List of previous General Hospital cast members#Main cast

| 2009–2011, 2015–2023

scope="row"| Crispin Alapag

| Heavy

| 2014–15

scope="row"| Christian Alexander

| Kiefer Bauer

| 2009–10

scope="row"| Denise Alexander

| Lesley Webber

| 1973–84, 1996–2009, 2013, 2017, 2019, 2021

scope="row" rowspan="2"| Kristen Alderson

| Starr Manning

| 2012–13

Kiki Jerome

| 2013–15

scope="row" | Aki Aleong

| Mr. Wu

| 1985

scope="row"| Jed Allan

| 2004–05

scope="row"| Christopher Allen

| CPO Hicks

| 2013

scope="row" rowspan="2"| Tessa Allen

| Molly Farrell

| 2004

Lulu Spencer

| 2004–2005

scope="row"| Cristela Alonzo

| Natalia Rodriguez

| 2015

scope="row"| George Alvarez

| Alex Garcia

| 1992-99

scope="row"| Rachel Ames

| Audrey Hardy

| 1964–2007, 2009, 2013, 2015

scope="row"| Richard Dean Anderson

| Jeff Webber

| 1976–81

scope="row"|Lori and Sevan Andonian

| Scout Cain

| 2017

scope="row"| Starr Andreeff

| Jessica Holmes

| 1991–93

scope="row"| Réal Andrews

| Marcus Taggert

| 1996–2003, 2020–23

scope="row"| Gerald Anthony

| Marco Dane

| 1992–93

scope="row"| Vinessa Antoine

| Jordan Ashford

| 2014–18

scope="row"| Ashton Arbab

| Dev Cerci

| 2019–20

scope="row"| Michelle Argyris

| Kendra Lennon

| 2019

scope="row"| India Arie

| Herself

| 2015{{cite web|title=General Hospital to air Nutcracker Gala storyline|url=http://soaps.sheknows.com/general-hospital/news/45867/general-hospital-to-air-nutcracker-gala-storyline|website=Soaps She Knows|publisher=SheKnows Media|access-date=December 3, 2015|location=United States|date=December 3, 2015}}

scope="row"| Dimitra Arliss

| Helena Cassadine

| 1996

scope="row"| Tom Arnold

| Billy Boggs

| 1994

scope="row"| Senait Ashenafi

| Keesha Ward

| 1994–98

scope="row"| Matthew Ashford

| Tom Hardy

| 1995–97

scope="row"| Barry Atwater

| John Prentice

| 1964–67

scope="row"| Jerry Ayres

| David Hamilton

| 1977–78

scope="row"| Donna Baccala

| Gina Dante-Lansing

| 1978–79

scope="row" | Philip Baker Hall

| Judge Simpson

| 1983

scope="row"| Scott Thompson Baker

| Colton Shore

| 1988–91

scope="row"| Stacey Baldwin

| Laura Spencer

| 1974–76

scope="row"| Brandon Barash

| Johnny Zacchara

| 2007–16

scope="row"| Harper Rose Barash

| Georgie Spinelli

| 2015

scope="row"| Adrienne Barbeau

| Suzanne Stanwyck

| 2010–11

scope="row"| Roseanne Barr

| Jennifer Smith

| 1994

scope="row"| Majel Barrett

| Bea

| 1983

scope="row" rowspan="2"| William H. Bassett

| Norton Carter

| 1983

Wolfgang Von Schuler

| 1987

scope="row"| Jennifer Bassey

| Quinn Danvers

| 2017

scope="row"| Susan Batten

| Flora Gardens

| 2022–23

scope="row"| Nicolas Bechtel

| Spencer Cassadine

| 2013–20

scope="row"| Kabir Bedi

| Rama

| 1983

scope="row"| Gregory Beecroft

| Jonathan Paget

| 1990

scope="row"| Brandon Beemer

| Seth

| 2005–06

scope="row"| Chris Beetem

| Nikolas Cassadine

| 2005

scope="row"| Sam Behrens

| Jake Meyer

| 1983–88

scope="row"| Robert Beitzel

| Steven Webber

| 1977

scope="row" | Shari Belafonte

| Janice Lomax

| 2016–17

scope="row"| Felecia Bell

| Simone Ravelle Hardy

| 1993–96

scope="row" rowspan="2"| Joshua Benard

| Sonny Corinthos

| 2018

Adam Wright

| 2022–23

scope="row"| Fran Bennett

| Flora Johnston

| 1983

scope="row"| Meg Bennett

| Allegra Montenegro

| 2005

scope="row"| Shaun Benson

| Steven Webber

| 2004–05

scope="row"| Daniel Benzali

| Theo Hoffman

| 2010–11

scope="row"| John Beradino

| Steve Hardy

| 1963–96

scope="row"| Milton Berle

| Mickey Miller

| 1981–82

scope="row"| Julie Marie Berman

| Lulu Spencer

| 2005–13

scope="row"| Robyn Bernard

| Terry Brock

| 1984–90

scope="row" rowspan="2"| Kevin Bernhardt

| Frisco Jones

| 1984

Kevin O'Connor

| 1985–86

scope="row"| Corbin Bernsen

| John Durant

| 2004–06

scope="row"| Blake Berris

| Damian Spinelli

| 2017

scope="row"| Jack Betts

| Ken Martin

| 1963

scope="row"| AnaSofia Bianchi{{cite web |last=Mistretta |first=Amy |title=General Hospital Just Snuck a Recast in Under Our Noses |url=https://soaps.sheknows.com/general-hospital/comings-and-goings/667581/who-plays-general-hospital-charlotte-cassadine-anasofia-bianchi/ |website=Soaps.com |publisher=SHE Media |access-date=April 16, 2023 |location=United States |date=April 11, 2023}}

| Charlotte Cassadine

| 2023

scope="row" rowspan="2"| Casey Biggs{{cite news|last1=Eades|first1=Chris|title=Everything You Need to Know About Dr. Lasiris on GENERAL HOSPITAL|url=https://www.abc.soapsindepth.com/posts/general-hospital-doctor-lazarus-lasiris-casey-biggs-163723|access-date=July 29, 2018|work=ABC Soaps In Depth|publisher=Bauer Media Group|date=July 27, 2018|location=United States}}

| Chad Wainwright

| 1990

Dr Lasaris

| 2018

scope="row"| Patricia Bethune

| Nurse Mary Pat

| 2018

scope="row"| Loanne Bishop

| Rose Kelly

| 1980–84

scope="row"| Martin Blaine

| Dr. Lyons

| 1965

scope="row"| Andrea Bogart

| Abby Haver

| 2010–11

scope="row"| John Bolger

| Prescott Floyd

| 2006–12

scope="row"| Steve Bond

| Jimmy Lee Holt

| 1983–87

scope="row"| Nazanin Boniadi

| Leyla Mir

| 2007–09

scope="row"| Jay Bontatibus

| Andy Capelli

| 2002–04

scope="row"| Angel Boris

| Angel Sorel Ellis

| 2001

scope="row" rowspan="4"| Wil Bowers

| Ward Administrator

| 2002

Doctor

| 2005

Maitre'd

| 2013

Ferncliff Aide

| 2014

scope="row"| Eileen April Boylan

| Sage Alcazar

| 2003

scope="row" rowspan="2"| Chad Brannon

| Zander Smith

| 2000–04, 2021

Aaron

| 2009

scope="row"| Jennifer Bransford

| 2005

scope="row" rowspan="2"| Tamara Braun

| 2001–05, 2014

Kim Nero

| 2017–19

scope="row"| Patricia Breslin

| Meg Baldwin

| 1965–69

scope="row"| Marc Brett

| Zander Smith

| 2000

scope="row"| Brianna Brown

| Lisa Niles

| 2010–11

scope="row"| Kimberly J. Brown

| Chloe Jennings

| 2021

scope="row" | Kimberlin Brown

| Rachel Locke

| 1999–2002

scope="row" rowspan="2"| Sarah Joy Brown

| 1996–2001, 2014

Claudia Zacchara

| 2008–09

scope="row"| Susan Brown

| Gail Adamson Baldwin

| 1977–85, 1989–90, 1992–2002, 2004

scope="row"| Tom Brown

| Al Weeks

| 1963–65, 1970–74

scope="row"| Argentina Brunetti

| Filomena Soltini

| 1985–88

scope="row"| Breck Bruns

| Georgie Jones

| 1997–2002

scope="row" rowspan="2"| Ian Buchanan

| Duke Lavery

| 1986–89, 2012–17, 2020

Cesar Faison

| 2012

scope="row"| Jensen Buchanan

| Melissa Bedford

| 2001–02

scope="row"| Rebecca Budig

| Hayden Barnes

| 2015–17, 2019

scope="row"| Paulina Bugembe

| Valerie Spencer

| 2019–20

scope="row" | Brooke Bundy

| Diana Taylor

| 1977–81

scope="row"| Dan Buran{{cite web |last=Mistretta |first=Amy |title=General Hospital{{'}}s Next Exit Will Be Music to Brook Lynn's Ears |url=https://soaps.sheknows.com/general-hospital/comings-and-goings/667273/is-linc-leaving-general-hospital-dan-buran-exits/ |website=Soaps.com |publisher=SHE Media |access-date=April 16, 2023 |location=United States |date=April 7, 2023 |quote=Dan Buran, who has played the role on and off since 2020, is leaving the ABC soap, as reported in this week's issue of Soap Opera Digest. As of yet, there is no word if he'll turn up again in the future.}}

