2021–22 UEFA Champions League qualifying phase and play-off round#PO CH1.1

The Champions Path includes all league champions which do not qualify directly for the group stage, and consists of the following rounds:

• Preliminary round (4 teams playing one-legged semi-finals and final): 4 teams which enter in this round.
• First qualifying round (32 teams): 31 teams which enter in this round, and 1 winner of the preliminary round.
• Second qualifying round (20 teams): 4 teams which enter in this round, and 16 winners of the first qualifying round.
• Third qualifying round (12 teams): 2 teams which enter in this round, and 10 winners of the second qualifying round.
• Play-off round (8 teams): 2 teams which enter in this round, and 6 winners of the third qualifying round.

All teams eliminated from the Champions Path enter either the Europa League or the Europa Conference League:

• The 3 losers of the preliminary round and 15 losers of the first qualifying round enter the Europa Conference League Champions Path second qualifying round.
• The 1 drawn loser of the first qualifying round enters the Europa Conference League Champions Path third qualifying round.
• The 10 losers of the second qualifying round enter the Europa League Champions Path qualifying round
• The 6 losers of the third qualifying round enter the Europa League play-off round.
• The 4 losers of the play-off round enter the Europa League group stage.

Below are the participating teams of the Champions Path (with their 2021 UEFA club coefficients),{{cite web |url=https://www.uefa.com/memberassociations/uefarankings/club/#/yr/2021 |archive-url=https://web.archive.org/web/20130113004406/http://www.uefa.com/memberassociations/uefarankings/club/#/yr/2021 |url-status=dead |archive-date=13 January 2013 |title=Club coefficients |website=UEFA |publisher=Union of European Football Associations |date=31 May 2021 |access-date=9 June 2021}} grouped by their starting rounds.

|

|

|}

The League Path includes all league non-champions which do not qualify directly for the group stage, and consists of the following rounds:

• Second qualifying round (6 teams): 6 teams which enter in this round.
• Third qualifying round (8 teams): 5 teams which enter in this round, and 3 winners of the second qualifying round.
• Play-off round (4 teams): 4 winners of the third qualifying round.

All teams eliminated from the League Path enter the Europa League:

• The 3 losers of the second qualifying round enter the Main Path qualifying round.
• The 4 losers of the third qualifying round and the 2 losers of the play-off round enter the group stage.

Below are the participating teams of the League Path (with their 2021 UEFA club coefficients), grouped by their starting rounds.

|

|}

Each tie, apart from the preliminary round, is played over two legs, with each team playing one leg at home. The team that scores more goals on aggregate over the two legs advance to the next round. If the aggregate score is level at the end of normal time of the second leg, the away goals rule is no longer applied starting from this season.{{cite web |url=https://www.uefa.com/news-media/news/026a-1298aeb73a7a-5b64cb68d920-1000--abolition-of-the-away-goals-rule-in-all-uefa-club-competitions/ |title=Abolition of the away goals rule in all UEFA club competitions |publisher=UEFA |date=24 June 2021}} To decide the winner of the tie, extra time is played, and if the same number of goals are scored by both teams during extra time, the tie is decided by a penalty shoot-out. In the preliminary round, where single-match semi-finals and final are hosted by one of the participating teams, if the score is level at the end of normal time, extra time is played, and if the same number of goals are scored by both teams during extra time, the tie is decided by a penalty shoot-out.

In the draws for each round, teams are seeded based on their UEFA club coefficients at the beginning of the season, with the teams divided into seeded and unseeded pots containing the same number of teams. A seeded team is drawn against an unseeded team, with the order of legs (or the administrative "home" team in the preliminary round matches) in each tie decided by draw. As the identity of the winners of the previous round is not known at the time of the draws, the seeding is carried out under the assumption that the team with the higher coefficient of an undecided tie advances to this round, which means if the team with the lower coefficient is to advance, it simply takes the seeding of its opponent. Prior to the draws, UEFA may form "groups" in accordance with the principles set by the Club Competitions Committee, but they are purely for convenience of the draw and do not resemble any real groupings in the sense of the competition. Teams from associations with political conflicts as decided by UEFA may not be drawn into the same tie. After the draws, the order of legs of a tie may be reversed by UEFA due to scheduling or venue conflicts.

