BC, Rimbault M, Liebers D, Ostrander EA, Sutter NB | title = The insulin-like growth factor 1 receptor (IGF1R) contributes to reduced size in dogs | journal = Mammalian Genome | volume = 23 | issue = 11–12 | pages = 780–90 | date = December 2012 | pmid = 22903739 | pmc = 3511640 | doi = 10.1007/s00335-012-9417-z }}

Deletion of the IGF-1 receptor gene in mice results in lethality during early embryonic development, and for this reason, IGF-1 insensitivity, unlike the case of growth hormone (GH) insensitivity (Laron syndrome), is not observed in the human population.{{cite book| vauthors = Harris JR, Lippman ME, Osborne CK, Morrow M |title=Diseases of the Breast|url=https://books.google.com/books?id=GLc8xYe239kC&pg=PT88|date=28 March 2012|publisher=Lippincott Williams & Wilkins |isbn=978-1-4511-4870-1 |pages=88–}}

The IGF-1R is implicated in several cancers,{{cite journal | vauthors = Warshamana-Greene GS, Litz J, Buchdunger E, García-Echeverría C, Hofmann F, Krystal GW | title = The insulin-like growth factor-I receptor kinase inhibitor, NVP-ADW742, sensitizes small cell lung cancer cell lines to the effects of chemotherapy | journal = Clinical Cancer Research | volume = 11 | issue = 4 | pages = 1563–71 | date = February 2005 | pmid = 15746061 | doi = 10.1158/1078-0432.CCR-04-1544 | s2cid = 12090402 | doi-access = }}{{cite journal | vauthors = Jones HE, Goddard L, Gee JM, Hiscox S, Rubini M, Barrow D, Knowlden JM, Williams S, Wakeling AE, Nicholson RI | title = Insulin-like growth factor-I receptor signalling and acquired resistance to gefitinib (ZD1839; Iressa) in human breast and prostate cancer cells | journal = Endocrine-Related Cancer | volume = 11 | issue = 4 | pages = 793–814 | date = December 2004 | pmid = 15613453 | doi = 10.1677/erc.1.00799 | hdl = 11392/523178 | s2cid = 19466790 | doi-access = free }} including breast, prostate, and lung cancers. In some instances its anti-apoptotic properties allow cancerous cells to resist the cytotoxic properties of chemotherapeutic drugs or radiotherapy. In breast cancer, where EGFR inhibitors such as erlotinib are being used to inhibit the EGFR signaling pathway, IGF-1R confers resistance by forming one half of a heterodimer (see the description of EGFR signal transduction in the erlotinib page), allowing EGFR signaling to resume in the presence of a suitable inhibitor. This process is referred to as crosstalk between EGFR and IGF-1R. It is further implicated in breast cancer by increasing the metastatic potential of the original tumour by conferring the ability to promote vascularisation.

Increased levels of the IGF-IR are expressed in the majority of primary and metastatic prostate cancer patient tumors.{{cite journal | vauthors = Hellawell GO, Turner GD, Davies DR, Poulsom R, Brewster SF, Macaulay VM | title = Expression of the type 1 insulin-like growth factor receptor is up-regulated in primary prostate cancer and commonly persists in metastatic disease | journal = Cancer Research | volume = 62 | issue = 10 | pages = 2942–50 | date = May 2002 | pmid = 12019176 }} Evidence suggests that IGF-IR signaling is required for survival and growth when prostate cancer cells progress to androgen independence.{{cite journal | vauthors = Krueckl SL, Sikes RA, Edlund NM, Bell RH, Hurtado-Coll A, Fazli L, Gleave ME, Cox ME | title = Increased insulin-like growth factor I receptor expression and signaling are components of androgen-independent progression in a lineage-derived prostate cancer progression model | journal = Cancer Research | volume = 64 | issue = 23 | pages = 8620–9 | date = December 2004 | pmid = 15574769 | doi = 10.1158/0008-5472.CAN-04-2446 | doi-access = free }} In addition, when immortalized prostate cancer cells mimicking advanced disease are treated with the IGF-1R ligand, IGF-1, the cells become more motile.{{cite journal | vauthors = Yao H, Dashner EJ, van Golen CM, van Golen KL | title = RhoC GTPase is required for PC-3 prostate cancer cell invasion but not motility | journal = Oncogene | volume = 25 | issue = 16 | pages = 2285–96 | date = April 2006 | pmid = 16314838 | doi = 10.1038/sj.onc.1209260 | doi-access = free }}