| Linc Brown

| 2020, 2022–23

scope="row"| Richard Burgi

| Paul Hornsby

| 2015–16

scope="row"| Molly Burnett

| Maxie Jones{{cite web|last1=Mason|first1=Charlie|title=General Hospital: Kirsten Storms' Maxie Recast Temporarily With Days Vet|url=http://tvline.com/2016/05/27/kirsten-storms-leaving-general-hospital-maxie-recast-melanie-burnett-gh/|work=TVLine|publisher=Penske Media Corporation|access-date=June 4, 2018|location=United States|date=May 27, 2016}}{{cite news|author1=SOD|title=EXCLUSIVE! MOLLY BURNETT FILLS IN FOR GH'S STORMS|url=https://www.soapoperadigest.com/content/exclusive-molly-burnett-fills-in-for-ghs-storms/|access-date=May 18, 2018|work=Soap Opera Digest|agency=American Media Inc.|date=May 18, 2018|location=United States}}{{cite web|author1=Soaps SheKnows|author-link1=Soaps.com|title=Molly Burnett temporarily fills in for Kirsten Storms|url=http://soaps.sheknows.com/general-hospital/comings-and-goings/1989/molly-burnett-in-at-gh-temporarily-fills-in-for-kirsten-storms|website=Soaps.com|publisher=SheKnows Media|access-date=May 18, 2018|location=United States|date=May 18, 2018}}

| 2016, 2018

scope="row"| Bonnie Burroughs

| Gladys Corbin

| 2019–23

scope="row"| Lindsay Bushman

| Kate Howard

| 2011

scope="row"| Nathin Butler

| Ewen Keenan

| 2011–12

scope="row"| Caitlyn Buton

| Hope Manning-Thornhart

| 2012

scope="row"| Martha Byrne

| Andrea Floyd

| 2009

scope="row"| Kurt Caceres

| Javier

| 2011

scope="row"| Inga Cadranel

| Harmony Miller

| 2019–23

scope="row"| Erin Cahill

| Cassandra

| 2007

scope="row"| John Cahill

| Bartender

| 2016–19

scope="row"| Tony Camp

| Scott Baldwin

| 1969–72

scope="row"| John Callahan{{cite web |last=Fix |first=Christine |title=John Callahan, Former All My Children, Days of our Lives & Santa Barbara Star Dies at 66 |url=https://soaps.sheknows.com/soaps/news/562326/obituary-john-callahan-all-my-children-santa-barbara-soap-star-dead-66/ |website=Soaps.com |publisher=SheKnows Media |access-date=March 29, 2020 |location=United States |date=March 28, 2020}}

| Leo Russell

| 1984–85

scope="row"| Mary Grace Canfield

| Lucille March Weeks

| 1978

scope="row"| John Capodice

| Carmine Cerullo

| 1994-95

scope="row"| Gloria Carlin

| Charity Gatlin

| 1986

scope="row"| Steve Carlson

| Gary Lansing

| 1977–79

scope="row" rowspan="2"| Ryan Carnes

| Lucas Jones

| 2004–05, 2014–20

Phil Brewer

| 2015

scope="row" | Veronica Cartwright

| Sibley Gamble

| 2019

scope="row" rowspan="2"| Paul Carr

| Peter Taylor

| 1967

Milton Stanus

| 1994

scope="row"| Tia Carrere

| Jade Soong Chung

| 1985–87

scope="row"| Laura Carrington

| Simone Ravelle Hardy

| 1987–89

scope="row"| Crystal Carson

| Julia Barrett

| 1991–93, 1997–98

scope="row"| Sharon Case

| Dawn Winthrop

| 1989–90

scope="row"| Dylan Cash

| Michael Corinthos

| 2002–08

scope="row"| Rosalind Cash

| Mary Mae Ward

| 1994–95

scope="row"| Shaun Cassidy

| Dusty Walker

| 1987–88

scope="row"| Gerald Castillo

| Judge Davis Wagner

| 1992-94

scope="row"| Teresa Castillo

| Sabrina Santiago

| 2012–16

scope="row"| Amy Castle

| Tara

| 2009

scope="row"| Jonathan Carter

| Jason Vining

| 1975–76

scope="row"| Lisa Cerasoli

| Venus Ardanowski

| 1997–99

scope="row"| Erin Chambers

| Siobhan McKenna

| 2010–11

scope="row" rowspan="2"| Brett Chapin

| Roger Barstow

| 2021

District Attorney

| 2021

scope="row"| Judith Chapman

| Ginny Blake

| 1984–86

scope="row" rowspan="2"| Leslie Charleson

| Caroline Chandler Baldwin

| 1977–2023

Mary Butler

| 2020

scope="row"| Don Chastain

| Tom Baldwin

| 1967–77

scope="row"| Nicholas Chavez

| Spencer Cassadine

| 2021–24

scope="row"| Maree Cheatham

| Charlene Simpson

| 1987–91, 1997

scope="row"| Nick Chinlund

| Mickey Diamond

| 2014

scope="row"| Paul Chirico

| Jason Morgan

| 2017

scope="row"| Maksim Chmerkovskiy

| Anton Ivanov

| 2013

scope="row"| Valentin Chmerkovskiy

| Boxer

| 2012

scope="row" rowspan="2"| Robin Christopher

| Abby Mitchell

| 1993

Skye Chandler

| 2001–08, 2010–12

scope="row" rowspan="2"| Tyler Christopher

| Nikolas Cassadine

| 1996–99, 2003–11, 2013–16

Connor Bishop

| 2004–05

scope="row"| Christie Clark

| Cindy

| 1992

scope="row" rowspan="2"| Brian Patrick Clarke

| Grant Andrews

| 1983–85

Grant Putnam

| 1983, 1985–88

scope="row"| Don Clarke

| Scott Baldwin

| 1973–74

scope="row"| Robert Clarke

| Roy Lansing

| 1963

scope="row" | Robert Clary

| French Man

| 1985

scope="row"| Tamara Clatterbuck

| Tammy Hansen

| 2000–01

scope="row"| Scott Clifton

| Dillon Quartermaine

| 2003–07

scope="row"| Gina Coconato

| Alicia

| 2015–16

scope="row"| Claire Coffee

| Nadine Crowell

| 2007–09

scope="row"| Matt Cohen

| Griffin Munro

| 2016–19

scope="row"| Bradley Cole

| Warren Bauer

| 2010

scope="row"| Michael Cole

| Harlan Barrett

| 1991

scope="row"| Booth Colman

| Prof. Hector Jerrold

| 1983

scope="row" rowspan="2"| John Colicos

| Mikkos Cassadine

| 1981

Petros Cassadine

| 1984–85

scope="row"| Marcus Coloma

| Nikolas Cassadine

| 2019–23

scope="row"| Jason Connery

| Sebastian Leeds

| 2013

scope="row"| Norma Connolly

| Ruby Anderson

| 1979–98

scope="row"| Jason Cook

| Matt Hunter

| 2008–12

scope="row"| Cami Cooper

| Nikki Langton

| 1992–93

scope="row"| Aneta Corsaut

| Jessie Brewer

| 1976

scope="row"| Joseph Cortese

| Frank Smith

| 2015

scope="row"| Ward Costello

| Martin Drake

| 1983–89

scope="row"| Katie Couric

| Kelly Curtis

| 2013

scope="row"| Christopher Cousins

| Warren Kirk

| 2020

scope="row"| Nikki Cox

| Gina Cates

| 1993–95

scope="row"| Patrick Cox{{cite web|first=Dustin|last=Cushman|title=General Hospital Casting Calls, Auditions & Dayplayer Roles|url=http://soaps.sheknows.com/general-hospital/news/51034/general-hospital-casting-calls-auditions-dayplayer-roles|website=Soaps.com|publisher=SheKnows Media|access-date=July 3, 2018|location=United States|date=July 2, 2018}}

| Rupert Watson

| 2018

scope="row"| Josh Coxx

| Brendan Byrne

| 2020, 2022

scope="row"| Bryan Craig

| Morgan Corinthos

| 2013–16, 2018, 2024

scope="row"| Gianna Marie Crane

| Lila Rae Alcazar

| 2006–08

scope="row"| Denise Crosby

| Carolyn Webber

| 2022–23

scope="row"| Jason Culp

| Julian Jerome

| 1988–90

scope="row"| Daniel Cummings

| Taylor Wallace

| 2010–11

scope="row"| Augusta Dabney

| 1975–76

scope="row"| Tyne Daly

| Caroline Beale

| 1968

scope="row"| Stuart Damon

| Alan Quartermaine

| 1977–2008, 2011–13

scope="row"| Tiffany Daniels

| Jordan Ashford

| 2021

scope="row"| Shell Danielson

| Dominique Baldwin

| 1991–93

scope="row" rowspan="2"| Henry Darrow

| Ambassador Tabris

| 1982

DVX-backed Colonel

| 1987

scope="row" | Jason David

| Aiden Spencer

| 2012–13, 2015–21

scope="row"| Lane Davies

| Cameron Lewis

| 2002–04

scope="row"| Kristin Davis

| Betsy Chilson

| 1991

scope="row"| Sammy Davis, Jr.

