Viral disease#Table

{{Short description|Animal or plant disease resulting from a viral infection}}

{{cs1 config|name-list-style=vanc}}

{{Infobox medical condition

| name = Viral disease

| image = Viral infections and involved species.svg

| caption = Types of viral diseases

| pronounce =

| field = Infectious disease

| synonyms = Viral infection

| symptoms =

| complications =

| onset =

| duration =

| types =

| causes = Virus

| risks =

| diagnosis =

| differential =

| prevention =

| treatment =

| medication = Antiviral drugs

| prognosis =

| frequency =

| deaths =

}}

A viral disease (or viral infection) occurs when an organism's body is invaded by pathogenic viruses, and infectious virus particles (virions) attach to and enter susceptible cells.{{cite journal |last1=Taylor |first1=M.P. |last2=Kobiler |first2=O. |last3=Enquist |first3=L. W. |year=2012 |title=Alphaherpesvirus axon-to-cell spread involves limited virion transmission |journal=Proceedings of the National Academy of Sciences |publisher=PNAS |volume=106 |issue=42 |pages=17046–17051 |bibcode=2012PNAS..10917046T |doi=10.1073/pnas.1212926109 |pmc=3479527 |pmid=23027939 |doi-access=free}}

Examples include the common cold, gastroenteritis, COVID-19, the flu, and rabies.see below in this article

Structural characteristics

File: Virus size.pngs of some of the most common human viruses with their relative size. Nucleic acids are not to scale. SARS stands for SARS-CoV-1 or COVID-19, variola viruses for smallpox.]]

Basic structural characteristics, such as genome type, virion shape and replication site, generally share the same features among virus species within the same family.{{cn|date=June 2021}}

=Pragmatic rules=

Human-infecting virus families offer rules that may assist physicians and medical microbiologists/virologists.{{cn|date=June 2021}}

As a general rule, DNA viruses replicate within the cell nucleus while RNA viruses replicate within the cytoplasm. Exceptions are known to this rule: poxviruses replicate within the cytoplasm and orthomyxoviruses and hepatitis D virus (RNA viruses) replicate within the nucleus.{{cn|date=June 2021}}

  • Segmented genomes: Bunyaviridae, Orthomyxoviridae, Arenaviridae, and Reoviridae (acronym BOAR). All are RNA viruses.
  • Viruses transmitted almost exclusively by arthropods: Bunyavirus, Flavivirus, and Togavirus. Some Reoviruses are transmitted from arthropod vectors. All are RNA viruses.{{cite web|url=http://pathmicro.med.sc.edu/mhunt/arbo.htm|title=Arboviruses|last1=Hunt|first1=M.|publisher=University of South Carolina School of Medicine}}
  • One family of enveloped viruses causes gastroenteritis (Coronaviridae). All other viruses associated with gastroenteritis are non-enveloped.

= Baltimore group =

This group of analysts defined multiple categories of virus. Groups:{{cn|date=June 2022}}

{{Anchor|Table}}

class="wikitable sortable"
+Clinically important virus families and species with characteristics
Family

!Baltimore group

! Important species

!Envelopment

Adenoviridae

|I{{cite book|last1=Fisher|first1=Bruce|title=Lippincott's Illustrated Reviews: Microbiology|last2=Harvey|first2=Richard P.|last3=Champe|first3=Pamela C.|publisher=Lippincott Williams & Wilkins|year=2007|isbn=978-0-7817-8215-9|series=Lippincott's Illustrated Reviews Series|location=Hagerstown MD|pages=354–366|url=http://med-mu.com/wp-content/uploads/2018/06/lippincotts_microbiology.pdf|access-date=7 September 2020|archive-date=22 October 2020|archive-url=https://web.archive.org/web/20201022124451/http://med-mu.com/wp-content/uploads/2018/06/lippincotts_microbiology.pdf|url-status=dead}}

|Adenovirus

| NTable 1 in: {{cite journal|last1=Dimitrov|first1=Dimiter S.|title=Virus entry: molecular mechanisms and biomedical applications|journal=Nature Reviews Microbiology|volume=2|issue=2|year=2004|pages=109–22|issn=1740-1526|doi=10.1038/nrmicro817|pmid=15043007|url=https://zenodo.org/record/1233550|pmc=7097642}}