The schedule of the competition is as follows (all draws are held at the UEFA headquarters in Nyon, Switzerland).

A total of four teams played in the preliminary round. Seeding of teams was based on their 2021 UEFA club coefficients, with two seeded teams and two unseeded teams in the semi-final round. The first team drawn in each tie in the semi-final round, and also the final round (between the two winners of the semi-finals, whose identity was not known at the time of draw), would be the "home" team for administrative purposes.

{{4TeamBracket-Info

|paramstyle=numbered

|score-width=40

|nowrap=y

|boldwinner=y

|RD1=Semi-final round

|RD2=Final round

|22 June – Elbasan|{{fbaicon|SMR}} Folgore|0|{{fbaicon|KOS}} Prishtina|2

|22 June – Durrës|{{fbaicon|FRO}} HB|0|{{fbaicon|AND}} Inter Club d'Escaldes|1

|25 June – Elbasan|{{fbaicon|KOS}} Prishtina|2|{{fbaicon|AND}} Inter Club d'Escaldes|0

}}

{{Football box

|date = {{Start date|2021|6|22|df=y}}

|time = 20:00

|team1 = Folgore {{fbaicon|SMR}}

|score = 0–2

|team2 = {{fbaicon|KOS}} Prishtina

|goals1 =

|goals2 =

• E. Krasniqi {{goal|51}}
• Hoti {{goal|90+1}}

|stadium = Elbasan Arena, Elbasan

|attendance = 0{{UEFA match attendance|2032545|Folgore vs. Prishtina|date=22 June 2021|access-date=22 June 2021}}{{refn|group=note|name=Behind closed doors|Due to the COVID-19 pandemic in Europe, the match was played behind closed doors.}}

|referee = Joni Hyytiä (Finland)

|report = https://www.uefa.com/uefachampionsleague/match/2032545/

}}

----

{{Football box

|date = {{Start date|2021|6|22|df=y}}

|time = 20:00

|team1 = HB {{fbaicon|FRO}}

|score = 0–1

|team2 = {{fbaicon|AND}} Inter Club d'Escaldes

|goals1 =

|goals2 =

• Betriu {{goal|61}}

|stadium = Niko Dovana Stadium, Durrës

|attendance = 0{{UEFA match attendance|2032546|HB Tórshavn vs. Inter Club d'Escaldes|date=22 June 2021|access-date=22 June 2021}}{{refn|group=note|name=Behind closed doors}}

|referee = Joonas Jaanovits (Estonia)

|report = https://www.uefa.com/uefachampionsleague/match/2032546/

}}

{{Football box

|date = {{Start date|2021|6|25|df=y}}

|time = 20:00

|team1 = Prishtina {{fbaicon|KOS}}

|score = 2–0

|team2 = {{fbaicon|AND}} Inter Club d'Escaldes

|goals1 =

• E. Krasniqi {{goal|45||58}}

|goals2 =

|stadium = Elbasan Arena, Elbasan

|attendance = 0{{UEFA match attendance|2032547|Prishtina vs. Inter Club d'Escaldes|date=22 June 2021|access-date=22 June 2021}}{{refn|group=note|name=Behind closed doors}}

|referee = Adam Ladebäck (Sweden)

|report = https://www.uefa.com/uefachampionsleague/match/2032547/

}}

A total of 32 teams played in the first qualifying round: 31 teams which entered in this round, and 1 winner of the preliminary round. Seeding of teams was based on their 2021 UEFA club coefficients. For the winner of the preliminary round, whose identity was not known at the time of draw, the club coefficient of the highest-ranked remaining team was used. Prior to the draw, UEFA formed four groups of four seeded teams and four unseeded teams in accordance with the principles set by the Club Competitions Committee. The first team drawn in each tie would be the home team of the first leg.

