Tapas Kumar Kundu

{{Infobox scientist

| name = Tapas Kumar Kundu

| image =

| alt =

| caption =

| birth_date = {{Birth date and age|df=yes|1962|1|2}}

| birth_place = Hili, West Bengal, India

| death_date =

| death_place =

| nationality = Indian

| fields = {{ublist | Molecular biology }}

| workplaces = {{ublist | Jawaharlal Nehru Centre for Advanced Scientific Research }}

| alma_mater = {{ublist | Indian Institute of Science | National Institute of Genetics | Rockefeller University }}

| doctoral_advisor = M. R. S. Rao

| doctoral_students =

| known_for = Studies on regulation of Gene expression

| awards = 1993 International Council of Scientific Union Award
1995 IISc Giri Memorial Award
2005 Shanti Swarup Bhatnagar Prize
2005 N-BIOS Prize
2008 NASI-Reliance Platinum Jubilee Award
2011 G. D. Birla Award for Scientific Research
2011 Ranbaxy Research Award
2012 MM India Innovation Award

}}

Tapas Kumar Kundu (born 2 January 1962) is an Indian molecular biologist, academician and at present the Director{{cite web|title=Prof. Tapas Kundu as Director, CDRI (CSIR), Lucknow|url=http://www.cdri.res.in/Directorpro.aspx}} of Central Drug Research Institute, a prestigious research institute of Council of Scientific and Industrial Research at Lucknow. He is the head of the Transcription and Disease Laboratory of Jawaharlal Nehru Centre for Advanced Scientific Research.{{cite web | url=http://www.jncasr.ac.in/tapas/tkk_pro.php | title=Prof. Tapas Kumar Kundu - TDL | publisher=Transcription and Disease Laboratory | date=2016 | access-date=20 October 2016}} He is known for his studies on the regulation of Gene expression and his contributions in cancer diagnostics and the development of new drug candidates for cancer and AIDS therapeutics.{{cite web | url=http://ssbprize.gov.in/content/Detail.aspx?AID=168 | title=Brief Profile of the Awardee | publisher=Shanti Swarup Bhatnagar Prize | date=2016 | access-date=5 October 2016}} He is an elected fellow of the Indian Academy of Sciences,{{cite web | url=http://www.ias.ac.in/describe/fellow/Kundu,_Dr_Tapas_Kumar | title=Fellow profile - T K Kundu | publisher=Indian Academy of Sciences | date=2016 | access-date=6 October 2016}} Indian National Science Academy{{cite web | url=http://www.insaindia.res.in/detail.php?id=P10-1515 | title=Indian fellow - T K Kundu | publisher=Indian National Science Academy | date=2016 | access-date=11 October 2016}} and the National Academy of Sciences, India{{cite web | url=http://www.nasi.org.in/fellows.asp?RsFilter=K | title=NASI fellows | publisher=National Academy of Sciences, India | date=2016 | access-date=20 October 2016 | archive-date=15 March 2016 | archive-url=https://web.archive.org/web/20160315081652/http://nasi.org.in/fellows.asp?RsFilter=K | url-status=dead }} and a J. C. Bose National Fellow of the Department of Science and Technology. The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards, in 2005, for his contributions to biological sciences.{{cite web | url=http://ssbprize.gov.in/Content/AwardeeList.aspx | title=View Bhatnagar Awardees | publisher=Shanti Swarup Bhatnagar Prize | date=2016 | access-date=5 October 2016}} He is also a recipient of the National Bioscience Award for Career Development of the Department of Biotechnology.{{cite web | url=http://dbtindia.nic.in/wp-content/uploads/2014/03/list_of_bioscience_awardees.pdf | title=Awardees of National Bioscience Awards for Career Development | publisher=Department of Biotechnology | date=2016 | access-date=17 October 2016 | archive-date=4 March 2018 | archive-url=https://web.archive.org/web/20180304191331/http://dbtindia.nic.in/wp-content/uploads/2014/03/list_of_bioscience_awardees.pdf | url-status=dead }}