Herpesviridae

|I

|Herpes simplex, type 1, Herpes simplex, type 2, Varicella-zoster virus, Epstein–Barr virus, Human cytomegalovirus, Human herpesvirus, type 8{{cite journal|last=Adams|first=MJ|author2=Carstens EB|title=Ratification vote on taxonomic proposals to the International Committee on Taxonomy of Viruses (2012)|journal=Arch. Virol.|date=Jul 2012|volume=157|pages=1411–22|doi=10.1007/s00705-012-1299-6|pmid=22481600|issue=7|pmc=7086667|url=http://eprints.gla.ac.uk/121363/1/121363.pdf|doi-access=free}}{{cite book | author = Whitley RJ | title = Herpesviruses. in: Baron's Medical Microbiology| editor = Baron S| display-editors = etal| edition = 4th | publisher = Univ of Texas Medical Branch | year = 1996 | url = https://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=mmed.chapter.3567 | isbn = 0-9631172-1-1 }}{{cite book |vauthors=Murray PR, Rosenthal KS, Pfaller MA | title = Medical Microbiology | edition = 5th | publisher = Elsevier Mosby | year = 2005 | isbn = 978-0-323-03303-9 }}

| Y

Papillomaviridae

|I{{cite journal |vauthors=de Villiers EM, Fauquet C, Broker TR, Bernard HU, zur Hausen H | title=Classification of papillomaviruses | journal=Virology | volume=324 |issue=1 | pages=17–27 | year=2004 | pmid=15183049 | doi=10.1016/j.virol.2004.03.033| doi-access=free }}

|Human papillomavirus

| N

Polyomaviridae

|I{{cite web|url=http://viralzone.expasy.org/all_by_species/58.html|title=Polyomavirus|website=ViralZone|access-date=2015-10-03|publisher=SIB Swiss Institute of Bioinformatics}}

|BK virus, JC virus

| N

Poxviridae

|I

|Smallpox

| Y

Parvoviridae

|II

|Parvovirus B19

| N

Reoviridae

|III

|Rotavirus, Orbivirus, Coltivirus, Banna virus

| N

Astroviridae

|IV{{cite journal |vauthors=Murillo A, Vera-Estrella R, Barkla BJ, Méndez E, Arias CF |title=Identification of Host Cell Factors Associated with Astrovirus Replication in Caco-2 Cells |journal=J. Virol. |volume=89 |issue=20 |pages=10359–70 |year=2015 |pmid=26246569 |doi=10.1128/JVI.01225-15 |pmc=4580174}}

|Human astrovirus

| N

Caliciviridae

|IV[https://books.google.com/books?id=l2PMBQAAQBAJ&pg=PA273 Page 273] in: {{cite book|title=Lennette's Laboratory Diagnosis of Viral Infections|edition=Fourth|publisher=CRC Press|year=2010|isbn=978-1420084962}}

|Norwalk virus

| N

Coronaviridae

|IV{{cite journal|last1=Stapleford|first1=Kenneth A.|last2=Miller|first2=David J.|title=Role of Cellular Lipids in Positive-Sense RNA Virus Replication Complex Assembly and Function|journal=Viruses|volume=2|issue=5|year=2010|pages=1055–68|issn=1999-4915|doi=10.3390/v2051055|pmc=3187604|pmid=21994671|doi-access=free}}

|Human coronavirus 229E, Human coronavirus NL63, Human coronavirus OC43, Human coronavirus HKU1, Middle East respiratory syndrome-related coronavirus, Severe acute respiratory syndrome coronavirus, Severe acute respiratory syndrome coronavirus 2

| Y

Flaviviridae

|IV{{cite journal|last1=Cook|first1=S.|last2=Moureau|first2=G.|last3=Harbach|first3=R. E.|last4=Mukwaya|first4=L.|last5=Goodger|first5=K.|last6=Ssenfuka|first6=F.|last7=Gould|first7=E.|last8=Holmes|first8=E. C.|last9=de Lamballerie|first9=X.|title=Isolation of a novel species of flavivirus and a new strain of Culex flavivirus (Flaviviridae) from a natural mosquito population in Uganda|journal=Journal of General Virology|volume=90|issue=11|year=2009|pages=2669–78|issn=0022-1317|doi=10.1099/vir.0.014183-0|pmc=2885038|pmid=19656970}}

|Hepatitis C virus, yellow fever virus, dengue virus, West Nile virus, TBE virus, Zika virus

| Y

Hepeviridae

|IV{{cite web|url=http://viralzone.expasy.org/all_by_species/714.html|title=Hepeviridae|website=ViralZone|publisher=SIB Swiss Institute of Bioinformatics |access-date=2015-10-03}}

