HDAC1

{{Short description|Protein-coding gene in the species Homo sapiens}}

Histone deacetylase 1 (HDAC1) is an enzyme that in humans is encoded by the HDAC1 gene.{{cite journal | vauthors = Taunton J, Hassig CA, Schreiber SL | title = A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p | journal = Science | location = New York, N.Y. | volume = 272 | issue = 5260 | pages = 408–411 | date = April 1996 | pmid = 8602529 | doi = 10.1126/science.272.5260.408 | bibcode = 1996Sci...272..408T | s2cid = 25717734 }}

Function

Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2 MTA2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.{{cite web | title = Entrez Gene: HDAC1 histone deacetylase 1 | url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3065 }}

Interactions

HDAC1 has been shown to interact with:

Androgen receptor,{{cite journal | vauthors = Gaughan L, Logan IR, Cook S, Neal DE, Robson CN | title = Tip60 and histone deacetylase 1 regulate androgen receptor activity through changes to the acetylation status of the receptor | journal = The Journal of Biological Chemistry | volume = 277 | issue = 29 | pages = 25904–25913 | date = July 2002 | pmid = 11994312 | doi = 10.1074/jbc.M203423200 | doi-access = free }}
BCL6,{{cite journal | vauthors = Deltour S, Guerardel C, Leprince D | title = Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: the case of HIC-1 and gammaFBP-B | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 26 | pages = 14831–14836 | date = December 1999 | pmid = 10611298 | pmc = 24733 | doi = 10.1073/pnas.96.26.14831 | bibcode = 1999PNAS...9614831D | doi-access = free }}
BTG2,{{cite journal | vauthors = Farioli-Vecchioli S, Tanori M, Micheli L, Mancuso M, Leonardi L, Saran A, Ciotti MT, Ferretti E, Gulino A, Pazzaglia S, Tirone F | title = Inhibition of medulloblastoma tumorigenesis by the antiproliferative and pro-differentiative gene PC3 | journal = FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology | volume = 21 | issue = 9 | pages = 2215–2225 | date = July 2007 | pmid = 17371797 | doi = 10.1096/fj.06-7548com | s2cid = 4974360 | doi-access = free }}{{cite journal | vauthors = Micheli L, D'Andrea G, Leonardi L, Tirone F | title = HDAC1, HDAC4, and HDAC9 Bind to PC3/Tis21/Btg2 and Are Required for Its Inhibition of Cell Cycle Progression and Cyclin D1 Expression | journal = Journal of Cellular Physiology | volume = 232 | issue = 7 | pages = 1696–1707 | date = July 2017 | pmid = 27333946 | doi = 10.1002/jcp.25467 | s2cid = 4070837 | url = http://www.inmm.cnr.it/tirone/pdfs/Micheli_et_al-2017-J_Cell_Physiol%20PC3-HDACs.pdf }}
BUB1B,
BUB1,
BUB3,
CBFA2T3,{{cite journal | vauthors = Hoogeveen AT, Rossetti S, Stoyanova V, Schonkeren J, Fenaroli A, Schiaffonati L, van Unen L, Sacchi N | title = The transcriptional corepressor MTG16a contains a novel nucleolar targeting sequence deranged in t (16; 21)-positive myeloid malignancies | journal = Oncogene | volume = 21 | issue = 43 | pages = 6703–6712 | date = September 2002 | pmid = 12242670 | doi = 10.1038/sj.onc.1205882 | s2cid = 19634011 }}{{cite journal | vauthors = Amann JM, Nip J, Strom DK, Lutterbach B, Harada H, Lenny N, Downing JR, Meyers S, Hiebert SW | title = ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain | journal = Molecular and Cellular Biology | volume = 21 | issue = 19 | pages = 6470–6483 | date = October 2001 | pmid = 11533236 | pmc = 99794 | doi = 10.1128/mcb.21.19.6470-6483.2001 }}
CDC20,{{cite journal | vauthors = Yoon YM, Baek KH, Jeong SJ, Shin HJ, Ha GH, Jeon AH, Hwang SG, Chun JS, Lee CW | title = WD repeat-containing mitotic checkpoint proteins act as transcriptional repressors during interphase | journal = FEBS Letters | volume = 575 | issue = 1–3 | pages = 23–29 | date = September 2004 | pmid = 15388328 | doi = 10.1016/j.febslet.2004.07.089 | s2cid = 21762011 | doi-access = free }}
CDH1,
CHD3,
CHD4,
COUP-TFII,{{cite journal | vauthors = Smirnov DA, Hou S, Ricciardi RP | title = Association of histone deacetylase with COUP-TF in tumorigenic Ad12-transformed cells and its potential role in shut-off of MHC class I transcription | journal = Virology | volume = 268 | issue = 2 | pages = 319–328 | date = March 2000 | pmid = 10704340 | doi = 10.1006/viro.1999.0181 | doi-access = free }}