Biography

Born on 2 January 1962 at Hili, a border town near Balurghat in Dakshin Dinajpur district in the Indian state of West Bengal to Kalachand Kundu and Dipali couple, Tapas Kumar Kundu graduated in agriculture (BSc hons) from Bidhan Chandra Krishi Viswavidyalaya in 1986 and completed his master's degree in biochemistry from University of Agricultural Sciences, Bangalore in 1989, winning a gold medal for standing first in the master's degree examination.{{cite web | url=http://www.jncasr.ac.in/tdl/cvsir.html | title=Biographical Information | publisher=Jawaharlal Nehru Centre for Advanced Scientific Research | date=2016 | access-date=20 October 2016}} He enrolled for doctoral studies at the Indian Institute of Science in 1990 and secured a PhD under the guidance of M. R. S. Rao{{cite web | url=http://www.jncasr.ac.in/profile/tapas.html | title=Academic Profile | publisher=Jawaharlal Nehru Centre for Advanced Scientific Research | date=2016 | access-date=22 October 2016}} in 1995 for his thesis, Zinc-Metalloprotein Nature of Rat Spermatidal Protein TP2 and its Interactions with DNA.{{cite web | url=http://alumni.iisc.ernet.in/profile/view/tapas-kumar-kundu | title=IISc Alumni | publisher=Indian Institute of Science | date=2016 | access-date=22 October 2016}}{{Refn|group=note|His thesis won the Giri Memorial Award for best thesis in Biochemistry.{{cite web | url=http://www.incredb.org/investigator.php?incredb_id=65 | title=Tapas K. Kundu on ICRD | publisher=India Cancer Research Database | date=2016 | access-date=22 October 2016}}}} After a short stint at the National Institute of Genetics, Japan during 1995–96 as a visiting foreign research associate, he did his post-doctoral studies at the Laboratory of Biochemistry and Molecular Biology of Rockefeller University during 1996–99. Returning to India the same year, he joined Jawaharlal Nehru Centre for Advanced Scientific Research at their Molecular Biology and Genetics Unit where he became an assistant professor in 2005 and heads the Transcription and Disease Laboratory of the institution in the capacity of a JNCASR Silver Jubillee Professor since 2015.

Kundu is a life member and a former vice president of the Society of Biological Chemists, India{{cite web | url=http://iiscp.iisc.ernet.in/sbci/images/LIST%20-OF%20-LIFE-MEMBERS.pdf | title=Life members | publisher=Society of Biological Chemists, India | date=2016 | access-date=20 October 2016}} and is its incumbent president.{{cite web | url=http://iiscp.iisc.ernet.in/sbci/images/SBCpastpresident.pdf | title=SBC(I) Presidents | publisher=Society of Biological Chemists, India | date=2016 | access-date=20 October 2016}} He is a nominated member of American Chemical Society and American Society for Biochemistry and Molecular Biology and a member of the American Society for Microbiology. He was among the biologists who founded the Chemical Biology Society, India of the Indian Institute of Chemical Biology in 2013 and serves as it secretary.{{cite web | url=http://iicb.res.in/chemical_biology_society/pc.htm | archive-url=https://web.archive.org/web/20140330104444/http://iicb.res.in/chemical_biology_society/pc.htm | url-status=dead | archive-date=2014-03-30 | title=Present Council | publisher=Chemical Biology Society, India | date=2016 | access-date=20 October 2016 }} An adjunct professor at the Special Centre for Molecular Medicine of Jawaharlal Nehru University, he served as a member of the Reader Panel of Nature and is a former member of the editorial board of the Journal of Biological Chemistry (June 2011–September 2016). In 2019, the School of Biological Sciences, Madurai Kamaraj University had appointed him as a distinguished member of the national and international advisory committee to organize ICGB'19 (International Conference on Genome Biology 2019).{{cite web|url=https://www.readkong.com/page/school-of-biological-sciences-madurai-kamaraj-university-6308630|title= School of Biological Sciences Madurai Kamaraj University Madurai - 625021, India|publisher= School of Biological Sciences Madurai Kamaraj University|access-date=1 May 2010}}

Legacy

File:Nucleosome 1KX5 2.png

Kundu's researches are principally focused on the regulation of transcription and P53 function using chromatin and associated proteins as well as on the functional genomics of transcriptional co-activators. His researches assisted in the identification of PC4 and its role as a functional component of chromatin and as an activator of P53.{{cite web | url=http://www.csirhrdg.res.in/ssb.pdf | title=Handbook of Shanti Swarup Bhatnagar Prize Winners | publisher=Council of Scientific and Industrial Research | date=1999 | access-date=5 October 2016 | pages=34}} He demonstrated the histone chaperone activity and the acetylation of chromatin transcription and these findings have been reported to have helped in identifying new drug candidates.{{cite web | url=http://csir.res.in/csir/external/heads/career/award/ssb2005.pdf | title=2005 Biological Sciences | publisher=CSIR | date=2016 | access-date=22 October 2016}} Extending his researches to cancer and AIDS therapeutics, he has identified small molecule modulators of chromatin modifying enzymes, a discovery which is reported to be helpful in developing new therapeutic protocols.