| Eddie Phillips

| 1983

scope="row"| Todd Davis

| Bryan Phillips

| 1978–87

scope="row"| Bruce Davison

| Wilhelm VonSchlagel

| 2010

scope="row"| Davey Davison

| Diana Taylor

| 1977

scope="row"| Trent Dawson

| Huxley Lynch

| 2016–17

scope="row"| Enzo De Angelis

| Aiden Spencer

| 2021–24

scope="row" rowspan="2"| Celesta DeAstis{{cite news|last1=Eades|first1=Chris|title=Who Is Nurse Francesca on GENERAL HOSPITAL? - Meet Celesta DeAstis!|url=http://www.abc.soapsindepth.com/posts/nurse-francesca-general-hospital-celesta-deastis-156118|access-date=March 15, 2018|work=ABC Soaps In Depth|publisher=Bauer Media Group|date=March 15, 2018|location=United States}}

| Avery Corinthos

| 2018

Francesca Cavallo

| 2018

scope="row" | Diane Delano

| Margarethe

| 2016

scope="row"| Michael Delano

| Mark Dante

| 1976

scope="row"|Isaiah Dell

| Leo Falconeri

| 2022

scope="row"| Kassie DePaiva

| Blair Cramer

| 2012, 2023

scope="row"| James DePaiva

| David Bensch

| 2017–18

scope="row"| Robb Derringer

| Kyle Sloane

| 2014–15

scope="row"| Jimmy Deshler

| Rafe Kovich

| 2013–14

scope="row"| William deVry

| Julian Jerome

| 2013–20

scope="row"| Stephanie Dicker

| Gina Cates

| 1996–97

scope="row"| Eileen Dietz

| Sarah Abbott

| 1981–83

scope="row" rowspan="2"| Susan Diol{{cite web |last=Mason |first=Charlie |title=A *Second* Alexis on General Hospital?!? |url=https://soaps.sheknows.com/general-hospital/comings-and-goings/673994/who-plays-nurse-clara/ |website=Soaps.com |publisher=SHE Media |location=June 6, 2023 |date=June 2, 2023}}

| 2001–2002

Clara

| 2023

scope="row"| Jeff Donnell

| Stella Fields

| 1979–88

scope="row"| Jack Donner

| Alfred

| 2006–2010

scope="row"| Tony Dow

| Ross Jeanelle

| 1975

scope="row"| Lieux Dressler

| Alice Grant

| 1978–1983

scope="row"| Chad Duell

| Michael Corinthos

| 2010–2025

scope="row"| Josh Duhon

| Logan Hayes

| 2007–2008

scope="row"| Linda Dona

| Nancy Eckert

| 1991

scope="row" rowspan="4"| Michael Easton

| 2012–2013

| 2013

| 2013–2015

| 2016–2024

scope="row"| Ted Eccles

| Bobby Chandler Baldwin

| 1975–1976

scope="row" | Sonya Eddy

| Epiphany Johnson

| 2006–2022

scope="row"| Hilary Edson

| Tania Jones

| 1984–1987

scope="row"| Evan Ellingson

| Young Luke Spencer

| 2001

scope="row"| Ross Elliott

| Lee Baldwin

| 1963–65

scope="row"| Saidah Arrika Ekulona

| Janice Lomax

| 2012–13, 2015

scope="row"| Gideon Emery

| Jasper Jacks

| 2008

scope="row" rowspan="2"| Kyler and Caleb Ends{{cite web |last=Young |first=Candace |title=General Hospital casting Kyler and Caleb Ends as recast James West |url=https://soaps.sheknows.com/general-hospital/comings-and-goings/550110/general-hospital-casting-caleb-kyler-ends-recast-james-west/ |website=Soaps.com |publisher=SheKnows Media |access-date=September 26, 2019 |location=United States |date=September 25, 2019}}

| James West

| 2019

Wiley Cooper-Jones

| 2021

scope="row"| Stephanie Erb

| 2022

scope="row"| Ethan Erickson

| Patrick Drake

| 2008

scope="row"| Kristen Erickson

| Claudia Johnston Phillips

| 2006

scope="row"| Hayley Erin

| Kiki Jerome

| 2015–19

scope="row"| Mary Beth Evans

| Katherine Bell

| 1993–99

scope="row"| Greg Evigan{{cite news|last1=Eades|first1=Chris|title=Yes, That Is Greg Evigan Playing Jim Harvey on GENERAL HOSPITAL!|url=http://www.abc.soapsindepth.com/posts/greg-evigan-general-hospital-150459|access-date=January 10, 2018|work=ABC Soaps In Depth|publisher=Bauer Media Group|date=January 10, 2018|location=United States}}

| Jim Harvey

| 2017–18

scope="row" rowspan="2"| Morgan Fairchild

| Sydney Chase

| 1996

Haven de Havilland

| 2022–23

scope="row"| Rick Falk

| Phil Brewer

| 1966

scope="row" rowspan="2"| Richard Fancy

| Bennie Abrahms

| 1997–03

Bernie Abrahms

| 2006–12

scope="row"| Gene Farber{{cite web|author1=Soaps SheKnows|author-link1=Soaps.com|title=General Hospital day players cast for September|url=http://soaps.sheknows.com/general-hospital/comings-and-goings/1844/general-hospital-day-players-cast-for-september|website=Soaps.com|publisher=SheKnows Media|access-date=September 28, 2017|location=United States|date=September 28, 2017}}

| Richard Klein

| 2017

scope="row"| Bianca Ferguson

| 1978–87

scope="row"| Sandra Ferguson

| Felicia Jones

| 2005

scope="row"| Jessica Ferrarone

| Lydia Karenin

| 2003

scope="row"| Mitchell Fink

| William Eichner

| 2014

scope="row"| Gail Fisher

| Judge Heller

| 1982

scope="row"| Chrissie Fit

| Mercedes Juarez

| 2007–11

scope="row"| Joe Flanigan{{cite web |last=Mistretta |first=Amy |title=Joe Flanigan exits General Hospital as Neil Byne |url=https://soaps.sheknows.com/general-hospital/comings-and-goings/577740/general-hospital-joe-flanigan-exits-neil-byrne-died-alexis-bed/ |website=Soaps.com |publisher=SheKnows Media |access-date=September 12, 2020 |location=United States |date=September 11, 2020}}

| Neil Byrne

| 2019–20

scope="row"| Eliza Frakes

| Julie

| 2023

scope="row"| Betsy Franco

| Betsy Frank

| 2010, 2013–14

scope="row"| James Franco

| Franco

| 2009–12

scope="row"| Margarita Franco

| Dolores Santiago

| 1994

scope="row"| Liam and Oliver Friedy

| Rocco Falconeri

| 2014–15

scope="row"| Kelly Frye

| Ivy Gatling

| 2014–15

scope="row"| Courtney Fulk{{efn|name=fn2|From December 18, 2023, to February 1, 2024, Courtney Fulk pinch-hit in the role of Josslyn Jacks for Eden McCoy.{{cite web |last=Rice |first=Lynette |title=General Hospital Temporarily Recasts Emmy Winner Eden McCoy |url=https://deadline.com/2023/12/general-hospital-temporarily-recasts-eden-mccoy-1235677920/ |website=Deadline Hollywood |publisher=Penske Media Corporation |access-date=December 19, 2023 |archive-url=https://web.archive.org/web/20231220030548/https://deadline.com/2023/12/general-hospital-temporarily-recasts-eden-mccoy-1235677920/ |archive-date=December 20, 2023 |location=United States |date=December 19, 2023 |url-status=live}}}}

| Josslyn Jacks

| 2023–24

scope="row" | John Gabriel

| Teddy Holmes

| 1972–73

scope="row"| Holly Gagnier

| Jennifer Smith

| 2015, 2022

scope="row"| Max Gail

| Mike Corbin

| 2018–21

scope="row"| Patrick Gallagher{{cite web|author1=Soaps SheKnows|author-link1=Soaps.com|title=Patrick Gallagher plays a guard on General Hospital|url=http://soaps.sheknows.com/general-hospital/comings-and-goings/1836/patrick-gallagher-plays-a-guard-on-general-hospital|website=Soaps.com|publisher=SheKnows Media|access-date=September 17, 2017|location=United States|date=September 11, 2017}}