CTBP1,{{cite journal | vauthors = Zhang CL, McKinsey TA, Lu JR, Olson EN | title = Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor | journal = The Journal of Biological Chemistry | volume = 276 | issue = 1 | pages = 35–39 | date = January 2001 | pmid = 11022042 | doi = 10.1074/jbc.M007364200 | doi-access = free }}{{cite journal | vauthors = Sundqvist A, Sollerbrant K, Svensson C | title = The carboxy-terminal region of adenovirus E1A activates transcription through targeting of a C-terminal binding protein-histone deacetylase complex | journal = FEBS Letters | volume = 429 | issue = 2 | pages = 183–188 | date = June 1998 | pmid = 9650586 | doi = 10.1016/s0014-5793(98)00588-2 | s2cid = 20660291 }}
DDX17,
DDX5,{{cite journal | vauthors = Wilson BJ, Bates GJ, Nicol SM, Gregory DJ, Perkins ND, Fuller-Pace FV | title = The p68 and p72 DEAD box RNA helicases interact with HDAC1 and repress transcription in a promoter-specific manner | journal = BMC Molecular Biology | volume = 5 | pages = 11 | date = August 2004 | pmid = 15298701 | pmc = 514542 | doi = 10.1186/1471-2199-5-11 | doi-access = free }}
DNMT3A,{{cite journal | vauthors = Fuks F, Burgers WA, Godin N, Kasai M, Kouzarides T | title = Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription | journal = The EMBO Journal | volume = 20 | issue = 10 | pages = 2536–2544 | date = May 2001 | pmid = 11350943 | pmc = 125250 | doi = 10.1093/emboj/20.10.2536 }}
DNMT3L,{{cite journal | vauthors = Aapola U, Liiv I, Peterson P | title = Imprinting regulator DNMT3L is a transcriptional repressor associated with histone deacetylase activity | journal = Nucleic Acids Research | volume = 30 | issue = 16 | pages = 3602–3608 | date = August 2002 | pmid = 12177302 | pmc = 134241 | doi = 10.1093/nar/gkf474 }}{{cite journal | vauthors = Deplus R, Brenner C, Burgers WA, Putmans P, Kouzarides T, de Launoit Y, Fuks F | title = Dnmt3L is a transcriptional repressor that recruits histone deacetylase | journal = Nucleic Acids Research | volume = 30 | issue = 17 | pages = 3831–3838 | date = September 2002 | pmid = 12202768 | pmc = 137431 | doi = 10.1093/nar/gkf509 }}
Death-associated protein 6,{{cite journal | vauthors = Li H, Leo C, Zhu J, Wu X, O'Neil J, Park EJ, Chen JD | title = Sequestration and inhibition of Daxx-mediated transcriptional repression by PML | journal = Molecular and Cellular Biology | volume = 20 | issue = 5 | pages = 1784–1796 | date = March 2000 | pmid = 10669754 | pmc = 85360 | doi = 10.1128/mcb.20.5.1784-1796.2000 }}
EED,
EVI1,{{cite journal | vauthors = Vinatzer U, Taplick J, Seiser C, Fonatsch C, Wieser R | title = The leukaemia-associated transcription factors EVI-1 and MDS1/EVI1 repress transcription and interact with histone deacetylase | journal = British Journal of Haematology | volume = 114 | issue = 3 | pages = 566–573 | date = September 2001 | pmid = 11552981 | doi = 10.1046/j.1365-2141.2001.02987.x | s2cid = 7643309 }}{{cite journal | vauthors = Chakraborty S, Senyuk V, Sitailo S, Chi Y, Nucifora G | title = Interaction of EVI1 with cAMP-responsive element-binding protein-binding protein (CBP) and p300/CBP-associated factor (P/CAF) results in reversible acetylation of EVI1 and in co-localization in nuclear speckles | journal = The Journal of Biological Chemistry | volume = 276 | issue = 48 | pages = 44936–44943 | date = November 2001 | pmid = 11568182 | doi = 10.1074/jbc.M106733200 | doi-access = free }}
EZH2,
FKBP3,{{cite journal | vauthors = Yang WM, Yao YL, Seto E | title = The FK506-binding protein 25 functionally associates with histone deacetylases and with transcription factor YY1 | journal = The EMBO Journal | volume = 20 | issue = 17 | pages = 4814–4825 | date = September 2001 | pmid = 11532945 | pmc = 125595 | doi = 10.1093/emboj/20.17.4814 }}
GATA1,{{cite journal | vauthors = Watamoto K, Towatari M, Ozawa Y, Miyata Y, Okamoto M, Abe A, Naoe T, Saito H | title = Altered interaction of HDAC5 with GATA-1 during MEL cell differentiation | journal = Oncogene | volume = 22 | issue = 57 | pages = 9176–9184 | date = December 2003 | pmid = 14668799 | doi = 10.1038/sj.onc.1206902 | s2cid = 24491249 }}
HMG20B,
HSPA4,
HUS1,
Histone deacetylase 2,{{cite journal | vauthors = Tong JK, Hassig CA, Schnitzler GR, Kingston RE, Schreiber SL | title = Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex | journal = Nature | volume = 395 | issue = 6705 | pages = 917–921 | date = October 1998 | pmid = 9804427 | doi = 10.1038/27699 | bibcode = 1998Natur.395..917T | s2cid = 4355885 }}{{cite journal | vauthors = van der Vlag J, Otte AP | title = Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation | journal = Nature Genetics | volume = 23 | issue = 4 | pages = 474–478 | date = December 1999 | pmid = 10581039 | doi = 10.1038/70602 | s2cid = 6748531 }}{{cite journal | vauthors = Hakimi MA, Bochar DA, Chenoweth J, Lane WS, Mandel G, Shiekhattar