|Hepatitis E virus

| N

Matonaviridae

|IV{{cite journal|last1=Simon-Loriere|first1=Etienne|last2=Holmes|first2=Edward C.|title=Why do RNA viruses recombine?|journal=Nature Reviews Microbiology|volume=9|issue=8|year=2011|pages=617–26|issn=1740-1526|doi=10.1038/nrmicro2614|pmid=21725337|pmc=3324781}}

|Rubella virus{{cite web|title=2018.013S.R.Matonaviridae|url=https://talk.ictvonline.org/files/ictv_official_taxonomy_updates_since_the_8th_report/m/animal-ssrna-viruses/8087|archive-url=https://web.archive.org/web/20191029221401/https://talk.ictvonline.org/files/ictv_official_taxonomy_updates_since_the_8th_report/m/animal-ssrna-viruses/8087|url-status=dead|archive-date=October 29, 2019|website=International Committee on Taxonomy of Viruses (ICTV)|language=en|access-date=2020-05-28}}

| Y

Picornaviridae

|IV{{cite book|last1=Tuthill|first1=Tobias J.|last2=Groppelli|first2=Elisabetta|last3=Hogle|first3=James M.|last4=Rowlands|first4=David J.|title=Picornaviruses|volume=343|year=2010|pages=43–89|issn=0070-217X|doi=10.1007/82_2010_37|series=Current Topics in Microbiology and Immunology|pmc=3018333|pmid=20397067|isbn=978-3-642-13331-2}}

|coxsackievirus, hepatitis A virus, poliovirus, rhinovirus

| N

Arenaviridae

|V{{cite web|url=http://viralzone.expasy.org/viralzone/all_by_species/501.html|title=Arenaviridae|website=ViralZone|publisher=SIB Swiss Institute of Bioinformatics|access-date=2015-10-03|archive-date=2015-10-04|archive-url=https://web.archive.org/web/20151004065947/http://viralzone.expasy.org/viralzone/all_by_species/501.html|url-status=dead}}

|Lassa virus

| Y

Bunyaviridae

|V{{cite web|url=http://viralzone.expasy.org/viralzone/all_by_species/82.html|title=Bunyaviridae|website=ViralZone|publisher=SIB Swiss Institute of Bioinformatics|access-date=2015-10-03|archive-date=2015-10-04|archive-url=https://web.archive.org/web/20151004062727/http://viralzone.expasy.org/viralzone/all_by_species/82.html|url-status=dead}}

|Crimean-Congo hemorrhagic fever virus, Hantaan virus

| Y

Filoviridae

|V{{cite web|url=http://viralzone.expasy.org/viralzone/all_by_species/23.html|title=Filoviridae|website=ViralZone|publisher=SIB Swiss Institute of Bioinformatics|access-date=2015-10-03|archive-date=2015-10-04|archive-url=https://web.archive.org/web/20151004110039/http://viralzone.expasy.org/viralzone/all_by_species/23.html|url-status=dead}}

|Ebola virus, Marburg virus

| Y

Orthomyxoviridae

|V{{cite web|url=http://viralzone.expasy.org/all_by_protein/223.html|title=Orthomyxoviridae|website=ViralZone|publisher=SIB Swiss Institute of Bioinformatics |access-date=2015-10-03}}

|Influenza virus

| Y

Paramyxoviridae

|V

|Measles virus, Mumps virus, Parainfluenza virus

| Y

Pneumoviridae

|V {{cite web|title=Pneumoviridae ~ ViralZone page|url=https://viralzone.expasy.org/7877?outline=complete_by_species|access-date=2020-08-17|website=viralzone.expasy.org}}

|Respiratory syncytial virus

|Y

Rhabdoviridae

|V{{cite web|url=http://viralzone.expasy.org/viralzone/all_by_species/2.html|title=Rhabdoviridae|website=ViralZone|publisher=SIB Swiss Institute of Bioinformatics|access-date=2015-10-03|archive-date=2015-10-04|archive-url=https://web.archive.org/web/20151004073838/http://viralzone.expasy.org/viralzone/all_by_species/2.html|url-status=dead}}

|Rabies virus

| Y

Unassigned{{cite web|url=http://viralzone.expasy.org/all_by_species/175.html|title=Deltavirus|website=ViralZone|publisher=SIB Swiss Institute of Bioinformatics |access-date=2015-10-03}}

|V

|Hepatitis D

| Y

Retroviridae

|VI{{cite web|url=http://viralzone.expasy.org/viralzone/all_by_species/71.html|title=Retroviridae|website=ViralZone|publisher=SIB Swiss Institute of Bioinformatics|access-date=2015-10-03|archive-date=2015-10-04|archive-url=https://web.archive.org/web/20151004105334/http://viralzone.expasy.org/viralzone/all_by_species/71.html|url-status=dead}}

|HIV

| Y

Hepadnaviridae

|VII

|Hepatitis B virus

| Y

=Clinical characteristics=

The clinical characteristics of viruses may differ substantially among species within the same family:

class="wikitable sortable"