| Prison guard

| 2017

scope="row"| Don Galloway

| Buzz Stryker

| 1985–1987

scope="row"| Guy Gansert{{cite magazine |last1=Falcone |first1=Dana Rose |title=The Golden Bachelorette Runner-Up Guy Gansert Reveals a Return to ABC in a 'Surreal' Role (Exclusive) |url=https://people.com/see-golden-bachelorette-guy-gansert-on-general-hospital-exclusive-11692692 |magazine=People |publisher=Dotdash Meredith |access-date=March 7, 2025 |archive-url=https://archive.today/20250307182459/https://people.com/see-golden-bachelorette-guy-gansert-on-general-hospital-exclusive-11692692 |archive-date=March 7, 2025 |location=United States |issn=0093-7673 |oclc=794712888 |date=March 7, 2025 |url-status=live}}

| Geoffrey

| 2025

scope="row"| Leif Gantvoort{{cite news|last1=Eades|first1=Chris|title=That's Leif Gantvoort as the Villain Holding Anna and Finn Captive on GENERAL HOSPITAL|url=https://www.abc.soapsindepth.com/posts/general-hospital-villain-carson-leif-gantvoort-164392|access-date=August 12, 2018|work=ABC Soaps In Depth|publisher=Bauer Media Group|date=August 9, 2018|location=United States}}{{cite web|author1=Soaps SheKnows|author-link1=Soaps.com|title=Leif Gantvoort joins General Hospital |url=http://soaps.sheknows.com/general-hospital/comings-and-goings/2038/leif-gantvoort-joins-general-hospital|website=Soaps.com|publisher=SheKnows Media|access-date=August 12, 2018|location=United States|date=August 8, 2018}}

| Carson

| 2018

scope="row" rowspan="2"| Priscilla Garita

| Lupe

| 2011

Harmony Miller

| 2022

scope="row"| Zachary Garred

| Levi Dunkleman

| 2014

scope="row"| Drew Garrett

| Michael Corinthos

| 2009–10

scope="row"| David Gautreaux

| Peter Harrell, Sr.

| 2014

scope="row"| George Gaynes

| Frank Smith

| 1980

scope="row" rowspan="4"| Anthony Geary

| Luke Spencer

| 1978–84, 1993–2015, 2017

Bill Eckert

| 1991–93

Cesar Faison

| 2014

Tim Spencer

| 2015

scope="row"| Jason Gerhardt

| Cooper Barrett

| 2007–08

scope="row" rowspan="3"| Jean Glaudé

| Waiter

| 1967

Committee Member 2

| 1994

Thomas Anderson

| 2013

scope="row"| Blake Gibbons

| Coleman Ratcliffe

| 2002–12, 2014

scope="row"| Nigel Gibbs

| Marcus Godfrey

| 2018–20

scope="row"| Mark Goddard

| Derek Barrington

| 1984–86

scope="row"| Gerald Gordon

| Mark Dante

| 1976–78, 1982–83

scope="row"| Amy Grabow

| Rachel Adair

| 2005

scope="row"| Juliet Grainger

| Lila Quartermaine

| 2003–04

scope="row"| Nathanyael Gray

| Mason Gatlin

| 2022–23{{cite magazine |last=Levinsky |first=Mara |title=Nathanyael Grey Exits General Hospital |url=https://www.soapoperadigest.com/content/nathanyael-grey-exits-general-hospital/ |magazine=Soap Opera Digest |publisher=A360media |access-date=November 20, 2023 |location=United States |issn=0164-3584 |date=November 15, 2023}}

scope="row"| Mary-Pat Green

| Nurse Fletcher

| 2012

scope="row"| David Greenman

| Danny McCall

| 2005–06

scope="row"| Michael Gregory

| Rick Webber

| 1976–78

scope="row"| David Groh

| D. L. Brock

| 1983–85

scope="row"| Ben Guillory

| David Walters

| 2013

scope="row"| Jennifer Guthrie

| Dawn Winthrop

| 1990–91

scope="row" rowspan="2"| Joyce Guy

| Betty

| 2011

Phyllis Caulfield

| 2020–2023

scope="row"| Ron Hale

| Mike Corbin

| 1995–10

scope="row"| Carla Hall

| Cook II

| 2018

scope="row"| Tamron Hall

| Herself

| 2019

scope="row"| Courtney Halverson

| Anna Donely

| 2013

scope="row"| Mark Hamill

| Kent Murray

| 1972–73

scope="row"| George Hamilton{{cite magazine|url=http://ew.com/tv/2018/07/04/general-hospital-george-hamilton-colonel-sanders/|title=General Hospital: See how George Hamilton will show up as Colonel Sanders|first=Lynette|last=Rice|magazine=Entertainment Weekly|publisher=Meredith Corporation|location=New York City|date=July 4, 2018|access-date=June 5, 2018|archive-date=July 4, 2018|archive-url=https://web.archive.org/web/20180704224556/http://ew.com/tv/2018/07/04/general-hospital-george-hamilton-colonel-sanders/|url-status=dead}}

| Colonel Sanders

| 2018

scope="row"| Kim Hamilton

| Tracy Adams

| 1968–69

scope="row"| Jennifer Hammon

| Karen Wexler

| 1997–99

scope="row"| Peter Hansen

| Lee Baldwin

| 1965–86, 1989–90, 1992–2004

scope="row"| Vanita Harbour

| Dara Jensen

| 1996–2003

scope="row"| Eden Harker

| Georgie Spinelli

| 2023

scope="row"| Adam J. Harrington

| John Cates

| 2024

scope="row"| Glenn Walker Harris, Jr.

| Sly Eckert

| 1991–95

scope="row"| Steve Richard Harris

| Mikkos Cassadine

| 2021

scope="row"| Gregory Harrison

| Gregory Chase

| 2020–24

scope="row"| Lindsay Hartley

| Sam McCall

| 2020, 2022, 2024

scope="row"| Donald Patrick Harvey

| Tom Baker

| 2016

scope="row"| Bob Hastings

| Burt Ramsey

| 1978–86

scope="row"| Billie Hayes

| Agent Brighton O'Reilly

| 1981, 1985

scope="row"| Ron Hayes

| Phil Brewer

| 1967

scope="row"| Patricia Healy

| Tammy Hansen

| 1998–2000

scope="row"| Gina Hecht{{cite web|last=Cushman|first=Dustin|title=Gina Hecht Returns to General Hospital as Judge Rachel Lasser|url=https://soaps.sheknows.com/general-hospital/comings-and-goings/551867/gina-hecht-general-hospital-judge-rachel-lasser/|website=Soaps.com|publisher=SheKnows Media|access-date=October 31, 2019|location=United States |date=October 24, 2019|url-status=live|archive-url=https://web.archive.org/web/20191031063153/https://soaps.sheknows.com/general-hospital/comings-and-goings/551867/gina-hecht-general-hospital-judge-rachel-lasser/|archive-date=October 31, 2019}}

| Rachel Lasser

| 2015–19

scope="row"| Elizabeth Hendrickson

| Margaux Dawson

| 2018–19

scope="row" rowspan="2"| Briana Nicole Henry

| Jordan Ashford

| 2018–21

1920 voter

| 2020

scope="row"| Kristin Herrera

| Lourdes Del Torro

| 2004–08

scope="row"| Brighton Hertford

| B.J. Jones

| 1986–94, 2024

scope="row"| Martin Hewitt

| Steven Webber

| 1979–81

scope="row"| Shelby Hiatt

| Jane Harland

| 1968–75

scope="row"| Alice Hirson

| Mrs Van Gelder

| 1982

scope="row"| Evan Hofer

| Dex Heller

| 2022–24{{cite magazine |last1=Coleman |first1=Ryan |title=General Hospital star Evan Hofer on Dex's shocking fate |url=https://ew.com/general-hospital-star-evan-hofer-dex-shocking-fate-8757187 |magazine=Entertainment Weekly |publisher=Dotdash Meredith |access-date=December 13, 2024 |archive-url=https://archive.today/20241213201047/https://ew.com/general-hospital-star-evan-hofer-dex-shocking-fate-8757187 |archive-date=December 13, 2024 |location=United States |issn=1049-0434 |oclc=21114137 |date=December 13, 2024 |url-status=live}}

scope="row"| Kara and Shelby Hoffman

| 2003

scope="row" rowspan="2"| Robert Hogan

| Phil Brewer

| 1966

Burt Marshall

| 1973

scope="row"| Gerald Hopkins

| A. J. Quartermaine

| 1991–92

scope="row"| Leslie Horan

| Miranda Jameson

| 1996–97

scope="row" rowspan="2"| Gavin Houston

| Sly Thomas

| 2010

Zeke Robinson

| 2023

scope="row" rowspan="4"| Roger Howarth

| Todd Manning

| 2012–13

Franco Baldwin

| 2013–21

Drew Cain

| 2019

Austin Gatlin-Holt

| 2021–23{{cite magazine |last=Levinsky |first=Mara |title=Exclusive: Roger Howarth On Exiting General Hospital |url=https://www.soapoperadigest.com/content/exclusive-roger-howarth-on-his-exit-from-general-hospital/ |magazine=Soap Opera Digest |publisher=A360media |access-date=November 20, 2023 |location=United States |issn=0164-3584 |date=November 20, 2023}}