R | title = A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 99 | issue = 11 | pages = 7420–7425 | date = May 2002 | pmid = 12032298 | pmc = 124246 | doi = 10.1073/pnas.112008599 | bibcode = 2002PNAS...99.7420H | doi-access = free }}{{cite journal | vauthors = Johnson CA, White DA, Lavender JS, O'Neill LP, Turner BM | title = Human class I histone deacetylase complexes show enhanced catalytic activity in the presence of ATP and co-immunoprecipitate with the ATP-dependent chaperone protein Hsp70 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 11 | pages = 9590–9597 | date = March 2002 | pmid = 11777905 | doi = 10.1074/jbc.M107942200 | doi-access = free }}{{cite journal | vauthors = Hakimi MA, Dong Y, Lane WS, Speicher DW, Shiekhattar R | title = A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes | journal = The Journal of Biological Chemistry | volume = 278 | issue = 9 | pages = 7234–7239 | date = February 2003 | pmid = 12493763 | doi = 10.1074/jbc.M208992200 | doi-access = free }}{{cite journal | vauthors = Fischle W, Dequiedt F, Hendzel MJ, Guenther MG, Lazar MA, Voelter W, Verdin E | title = Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR | journal = Molecular Cell | volume = 9 | issue = 1 | pages = 45–57 | date = January 2002 | pmid = 11804585 | doi = 10.1016/s1097-2765(01)00429-4 | hdl = 11858/00-001M-0000-002C-9FF7-D | hdl-access = free }}{{cite journal | vauthors = Fischle W, Dequiedt F, Fillion M, Hendzel MJ, Voelter W, Verdin E | title = Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo | journal = The Journal of Biological Chemistry | volume = 276 | issue = 38 | pages = 35826–35835 | date = September 2001 | pmid = 11466315 | doi = 10.1074/jbc.M104935200 | doi-access = free }}{{cite journal | vauthors = Ashburner BP, Westerheide SD, Baldwin AS | title = The p65 (RelA) subunit of NF-kappaB interacts with the histone deacetylase (HDAC) corepressors HDAC1 and HDAC2 to negatively regulate gene expression | journal = Molecular and Cellular Biology | volume = 21 | issue = 20 | pages = 7065–7077 | date = October 2001 | pmid = 11564889 | pmc = 99882 | doi = 10.1128/MCB.21.20.7065-7077.2001 }}{{cite journal | vauthors = Zhang Y, Ng HH, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D | title = Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation | journal = Genes & Development | volume = 13 | issue = 15 | pages = 1924–1935 | date = August 1999 | pmid = 10444591 | pmc = 316920 | doi = 10.1101/gad.13.15.1924 }}{{cite journal | vauthors = Hassig CA, Tong JK, Fleischer TC, Owa T, Grable PG, Ayer DE, Schreiber SL | title = A role for histone deacetylase activity in HDAC1-mediated transcriptional repression | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 7 | pages = 3519–3524 | date = March 1998 | pmid = 9520398 | pmc = 19868 | doi = 10.1073/pnas.95.7.3519 | bibcode = 1998PNAS...95.3519H | doi-access = free }}{{cite journal | vauthors = Zhang Y, Iratni R, Erdjument-Bromage H, Tempst P, Reinberg D | title = Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex | journal = Cell | volume = 89 | issue = 3 | pages = 357–364 | date = May 1997 | pmid = 9150135 | doi = 10.1016/s0092-8674(00)80216-0 | doi-access = free }}
Homeobox protein TGIF1,{{cite journal | vauthors = Melhuish TA, Wotton D | title = The interaction of the carboxyl terminus-binding protein with the Smad corepressor TGIF is disrupted by a holoprosencephaly mutation in TGIF | journal = The Journal of Biological Chemistry | volume = 275 | issue = 50 | pages = 39762–39766 | date = December 2000 | pmid = 10995736 | doi = 10.1074/jbc.C000416200 | doi-access = free }}{{cite journal | vauthors = Melhuish TA, Gallo CM, Wotton D | title = TGIF2 interacts with histone deacetylase 1 and represses transcription | journal = The Journal of Biological Chemistry | volume = 276 | issue = 34 | pages = 32109–32114 | date = August 2001 | pmid = 11427533 | doi = 10.1074/jbc.M103377200 | doi-access = free }}
Host cell factor C1,{{cite journal | vauthors = Wysocka J, Myers MP, Laherty CD, Eisenman RN, Herr W | title = Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1 | journal = Genes & Development | volume = 17 | issue = 7 | pages = 896–911 | date = April 2003 | pmid = 12670868 | pmc = 196026 | doi = 10.1101/gad.252103 }}
IFRD1,{{cite journal | vauthors = Vietor I, Vadivelu SK, Wick N, Hoffman R, Cotten M, Seiser C, Fialka I, Wunderlich W, Haase A, Korinkova G, Brosch G, Huber LA | title = TIS7 interacts with the mammalian SIN3 histone deacetylase complex in epithelial cells | journal = The EMBO Journal | volume = 21 | issue = 17 | pages = 4621–4631 | date = September 2002 | pmid = 12198164 | pmc = 125408 | doi = 10.1093/emboj/cdf461 }}
