yfr1

{{Short description|Cyanobacterial functional RNA}}

{{Infobox rfam

| Name = Cyanobacterial functional RNA 1

| image = Yfr1_secondary_structure.jpg

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| caption = Predicted secondary structure and sequence conservation of Yfr1

| Symbol = Yfr1

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| Rfam = RF01116

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| RNA_type = Gene; sRNA

| Tax_domain = Bacteria

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| SO = {{SO|0001263}}

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Yfr1 is a Cyanobacterial functional RNA that was identified by a comparative genome based screen for RNAs in cyanobacteria.{{cite journal |vauthors=Axmann IM, Kensche P, Vogel J, Kohl S, Herzel H, Hess WR |title=Identification of cyanobacterial non-coding RNAs by comparative genome analysis. |journal=Genome Biol |volume=6 |issue=9 |pages=R73 |year=2005 |pmid=16168080 |doi=10.1186/gb-2005-6-9-r73 |pmc=1242208 |doi-access=free }} Further analysis has shown that the RNA is well conserved and highly expressed in cyanobacteria.{{cite journal |vauthors=Voss B, Gierga G, Axmann IM, Hess WR |title=A motif-based search in bacterial genomes identifies the ortholog of the small RNA Yfr1 in all lineages of cyanobacteria. |journal=BMC Genomics |volume=8|pages=375 |year=2007 |pmid=17941988 |doi=10.1186/1471-2164-8-375 |pmc=2190773 |doi-access=free }} and is required for growth under several stress condition{{cite journal |vauthors=Nakamura T, Naito K, Yokota N, Sugita C, Sugita M |title=A cyanobacterial non-coding RNA, Yfr1, is required for growth under multiple stress conditions |journal=Plant Cell Physiol |volume=48 |issue=9 |pages=1309–1318 |year=2007 |pmid=17664182 |doi=10.1093/pcp/pcm098|doi-access=free }} Bioinformatics research combined with follow-up experiments have shown that Yfr1 inhibits the translation of the proteins PMM1119 and PMM1121 by an antisense interaction by base pairing at the ribosomal binding site.{{cite journal |vauthors=Richter AS, Schleberger C, Backofen R, Steglich C |title=Seed-based INTARNA prediction combined with GFP-reporter system identifies mRNA targets of the small RNA Yfr1 |journal=Bioinformatics |volume=26 |issue=1 |pages=1–5 |year=2010 |pmid=19850757 |doi=10.1093/bioinformatics/btp609 |pmc=2796815}}