Members of the IGF receptor family and their ligands also seem to be involved in the carcinogenesis of mammary tumors of dogs.{{cite journal | vauthors = Klopfleisch R, Hvid H, Klose P, da Costa A, Gruber AD | title = Insulin receptor is expressed in normal canine mammary gland and benign adenomas but decreased in metastatic canine mammary carcinomas similar to human breast cancer | journal = Veterinary and Comparative Oncology | volume = 8 | issue = 4 | pages = 293–301 | date = December 2010 | pmid = 21062411 | doi = 10.1111/j.1476-5829.2009.00232.x | doi-access = }}{{cite journal | vauthors = Klopfleisch R, Lenze D, Hummel M, Gruber AD | title = Metastatic canine mammary carcinomas can be identified by a gene expression profile that partly overlaps with human breast cancer profiles | journal = BMC Cancer | volume = 10 | pages = 618 | date = November 2010 | pmid = 21062462 | pmc = 2994823 | doi = 10.1186/1471-2407-10-618 | doi-access = free }} IGF1R is amplified in several cancer types based on analysis of TCGA data, and gene amplification could be one mechanism for overexpression of IGF1R in cancer.{{cite journal | vauthors = Chen Y, McGee J, Chen X, Doman TN, Gong X, Zhang Y, Hamm N, Ma X, Higgs RE, Bhagwat SV, Buchanan S, Peng SB, Staschke KA, Yadav V, Yue Y, Kouros-Mehr H | title = Identification of druggable cancer driver genes amplified across TCGA datasets | journal = PLOS ONE | volume = 9 | issue = 5 | pages = e98293 | date = 2014 | pmid = 24874471 | pmc = 4038530 | doi = 10.1371/journal.pone.0098293 | bibcode = 2014PLoSO...998293C | doi-access = free }}

Lung cancer cells stimulated using glucocorticoids were induced into a reversible dormancy state which was dependent on the IGF-1R and its accompanying survival signaling pathways.{{cite journal| vauthors = Prekovic S, Schuurman K, Mayayo-Peralta I, Manjón AG, Buijs M, Yavuz S, Wellenstein MD, Barrera A, Monkhorst K, Huber A, Morris B|title=Glucocorticoid receptor triggers a reversible drug-tolerant dormancy state with acquired therapeutic vulnerabilities in lung cancer|journal=Nature Communications|volume=12|issue=1|date=July 2021| page = 4360|doi = 10.1038/s41467-021-24537-3| pmid = 34272384| pmc = 8285479| bibcode = 2021NatCo..12.4360P| doi-access = free }}

Due to the similarity of the structures of IGF-1R and the insulin receptor (IR), especially in the regions of the ATP binding site and tyrosine kinase regions, synthesising selective inhibitors of IGF-1R is difficult. Prominent in current research are three main classes of inhibitor:

1. Tyrphostins such as AG538{{cite journal | vauthors = Blum G, Gazit A, Levitzki A | title = Substrate competitive inhibitors of IGF-1 receptor kinase | journal = Biochemistry | volume = 39 | issue = 51 | pages = 15705–12 | date = December 2000 | pmid = 11123895 | doi = 10.1021/bi001516y }} and AG1024. These are in early pre-clinical testing. They are not thought to be ATP-competitive, although they are when used in EGFR as described in QSAR studies. These show some selectivity towards IGF-1R over IR.
2. Pyrrolo(2,3-d)-pyrimidine derivatives such as NVP-AEW541, invented by Novartis, which show far greater (100 fold) selectivity towards IGF-1R over IR.{{Cite web |url=http://www.targeting-the-kinome.org/images/Garcia-Echeverria3.pdf |title=Archived copy |access-date=2012-07-18 |archive-date=2016-03-04 |archive-url=https://web.archive.org/web/20160304090810/http://www.targeting-the-kinome.org/images/Garcia-Echeverria3.pdf |url-status=dead }}
3. Monoclonal antibodies are probably the most specific and promising therapeutic compounds. Teprotumumab is a novel therapy showing significant benefit for Thyroid Eye Disease.