IKZF1,{{cite journal | vauthors = Koipally J, Renold A, Kim J, Georgopoulos K | title = Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes | journal = The EMBO Journal | volume = 18 | issue = 11 | pages = 3090–3100 | date = June 1999 | pmid = 10357820 | pmc = 1171390 | doi = 10.1093/emboj/18.11.3090 }}{{cite journal | vauthors = Koipally J, Georgopoulos K | title = A molecular dissection of the repression circuitry of Ikaros | journal = The Journal of Biological Chemistry | volume = 277 | issue = 31 | pages = 27697–27705 | date = August 2002 | pmid = 12015313 | doi = 10.1074/jbc.M201694200 | doi-access = free }}
ING1,{{cite journal | vauthors = Vieyra D, Loewith R, Scott M, Bonnefin P, Boisvert FM, Cheema P, Pastyryeva S, Meijer M, Johnston RN, Bazett-Jones DP, McMahon S, Cole MD, Young D, Riabowol K | title = Human ING1 proteins differentially regulate histone acetylation | journal = The Journal of Biological Chemistry | volume = 277 | issue = 33 | pages = 29832–29839 | date = August 2002 | pmid = 12015309 | doi = 10.1074/jbc.M200197200 | doi-access = free }}
MBD3,{{cite journal | vauthors = Sakai H, Urano T, Ookata K, Kim MH, Hirai Y, Saito M, Nojima Y, Ishikawa F | title = MBD3 and HDAC1, two components of the NuRD complex, are localized at Aurora-A-positive centrosomes in M phase | journal = The Journal of Biological Chemistry | volume = 277 | issue = 50 | pages = 48714–48723 | date = December 2002 | pmid = 12354758 | doi = 10.1074/jbc.M208461200 | doi-access = free }}{{cite journal | vauthors = Saito M, Ishikawa F | title = The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 38 | pages = 35434–35439 | date = September 2002 | pmid = 12124384 | doi = 10.1074/jbc.M203455200 | doi-access = free }}
MIER1,{{cite journal | vauthors = Ding Z, Gillespie LL, Paterno GD | title = Human MI-ER1 alpha and beta function as transcriptional repressors by recruitment of histone deacetylase 1 to their conserved ELM2 domain | journal = Molecular and Cellular Biology | volume = 23 | issue = 1 | pages = 250–258 | date = January 2003 | pmid = 12482978 | pmc = 140656 | doi = 10.1128/mcb.23.1.250-258.2003 }}
MLL,{{cite journal | vauthors = Xia ZB, Anderson M, Diaz MO, Zeleznik-Le NJ | title = MLL repression domain interacts with histone deacetylases, the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding protein | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 100 | issue = 14 | pages = 8342–8347 | date = July 2003 | pmid = 12829790 | pmc = 166231 | doi = 10.1073/pnas.1436338100 | bibcode = 2003PNAS..100.8342X | doi-access = free }}
MTA1,{{cite journal | vauthors = Yao YL, Yang WM | title = The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity | journal = The Journal of Biological Chemistry | volume = 278 | issue = 43 | pages = 42560–42568 | date = October 2003 | pmid = 12920132 | doi = 10.1074/jbc.M302955200 | doi-access = free }}{{cite journal | vauthors = Mazumdar A, Wang RA, Mishra SK, Adam L, Bagheri-Yarmand R, Mandal M, Vadlamudi RK, Kumar R | title = Transcriptional repression of oestrogen receptor by metastasis-associated protein 1 corepressor | journal = Nature Cell Biology | volume = 3 | issue = 1 | pages = 30–37 | date = January 2001 | pmid = 11146623 | doi = 10.1038/35050532 | s2cid = 23477845 }}
MTA2,
Mad1,
Mdm2,{{cite journal | vauthors = Ito A, Kawaguchi Y, Lai CH, Kovacs JJ, Higashimoto Y, Appella E, Yao TP | title = MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation | journal = The EMBO Journal | volume = 21 | issue = 22 | pages = 6236–6245 | date = November 2002 | pmid = 12426395 | pmc = 137207 | doi = 10.1093/emboj/cdf616 }}
Methyl-CpG-binding domain protein 2,{{cite journal | vauthors = Brackertz M, Boeke J, Zhang R, Renkawitz R | title = Two highly related p66 proteins comprise a new family of potent transcriptional repressors interacting with MBD2 and MBD3 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 43 | pages = 40958–40966 | date = October 2002 | pmid = 12183469 | doi = 10.1074/jbc.M207467200 | doi-access = free }}
Mothers against decapentaplegic homolog 2,{{cite journal | vauthors = Wotton D, Lo RS, Lee S, Massagué J | title = A Smad transcriptional corepressor | journal = Cell | volume = 97 | issue = 1 | pages = 29–39 | date = April 1999 | pmid = 10199400 | doi = 10.1016/s0092-8674(00)80712-6 | s2cid = 6907878 | doi-access = free }}