Kundu has published one book, Epigenetics: Development and Disease,{{cite book|author=Tapas Kumar Kundu|title=Epigenetics: Development and Disease|url=https://books.google.com/books?id=O2OBaKOyavwC|date=13 November 2012|publisher=Springer Science & Business Media|isbn=978-94-007-4525-4}} and a number of articles in peer-reviewed journals{{Refn|group=note|Please see Selected bibliography section}} and Google Scholar, an online article repository, has listed 215 of them.{{cite web | url=https://scholar.google.co.in/citations?user=tXbKltMAAAAJ | title=T K Kundu on Google Scholar | publisher=Google Scholar | date=2015 | access-date=21 October 2016}} Several of his research findings have been put to commercial use by various companies and he holds several patents for his works which include processes and compounds.{{cite web | url=http://patents.justia.com/inventor/tapas-kumar-kundu | title=T K KUndu Patents | publisher=Justia Patents | work=2016 | access-date=21 October 2016}} He has delivered a number of featured lectures{{cite web | url=http://www.iitbbs.ac.in/events-archives.php?id=119 | title=Epigenetic Regulation of Chromatin Dynamics and Gene Expression: Implications in Differentiation, Disease and Therapeutics | publisher=Indian Institute of Technology Bhubaneswar | date=8 August 2014 | access-date=22 October 2016}} and is one of the organizers of the Asian Forum for the Chromatin and Chromosome Biology, a biennial event for the students and researchers of epigenetics and chromatin biology from Asian countries. He is also involved in popularizing science in the rural areas through science outreach programs and has delivered a series of lectures on Genes, Disease and Therapeutics, with student community as the audience.{{cite web | url=http://www.jnu.ac.in/SCMM/PROF-KUNDU-CV.pdf | title=Prof. Tapas K. Kundu on JNU | publisher=Jawaharlal Nehru University | date=2016 | access-date=22 October 2016}}

Awards and honors

The Council of Scientific and Industrial Research (CSIR) awarded him the Shanti Swarup Bhatnagar Prize, one of the highest Indian science awards in 2005 and he received the National Bioscience Award for Career Development (N-BIOS Prize) from the Department of Biotechnology, the same year. Three years later, he was selected for the National Academy of Sciences, India-Reliance Industries Platinum Jubilee Award in 2008 for his contributions to biological sciences.{{cite web | url=http://nasi.nic.in/ripja.htm | title=NASI-Reliance Platinum Jubilee Award | publisher=National Academy of Sciences, India | date=2016 | access-date=22 October 2016}} In 2011, he received the G. D. Birla Award for Scientific Research of the K. K. Birla Foundation{{cite web | url=http://www.indiaeducationreview.com/news/tapas-kumar-kundu-receives-gd-birla-award-research | title=Tapas Kumar Kundu receives GD Birla Award for research | publisher=India Education Review | date=2 September 2012 | access-date=22 October 2016}} and the Ranbaxy Research Award.{{cite web | url=http://www.pharmabiz.com/NewsDetails.aspx?aid=73580&sid=2 | title=Ranbaxy honours scientists, scholars in pharma, medical research | publisher=Pharma Biz | date=5 February 2013 | access-date=22 October 2016}} He is also a recipient of the India Innovation Award 2012 of Merck Millipore.{{cite web | url=http://www.iitbbs.ac.in/docs2/Prof%20Kundu%20Biography.pdf | title=Kundu on IITB | publisher=Indian Institute of Technology Bhubaneswar | date=2016 | access-date=22 October 2016}}