Insulin-like growth factor 1 receptor has been shown to interact with:

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• ARHGEF12,{{cite journal | vauthors = Taya S, Inagaki N, Sengiku H, Makino H, Iwamatsu A, Urakawa I, Nagao K, Kataoka S, Kaibuchi K | title = Direct interaction of insulin-like growth factor-1 receptor with leukemia-associated RhoGEF | journal = The Journal of Cell Biology | volume = 155 | issue = 5 | pages = 809–20 | date = November 2001 | pmid = 11724822 | pmc = 2150867 | doi = 10.1083/jcb.200106139 }}
• C-src tyrosine kinase,{{cite journal | vauthors = Arbet-Engels C, Tartare-Deckert S, Eckhart W | title = C-terminal Src kinase associates with ligand-stimulated insulin-like growth factor-I receptor | journal = The Journal of Biological Chemistry | volume = 274 | issue = 9 | pages = 5422–8 | date = February 1999 | pmid = 10026153 | doi = 10.1074/jbc.274.9.5422 | doi-access = free }}
• Cbl gene,{{cite journal | vauthors = Sehat B, Andersson S, Girnita L, Larsson O | title = Identification of c-Cbl as a new ligase for insulin-like growth factor-I receptor with distinct roles from Mdm2 in receptor ubiquitination and endocytosis | journal = Cancer Research | volume = 68 | issue = 14 | pages = 5669–77 | date = July 2008 | pmid = 18632619 | doi = 10.1158/0008-5472.CAN-07-6364 | doi-access = }}
• EHD1,{{cite journal | vauthors = Rotem-Yehudar R, Galperin E, Horowitz M | title = Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29 | journal = The Journal of Biological Chemistry | volume = 276 | issue = 35 | pages = 33054–60 | date = August 2001 | pmid = 11423532 | doi = 10.1074/jbc.M009913200 | doi-access = free }}
• GRB10,{{cite journal | vauthors = Vecchione A, Marchese A, Henry P, Rotin D, Morrione A | title = The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor | journal = Molecular and Cellular Biology | volume = 23 | issue = 9 | pages = 3363–72 | date = May 2003 | pmid = 12697834 | pmc = 153198 | doi = 10.1128/mcb.23.9.3363-3372.2003 }}{{cite journal | vauthors = Dey BR, Frick K, Lopaczynski W, Nissley SP, Furlanetto RW | title = Evidence for the direct interaction of the insulin-like growth factor I receptor with IRS-1, Shc, and Grb10 | journal = Molecular Endocrinology | volume = 10 | issue = 6 | pages = 631–41 | date = June 1996 | pmid = 8776723 | doi = 10.1210/mend.10.6.8776723 | doi-access = free }}{{cite journal | vauthors = He W, Rose DW, Olefsky JM, Gustafson TA | title = Grb10 interacts differentially with the insulin receptor, insulin-like growth factor I receptor, and epidermal growth factor receptor via the Grb10 Src homology 2 (SH2) domain and a second novel domain located between the pleckstrin homology and SH2 domains | journal = The Journal of Biological Chemistry | volume = 273 | issue = 12 | pages = 6860–7 | date = March 1998 | pmid = 9506989 | doi = 10.1074/jbc.273.12.6860 | doi-access = free }}{{cite journal | vauthors = Morrione A, Valentinis B, Li S, Ooi JY, Margolis B, Baserga R | title = Grb10: A new substrate of the insulin-like growth factor I receptor | journal = Cancer Research | volume = 56 | issue = 14 | pages = 3165–7 | date = July 1996 | pmid = 8764099 }}
