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Transcription factor Sp3

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}{{Not to be confused with|Sp³ bond}}

Transcription factor Sp3 is a protein that in humans is encoded by the SP3 gene.

This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes. Transcript variants encoding different isoforms have been described for this gene, and one has been reported to initiate translation from a non-AUG (AUA) start codon. Additional isoforms, resulting from the use of alternate downstream translation initiation sites, have also been noted.{{cite web | title = Entrez Gene: SP3 Sp3 transcription factor| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6670| accessdate = }}

Interactions

Transcription factor Sp3 has been shown to interact with Histone deacetylase 2,{{cite journal |last=Won |first=Jaejoon |author2=Yim Jeongbin |author3=Kim Tae Kook |date=October 2002|title=Sp1 and Sp3 recruit histone deacetylase to repress transcription of human telomerase reverse transcriptase (hTERT) promoter in normal human somatic cells |journal=J. Biol. Chem. |volume=277 |issue=41 |pages=38230–8 | issn = 0021-9258| pmid = 12151407 |doi = 10.1074/jbc.M206064200 |doi-access=free }}{{cite journal |last=Sun |first=Jian-Min |author2=Chen Hou Yu |author3=Moniwa Mariko |author4=Litchfield David W |author5=Seto Edward |author6=Davie James R |date=September 2002|title=The transcriptional repressor Sp3 is associated with CK2-phosphorylated histone deacetylase 2 |journal=J. Biol. Chem. |volume=277 |issue=39 |pages=35783–6 | issn = 0021-9258| pmid = 12176973 |doi = 10.1074/jbc.C200378200 |doi-access=free }} PIAS1,{{cite journal |last=Sapetschnig |first=Alexandra |author2=Rischitor Grigore |author3=Braun Harald |author4=Doll Andreas |author5=Schergaut Marion |author6=Melchior Frauke |author7=Suske Guntram |date=October 2002|title=Transcription factor Sp3 is silenced through SUMO modification by PIAS1 |journal=EMBO J. |volume=21 |issue=19 |pages=5206–15 | issn = 0261-4189| pmid = 12356736 |doi=10.1093/emboj/cdf510 |pmc=129032 }} E2F1{{cite journal |last=Rotheneder |first=H |author2=Geymayer S |author3=Haidweger E |date=November 1999|title=Transcription factors of the Sp1 family: interaction with E2F and regulation of the murine thymidine kinase promoter |journal=J. Mol. Biol. |volume=293 |issue=5 |pages=1005–15 | issn = 0022-2836| pmid = 10547281 |doi = 10.1006/jmbi.1999.3213 }} and GABPA.{{cite journal |last=Galvagni |first=F |author2=Capo S |author3=Oliviero S |date=March 2001|title=Sp1 and Sp3 physically interact and co-operate with GABP for the activation of the utrophin promoter |journal=J. Mol. Biol. |volume=306 |issue=5 |pages=985–96 | issn = 0022-2836| pmid = 11237613 |doi = 10.1006/jmbi.2000.4335 |hdl=2318/141203 |url=https://iris.unito.it/bitstream/2318/141203/1/Sp1%20and%20Sp3%20Physically%20Interact%20and%20Co_4aperto.pdf |hdl-access=free }}

References

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Further reading

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  • {{cite journal |vauthors=Tseng L, Gao J, Mazella J, etal |title=Differentiation-dependent and cell-specific regulation of the hIGFBP-1 gene in human endometrium. |journal=Ann. N. Y. Acad. Sci. |volume=828 |issue= 1|pages= 27–37 |year= 1997 |pmid= 9329821 |doi=10.1111/j.1749-6632.1997.tb48521.x |bibcode=1997NYASA.828...27T |s2cid=1601677 |doi-access=free }}
  • {{cite journal | author=Zhang Y, Dufau ML |title=Dual mechanisms of regulation of transcription of luteinizing hormone receptor gene by nuclear orphan receptors and histone deacetylase complexes. |journal=J. Steroid Biochem. Mol. Biol. |volume=85 |issue= 2–5 |pages= 401–14 |year= 2003 |pmid= 12943729 |doi=10.1016/S0960-0760(03)00230-9 |s2cid=28512341 |url=https://zenodo.org/record/1260176 }}

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{{PDB Gallery|geneid=6670}}

{{Transcription factors}}

{{DEFAULTSORT:Sp3 Transcription Factor}}

Category:Transcription factors

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