PIK3CG

{{Short description|Protein-coding gene in the species Homo sapiens}}

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform is an enzyme that in humans is encoded by the PIK3CG gene.

Function

This gene encodes a protein that belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias.{{cite web | title = Entrez Gene: PIK3CG phosphoinositide-3-kinase, catalytic, gamma polypeptide| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5294}} More recently, this gene has been shown to be a critical myeloid-restricted vulnerability in Acute Myeloid Leukemia (AML). Its targeting, either by the small-molecule inhibitor IPI-549 or by a first-in-class proteolysis-targeting chimera (PROTAC) named ARM165, has been shown to reduce AML cell progression both in vitro and in vivo. https://pubmed.ncbi.nlm.nih.gov/38720074/ https://pubmed.ncbi.nlm.nih.gov/38816660/

Interactions

PIK3CG has been shown to interact with:

BCR gene,{{cite journal | vauthors = Bai RY, Jahn T, Schrem S, Munzert G, Weidner KM, Wang JY, Duyster J | title = The SH2-containing adapter protein GRB10 interacts with BCR-ABL | journal = Oncogene | volume = 17 | issue = 8 | pages = 941–8 | date = August 1998 | pmid = 9747873 | doi = 10.1038/sj.onc.1202024 | s2cid = 20866214 | doi-access = }}{{cite journal | vauthors = Salgia R, Sattler M, Pisick E, Li JL, Griffin JD | title = p210BCR/ABL induces formation of complexes containing focal adhesion proteins and the protooncogene product p120c-Cbl | journal = Exp. Hematol. | volume = 24 | issue = 2 | pages = 310–3 | date = February 1996 | pmid = 8641358 }}{{cite journal | vauthors = Skorski T, Kanakaraj P, Nieborowska-Skorska M, Ratajczak MZ, Wen SC, Zon G, Gewirtz AM, Perussia B, Calabretta B | title = Phosphatidylinositol-3 kinase activity is regulated by BCR/ABL and is required for the growth of Philadelphia chromosome-positive cells | journal = Blood | volume = 86 | issue = 2 | pages = 726–36 | date = July 1995 | pmid = 7606002 | doi = 10.1182/blood.V86.2.726.bloodjournal862726| doi-access = free }}
KRAS,{{cite journal | vauthors = Rubio I, Wittig U, Meyer C, Heinze R, Kadereit D, Waldmann H, Downward J, Wetzker R | title = Farnesylation of Ras is important for the interaction with phosphoinositide 3-kinase gamma | journal = Eur. J. Biochem. | volume = 266 | issue = 1 | pages = 70–82 | date = November 1999 | pmid = 10542052 | doi = 10.1046/j.1432-1327.1999.00815.x| doi-access = free }}
PIK3CD,{{cite journal | vauthors = Vanhaesebroeck B, Welham MJ, Kotani K, Stein R, Warne PH, Zvelebil MJ, Higashi K, Volinia S, Downward J, Waterfield MD | title = P110delta, a novel phosphoinositide 3-kinase in leukocytes | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 94 | issue = 9 | pages = 4330–5 | date = April 1997 | pmid = 9113989 | pmc = 20722 | doi = 10.1073/pnas.94.9.4330| bibcode = 1997PNAS...94.4330V | doi-access = free }} and
PIK3R5.{{cite journal | vauthors = Brock C, Schaefer M, Reusch HP, Czupalla C, Michalke M, Spicher K, Schultz G, Nürnberg B | title = Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma | journal = J. Cell Biol. | volume = 160 | issue = 1 | pages = 89–99 | date = January 2003 | pmid = 12507995 | pmc = 2172741 | doi = 10.1083/jcb.200210115 }}

PIK3CG

Function

Interactions

See also

References

Further reading