;Notes

{{Cnote2 Begin|liststyle=disc}}

{{Cnote2|†|n=0|group=Q1|^† Winner of the preliminary round, whose identity was not known at the time of draw. Teams in italics defeated a team with a higher coefficient, thus effectively taking the coefficient of their opponent in the draw.}}

{{Cnote2 End}}

{{Football box

|date = {{Start date|2021|7|6|df=y}}

|time = 19:30

|team1 = Fola Esch {{fbaicon|LUX}}

|score = 2–2

|team2 = {{fbaicon|GIB}} Lincoln Red Imps

|goals1 =

• Bensi {{goal|65}}
• Ahmetxheka {{goal|66}}

|goals2 =

• Carralero {{goal|26}}
• Britto {{goal|50}}

|stadium = Stade Émile Mayrisch, Esch-sur-Alzette

|attendance = 385{{UEFA match attendance|2032548|Fola Esch vs. Lincoln Red Imps|date=6 July 2021|access-date=6 July 2021}}

|referee = Michal Ocenáš (Slovakia)

|report = https://www.uefa.com/uefachampionsleague/match/2032548/

}}

{{Football box

|date = {{Start date|2021|7|13|df=y}}

|time = 18:00

|team1 = Lincoln Red Imps {{fbaicon|GIB}}

|score = 5–0

|team2 = {{fbaicon|LUX}} Fola Esch

|goals1 =

• De Barr {{goal|19||73}}
• Walker {{goal|39|pen.|68|pen.}}
• Ronan {{goal|58}}

|goals2 =

|stadium = Victoria Stadium, Gibraltar

|attendance = 621{{UEFA match attendance|2032564|Lincoln Red Imps vs. Fola Esch|date=13 July 2021|access-date=13 July 2021}}

|referee = Ian McNabb (Northern Ireland)

|report = https://www.uefa.com/uefachampionsleague/match/2032564/

}}

Lincoln Red Imps won 7–2 on aggregate.

----

{{Football box

|date = {{Start date|2021|7|7|df=y}}

|time = 18:30

|team1 = Slovan Bratislava {{fbaicon|SVK}}

|score = 2–0

|team2 = {{fbaicon|IRL}} Shamrock Rovers

|goals1 =

• Ratão {{goal|28||47}}

|goals2 =

|stadium = Tehelné pole, Bratislava

|attendance = 500{{UEFA match attendance|2032549|Slovan Bratislava vs. Shamrock Rovers|date=7 July 2021|access-date=7 July 2021}}

|referee = Sebastian Gishamer (Austria)

|report = https://www.uefa.com/uefachampionsleague/match/2032549/

}}

{{Football box

|date = {{Start date|2021|7|13|df=y}}

|time = 21:00 {{small|(20:00 UTC+1)}}

|team1 = Shamrock Rovers {{fbaicon|IRL}}

|score = 2–1

|team2 = {{fbaicon|SVK}} Slovan Bratislava

|goals1 =

• Burke {{goal|16|pen.}}
• Towell {{goal|64}}

|goals2 =

• Weiss {{goal|73}}

|stadium = Tallaght Stadium, Tallaght

|attendance = 1,500{{UEFA match attendance|2032565|Shamrock Rovers vs. Slovan Bratislava|date=13 July 2021|access-date=13 July 2021}}

|referee = Mario Zebec (Croatia)

|report = https://www.uefa.com/uefachampionsleague/match/2032565/

}}

Slovan Bratislava won 3–2 on aggregate.