scope="row"| Tina Huang

| Linda Chu

| 2013–14

scope="row"| Janet Hubert

| Yvonne Godfrey

| 2018–20

scope="row" rowspan="2"| Craig Huebing

| Phil Brewer

| 1967

Peter Taylor

| 1969–79

scope="row"| Van Hughes

| Cole Thornhart

| 2012

scope="row"| Duncan Hursley

| Mechanic Bill

| 2014

scope="row"| Rif Hutton

| Lenny Caulfield

| 2021–22

scope="row"| Julio Iglesias

| Himself

| 1994

scope="row"| Mele Ihara

| Reiko Finn

| 2022

scope="row"| Annie Ilonzeh

| Maya Ward

| 2010–11

scope="row"| John Ingle

| 1993–2004, 2006–12

scope="row" | Steve Inwood

| Moreno

| Unknown

scope="row"| Conor Jackson

| Physical Therapist

| 2009

scope="row"| Jonathan Jackson

| Lucky Spencer

| 1993–1999, 2009–2011, 2015, 2024–2025

scope="row"| Titus Jackson

| Aiden Spencer

| 2011–12

scope="row"| Kevin and Michael Jacobson

| Dillon Quartermaine

| 1992–93

scope="row"| Donnie Jeffcoat

| Craig

| 1990

scope="row"| Anne Jeffreys

| Amanda Barrington

| 1984–2004

scope="row"| Johnny Jensen

| Scott Baldwin

| 1974–75

scope="row"| Mikey Jerome

| Eddie

| 2021

scope="row"| Arte Johnson

| Finian O'Toole

| 1991–92

scope="row"| Sarah Johnson

| Josslyn Jacks

| 2012–13

scope="row"| Ashley Jones

| Parker Forsyth

| 2016–17

scope="row"| Asante Jones

| Marcus Taggert

| 2020–22

scope="row"| Christine Jones

| Tracy Quartermaine

| 1989

scope="row" rowspan="3"| Jamison Jones

| William Peavy

| 2004–05

Brady Bevin

| 2016

Warren Kirk

| 2020

scope="row"| Shirley Jones

| Mrs McClain

| 2014

scope="row"| Kathryn Joosten

| Ida Warren

| 2002–03

scope="row"| Bobbi Jordan

| Terri Webber

| 1976–77

scope="row"| Patrick J Gibbons Jr.

| Wyatt Hoover

| 2018–19, 2021

scope="row"| Stanley Kamel

| Cody McCall

| 2003–04

scope="row"| Sean Kanan

| A. J. Quartermaine

| 1993–97, 2012–14

scope="row"| Holly Kaplan

| 2022

scope="row"| Casey Kasem

| Jack Collins

| 1982

scope="row"| Lesli Kay

| Lois Cerullo

| 2004–05

scope="row"| Stephen Kay

| Reginald Jennings

| 1992–2004

scope="row"| Braiden and Dylan Kazowski

| Danny Morgan

| 2015–16

scope="row"| Robert Kelker-Kelly

| Stavros Cassadine

| 2001–03, 2013–14

scope="row"| Jim Kelly{{cite web|url=https://www.welovesoaps.net/2012/11/6-athlete-cameos.html|title=6 Memorable Athlete Soap Opera Cameos|date=November 9, 2012|author=|work=We Love Soaps|publisher=Blogger|location=United States|access-date=August 22, 2013}}

| Himself

| 1992

scope="row"| Sandy Kenyon

| Guard

| 2015

scope="row"| Shell Kepler

| Amy Vining

| 1979–2002

scope="row"| B.B. King

| Himself

| 1995

scope="row" rowspan="2"| Ted King

| Luis Alcazar

| 2002

Lorenzo Alcazar

| 2003–07

scope="row"| Nick Kiriazis

| Ric Lansing

| 2007

scope="row"| Kodi Kitchen

| Maggie Wurth

| 2011–12

scope="row"| Jeff Kober

| Cyrus Renault

| 2020–2025

scope="row"| Walter Koenig

| Charlie Turner

| 1963

scope="row"| Alla Korot

| Nurse Darya

| 2017

scope="row"| Holiday Mia Kriegel

| Molly Lansing

| 2023

scope="row"| Jaxon and Jakob Kring

| 2012–14

scope="row"| Ilene Kristen

| Delia Ryan

| 2013–15

scope="row"| Michael Blake Kruse

| Rory Cabrera

| 2022

scope="row"| Peter Kwong

| The Psychiatrist

| 2004

scope="row"| Mary Laina

| Reporter

| 2000–02

scope="row"| Sarah Laine

| Sarah Webber

| 2002

scope="row"| Shayne Lamas

| 2003–05

scope="row"| Briana Lane

| Brook Lynn Ashton

| 2020, 2022

scope="row"| Archie Lang

| Forbes

| 1982

scope="row"| George Lako

| Frankie

| 2015–16

scope="row" rowspan="2"| Chloe Lanier

| Pat Spencer

| 2015

Nelle Benson{{cite web|first=Amy|last=Mistretta|title=General Hospital's Chloe Lanier exits as Nelle Benson Comings & Goings|url=https://soaps.sheknows.com/general-hospital/comings-and-goings/577172/general-hospital-chloe-lanier-exits-nelle-benson-fell-over-cliff/|website=soaps.sheknows.com|publisher=SheKnows Media|access-date=September 14, 2020|location=United States|date=September 4, 2020}}

| 2016–20, 2022

scope="row"| Georganne LaPiere

| Heather Webber

| 1976–77

scope="row"| Karleigh Larson

| [Children of General Hospital#Josslyn Jacks|Josslyn Jacks

| 2009–12

scope="row"| Ken Lally

| Greg

| 2002-03

scope="row" rowspan="2"| Robert LaSardo

| Manny Ruiz

| 2005–06

Mateo Ruiz

| 2006–07

scope="row"| Carol Lawrence

| Angela Eckart

| 1991–93

scope="row"| Mark Lawson

| Dustin Phillips

| 2019–20

scope="row"| George Lazenby

| Reginald Durban

| 1982

scope="row"| Tiana Le

| Trina Robinson

| 2017–18

scope="row"| Michael Learned

| Shirley Smith

| 2010

scope="row"| Anna Lee

| Lila Quartermaine

| 1978–2003

scope="row"| David S. Lee

| Winston Rudge

| 2016–17, 2020

scope="row"| Andrew T. Lee

| Marty Brown

| 2006–09

scope="row"| Damien Leeke

| Marshall Ashford

| 2022

scope="row"| Edie Lehmann

| Katherine Delafield

| 1988–90

scope="row"| Colby Lemmo

| Holly Sutton-Scorpio

| 2022

scope="row"| Ella Lentini

| Betty Rutherford

| 2023

scope="row"| Adrianne León

| Brook Lynn Ashton

| 2004–06, 2010–11

scope="row"| Lindze Letherman

| Georgie Jones

| 2002–07, 2010, 2013, 2018

scope="row"| David Lewis

| 1978–93

scope="row"| Judy Lewis

| Barbara Vining

| 1975–76, 1978

scope="row"| Brit Lind

| Miss Bixby

| 1988

scope="row"| Jen Lilley

| Maxie Jones

| 2011–12

scope="row" rowspan="2"| Natalia Livingston

| Emily Quartermaine

| 2003–09, 2013–14

Rebecca Shaw

| 2009

scope="row" rowspan="2"| Bradley Lockerman

| Casey Rogers

| 1990

Shep Casey

| 1990

scope="row"| June Lockhart

| Maria

| 1991–94

scope="row"| Samantha Logan

| Taylor DuBois

| 2013

scope="row"| Mitch Longley

| Matt Harmon

| 1997–99

scope="row"| Eva Longoria

| Brenda Barrett Lookalike

| 2000

scope="row" rowspan="2"| Jacqueline Grace Lopez{{cite web |last=Mistretta |first=Amy |title=An Unexpected Swan Song for General Hospital Singer |url=https://soaps.sheknows.com/general-hospital/comings-and-goings/668065/what-happened-to-general-hospital-blaze-jacqueline-grace-lopez-exit/ |website=Soaps.com |publisher=SHE Media |access-date=April 16, 2023 |location=United States |date=April 14, 2023}}

| unnamed babysitter

| 2015–16

Blaze

| 2022–24

scope="row"| Charles and Ethan Losie

| Rocco Falconeri

| 2015–16

scope="row"| Jophielle Love

| Violet Finn

| 2019–24{{cite magazine |last1=Brounstein |first1=Diane |title=Comings and Goings: The Latest Cast Changes as of October 21 |url=https://www.soapoperadigest.com/content/comings-and-goings-the-latest-cast-changes-as-of-october-21/ |magazine=Soap Opera Digest |publisher=A360media |access-date=October 21, 2024 |location=United States |issn=0164-3584 |date=October 21, 2024}}