MyoD,{{cite journal | vauthors = Polesskaya A, Rudnicki MA | title = A MyoD-dependent differentiation checkpoint: ensuring genome integrity | journal = Developmental Cell | volume = 3 | issue = 6 | pages = 757–758 | date = December 2002 | pmid = 12479798 | doi = 10.1016/s1534-5807(02)00372-6 | doi-access = free }}{{cite journal | vauthors = Mal A, Sturniolo M, Schiltz RL, Ghosh MK, Harter ML | title = A role for histone deacetylase HDAC1 in modulating the transcriptional activity of MyoD: inhibition of the myogenic program | journal = The EMBO Journal | volume = 20 | issue = 7 | pages = 1739–1753 | date = April 2001 | pmid = 11285237 | pmc = 145490 | doi = 10.1093/emboj/20.7.1739 }}
NFKB1,
Nuclear receptor co-repressor 2,{{cite journal | vauthors = Fischer DD, Cai R, Bhatia U, Asselbergs FA, Song C, Terry R, Trogani N, Widmer R, Atadja P, Cohen D | title = Isolation and characterization of a novel class II histone deacetylase, HDAC10 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 8 | pages = 6656–6666 | date = February 2002 | pmid = 11739383 | doi = 10.1074/jbc.M108055200 | doi-access = free }}{{cite journal | vauthors = Underhill C, Qutob MS, Yee SP, Torchia J | title = A novel nuclear receptor corepressor complex, N-CoR, contains components of the mammalian SWI/SNF complex and the corepressor KAP-1 | journal = The Journal of Biological Chemistry | volume = 275 | issue = 51 | pages = 40463–40470 | date = December 2000 | pmid = 11013263 | doi = 10.1074/jbc.M007864200 | doi-access = free }}
P21,{{cite journal | vauthors = Zupkovitz G, Lagger S, Martin D, Steiner M, Hagelkruys A, Seiser C, Schöfer C, Pusch O | title = Histone deacetylase 1 expression is inversely correlated with age in the short-lived fish Nothobranchius furzeri | journal = Histochemistry and Cell Biology | volume = 150 | issue = 3 | pages = 255–269 | date = 28 June 2018 | pmid = 29951776 | pmc = 6096771 | doi = 10.1007/s00418-018-1687-4 }}
PCNA,{{cite journal | vauthors = Milutinovic S, Zhuang Q, Szyf M | title = Proliferating cell nuclear antigen associates with histone deacetylase activity, integrating DNA replication and chromatin modification | journal = The Journal of Biological Chemistry | volume = 277 | issue = 23 | pages = 20974–20978 | date = June 2002 | pmid = 11929879 | doi = 10.1074/jbc.M202504200 | doi-access = free }}
PHF21A,{{cite journal | vauthors = Iwase S, Januma A, Miyamoto K, Shono N, Honda A, Yanagisawa J, Baba T | title = Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression | journal = Biochemical and Biophysical Research Communications | volume = 322 | issue = 2 | pages = 601–608 | date = September 2004 | pmid = 15325272 | doi = 10.1016/j.bbrc.2004.07.163 }}
Prohibitin,{{cite journal | vauthors = Joshi B, Ko D, Ordonez-Ercan D, Chellappan SP | title = A putative coiled-coil domain of prohibitin is sufficient to repress E2F1-mediated transcription and induce apoptosis | journal = Biochemical and Biophysical Research Communications | volume = 312 | issue = 2 | pages = 459–466 | date = December 2003 | pmid = 14637159 | doi = 10.1016/j.bbrc.2003.10.148 }}{{cite journal | vauthors = Wang S, Fusaro G, Padmanabhan J, Chellappan SP | title = Prohibitin co-localizes with Rb in the nucleus and recruits N-CoR and HDAC1 for transcriptional repression | journal = Oncogene | volume = 21 | issue = 55 | pages = 8388–8396 | date = December 2002 | pmid = 12466959 | doi = 10.1038/sj.onc.1205944 | s2cid = 22880111 }}
Promyelocytic leukemia protein,{{cite journal | vauthors = Khan MM, Nomura T, Kim H, Kaul SC, Wadhwa R, Shinagawa T, Ichikawa-Iwata E, Zhong S, Pandolfi PP, Ishii S | title = Role of PML and PML-RARalpha in Mad-mediated transcriptional repression | journal = Molecular Cell | volume = 7 | issue = 6 | pages = 1233–1243 | date = June 2001 | pmid = 11430826 | doi = 10.1016/s1097-2765(01)00257-x | doi-access = free }}{{cite journal | vauthors = Wu WS, Vallian S, Seto E, Yang WM, Edmondson D, Roth S, Chang KS | title = The growth suppressor PML represses transcription by functionally and physically interacting with histone deacetylases | journal = Molecular and Cellular Biology | volume = 21 | issue = 7 | pages = 2259–2268 | date = April 2001 | pmid = 11259576 | pmc = 86860 | doi = 10.1128/MCB.21.7.2259-2268.2001 }}
RAD9A,{{cite journal | vauthors = Cai RL, Yan-Neale Y, Cueto MA, Xu H, Cohen D | title = HDAC1, a histone deacetylase, forms a complex with Hus1 and Rad9, two G2/M checkpoint Rad proteins | journal = The Journal of Biological Chemistry | volume = 275 | issue = 36 | pages = 27909–27916 | date = September 2000 | pmid = 10846170 | doi = 10.1074/jbc.M000168200 | doi-access = free }}