• IRS1,{{cite journal | vauthors = Tartare-Deckert S, Sawka-Verhelle D, Murdaca J, Van Obberghen E | title = Evidence for a differential interaction of SHC and the insulin receptor substrate-1 (IRS-1) with the insulin-like growth factor-I (IGF-I) receptor in the yeast two-hybrid system | journal = The Journal of Biological Chemistry | volume = 270 | issue = 40 | pages = 23456–60 | date = October 1995 | pmid = 7559507 | doi = 10.1074/jbc.270.40.23456 | doi-access = free }}
• Mdm2,
• NEDD4,
• PIK3R3,{{cite journal | vauthors = Mothe I, Delahaye L, Filloux C, Pons S, White MF, Van Obberghen E | title = Interaction of wild type and dominant-negative p55PIK regulatory subunit of phosphatidylinositol 3-kinase with insulin-like growth factor-1 signaling proteins | journal = Molecular Endocrinology | volume = 11 | issue = 13 | pages = 1911–23 | date = December 1997 | pmid = 9415396 | doi = 10.1210/mend.11.13.0029 | doi-access = free }}
• PTPN11,{{cite journal | vauthors = Mañes S, Mira E, Gómez-Mouton C, Zhao ZJ, Lacalle RA, Martínez-A C | title = Concerted activity of tyrosine phosphatase SHP-2 and focal adhesion kinase in regulation of cell motility | journal = Molecular and Cellular Biology | volume = 19 | issue = 4 | pages = 3125–35 | date = April 1999 | pmid = 10082579 | pmc = 84106 | doi = 10.1128/mcb.19.4.3125 }}{{cite journal | vauthors = Seely BL, Reichart DR, Staubs PA, Jhun BH, Hsu D, Maegawa H, Milarski KL, Saltiel AR, Olefsky JM | title = Localization of the insulin-like growth factor I receptor binding sites for the SH2 domain proteins p85, Syp, and GTPase activating protein | journal = The Journal of Biological Chemistry | volume = 270 | issue = 32 | pages = 19151–7 | date = August 1995 | pmid = 7642582 | doi = 10.1074/jbc.270.32.19151 | doi-access = free}}
• RAS p21 protein activator 1,
• SHC1{{cite journal | vauthors = Santen RJ, Song RX, Zhang Z, Kumar R, Jeng MH, Masamura A, Lawrence J, Berstein L, Yue W | title = Long-term estradiol deprivation in breast cancer cells up-regulates growth factor signaling and enhances estrogen sensitivity | journal = Endocrine-Related Cancer | volume = 12 | pages = S61-73 | date = July 2005 | pmid = 16113100 | doi = 10.1677/erc.1.01018 | series = 12 | issue = Suppl 1 | s2cid = 18995886 }}
• SOCS2,{{cite journal | vauthors = Dey BR, Spence SL, Nissley P, Furlanetto RW | title = Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor | journal = The Journal of Biological Chemistry | volume = 273 | issue = 37 | pages = 24095–101 | date = September 1998 | pmid = 9727029 | doi = 10.1074/jbc.273.37.24095 | doi-access = free }}
• SOCS3,{{cite journal | vauthors = Dey BR, Furlanetto RW, Nissley P | title = Suppressor of cytokine signaling (SOCS)-3 protein interacts with the insulin-like growth factor-I receptor | journal = Biochemical and Biophysical Research Communications | volume = 278 | issue = 1 | pages = 38–43 | date = November 2000 | pmid = 11071852 | doi = 10.1006/bbrc.2000.3762 | url = https://zenodo.org/record/1229526 }} and
• YWHAE.{{cite journal | vauthors = Craparo A, Freund R, Gustafson TA | title = 14-3-3 (epsilon) interacts with the insulin-like growth factor I receptor and insulin receptor substrate I in a phosphoserine-dependent manner | journal = The Journal of Biological Chemistry | volume = 272 | issue = 17 | pages = 11663–9 | date = April 1997 | pmid = 9111084 | doi = 10.1074/jbc.272.17.11663 | doi-access = free }}