scope="row"| Christine Lozano

| Christi Limg

| 2012–18

scope="row"| Florencia Lozano

| Téa Delgado

| 2012

scope="row"| Henry Lubatti

| Danny McCall

| 2004

scope="row"| Keye Luke

| The Ancient One

| 1985

scope="row" rowspan="2"| Joey Luthman

| Luke Spencer

| 2015

Bill Eckert

| 2015

scope="row"| Stephen Macht

| Trevor Lansing

| 2007–09

scope="row"| Elizabeth MacRae

| Meg Baldwin

| 1969–73

scope="row"| Sheila MacRae

| Madelyn Richmond

| 1991

scope="row"| Martha Madison

| Elizabeth Webber

| 2011

scope="row"| Christian Malmin

| Fred Gray

| 2016–17

scope="row"| Rio Mangini

| Oscar Nero

| 2017

scope="row"| Randolph Mantooth

| Richard Halifax

| 1991–93

scope="row"| Mary Mara

| Selma

| 2014

scope="row"| Gregory Marcel

| Orderly Gordon

| 2018

scope="row"| Vanessa Marcil

| Brenda Barrett

| 1992–98, 2002–03, 2010–11, 2013

scope="row"| Lisa Marie

| Jennifer Smith

| 1980

scope="row" | Joe Marinelli

| Joseph Sorel

| 1999-2001

scope="row"| Marcella Markham

| Beatrice LeSeur

| 1984

scope="row"| Meghan Markle

| Jill

| 2002

scope="row"| Ronnie Marmo

| Ronnie Dimestico

| 2009–12

scope="row"| Matt Marraccini

| Jesse Beaudry

| 2005–06

scope="row"| Jason Marsden

| A. J. Quartermaine

| 1986–88

scope="row"| Mia Martin

| Kristin Bergman

| 2002

scope="row"| Ricky Martin

| Miguel Morez

| 1994–96

scope="row"| A Martinez

| Roy DiLucca

| 1999–02

scope="row"| Cyndi Martino

| Nurse

| 2000

scope="row"| John Martinuzzi

| Stavros Cassadine

| 1983

scope="row"| Joseph Mascolo

| Nicholas Van Buren

| 1989

scope="row"| Kerwin Mathews

| Duncan Stewart

| 1972

scope="row"| Lee Mathis

| John Hanley

| 1995–96

scope="row"| Eddie Matos

| Pete Marquez

| 2006–07

scope="row"| DeLane Matthews

| Janine Matthews

| 2001–03

scope="row"| Helena Mattsson

| Sasha Gilmore

| 2022

scope="row"| Robin Mattson

| Heather Webber

| 1980–83, 2004, 2012–16

scope="row"| Brad Maule

| Tony Jones

| 1984–2006, 2019

scope="row"| Richard Mawe

| Hospital Review Board Chairman

| 2015

scope="row"| Frank Maxwell

| Dan Rooney

| 1978–90

scope="row"| Heather Mazur

| Eileen Ashby

| 2021–23

scope="row"| Diane McBain

| Claire Howard

| 1988

scope="row"| Amelie McClain

| Charlotte Cassadine

| 2021–23

scope="row"| Leigh McCloskey

| Damian Smith

| 1993–96

scope="row"| Judith McConnell

| Augusta McLeod

| 1973–75

scope="row"| Patty McCormack

| 2018

scope="row"| Peyton McCormick

| Penny

| 2013

scope="row"| Grayson McCouch

| Kyle Sloane

| 2015

scope="row"| Kimberly McCullough

| Robin Scorpio

| 1985–2000, 2004–18, 2021

scope="row"| Maura McGiveney

| Audrey Hardy

| 1971

scope="row"| Beverlee McKinsey

| Myrna Slaughter

| 1994

scope="row"| Kurt McKinney

| Ned Ashton

| 1988–91

scope="row"| Amelie McLain

| Charlotte Cassadine

| 2021–23

scope="row"| Coby Ryan McLaughlin

| Shiloh

| 2018–19

scope="row"| Emily McLaughlin

| Jessie Brewer

| 1963–91

scope="row"| Cade McWatt

| Cameron Spencer

| 2018

scope="row"| Jeffrey Meek

| Thomas Dade

| 2002

scope="row"| Ron Melendez

| Andy Archer

| 2007–09

scope="row" rowspan="2"| Lilly Melgar

| Lily Rivera Corinthos

| 1994–96, 2001, 2003

Marcella Montoya

| 2003

scope="row"| Bridgit Mendler

| Lulu's Dream Daughter

| 2006

scope="row"| Dawn Merrick

| Samantha Welles

| 1985–89

scope="row"| Charles Mesure

| Jack Brennan

| 2023–2025

scope="row"| Katie Mewes

| Bobbie Spencer

| 2015

scope="row"| Krys Meyer

| TJ Ashford

| 2012

scope="row"| Robert Miano

| Joe Scully Sr.

| 1995

scope="row"| Amanda Michalka

| Ashley B

| 2004

scope="row"| Sydney Mikayla

| Trina Robinson

| 2019–22

scope="row"| Allison Miller

| Tracy Quartermaine

| 2006

scope="row" rowspan="3"| Billy Miller

| Jake Doe

| 2014–15

Jason Morgan

| 2014–17

Drew Cain

| 2017–19

scope="row"| J. Robin Miller

| Lydia Karenin

| 2003

scope="row"| Mark Miller

| Randy Washburn

| 1965

scope="row"| Alley Mills

| Heather Webber

| 2022–24

scope="row"| Donna Mills

| Madeline Reeves

| 2014–2015, 2018

scope="row"| Melanie Minichino

| Kristin Bergman

| 2021

scope="row"| Mary Ann Mobley

| Jonelle Andrews

| 1979

scope="row" rowspan="2"| Kelly Monaco

| Sam McCall

| 2003–24

Alicia Montenegro

| 2005

scope="row"| Julie Mond

| Lisa Niles

| 2009

scope="row" rowspan="2"| Anthony Montgomery

| Aaron

| 2011

Andre Maddox

| 2015–19, 2022

scope="row"| Elizabeth Montgomery

| Elizabeth Clarke Brown

| 1986; 1991–94

scope="row"| Rebeka Montoya

| Delores Padilla

| 2011–12

scope="row"| Christian Monzon

| Eddie Cabrera

| 2012

scope="row"| Lynne Moody

| Florence Campbell

| 2000–02

scope="row"| Chris Moore

| Himself

| 1992

scope="row"| Demi Moore

| Jackie Templeton

| 1982–84

scope="row"| Camilla More

| Anna Devane

| 1991–92

scope="row"| Debbi Morgan

| Ellen Burgess

| 1997–98

scope="row"| Lindsey Morgan

| 2012–13

scope="row"| Ann Morrison

| Peggy Nelson

| 1971

scope="row"| M'fundo Morrison

| Justus Ward

| 2003–06

scope="row"| Ronn Moss

| Himself

| 2014

scope="row"| Oliver Muirhead{{cite web|author=Soaps.com|title=Oliver Muirhead recast as General Hospital's Lord Larry Ashton|url=http://soaps.sheknows.com/general-hospital/comings-and-goings/1699/oliver-muirhead-joins-general-hospital-as-lord-larry-ashton|website=Soaps.com|publisher=SheKnows Media|access-date=March 24, 2017|location=United States|date=March 24, 2017}}

