daf-1

{{short description|Protein-coding gene in the species Caenorhabditis elegans}}

{{Infobox nonhuman protein

| Name = abnormal dauer formation protein 1

| image =

| width =

| caption =

| Organism = Caenorhabditis elegans

| TaxID = 6239

| Symbol = daf-1

| AltSymbols =

| EntrezGene = 176829

| HomoloGene = 134382

| PDB =

| RefSeqmRNA =

| RefSeqProtein =

| UniProt = P20792

| Chromosome = IV

| EntrezChromosome =

| GenLoc_start = 132416

| GenLoc_end = 138076

}}

The DAF-1 gene encodes for a cell surface Enzyme-linked receptor of TGF-beta signaling pathway in the worm Caenorhabditis elegans.{{cite journal | vauthors = Georgi LL, Albert PS, Riddle DL | title = daf-1, a C. elegans gene controlling dauer larva development, encodes a novel receptor protein kinase | journal = Cell | volume = 61 | issue = 4 | pages = 635–45 | date = May 1990 | pmid = 2160853 | doi = 10.1016/0092-8674(90)90475-t | s2cid = 205020137 }} DAF-1 is one of the type I receptor of TGF-beta pathway.{{cite journal | vauthors = Morita K, Shimizu M, Shibuya H, Ueno N | title = A DAF-1-binding protein BRA-1 is a negative regulator of DAF-7 TGF-beta signaling | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 98 | issue = 11 | pages = 6284–8 | date = May 2001 | pmid = 11353865 | doi = 10.1073/pnas.111409798 | pmc = 33460 | bibcode = 2001PNAS...98.6284M | doi-access = free }} DAF-1 acts as a receptor protein serine/threonine kinase, is activated by type II receptor Daf-4 phosphorylation after the ligand Daf-7 binds to the receptor heterotetramer, and then phosphorylates Daf-8 or Daf-14, the SMAD proteins in C. elegans.{{cite journal | vauthors = Krishna S, Maduzia LL, Padgett RW | title = Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans | journal = Development | volume = 126 | issue = 2 | pages = 251–60 | date = January 1999 | doi = 10.1242/dev.126.2.251 | pmid = 9847239 | s2cid = 2460114 }}