----

{{Football box

|date = {{Start date|2021|7|7|df=y}}

|time = 19:00

|team1 = Malmö FF {{fbaicon|SWE}}

|score = 1–0

|team2 = {{fbaicon|LVA}} Riga

|goals1 =

• Čolak {{goal|50}}

|goals2 =

|stadium = Stadion, Malmö

|attendance = 4,012{{UEFA match attendance|2032550|Malmö FF vs. Riga|date=7 July 2021|access-date=7 July 2021}}

|referee = Kaarlo Oskari Hämäläinen (Finland)

|report = https://www.uefa.com/uefachampionsleague/match/2032550/

}}

{{Football box

|date = {{Start date|2021|7|13|df=y}}

|time = 18:00 {{small|(19:00 UTC+3)}}

|team1 = Riga {{fbaicon|LVA}}

|score = 1–1

|team2 = {{fbaicon|SWE}} Malmö FF

|goals1 =

• Paurević {{goal|57}}

|goals2 =

• Čolak {{goal|33}}

|stadium = Skonto Stadium, Riga

|attendance = 637{{UEFA match attendance|2032566|Riga vs. Malmö FF|date=13 July 2021|access-date=13 July 2021}}

|referee = Gergő Bogár (Hungary)

|report = https://www.uefa.com/uefachampionsleague/match/2032566/

}}

Malmö FF won 2–1 on aggregate.

----

{{Football box

|date = {{Start date|2021|7|7|df=y}}

|time = 18:00

|team1 = Bodø/Glimt {{fbaicon|NOR}}

|score = 2–3

|team2 = {{fbaicon|POL}} Legia Warsaw

|goals1 =

• Botheim {{goal|45+1}}
• Pernambuco {{goal|78}}

|goals2 =

• Luquinhas {{goal|2}}
• Emreli {{goal|41||61}}

|stadium = Aspmyra Stadion, Bodø

|attendance = 2,283{{UEFA match attendance|2032551|Bodø/Glimt vs. Legia Warsaw|date=7 July 2021|access-date=7 July 2021}}

|referee = Juxhin Xhaja (Albania)

|report = https://www.uefa.com/uefachampionsleague/match/2032551/

}}

{{Football box

|date = {{Start date|2021|7|14|df=y}}

|time = 20:00

|team1 = Legia Warsaw {{fbaicon|POL}}

|score = 2–0

|team2 = {{fbaicon|NOR}} Bodø/Glimt

|goals1 =

• Luquinhas {{goal|40}}
• Pekhart {{goal|90+5}}

|goals2 =

|stadium = Stadion Wojska Polskiego, Warsaw

|attendance = 17,473{{UEFA match attendance|2032567|Legia Warsaw vs. Bodø/Glimt|date=14 July 2021|access-date=14 July 2021}}

|referee = Aristotelis Diamantopoulos (Greece)

|report = https://www.uefa.com/uefachampionsleague/match/2032567/

}}

Legia Warsaw won 5–2 on aggregate.

----

{{Football box

|date = {{Start date|2021|7|7|df=y}}

|time = 20:00 {{small|(19:00 UTC+1)}}

|team1 = Connah's Quay Nomads {{fbaicon|WAL}}

|score = 2–2

|team2 = {{fbaicon|ARM}} Alashkert

|goals1 =

• Curran {{goal|19}}
• Horan {{goal|79}}

|goals2 =

• Khurtsidze {{goal|21||45}}

|stadium = Park Avenue, Aberystwyth{{refn|group=note|name=Connah's Quay Nomads|Connah's Quay Nomads played their home match at Park Avenue, Aberystwyth, instead of their regular stadium Deeside Stadium, Connah's Quay, which did not meet UEFA requirements.}}

|attendance = 145{{UEFA match attendance|2032552|Connah's Quay Nomads vs. Alashkert|date=7 July 2021|access-date=7 July 2021}}

|referee = Vasilis Dimitriou (Cyprus)

|report = https://www.uefa.com/uefachampionsleague/match/2032552/

}}

{{Football box

|date = {{Start date|2021|7|14|df=y}}

|time = 17:00 {{small|(19:00 UTC+4)}}

|team1 = Alashkert {{fbaicon|ARM}}

|score = 1–0

|aet = yes

|team2 = {{fbaicon|WAL}} Connah's Quay Nomads

|goals1 =

• Bezecourt {{goal|113}}

|goals2 =

|stadium = Vazgen Sargsyan Republican Stadium, Yerevan{{refn|group=note|name=Alashkert|Alashkert played their home matches at Vazgen Sargsyan Republican Stadium, Yerevan, instead of their regular stadium Alashkert Stadium, Yerevan, which did not meet UEFA requirements.}}