| Larry Ashton

| 2017

scope="row"| Mandy Musgrave

| Carol Lockhart

| 2019

scope="row"| Manuel Nardi

| Jackie

| 2006

scope="row"| Guy Nardulli

| Pete

| 2016

scope="row"| Hugo Napier

| Larry Ashton

| 1988–89, 1991–92, 2014, 2016

scope="row"| Jaime Ray Newman

| Kristina Cassadine

| 2001–03

scope="row"| Robert Newman

| Prescott Harrell

| 1985

scope="row"| Stephen Nichols

| Stefan Cassadine

| 1996–2003

scope="row"| James Nigbor

| Jake Spencer

| 2009–11

scope="row"| Leonard Nimoy

| Bernie Smith

| 1963

scope="row"| Minae Noji

| Kelly Lee

| 2006–12, 2015–16

scope="row"| Hannah Nordberg

| Josslyn Jacks

| 2014–15

scope="row" | Jay North

| Al Barker

| 1981

scope="row"| Noshir Dalal

| Raj

| 2015, 2019

scope="row"| Mary O'Brien

| Heather Webber

| 1977–79

scope="row"| Alyshia Ochse

| Irina Cassadine

| 2011–12

scope="row"| John O'Hurley

| Greg Bennett

| 1992

Ronan O'Reilly

| 2010

scope="row"| Jonathan Ohye

| Dr Andy

| 2015–19

scope="row"| Agnes Olech

| Larisa

| 2017

scope="row" rowspan="2"| Ron Ostrow

| Pilot

| 1996–2001

Dr Austin

| 2008

scope="row"| David Otunga

| Himself

| 2014

scope="row"| Ryan Paevey

| Nathan West

| 2013–18

scope="row"| Janis Paige

| Aunt Iona Huntington

| 1980-90

scope="row" rowspan="2"| Johnny Palermo

| Bus Boy

| 2005

Vinnie

| 2007

scope="row"| Ken Parham

| Fireman Hawkeye

| 1998–99

scope="row" rowspan="2"| Jeffrey Vincent Parise

| Carlos Rivera

| 2013–16

Joe Rivera

| 2016

scope="row"| Palmer and Poe Parker{{cite web|last=Cushman|first=Dustin|title=General Hospital recasts Scout Cain with Ella Ramacieri|url=https://soaps.sheknows.com/general-hospital/comings-and-goings/544860/gh-emily-scout-cain-recast-ella-ramacieri/|website=Soaps.com|publisher=SheKnows Media|access-date=July 3, 2019|location=United States|date=July 2, 2019|archive-url=https://web.archive.org/web/20190703055738/https://soaps.sheknows.com/general-hospital/comings-and-goings/544860/gh-emily-scout-cain-recast-ella-ramacieri/|archive-date=July 3, 2019}}

| Scout Cain

| 2017–19

scope="row"| Nathan Parsons

| Ethan Lovett

| 2009–13, 2015, 2020

scope="row"| Rick Pasqualone

| Vincent Marino

| 2018

scope="row"| Vincent Pastore

| Maximus Giambetti

| 2008

scope="row"| Alina Patra

| Susan Hornsby

| 2016

scope="row"| Ciera Payton

| Grace

| 2017

scope="row" | Lindsey Pearlman

| Margaret McMorris

| 2020

scope="row"| Andrea Pearson

| Gia Campbell

| 2002–03

scope="row"| Nia Peeples

| Carla Escobar

| 1983–84

scope="row"| Thaao Penghlis

| Victor Cassadine

| 1981, 2014

scope="row"| George Pennacchio

| George

| 2013–18

scope="row"| Christopher Pennock

| Mitch Williams

| 1979–80

scope="row" | Melissa Peterman

| Mel

| 2015

scope="row" | Beth Peters

| Agnes Whitaker

| 1982-84

scope="row"| Joseph C. Phillips

| Justus Ward

| 1994–98

scope="row" rowspan="2"| Jay Pickett

| Lorenzo Alcazar

| 2006

David Harper

| 2007–08

scope="row"| Cara Pifko

| Louise Addison

| 2009

scope="row"| Edward Platt

| Dr Miller

| 1963

scope="row"| Avery Kristen Pohl

| Esme Prince

| 2021–24

scope="row"| Larry Poindexter

| Asher Thomas

| 2005

scope="row"| Ely Pouget

| Jeannette Marino

| 2018

scope="row"| Brittney Powell

| Summer Halloway

| 2002–03

scope="row"| Haley Pullos

| Molly Lansing

| 2009–23

scope="row"| Susan Pratt

| Anne Logan

| 1978–82

scope="row"| Erin Hershey Presley

| Alison Barrington

| 2013

scope="row"| Cynthia Preston

| Faith Rosco

| 2002–05

scope="row"| Nicholas Pryor

| Victor Collins

| 1997–2003

scope="row"| Teddy Quinn

| Scott Baldwin

| 1966

scope= "row" | Alan Rachins

| Judge James Horowitz

| 2016-18

scope="row"| Brooke Radding

| Brook Lynn Ashton

| 1996–2001

scope="row"| Patsy Rahn

| 1976–77

scope="row"| Marisa Ramirez

| Gia Campbell

| 2000–02

scope="row"| Trish Ramish

| Herself

| 2011, 2019

scope="row"| Gail Ramsey

| Susan Moore

| 1978–83

scope="row"| Wes Ramsey

| Peter August

| 2017–22

scope="row"| Lak Rana

| Lak Rashi

| 2013

scope="row"| Lou Rawls

| Himself

| 1995

scope="row"| Jen Ray

| Chelsea Lambas

| 2019

scope="row"| James Read

| Gregory Chase

| 2018

scope="row"| Scott Reeves

| Steven Webber

| 2009–13, 2024

scope="row"| Caitlin Reilly

| Anna Donely

| 2021

scope="row"| John Reilly

| Sean Donely

| 1984–95, 2013

scope="row"| Peter Renaday

| John Jacks

| 1996–2003, 2012

scope="row"| Robyn Richards

| Maxie Jones

| 1993–2004

scope="row"| Cheryl Richardson

| Jenny Eckert

| 1991–94, 1996

scope="row"| Tequan Richmond

| TJ Ashford

| 2012–18

scope="row"| Matt Riedy

| Matthew Mayes

| 2016

scope="row"| Tristan Riggs

| Aiden Spencer

| 2024

scope="row"| Robin Riker

| Naomi Dreyfus

| 2016

scope="row"| Zakary Risinger{{cite news|last1=Eades|first1=Chris|title=Zakary Risinger Is the New Danny on General Hospital|url=https://www.soapsindepth.com/posts/general-hospital/zakary-risinger-is-the-new-danny-on-general-hospital|access-date=November 29, 2021|work=ABC Soaps In Depth|publisher=Bauer Media Group|date=November 29, 2021|location=United States}}

| 2021

scope="row"| Renie Rivas

| Gallery assistant

| 2017

scope="row"| Alexia Robinson

| Meg Lawson

| 1990–94

scope="row"| Chris Robinson

| Rick Webber

| 1978–86, 2002, 2013

scope="row"| Sebastian Roché

| Jerry Jacks

| 2007–10, 2012–15

scope="row"| Michael Rodrick

| Seth Baker

| 2016

scope="row"| Kali Rodriguez

| Kristina Davis

| 2005–2008

scope="row"| Tristan Rogers

| Robert Scorpio

| 1980–1992, 1995, 2006, 2008, 2012–2016, 2018–2024

scope="row"| Willa Rose

| Nelle Benson

| 2020

scope="row"| Ricco Ross

| Sterling Robinson

| 2023

scope="row"| Paul Rosilli

| David Grey

| 1981–82

scope="row"| Caden and Corben Rothweiler

| 2014–15

scope="row"| Curtis & James Rufca{{cite web |last=Cushman |first=Dustin |website=Soap She Knows |title=General Hospital Recasts James West With Owen and Curtis Rufca |url=https://soaps.sheknows.com/general-hospital/comings-and-goings/556377/general-hospital-recasts-james-west-owen-curtis-rufca/ |date=December 23, 2019 |access-date=October 31, 2022}}

| James West

| 2019

scope="row"| Tim Russ

| Dr Trent

| 2006–07

scope="row"| Richard Rust

| James Vining

| 1975

scope="row"| James Ryan

| Ethan Lovett

| 2023

scope="row"| Mitchell Ryan

| Frank Smith

| 1993–94

scope="row"| Roz Ryan

| Esther Love

| 2012

scope="row"| Emme Rylan

| Lulu Spencer

| 2013–20

scope="row"| Antonio Sabàto Jr.

| Jagger Cates

| 1992–95

scope="row" | Dahlia Salem

| Claire Walsh

| 2010–11

scope="row" rowspan="2"| Emma Samms

| Holly Sutton-Scorpio

| 1982–1985, 1992–1993, 2006, 2009, 2012–2013, 2015, 2020, 2022–2024

Paloma Stuart

| 1992–1993

scope="row"| David Sampen

| Photographer/ Port Charles Resident

| 2014–19

scope="row"| Brytni Sarpy

| Valerie Spencer

| 2015–19

scope="row"| Richard Sarradet

| Howard Lansing

| 1978–81

scope="row"| Paul Satterfield

| Paul Hornsby

| 1991–94

scope="row"| Michael Saucedo

| Juan Santiago

| 1999–01, 2013–14

scope="row"| Paul Savoir

| Tom Baldwin

| 1967–72

scope="row"| Owen Saxon{{cite news|last1=Eades|first1=Chris|title=Who Kidnapped Anna on GENERAL HOSPITAL? — Meet Owen Saxon|url=https://www.abc.soapsindepth.com/posts/general-hospital-anna-kidnapped-owen-saxon-164326|access-date=August 12, 2018|work=ABC Soaps In Depth|publisher=Bauer Media Group|date=August 8, 2018|location=United States}}

