Pertine

File:Oxypertine.svg of oxypertine, the most well-known drug of the pertine group.]]

The pertines are a group of antipsychotics of the cyclized tryptamine and phenylpiperazine families that includes the following drugs:{{cite book | last=Elks | first=J. | title=The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies | publisher=Springer | date=14 November 2014 | isbn=978-1-4757-2085-3 | url=https://books.google.com/books?id=0vXTBwAAQBAJ | access-date=18 June 2025 | page=}}{{cite journal | vauthors = Megens AA, Kennis LE | title = Risperidone and related 5HT2/D2 antagonists: a new type of antipsychotic agent? | journal = Prog Med Chem | series = Progress in Medicinal Chemistry | volume = 33 | issue = | pages = 185–232 | date = 1996 | pmid = 8776944 | doi = 10.1016/s0079-6468(08)70306-0 | isbn = 978-0-444-82310-6 | url = }}

• Alpertine (WIN-31665)
• Milipertine (WIN-18935)
• Oxypertine (WIN-18501)
• Solypertine (WIN-18413)

Oxypertine is known to show high affinity for the serotonin 5-HT₂ and dopamine D₂ receptors (K_i = 8.6{{nbsp}}nM and 30{{nbsp}}nM, respectively) and to also act as a catecholamine depleting agent.{{cite journal | vauthors = Bak IJ, Hassler R, Kim JS | title = Differential monoamine depletion by oxypertine in nerve terminals. Granulated synaptic vesicles in relation to depletion of norepinephrine, dopamine and serotonin | journal = Zeitschrift für Zellforschung und Mikroskopische Anatomie | volume = 101 | issue = 3 | pages = 448–462 | year = 1969 | pmid = 5362847 | doi = 10.1007/BF00335580 | s2cid = 32583722 }} Oxypertine, milipertine, and solypertine all antagonize the behavioral effects of tryptamine, a serotonin receptor agonist, and apomorphine, a dopamine receptor agonist, in animals.{{cite journal | vauthors = Niemegeers CJ, Janssen PA | title = A systematic study of the pharmacological activities of dopamine antagonists | journal = Life Sciences | volume = 24 | issue = 24 | pages = 2201–2216 | date = June 1979 | pmid = 388130 | doi = 10.1016/0024-3205(79)90096-1 | publisher = Elsevier BV }}

Some of the pertines, like milipertine and solypertine, are notable in containing an NBOMe-like moiety.

The pertines were developed and initially described in the 1960s and 1970s.