Kundu, a recipient of the 1993 International Council of Scientific Union Award, is an elected member of the Guha Research Conference and a fellow of the Union for International Cancer Control (2001 and 2005).{{cite web | url=http://www.jncasr.ac.in/tdl/cvsir.html | title=Honors and Awards | publisher=Jawaharlal Nehru Centre for Advanced Scientific Research | date=2016 | access-date=22 October 2016}} He was elected as a fellow by the National Academy of Sciences, India in 2005 and he became an elected fellow of the Indian Academy of Sciences and the Indian National Science Academy in 2008 and 2009 respectively. The Department of Science and Technology awarded him the J. C. Bose National Fellowship in 2010 and he has delivered several award orations including the 2010 lecture of the Tohoku Medical Society, Japan. He is also a recipient of Monbukagakusho Scholarship of the Government of Japan (1996), Post-doctoral fellowship of the Human Frontier Science Program (2001) and Collaborative Research fellowship of ARCUS-India (2005–08).

Selected bibliography

= Books =

{{cite book|author=Tapas Kumar Kundu|title=Epigenetics: Development and Disease|date=13 November 2012|publisher=Springer Science & Business Media|isbn=978-94-007-4525-4}}

= Articles =

{{cite journal | title=HATs off: selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF |author1=Ontario D Lau |author2=Tapas K Kundu |author3=Raymond E Soccio |author4=Slimane Ait-Si-Ali |author5=Ehab M Khalil |author6=Alex Vassilev |author7=Alan P Wolffe |author8=Yoshihiro Nakatani |author9=Robert G Roeder |author10=Philip A Cole | journal=Molecular Cell | date=March 2000 | volume=5 | issue=3 | pages=589–595 | pmid=10882143|doi=10.1016/S1097-2765(00)80452-9|doi-access=free }}
{{cite journal | title=Activator-dependent transcription from chromatin in vitro involving targeted histone acetylation by p300 |author1=Tapas K Kundu |author2=Vikas B Palhan |author3=Zhengxin Wang |author4=Woojin An |author5=Philip A Cole |author6=Robert G Roeder | journal=Molecular Cell | date=September 2000 | volume=6 | issue=3 | pages=551–561 | pmid=11030335 | doi=10.1016/s1097-2765(00)00054-x| doi-access=free }}
{{cite journal | title=Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo |author1=Ernest Martinez |author2=Vikas B Palhan |author3=Agneta Tjernberg |author4=Elena S Lymar |author5=Armin M Gamper |author6=Tapas K Kundu |author7=Brian T Chait |author8=Robert G Roeder | journal=Molecular and Cellular Biology | date=October 2001 | volume=21 | issue=10 | pages=6782–6795 | pmid=11564863 | doi=10.1128/MCB.21.20.6782-6795.2001 | pmc=99856}}
{{cite journal | title=Small molecule modulators of histone acetyltransferase p300 |author1=Karanam Balasubramanyam |author2=V Swaminathan |author3=Anupama Ranganathan |author4=Tapas K Kundu | journal=Journal of Biological Chemistry | date=May 2003 | volume=278 | issue=21 | pages=19134–19140 | doi=10.1074/jbc.M301580200|pmid=12624111 | doi-access=free }}
{{cite journal | title=Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression |author1=Karanam Balasubramanyam |author2=M Altaf |author3=Radhika A Varier |author4=V Swaminathan |author5=Aarti Ravindran |author6=Parag P Sadhale |author7=Tapas K Kundu | journal=Journal of Biological Chemistry | date=August 2004 | volume=279 | issue=32 | pages=33716–33726 | doi=10.1074/jbc.M402839200 | pmid=15155757| doi-access=free }}
{{cite journal | title=Curcumin, a novel p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription |author1=Karanam Balasubramanyam |author2=Radhika A Varier |author3=Mohammed Altaf |author4=Venkatesh Swaminathan |author5=Nagadenahalli B Siddappa |author6=Udaykumar Ranga |author7=Tapas K Kundu | journal=Journal of Biological Chemistry | date=December 2004 | volume=279 | issue=49 | pages=51163–51171 | doi=10.1074/jbc.M409024200 | pmid=15383533| doi-access=free }}
{{cite journal | title=Human histone chaperone nucleophosmin enhances acetylation-dependent chromatin transcription |author1=V Swaminathan |author2=A Hari Kishore |author3=KK Febitha |author4=Tapas K Kundu | journal=Molecular and Cellular Biology | date=September 2005 | volume=25 | issue=17 | pages=7534–7545 | doi=10.1128/MCB.25.17.7534-7545.2005|pmid=16107701 |pmc=1190275 |url=http://repository.ias.ac.in/18943/1/310.pdf }}
{{cite journal | title=Intrinsically fluorescent carbon nanospheres as a nuclear targeting vector: delivery of membrane-impermeable molecule to modulate gene expression in vivo |author1=B Ruthrotha Selvi |author2=Dinesh Jagadeesan |author3=BS Suma |author4=G Nagashankar |author5=M Arif |author6=K Balasubramanyam |author7=M Eswaramoorthy |author8=Tapas K Kundu | journal=Nano Letters | date=September 2008 | volume=8 | issue=10 | pages=3182–3188 | doi=10.1021/nl801503m|pmid=18800851 |bibcode=2008NanoL...8.3182S }}

