Tricyclic

• Promethazine and other first generation antihistamines with a tricyclic structure were discovered in the 1940s.
• Chlorpromazine, derived from promethazine originally as a sedative, was found to have neuroleptic properties in the early 1950s, and was the first typical antipsychotic.
• Imipramine, originally investigated as an antipsychotic, was discovered in the early 1950s, and was the first tricyclic antidepressant.
• Carbamazepine was discovered in 1953, and was subsequently introduced as an anticonvulsant in 1965.
• Clozapine, a derivative of imipramine, was synthesized in 1958 and entered the European market in 1972 under the name Leponex.
• Antidepressants with a tetracyclic structure such as mianserin and maprotiline were first developed in the 1970s as tetracyclic antidepressants.
• Loratadine was introduced as a non-sedating second generation antihistamine in the 1990s.{{Cite journal

| pmid = 10444229

| year = 1999

| last1 = Kay | first1 = G. G.

| last2 = Harris | first2 = A. G.

| title = Loratadine: a non-sedating antihistamine. Review of its effects on cognition, psychomotor performance, mood and sedation

| volume = 29 Suppl 3

| pages = 147–150

| journal = Clinical and Experimental Allergy

| doi=10.1046/j.1365-2222.1999.0290s3147.x

}}

• Bisulepin
• Tetracyclic
• Tricyclic tropane analogs
• Heterocyclic

{{Reflist}}

{{Tricyclics}}

{{Chemical classes of psychoactive drugs}}