RBBP4,{{cite journal | vauthors = Nicolas E, Ait-Si-Ali S, Trouche D | title = The histone deacetylase HDAC3 targets RbAp48 to the retinoblastoma protein | journal = Nucleic Acids Research | volume = 29 | issue = 15 | pages = 3131–3136 | date = August 2001 | pmid = 11470869 | pmc = 55834 | doi = 10.1093/nar/29.15.3131 }}{{cite journal | vauthors = Hassig CA, Fleischer TC, Billin AN, Schreiber SL, Ayer DE | title = Histone deacetylase activity is required for full transcriptional repression by mSin3A | journal = Cell | volume = 89 | issue = 3 | pages = 341–347 | date = May 1997 | pmid = 9150133 | doi = 10.1016/s0092-8674(00)80214-7 | s2cid = 14233219 | doi-access = free }}
RBBP7,{{cite journal | vauthors = Ng HH, Zhang Y, Hendrich B, Johnson CA, Turner BM, Erdjument-Bromage H, Tempst P, Reinberg D, Bird A | title = MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex | journal = Nature Genetics | volume = 23 | issue = 1 | pages = 58–61 | date = September 1999 | pmid = 10471499 | doi = 10.1038/12659 | hdl = 1842/684 | s2cid = 6147725 | hdl-access = free }}
RCOR1,
RELA,{{cite journal | vauthors = Zhong H, May MJ, Jimi E, Ghosh S | title = The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1 | journal = Molecular Cell | volume = 9 | issue = 3 | pages = 625–636 | date = March 2002 | pmid = 11931769 | doi = 10.1016/s1097-2765(02)00477-x | doi-access = free }}{{cite journal | vauthors = Kiernan R, Brès V, Ng RW, Coudart MP, El Messaoudi S, Sardet C, Jin DY, Emiliani S, Benkirane M | title = Post-activation turn-off of NF-kappa B-dependent transcription is regulated by acetylation of p65 | journal = The Journal of Biological Chemistry | volume = 278 | issue = 4 | pages = 2758–2766 | date = January 2003 | pmid = 12419806 | doi = 10.1074/jbc.M209572200 | doi-access = free }}
RFC1,{{cite journal | vauthors = Anderson LA, Perkins ND | title = The large subunit of replication factor C interacts with the histone deacetylase, HDAC1 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 33 | pages = 29550–29554 | date = August 2002 | pmid = 12045192 | doi = 10.1074/jbc.M200513200 | doi-access = free }}
Retinoblastoma protein,{{cite journal | vauthors = Dick FA, Sailhamer E, Dyson NJ | title = Mutagenesis of the pRB pocket reveals that cell cycle arrest functions are separable from binding to viral oncoproteins | journal = Molecular and Cellular Biology | volume = 20 | issue = 10 | pages = 3715–3727 | date = May 2000 | pmid = 10779361 | pmc = 85672 | doi = 10.1128/mcb.20.10.3715-3727.2000 }}{{cite journal | vauthors = Fuks F, Burgers WA, Brehm A, Hughes-Davies L, Kouzarides T | title = DNA methyltransferase Dnmt1 associates with histone deacetylase activity | journal = Nature Genetics | volume = 24 | issue = 1 | pages = 88–91 | date = January 2000 | pmid = 10615135 | doi = 10.1038/71750 | s2cid = 20428600 }}{{cite journal | vauthors = Luo RX, Postigo AA, Dean DC | title = Rb interacts with histone deacetylase to repress transcription | journal = Cell | volume = 92 | issue = 4 | pages = 463–473 | date = February 1998 | pmid = 9491888 | doi = 10.1016/s0092-8674(00)80940-x | s2cid = 18857544 | doi-access = free }}
Retinoblastoma-like protein 1,{{cite journal | vauthors = Lai A, Lee JM, Yang WM, DeCaprio JA, Kaelin WG, Seto E, Branton PE | title = RBP1 recruits both histone deacetylase-dependent and -independent repression activities to retinoblastoma family proteins | journal = Molecular and Cellular Biology | volume = 19 | issue = 10 | pages = 6632–6641 | date = October 1999 | pmid = 10490602 | pmc = 84642 | doi = 10.1128/mcb.19.10.6632 }}
Retinoblastoma-like protein 2,{{cite journal | vauthors = Ferreira R, Magnaghi-Jaulin L, Robin P, Harel-Bellan A, Trouche D | title = The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 18 | pages = 10493–10498 | date = September 1998 | pmid = 9724731 | pmc = 27922 | doi = 10.1073/pnas.95.18.10493 | bibcode = 1998PNAS...9510493F | doi-access = free }}{{cite journal | vauthors = Bouzahzah B, Fu M, Iavarone A, Factor VM, Thorgeirsson SS, Pestell RG | title = Transforming growth factor-beta1 recruits histone deacetylase 1 to a p130 repressor complex in transgenic mice in vivo | journal = Cancer Research | volume = 60 | issue = 16 | pages = 4531–4537 | date = August 2000 | pmid = 10969803 }}