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There is evidence to suggest that IGF1R is negatively regulated by the microRNA miR-7.{{cite journal | vauthors = Jiang L, Liu X, Chen Z, Jin Y, Heidbreder CE, Kolokythas A, Wang A, Dai Y, Zhou X | title = MicroRNA-7 targets IGF1R (insulin-like growth factor 1 receptor) in tongue squamous cell carcinoma cells | journal = The Biochemical Journal | volume = 432 | issue = 1 | pages = 199–205 | date = November 2010 | pmid = 20819078 | pmc = 3130335 | doi = 10.1042/BJ20100859 }}

• Hypothalamic–pituitary–somatic axis
• Insulin receptor
• Linsitinib, an inhibitor of IGF-1R in clinical trials for cancer treatment

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{{refbegin|35em}}

• {{cite journal | vauthors = Benito M, Valverde AM, Lorenzo M | title = IGF-I: a mitogen also involved in differentiation processes in mammalian cells | journal = The International Journal of Biochemistry & Cell Biology | volume = 28 | issue = 5 | pages = 499–510 | date = May 1996 | pmid = 8697095 | doi = 10.1016/1357-2725(95)00168-9 }}
• {{cite journal | vauthors = Butler AA, Yakar S, Gewolb IH, Karas M, Okubo Y, LeRoith D | title = Insulin-like growth factor-I receptor signal transduction: at the interface between physiology and cell biology | journal = Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology | volume = 121 | issue = 1 | pages = 19–26 | date = September 1998 | pmid = 9972281 | doi = 10.1016/S0305-0491(98)10106-2 | url = https://zenodo.org/record/1260019 }}
• {{cite journal | vauthors = Zhang X, Yee D | title = Tyrosine kinase signalling in breast cancer: insulin-like growth factors and their receptors in breast cancer | journal = Breast Cancer Research | volume = 2 | issue = 3 | pages = 170–5 | year = 2001 | pmid = 11250706 | pmc = 138771 | doi = 10.1186/bcr50 | doi-access = free }}
• {{cite journal | vauthors = Gross JM, Yee D | title = The type-1 insulin-like growth factor receptor tyrosine kinase and breast cancer: biology and therapeutic relevance | journal = Cancer and Metastasis Reviews | volume = 22 | issue = 4 | pages = 327–36 | date = December 2003 | pmid = 12884909 | doi = 10.1023/A:1023720928680 | s2cid = 35963688 }}
• {{cite journal | vauthors = Adams TE, McKern NM, Ward CW | title = Signalling by the type 1 insulin-like growth factor receptor: interplay with the epidermal growth factor receptor | journal = Growth Factors | volume = 22 | issue = 2 | pages = 89–95 | date = June 2004 | pmid = 15253384 | doi = 10.1080/08977190410001700998 | s2cid = 86844427 }}
• {{cite journal | vauthors = Surmacz E, Bartucci M | title = Role of estrogen receptor alpha in modulating IGF-I receptor signaling and function in breast cancer | journal = Journal of Experimental & Clinical Cancer Research | volume = 23 | issue = 3 | pages = 385–94 | date = September 2004 | pmid = 15595626 }}
• {{cite book | vauthors = Wood AW, Duan C, Bern HA | title = Insulin-like growth factor signaling in fish | volume = 243 | pages = 215–85 | year = 2005 | pmid = 15797461 | doi = 10.1016/S0074-7696(05)43004-1 | isbn = 978-0-12-364647-7 | series = International Review of Cytology }}
• {{cite journal | vauthors = Sarfstein R, Maor S, Reizner N, Abramovitch S, Werner H | title = Transcriptional regulation of the insulin-like growth factor-I receptor gene in breast cancer | journal = Molecular and Cellular Endocrinology | volume = 252 | issue = 1–2 | pages = 241–6 | date = June 2006 | pmid = 16647191 | doi = 10.1016/j.mce.2006.03.018 | s2cid = 24895685 | doi-access = free }}

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• {{MeshName|IGF-1+Receptor}}
• {{PDBe-KB2|P08069|Insulin-like growth factor 1 receptor}}

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Category:Clusters of differentiation

Category:Tyrosine kinase receptors

Category:Integral membrane proteins