! Type

! Family

! Transmission

! Diseases

! Treatment

! Prevention

Adenovirus

| Adenoviridae

|

  • droplet contact
  • fecal-oral
  • venereal
  • direct eye contact

|

| None

|

  • Adenovirus vaccine
  • hand washing
  • covering mouth when coughing or sneezing
  • avoiding close contact with the sick
Coxsackievirus

| Picornaviridae

|

  • fecal-oral{{cite web|url=http://viralzone.expasy.org/all_by_species/97.html|title=Enterovirus|website=ViralZone|access-date=2015-10-12|publisher=SIB Swiss Institute of Bioinformatics}}
  • respiratory droplet contact

|

  • Hand, foot and mouth disease{{cite journal|vauthors=Repass GL, Palmer WC, Stancampiano FF |title=Hand, foot, and mouth disease: Identifying and managing an acute viral syndrome |journal=Cleve Clin J Med |volume=81 |issue=9 |pages=537–43|date=September 2014|pmid=25183845|url=http://www.ccjm.org/content/81/9/537.long |doi=10.3949/ccjm.81a.13132|doi-access=free }}
  • pleurodynia
  • aseptic meningitis
  • pericarditis
  • myocarditis

| None

|

  • hand washing
  • covering mouth when coughing/sneezing
  • avoiding contaminated food/water
  • improved sanitation
Cytomegalovirus

| Herpesviridae

|

|

|

|

  • hand washing
  • avoid sharing food and drinks with others
  • safe sex
Epstein–Barr virus

| Herpesviridae

|

  • saliva

|

| None

|

  • avoiding close contact with the sick
Hepatitis A virus

| Picornaviridae

|

  • fecal-oral{{cite web|url=http://viralzone.expasy.org/viralzone/all_by_species/33.html|title=Picornaviridae|website=ViralZone|access-date=2015-10-10|publisher=SIB Swiss Institute of Bioinformatics|archive-date=2015-12-20|archive-url=https://web.archive.org/web/20151220105508/http://viralzone.expasy.org/viralzone/all_by_species/33.html|url-status=dead}}

|

| Immunoglobulin (post-exposure prophylaxis)

|

Hepatitis B virus

| Hepadnaviridae

|

Vertical and sexual

|

|

|

  • Hepatitis B vaccine{{cite web|url=http://viralzone.expasy.org/viralzone/all_by_species/9.html|title=Hepadnaviridae|website=ViralZone|access-date=2015-10-10|publisher=SIB Swiss Institute of Bioinformatics|archive-date=2016-03-04|archive-url=https://web.archive.org/web/20160304112829/http://viralzone.expasy.org/viralzone/all_by_species/9.html|url-status=dead}}
  • immunoglobulin (perinatal and post-exposure prophylaxis)
  • avoiding shared needles/syringes
  • safe sex
Hepatitis C virus

| Flaviviridae

|

  • blood
  • sexual contact

|

  • acute hepatitis{{cite web|url=http://viralzone.expasy.org/viralzone/all_by_species/43.html|title=Flaviviridae|website=ViralZone|access-date=2015-10-10|publisher=SIB Swiss Institute of Bioinformatics|archive-date=2016-02-17|archive-url=https://web.archive.org/web/20160217185620/http://viralzone.expasy.org/viralzone/all_by_species/43.html|url-status=dead}}
  • chronic hepatitis
  • hepatic cirrhosis
  • hepatocellular carcinoma

|

|

  • avoiding shared needles/syringes
  • safe sex
Herpes simplex virus, type 1

| Herpesviridae

|

  • direct contact{{cite web|url=http://viralzone.expasy.org/viralzone/all_by_species/176.html|title=Herpesviridae|website=ViralZone|access-date=2015-10-10|publisher=SIB Swiss Institute of Bioinformatics|archive-date=2016-02-02|archive-url=https://web.archive.org/web/20160202194635/http://viralzone.expasy.org/viralzone/all_by_species/176.html|url-status=dead}}
  • saliva