| Carson's Henchman

| 2018

scope="row"| Travis Schuldt

| Dr. Zajac

| 2017

scope="row" rowspan="2"| Brad Schmidt

| Brando Corbin

| 2022

Book

| 2022–23

scope="row"| Coltin Scott

| Nikolas Cassadine

| 1999–03

scope="row"| Ignacio Serricchio

| Diego Alcazar

| 2004–06, 2008

scope="row"| Aaron Seville

| Bradley Ward

| 1994–96

scope="row"| Monti Sharp

| Justus Ward

| 1998–99

scope="row" rowspan="2"| Charles Shaughnessy

| Alistair Durban

| 1984

Victor Cassadine

| 2021–23

scope="row"| Cari Shayne

| Karen Wexler

| 1992–94

scope="row"| Doug Sheehan

| Joe Kelly

| 1979–82

scope="row"| Blake Sheldon

| Hale Garrett

| 2016

scope="row"| Graham Shiels

| Cody Paul

| 2007–08

scope="row"| James Sikking

| James Hobart

| 1973–76

scope="row"| Londyn Silzer

| Bailey

| 2017

scope="row"| Richard Simmons

| Himself

| 1979–82, 2013

scope="row"| Peggy Sinclair

| Sister Ellen Chapman

| 1972–73

scope="row"| Brooklyn Rae Silzer

| Emma Drake

| 2011–18, 2020

scope="row"| Jennifer Sky

| Sarah Webber

| 1997–98

scope="row"| Tava Smiley

| Chloe Morgan

| 1999–2001

scope="row"| Brooke Anne Smith

| Molly Lansing

| 2023

scope="row"| Emma and Sarah Smith

| 2003–05

scope="row"| Hillary B. Smith

| Nora Buchanan

| 2017, 2019

scope="row"| Justin Smith

| Holt

| 2016

scope="row" rowspan="3"| Rick Springfield

| Noah Drake

| 1981–83, 2005–08, 2012–13

Eli Love

| 2007–08

Himself

| 2013

scope="row"| Nick Stabile

| Nikolas Cassadine

| 2016

scope="row"| Kelly Stables

| Bobbie Spencer

| 2003

scope="row"| Michelle Stafford

| Nina Reeves

| 2014–19

scope="row"| John Stamos

| Blackie Parrish

| 1982–84

scope="row"| Darby Stanchfield

| Amelia Joffe

| 2007

scope="row"| Jonathan Stanley

| Billy Pryce

| 2019

scope="row"| Anthony Starke

| Kevin Collins

| 2015

scope="row"| Valerie Starrett

| Diana Taylor

| 1969–77

scope="row"| Richard Steinmetz

| Joe Scully, Jr.

| 2012

scope="row" | Stella Stevens

| Jake

| 1996-99

scope="row"| Danica Stewart

| Maxie Jones

| 2002

scope="row"| Garren Stitt

| Oscar Nero

| 2017–19

scope="row"| Julian Stone

| Jerry Jacks

| 1998–99

scope="row"| Deborah Strang

| Betsy Frank

| 2017–18

scope="row"| Sally Struthers

| Jennifer Smith

| 2002

scope="row"| Anna Stuart

| Gina Dante-Lansing

| 1977–78

scope="row"| Gloria Stuart

| Catherine Flynn

| 2002–03

scope="row" rowspan="2"| James Patrick Stuart

| Valentin Cassadine

| 2016–2025

Frank Benson

| 2020

scope="row"| Katie Stuart

| Sage Alcazar

| 2003–04

scope="row"| Coleen Sullivan

| Herself

| 2018

scope="row"| Kelly Sullivan

| Connie Falconeri

| 2011–14

scope="row" rowspan="2"| Liam Sullivan

| Roy Lansing

| 1963–64

Dr Wallace

| 1988

scope="row"| Michael Sutton

| Stone Cates

| 1993–95, 2010, 2017

scope="row"| Gable Swanlund

| 2021

scope="row"| George Takei

| Mr Diem

| 1985

scope="row"| Amber Tamblyn

| Emily Quartermaine

| 1995–01

scope="row"| Philip Tanzini

| Jeremy Logan

| 1978–82

scope="row"| Barbara Tarbuck

| Jane Jacks

| 1996–2010

scope="row"| Milt Tarver

| Justice of the Peace

| 2000

scope="row"| Elizabeth Taylor

| Helena Cassadine

| 1981

scope="row"| Jana Taylor

| Angie Costello-Weeks

| 1963–65, 1993

scope="row" rowspan="2"| Kelly Thiebaud

| Britt Westbourne

| 2012–15, 2017–18, 2020–23

Bertha Halifax

| 2020

scope="row"| Roy Thinnes

| Phil Brewer

| 1963–66

scope="row" rowspan="2"| Jason Thompson

| Patrick Drake

| 2005–16

Steve Hardy

| 2015

scope="row"| Pam Tillis

| Herself

| 1998

scope="row"| Marcus Toji

| Brad Cooper

| 2013

scope="row"| Constance Towers

| Helena Cassadine

| 1997–2007, 2009–17, 2019–20, 2022–23

scope="row"| Daniel J. Travanti

| Spence Andrews

| 1979

scope="row"| Les Tremayne

| 1987–88

scope="row" rowspan="2"| Craig Tsuyumine

| Dr Hillier

| 2001

Clerk

| 2017

scope="row"| Jessica Tuck

| Cassandra Pierce

| 2017–19

scope="row"| Janine Turner

| Laura Templeton

| 1982–83

scope="row"| Michael Tylo

| Charlie Prince

| 1989

scope="row"| Daya Vaidya

| Martina Morales

| 2017

scope="row"| Erik Valdez

| Trey Mitchell

| 2012–13

scope="row"| Chris Van Etten

| Chet Driscoll

| 2017–19, 2022

scope="row"| Greg Vaughan

| Lucky Spencer

| 2003–09

scope="row"| Reginald VelJohnson

| Reverend Winston Love

| 2012

scope="row"| Nick Viall{{cite web|author1=Soaps SheKnows|author-link1=Soaps.com|title=General Hospital Comings & Goings|url=http://soaps.sheknows.com/comings-and-goings|website=Soaps.com|publisher=SheKnows Media|access-date=September 14, 2020|location=United States|date=April 24, 2018}}{{cite news|last1=Eades|first1=Chris|title=THE BACHELOR's Nick Viall Joins GENERAL HOSPITAL for This Year's Nurses Ball|url=http://www.abc.soapsindepth.com/posts/nick-viall-general-hospital-158636|access-date=April 24, 2018|work=ABC Soaps In Depth|publisher=Bauer Media Group|date=April 23, 2018|location=United States}}{{cite web|url=https://www.tvinsider.com/683777/general-hospital-nurses-ball-2018-nick-viall/|title='General Hospital' Taps 'Bachelor' Nick Viall as Host of the 2018 Nurses Ball|first=Michael|last=Maloney|work=TV Insider|publisher=NTVB Media, Inc.|location=United States|date=April 23, 2018|access-date=April 24, 2018}}

| Himself

| 2018

scope="row"| Meredith Vieira

| Bree Flanders

| 2003, 2012

scope="row"| Anthony Vitale

| Aldo

| 2015–16

scope="row"| Danielle von Zerneck

| Louisa "Lou" Swenson

| 1983–84

scope="row"| Lisa Vultaggio

| Hannah Scott

| 1999–2001

scope="row"| Johnny Wactor

| Brando Corbin

| 2020–22

scope="row"| Catherine Wadkins

| Mary Bishop

| 2004

scope="row"| Jack Wagner

| Frisco Jones

| 1984–91, 1994–95, 2013

scope="row"| Tonja Walker

| Olivia St. John

| 1988–90, 2017

scope="row"| Jamil Walker Smith

| Jeffrey Scribner

| 2014

scope="row"| Braden Walkes

| Cameron Spencer

| 2006–2012

scope="row"| Lucille Wall

| Lucille Weeks

| 1963–76, 1982

scope="row"| David Wallace

| Tom Hardy

| 1987–93

scope="row"| Dee Wallace

| Pat Spencer

| 2015

scope="row"| Sydney Walsh

| Maggie

| 2021

scope="row"| Kelsey Wang{{cite news|last1=Eades|first1=Chris|title=Daisy on General Hospital — Everything You Need to Know! |url=https://www.abc.soapsindepth.com/posts/general-hospital-daisy-kelsey-wang-166996|work=ABC Soaps In Depth|publisher=Bauer Media Group|access-date=November 9, 2018|location=United States|date=November 9, 2018}}

| Daisy Kwan

| 2018–20

scope="row"| Burt Ward

| Himself

| 1991–94

scope="row"| Megan Ward

| Kate Howard

| 2007–10, 2018, 2020

scope="row"| Cari Ann Warder

| Amy Vining

| 1975

scope="row"| Billy Warlock

| A. J. Quartermaine

| 1997–2003, 2005

scope="row"| Lee Warrick

| Mary Ellen Dante

| 1976–77

scope="row"| Tuc Watkins

| Pierce Dorman

| 1996–97

scope="row"| Robert Palmer Watkins

| Dillon Quartermaine

| 2015–17

scope="row"| Michael Watson

| Decker Moss

| 1989–91

scope="row"| Kristina Wayborn

| Greta Ingstorm

| 1987–88

scope="row"| TK Weaver