SAP30,{{cite journal | vauthors = Huang NE, Lin CH, Lin YS, Yu WC | title = Modulation of YY1 activity by SAP30 | journal = Biochemical and Biophysical Research Communications | volume = 306 | issue = 1 | pages = 267–275 | date = June 2003 | pmid = 12788099 | doi = 10.1016/S0006-291X(03)00966-5 }}{{cite journal | vauthors = Zhang Y, Sun ZW, Iratni R, Erdjument-Bromage H, Tempst P, Hampsey M, Reinberg D | title = SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex | journal = Molecular Cell | volume = 1 | issue = 7 | pages = 1021–1031 | date = June 1998 | pmid = 9651585 | doi = 10.1016/s1097-2765(00)80102-1 | doi-access = free }}{{cite journal | vauthors = Swanson KA, Knoepfler PS, Huang K, Kang RS, Cowley SM, Laherty CD, Eisenman RN, Radhakrishnan I | title = HBP1 and Mad1 repressors bind the Sin3 corepressor PAH2 domain with opposite helical orientations | journal = Nature Structural & Molecular Biology | volume = 11 | issue = 8 | pages = 738–746 | date = August 2004 | pmid = 15235594 | doi = 10.1038/nsmb798 | s2cid = 44324333 }}{{cite journal | vauthors = Yochum GS, Ayer DE | title = Pf1, a novel PHD zinc finger protein that links the TLE corepressor to the mSin3A-histone deacetylase complex | journal = Molecular and Cellular Biology | volume = 21 | issue = 13 | pages = 4110–4118 | date = July 2001 | pmid = 11390640 | pmc = 87072 | doi = 10.1128/MCB.21.13.4110-4118.2001 }}
SATB1,
SIN3A,{{cite journal | vauthors = Kuzmichev A, Zhang Y, Erdjument-Bromage H, Tempst P, Reinberg D | title = Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1) | journal = Molecular and Cellular Biology | volume = 22 | issue = 3 | pages = 835–848 | date = February 2002 | pmid = 11784859 | pmc = 133546 | doi = 10.1128/mcb.22.3.835-848.2002 }}{{cite journal | vauthors = Grozinger CM, Hassig CA, Schreiber SL | title = Three proteins define a class of human histone deacetylases related to yeast Hda1p | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 9 | pages = 4868–4873 | date = April 1999 | pmid = 10220385 | pmc = 21783 | doi = 10.1073/pnas.96.9.4868 | bibcode = 1999PNAS...96.4868G | doi-access = free }}{{cite journal | vauthors = You A, Tong JK, Grozinger CM, Schreiber SL | title = CoREST is an integral component of the CoREST- human histone deacetylase complex | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 98 | issue = 4 | pages = 1454–1458 | date = February 2001 | pmid = 11171972 | pmc = 29278 | doi = 10.1073/pnas.98.4.1454 | bibcode = 2001PNAS...98.1454Y | doi-access = free }}{{cite journal | vauthors = Yasui D, Miyano M, Cai S, Varga-Weisz P, Kohwi-Shigematsu T | title = SATB1 targets chromatin remodelling to regulate genes over long distances | journal = Nature | volume = 419 | issue = 6907 | pages = 641–645 | date = October 2002 | pmid = 12374985 | doi = 10.1038/nature01084 | bibcode = 2002Natur.419..641Y | s2cid = 25822700 | url = https://digital.library.unt.edu/ark:/67531/metadc733622/ }}{{cite journal | vauthors = Zhang Y, Dufau ML | title = Dual mechanisms of regulation of transcription of luteinizing hormone receptor gene by nuclear orphan receptors and histone deacetylase complexes | journal = The Journal of Steroid Biochemistry and Molecular Biology | volume = 85 | issue = 2–5 | pages = 401–414 | date = June 2003 | pmid = 12943729 | doi = 10.1016/s0960-0760(03)00230-9 | s2cid = 28512341 | url = https://zenodo.org/record/1260176 }}{{cite journal | vauthors = Zhang Y, Dufau ML | title = Silencing of transcription of the human luteinizing hormone receptor gene by histone deacetylase-mSin3A complex | journal = The Journal of Biological Chemistry | volume = 277 | issue = 36 | pages = 33431–33438 | date = September 2002 | pmid = 12091390 | doi = 10.1074/jbc.M204417200 | doi-access = free }}{{cite journal | vauthors = Fleischer TC, Yun UJ, Ayer DE | title = Identification and characterization of three new components of the mSin3A corepressor complex | journal = Molecular and Cellular Biology | volume = 23 | issue = 10 | pages = 3456–3467 | date = May 2003 | pmid = 12724404 | pmc = 164750 | doi = 10.1128/mcb.23.10.3456-3467.2003 }}{{cite journal | vauthors = Yang L, Mei Q, Zielinska-Kwiatkowska A, Matsui Y, Blackburn ML, Benedetti D, Krumm AA, Taborsky GJ, Chansky HA | title = An ERG (ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co-repressors mSin3A/B | journal = The Biochemical Journal | volume = 369 | issue = Pt 3 | pages = 651–657 | date = February 2003 | pmid = 12398767 | pmc = 1223118 | doi = 10.1042/BJ20020854 }}{{cite journal | vauthors = Zhang J, Kalkum M, Chait BT, Roeder RG | title = The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2 | journal = Molecular Cell | volume = 9 | issue = 3 | pages = 611–623 | date = March 2002 | pmid = 11931768 | doi = 10.1016/s1097-2765(02)00468-9 | doi-access = free }}{{cite journal | vauthors = Huang EY, Zhang J, Miska EA, Guenther MG, Kouzarides T, Lazar MA | title = Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway | journal = Genes & Development | volume = 14 | issue = 1 | pages = 45–54 | date = January 2000 | pmid = 10640275 | pmc = 316335 | doi = 10.1101/gad.14.1.45 }}
