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List of adverse effects of paroxetine

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This is a list of adverse effects of the antidepressant paroxetine, sorted by frequency of occurrence.{{cite web|title=PRODUCT INFORMATION PAROXETINE SANDOZ 20mg FILM-COATED TABLETS|work=TGA eBusiness Services|publisher=Sandoz Pty Ltd|date=18 January 2012|access-date=22 November 2013|url=https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2010-PI-03771-3|format=PDF}}{{cite web|title=PAROXETINE (paroxetine hydrochloride hemihydrate) tablet, film coated [Mylan Institutional Inc.]|work=DailyMed|publisher=Mylan Institutional Inc.|date=January 2012|access-date=22 November 2013|url=http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=f235ee45-9517-45de-8df7-9a06fdb43380}}{{cite web|title=Paroxetine 20 mg Tablets - Summary of Product Characteristics (SPC)|work=electronic Medicines Compendium|publisher=Sandoz Limited|date=21 March 2013|access-date=22 November 2013|url=http://www.medicines.org.uk/emc/medicine/26634/SPC/Paroxetine+20+mg+Tablets/}}{{cite web|title=Paxil, Paxil CR (paroxetine) dosing, indications, interactions, adverse effects, and more|work=Medscape Reference|publisher=WebMD|access-date=22 November 2013|url=http://reference.medscape.com/drug/paxil-brisdelle-paroxetine-342959}}

Very common

Very common (10-100% incidence) adverse effects include:

  • Nausea
  • Sexual dysfunction (including anorgasmia (difficulty achieving an orgasm), erectile dysfunction, genital anaesthesia, ejaculation disorder, loss of libido etc.). Paroxetine is associated with a higher rate of sexual dysfunction than other SSRIs.{{cite book | isbn = 978-0-470-97948-8 | title = The Maudsley prescribing guidelines in psychiatry |edition=11th |series=Prescribing guidelines in psychiatry | last1 = Taylor | first1 = David |last2=Paton |first2=Carol |last3=Shitij |first3=Kapur | year = 2012 | publisher = Wiley-Blackwell | location = West Sussex |oclc=780368001 }}{{Page needed|date=January 2017}}
  • Impaired concentration
  • Somnolence is more common with paroxetine than with other SSRIs.{{cite book | isbn = 978-1-60327-434-0 | title = Pharmacotherapy of Depression | edition = 2nd | year = 2011 | publisher = Humana Press | location = New York, NY | doi = 10.1007/978-1-60327-435-7 |editor1-last=Ciraulo |editor1-first=Domenic A. |editor2-last=Shader |editor2-first=Richard Irwin |oclc=697508697 }}{{Page needed|date=January 2017}}
  • Insomnia
  • Headache
  • Dry mouth

Common

Common (1-10% incidence) adverse effects include:

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  • Changes in appetite
  • Dyspepsia (indigestion)
  • Tooth disorder
  • Stomatitis
  • Oropharyngeal disorder
  • Flatulence
  • Impaired urination
  • Urinary frequency
  • Agitation
  • Abnormal dreams (including intense dreams or nightmares)
  • Hypercholesterolaemia (elevated blood cholesterol)
  • Dizziness
  • Tremor
  • Blurred vision
  • Yawning
  • Diarrhoea which is less common with paroxetine than with other SSRIs.
  • Constipation (if chronic may lead to hemorrhoids)
  • Vomiting
  • Anxiety
  • Nervousness
  • Hypomania,{{cite journal |vauthors=Vesely C, Fischer P, Goessler R, Kasper S |title=Mania associated with serotonin selective reuptake inhibitors |journal=J Clin Psychiatry|volume=58|issue=2|page=88|date=February 1997 |pmid=9062382 |doi= 10.4088/JCP.v58n0206e|doi-access=free}}{{Unreliable medical source |sure=y |date=January 2017 |reason=Letter to the editor. }}{{cite journal |last=Ramasubbu |first=Rajamannar |name-list-style=vanc |title=Antidepressant treatment-associated behavioural expression of hypomania: a case series |journal=Prog Neuropsychopharmacol Biol Psychiatry |volume=28|issue=7 |pages=1201–7 |date=November 2004 |pmid=15610935|doi=10.1016/j.pnpbp.2004.06.015 |s2cid=13609988 }}{{cite journal|author=Grubbs JH|title=SSRI-induced mania|journal=J Am Acad Child Adolesc Psychiatry |volume=36 |issue=4 |page=445|date=April 1997|pmid=9100415 |doi= 10.1097/00004583-199704000-00003}}{{Unreliable medical source |sure=y |date=January 2017 |reason=Letter to the editor. }} may occur in as many as 8% of patients being treated with paroxetine. May be more common in those with bipolar disorder.
  • Asthenia
  • Weight gain or loss. Usually gain, paroxetine tends to produce more weight gain than other SSRIs.{{rp|page=[{{google books|Rf8aGXexUKMC|page=58|plainurl=y}} 58]}}
  • Confusion
  • Emotional lability
  • Myoclonus
  • Myopathy
  • Myalgia
  • Myasthenia
  • Drugged feeling
  • Hyperthesia
  • Respiratory disorder
  • Pharyngitis
  • Increased cough
  • Rhinitis
  • Taste perversion
  • Abnormal vision
  • Pruritus (itching)
  • Sweat gland disorder
  • Abdominal pain
  • Fever
  • Chest pain
  • Trauma
  • Back pain
  • Malaise
  • Pain
  • Palpitations
  • Vasodilatation
  • Postural hypotension (a drop in blood pressure upon standing up)
  • Hypertension (high blood pressure)
  • Syncope (fainting)
  • Tachycardia (high heart rate)

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Uncommon

Uncommon (0.1-1% incidence) adverse effects include:

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Rare

Rare (0.01-0.1% incidence) adverse effects include:

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  • Mania, may be more common in those that either have or have a family history of bipolar disorder.{{cite journal|vauthors=Morishita S, Arita S |title=Induction of mania in depression by paroxetine |journal=Hum Psychopharmacol

|volume=18 |issue=7|pages=565–8 |date=October 2003 |pmid=14533140 |doi=10.1002/hup.531|s2cid=32168369 }}

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Very rare

Rare (<0.01% incidence) adverse effects include:

  • Thrombocytopenia
  • Syndrome of inappropriate secretion of antidiuretic hormone (SIADH)
  • Serotonin syndrome (symptoms may include agitation, confusion, diaphoresis, hallucinations, hyperreflexia, myoclonus, shivering, tachycardia and tremor){{cite journal |vauthors=Ochiai Y, Katsu H, Okino S, Wakutsu N, Nakayama K |title=[Case of prolonged recovery from serotonin syndrome caused by paroxetine] |language=ja |journal=Seishin Shinkeigaku Zasshi |volume=105 |issue=12 |pages=1532–8|year=2003 |pmid=15027311 }}{{cite journal |vauthors=Terao T, Hikichi T |title=Serotonin syndrome in a case of depression with various somatic symptoms: the difficulty in differential diagnosis |journal=Prog. Neuropsychopharmacol. Biol. Psychiatry |volume=31 |issue=1 |pages=295–6|year=2007 |pmid=16916568 |doi=10.1016/j.pnpbp.2006.07.007 |s2cid=30260512 }}
  • Gastrointestinal bleeding
  • Hepatic events (such as hepatitis, sometimes associated with jaundice and/or liver failure)
  • Priapism
  • Severe cutaneous adverse reactions (including erythema multiforme, Stevens–Johnson syndrome and toxic epidermal necrolysis)
  • Photosensitivity reactions

References

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Paroxetine