MDPHP

{{Short description|Chemical compound}}

{{cs1 config|name-list-format=vanc|display-authors=6}}

{{drugbox

| IUPAC_name = 1-(2H-1,3-Benzodioxol-5-yl)-2-(pyrrolidin-1-yl)hexan-1-one

| image = MDPHP.svg

| image2 = 3',4'-Methylenedioxy-α-pyrrolidinohexiophenone.png

| CAS_number = 776994-64-0

| ATC_prefix =

| ATC_suffix =

| PubChem = 119057580

| UNII = 7P3X2C24CS

| DrugBank =

| ChemSpiderID = 52085733

| C=17|H=23|N=1|O=3

| smiles = CCCCC(N1CCCC1)C(=O)c2ccc3OCOc3c2

| StdInChI = 1S/C17H23NO3/c1-2-3-6-14(18-9-4-5-10-18)17(19)13-7-8-15-16(11-13)21-12-20-15/h7-8,11,14H,2-6,9-10,12H2,1H3

| StdInChIKey = OBLFRFGUZZRECT-UHFFFAOYSA-N

| SMILES = CCCCC(C(=O)C1=CC2=C(C=C1)OCO2)N3CCCC3

| bioavailability =

| protein_bound =

| metabolism =

| elimination_half-life =

| excretion =

| pregnancy_AU =

| pregnancy_US =

| pregnancy_category=

| legal_AU =

| legal_CA = Schedule I

| legal_DE = NpSG

| legal_UK = Class B

| legal_US =

| legal_status = Illegal in Japan and Hungary

| routes_of_administration =

| UNII_Ref = {{fdacite|correct|FDA}}

}}

MDPHP (3',4'-Methylenedioxy-α-pyrrolidinohexiophenone) is a stimulant of the cathinone class originally developed in the 1960s,{{cite patent | country = DE | number = 1545591 | inventor = Koeppe H, Zeile K, Ludwig G |title=Patent DE - Verfahren zur Herstellung von α-Aminoketonen mit heterocyclischer Aminogruppe |url=https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19690807&DB=&locale=en_EP&CC=DE&NR=1545591A1&KC=A1|gdate =28 May 1965}} which has been reported as a novel designer drug. In the UK its slang name is monkey dust.{{cite web |url= https://www.bbc.com/news/uk-england-stoke-staffordshire-45144531 |title= Monkey Dust drug use 'an epidemic', emergency workers warn |work= BBC |date= 10 August 2018 |access-date= 16 August 2018}}[https://www.bbc.com/news/health-65556046 Roberts M. Monkey dust drug clampdown could be coming in UK. BBC News, 11 May 2023] It is closely related to the potent stimulant MDPV though with slightly milder effects, and has been used as an alternative in some countries following the banning of MDPV.{{cite journal | vauthors = Zaitsu K, Katagi M, Tsuchihashi H, Ishii A |s2cid=25604845|doi=10.1007/s11419-013-0218-1|title=Recently abused synthetic cathinones, α-pyrrolidinophenone derivatives: A review of their pharmacology, acute toxicity, and metabolism|journal=Forensic Toxicology|volume=32|pages=1–8|year=2013 }}{{cite journal | vauthors = Kaizaki-Mitsumoto A, Noguchi N, Yamaguchi S, Odanaka Y, Matsubayashi S, Kumamoto H, Fukuhara K, Funada M, Wada K, Numazawa S | s2cid = 45890497 | title = Three 25-NBOMe-type drugs, three other phenethylamine-type drugs (25I-NBMD, RH34, and escaline), eight cathinone derivatives, and a phencyclidine analog MMXE, newly identified in ingredients of drug products before they were sold on the drug market. | journal = Forensic Toxicology | date = January 2016 | volume = 34 | issue = 1 | pages = 108–14 | doi = 10.1007/s11419-015-0293-6 }}{{cite journal | vauthors = Beck O, Bäckberg M, Signell P, Helander A | s2cid = 3401681 | title = Intoxications in the STRIDA project involving a panorama of psychostimulant pyrovalerone derivatives, MDPV copycats | journal = Clinical Toxicology | location = Philadelphia, Pa. | volume = 56 | issue = 4 | pages = 256–263 | date = April 2018 | pmid = 28895757 | doi = 10.1080/15563650.2017.1370097 | doi-access = free }}{{cite journal | vauthors = Fowble KL, Shepard JR, Musah RA | title = Identification and classification of cathinone unknowns by statistical analysis processing of direct analysis in real time-high resolution mass spectrometry-derived "neutral loss" spectra | journal = Talanta | volume = 179 | pages = 546–553 | date = March 2018 | pmid = 29310273 | doi = 10.1016/j.talanta.2017.11.020 | doi-access = free }}