Patents

The list may be incomplete.

{{cite web | title=Nanosphere-histone acetyltransferase (HAT) activator composition, process and methods thereof | work=A composition including nanosphere and histone acetyltransferase (HAT) activator - Patent No. 9314539 | date=19 April 2016 |author1=Tapas Kumar Kundu |author2=Anne-Laurence Boutillier |author3=Snehajyoti Chatterjee |author4=Muthusamy Eswaramoorthy |author5=Pushpak Mizar |author6=Chantal Mathis |author7=Jean-Christophe Cassel |author8=Romain Neidl |author9=Mohankrishna Dalvoy Vasudevarao |author10=Vedamurthy Bhusainahalli Maheshwarappa }}
{{cite web | title=Intrinsically fluorescent carbon nanospheres and a process thereof | work=Delivery of active molecules to nucleus - Patent No. 9034387 | date=19 May 2016 |author1=Tapas Kumar Kundu |author2=Eswaramoorthy Muthusamy, Sr. |author3=Ruthrotha Selvi Bharatha Vikru |author4=Dinesh Jagadeesan }}
{{cite web | title=Julolidine conjugates and methods for their preparation and use | work=Compounds that selectively bind to copper ions in a sample and methods of preparation and use - Patent No. 8642764 | date=4 February 2014 |author1=Govindaraju Thimmaiah |author2=Debabrata Maity |author3=Swapan Kumar Pati |author4=Tapas Kumar Kundu |author5=Arun Kumar Manna |author6=Karthigeyan Dhanasekaran }}
{{cite web | title=Inhibition of Histone Acetyltransferases by CTK7A and Mthods thereof | work=Method for inhibiting histone acetyltransferases by derivative of curcumin, particularly CTK7A - Patent No. 20120165384 | date=28 June 2012 |author1=Tapas Kumar Kundu |author2=Mohammed Arif |author3=Kempegowra Mantelingu |author4=Gopinath Kadaganur Srinivasachar }}
{{cite web | title=Site-specific inhibitors of histone methyltransferase (HMTASE) and process of preparation thereof | work=compounds of structural formula I as site-specific inhibitors of histone methyltransferase - Patent No. 8003698 | date=23 August 2011 |author1=Tapas Kumar Kundu |author2=Ruthrotha Selvi Bharatha Vikru |author3=Hari Kishore Annavarapu |author4=Mantelingu Kempegowda }}
{{cite web | title=Modulators (inhibitors/activators) of histone acetyltransferases | work=Use of certain benzoic acid and benzamide compounds as modulators of enzymes histone acetyltransferases - Patent No. 7332629 | date=6 July 2010 |author1=Tapas Kumar Kundu |author2=Kanchugarakoppal Subbegowda Rangappa |author3=Badi Sri Sailaja |author4=Radhika Ashish Varier |author5=Nanjundaswamy Shivananju }}

Notes

References

External links

{{cite web | url=https://pubmed.ncbi.nlm.nih.gov/?term=Kundu%20TK%5BAuthor%5D&cauthor=true&cauthor_uid=11030335 | title=Kundu TK [Author] | work=Author profile | date=2016 | access-date=22 October 2016}}
{{cite web | url=http://www.jncasr.ac.in/tapas/ | title=Transcription and Disease Laboratory | publisher=Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research | date=2016 | access-date=22 October 2016}}