|

|

|

  • avoiding close contact with lesions
  • safe sex
Herpes simplex virus, type 2

| Herpesviridae

|

  • sexual contact
  • vertical transmission

|

|

|

  • avoiding close contact with lesions
  • safe sex
HIV

| Retroviridae

|

  • sexual contact{{cite web|url=http://viralzone.expasy.org/all_by_protein/7.html|title=Human immunodeficiency virus 1|website=ViralZone|access-date=2015-10-10|publisher=SIB Swiss Institute of Bioinformatics}}
  • blood
  • breast milk
  • vertical transmission

|

| HAART, such as protease inhibitors and reverse-transcriptase inhibitors

|

  • zidovudine (perinatally)
  • blood product screening
  • safe sex
  • avoiding shared needles/syringes
Human coronavirus 229E (HCoV-229E)

| Coronaviridae

|

|

|

|

Human coronavirus NL63 (HCoV-NL63)

| Coronaviridae

|

  • droplet contact

|

|

|

Human coronavirus OC43 (HCoV-OC43)

| Coronaviridae

|

|

|

|

Human coronavirus HKU1 (HCoV-HKU1)

| Coronaviridae

|

|

|

|

Human herpesvirus, type 8

| Herpesviridae

|

  • Saliva
  • Sexual

|

| many in evaluation-stage

|

  • avoid close contact with lesions
  • safe sex
Human papillomavirus

| Papillomaviridae

|

  • direct contact{{cite web|url=http://viralzone.expasy.org/viralzone/all_by_species/5.html|title=Papillomaviridae|website=ViralZone|access-date=2015-10-10|publisher=SIB Swiss Institute of Bioinformatics|archive-date=2015-03-05|archive-url=https://web.archive.org/web/20150305205831/http://viralzone.expasy.org/viralzone/all_by_species/5.html|url-status=dead}}
  • sexual contact
  • vertical transmission

|

|

|

  • HPV vaccine
  • avoiding close contact with lesions
  • safe sex
Influenza virus

| Orthomyxoviridae

|

  • droplet contact

|

|

|

Measles virus

| Paramyxoviridae

|

  • droplet contact{{cite web|url=http://viralzone.expasy.org/viralzone/all_by_species/556.html|title=Paramyxoviridae|website=ViralZone|access-date=2015-10-10|publisher=SIB Swiss Institute of Bioinformatics|archive-date=2015-10-04|archive-url=https://web.archive.org/web/20151004092214/http://viralzone.expasy.org/viralzone/all_by_species/556.html|url-status=dead}}

|

| None

|

  • MMR vaccine
  • quarantining the sick
  • avoiding contact with the sick
Middle East respiratory syndrome-related coronavirus (MERS-CoV)

| Coronaviridae

|

  • close human contact

|

|

|

Mumps virus

| Paramyxoviridae

|

  • droplet contact

|

| None

|

Parainfluenza virus

| Paramyxoviridae

|

  • droplet contact

|

| None

|

  • hand washing
  • covering mouth when coughing/sneezing
Poliovirus

| Picornaviridae

|

  • fecal-oral

|

| None

|

  • Polio vaccine
  • avoiding contaminated food and water
  • improved sanitation
Rabies virus

| Rhabdoviridae

|

  • animal bite
  • droplet contact

|

| Post-exposure prophylaxis

|

Respiratory syncytial virus

| Pneumoviridae

|

  • droplet contact
  • hand to mouth

|

| (ribavirin)

|

  • hand washing
  • avoiding close contact with the sick
  • palivizumab in high risk individuals
  • covering mouth when coughing/sneezing
Rubella virus

| Togaviridae

|

  • Respiratory{{cite web|url=http://viralzone.expasy.org/viralzone/all_by_species/3.html|title=Togaviridae|website=ViralZone|access-date=2015-10-10|publisher=SIB Swiss Institute of Bioinformatics|archive-date=2016-02-20|archive-url=https://web.archive.org/web/20160220111137/http://viralzone.expasy.org/viralzone/all_by_species/3.html|url-status=dead}} droplet contact

|

| None

|

Severe acute respiratory syndrome coronavirus (SARS-CoV)

| Coronaviridae

|

  • droplet contact

|

|

|

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

| Coronaviridae

|

  • droplet contact

|

|

|

Varicella-zoster virus

| Herpesviridae

|

  • droplet contact
  • direct contact

|

|

Varicella:

Zoster:

|

Varicella:

Zoster:

  • vaccine
  • varicella-zoster immunoglobulin

See also

References

{{Reflist}}