SIN3B,
SPEN,{{cite journal | vauthors = Shi Y, Downes M, Xie W, Kao HY, Ordentlich P, Tsai CC, Hon M, Evans RM | title = Sharp, an inducible cofactor that integrates nuclear receptor repression and activation | journal = Genes & Development | volume = 15 | issue = 9 | pages = 1140–1151 | date = May 2001 | pmid = 11331609 | pmc = 312688 | doi = 10.1101/gad.871201 }}
SUDS3,{{cite journal | vauthors = Alland L, David G, Shen-Li H, Potes J, Muhle R, Lee HC, Hou H, Chen K, DePinho RA | title = Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex | journal = Molecular and Cellular Biology | volume = 22 | issue = 8 | pages = 2743–2750 | date = April 2002 | pmid = 11909966 | pmc = 133736 | doi = 10.1128/mcb.22.8.2743-2750.2002 }}
SUV39H1,{{cite journal | vauthors = Vaute O, Nicolas E, Vandel L, Trouche D | title = Functional and physical interaction between the histone methyl transferase Suv39H1 and histone deacetylases | journal = Nucleic Acids Research | volume = 30 | issue = 2 | pages = 475–481 | date = January 2002 | pmid = 11788710 | pmc = 99834 | doi = 10.1093/nar/30.2.475 }}
Sp1 transcription factor,{{cite journal | vauthors = Di Padova M, Bruno T, De Nicola F, Iezzi S, D'Angelo C, Gallo R, Nicosia D, Corbi N, Biroccio A, Floridi A, Passananti C, Fanciulli M | title = Che-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoter | journal = The Journal of Biological Chemistry | volume = 278 | issue = 38 | pages = 36496–36504 | date = September 2003 | pmid = 12847090 | doi = 10.1074/jbc.M306694200 | doi-access = free }}{{cite journal | vauthors = Singh J, Murata K, Itahana Y, Desprez PY | title = Constitutive expression of the Id-1 promoter in human metastatic breast cancer cells is linked with the loss of NF-1/Rb/HDAC-1 transcription repressor complex | journal = Oncogene | volume = 21 | issue = 12 | pages = 1812–1822 | date = March 2002 | pmid = 11896613 | doi = 10.1038/sj.onc.1205252 | s2cid = 30129174 }}{{cite journal | vauthors = Sun JM, Chen HY, Moniwa M, Litchfield DW, Seto E, Davie JR | title = The transcriptional repressor Sp3 is associated with CK2-phosphorylated histone deacetylase 2 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 39 | pages = 35783–35786 | date = September 2002 | pmid = 12176973 | doi = 10.1074/jbc.C200378200 | doi-access = free }}
TOP2A,
TOP2B,{{cite journal | vauthors = Tsai SC, Valkov N, Yang WM, Gump J, Sullivan D, Seto E | title = Histone deacetylase interacts directly with DNA topoisomerase II | journal = Nature Genetics | volume = 26 | issue = 3 | pages = 349–353 | date = November 2000 | pmid = 11062478 | doi = 10.1038/81671 | s2cid = 19301396 }}{{cite journal | vauthors = Johnson CA, Padget K, Austin CA, Turner BM | title = Deacetylase activity associates with topoisomerase II and is necessary for etoposide-induced apoptosis | journal = The Journal of Biological Chemistry | volume = 276 | issue = 7 | pages = 4539–4542 | date = February 2001 | pmid = 11136718 | doi = 10.1074/jbc.C000824200 | doi-access = free }} and
Zinc finger and BTB domain-containing protein 16.{{cite journal | vauthors = David G, Alland L, Hong SH, Wong CW, DePinho RA, Dejean A | title = Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein | journal = Oncogene | volume = 16 | issue = 19 | pages = 2549–2556 | date = May 1998 | pmid = 9627120 | doi = 10.1038/sj.onc.1202043 | s2cid = 655636 }}{{cite journal | vauthors = Chauchereau A, Mathieu M, de Saintignon J, Ferreira R, Pritchard LL, Mishal Z, Dejean A, Harel-Bellan A | title = HDAC4 mediates transcriptional repression by the acute promyelocytic leukaemia-associated protein PLZF | journal = Oncogene | volume = 23 | issue = 54 | pages = 8777–8784 | date = November 2004 | pmid = 15467736 | doi = 10.1038/sj.onc.1208128 | s2cid = 26092755 }}{{cite journal | vauthors = Wong CW, Privalsky ML | title = Components of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF, PLZF-RARalpha, and BCL-6 | journal = The Journal of Biological Chemistry | volume = 273 | issue = 42 | pages = 27695–27702 | date = October 1998 | pmid = 9765306 | doi = 10.1074/jbc.273.42.27695 | doi-access = free }}

References

External links

{{MeshName|HDAC1+protein,+human}}

Category:EC 3.5.1

Category:Genes mutated in mice

Δ1

HDAC1

Function

Interactions

See also

References

Further reading

External links