|attendance = 4,000{{UEFA match attendance|2032568|Alashkert vs. Connah's Quay Nomads|date=14 July 2021|access-date=14 July 2021}}

|referee = Ondřej Pechanec (Czech Republic)

|report = https://www.uefa.com/uefachampionsleague/match/2032568/

}}

Alashkert won 3–2 on aggregate.

----

{{Football box

|date = {{Start date|2021|7|6|df=y}}

|time = 18:00 {{small|(19:00 UTC+3)}}

|team1 = HJK {{fbaicon|FIN}}

|score = 3–1

|team2 = {{fbaicon|MNE}} Budućnost Podgorica

|goals1 =

• Ro. Riski {{goal|5}}
• Valenčič {{goal|7}}
• Saksela {{goal|13}}

|goals2 =

• Raičković {{goal|35|pen.}}

|stadium = Bolt Arena, Helsinki

|attendance = 2,365{{UEFA match attendance|2032553|HJK vs. Budućnost Podgorica|date=6 July 2021|access-date=6 July 2021}}

|referee = Nicolas Laforge (Belgium)

|report = https://www.uefa.com/uefachampionsleague/match/2032553/

}}

{{Football box

|date = {{Start date|2021|7|13|df=y}}

|time = 20:30

|team1 = Budućnost Podgorica {{fbaicon|MNE}}

|score = 0–4

|team2 = {{fbaicon|FIN}} HJK

|goals1 =

|goals2 =

• Ro. Riski {{goal|6||49}}
• Valenčič {{goal|35}}
• Jair {{goal|40}}

|stadium = Stadion pod Goricom, Podgorica

|attendance = 1,450{{UEFA match attendance|2032569|Budućnost Podgorica vs. HJK|date=13 July 2021|access-date=13 July 2021}}

|referee = Dragomir Draganov (Bulgaria)

|report = https://www.uefa.com/uefachampionsleague/match/2032569/

}}

HJK won 7–1 on aggregate.

----

{{Football box

|date = {{Start date|2021|7|6|df=y}}

|time = 19:00 {{small|(20:00 UTC+3)}}

|team1 = CFR Cluj {{fbaicon|ROU}}

|score = 3–1

|team2 = {{fbaicon|BIH}} Borac Banja Luka

|goals1 =

• Omrani {{goal|11}}
• Deac {{goal|28}}
• Sigurjónsson {{goal|60}}

|goals2 =

• Moraitis {{goal|45+1}}

|stadium = Dr. Constantin Rădulescu, Cluj-Napoca

|attendance = 4,500{{UEFA match attendance|2032554|CFR Cluj vs. Borac Banja Luka|date=6 July 2021|access-date=6 July 2021}}

|referee = Jochem Kamphuis (Netherlands)

|report = https://www.uefa.com/uefachampionsleague/match/2032554/

}}

{{Football box

|date = {{Start date|2021|7|13|df=y}}

|time = 20:00

|team1 = Borac Banja Luka {{fbaicon|BIH}}

|score = 2–1

|aet = yes

|team2 = {{fbaicon|ROU}} CFR Cluj

|goals1 =

• Vranješ {{goal|60}}
• Moraitis {{goal|64}}

|goals2 =

• Chipciu {{goal|118}}

|stadium = Banja Luka City Stadium, Banja Luka

|attendance = 8,300{{UEFA match attendance|2032570|Borac Banja Luka vs. CFR Cluj|date=13 July 2021|access-date=13 July 2021}}

|referee = Urs Schnyder (Switzerland)

|report = https://www.uefa.com/uefachampionsleague/match/2032570/

}}

CFR Cluj won 4–3 on aggregate.

----

{{Football box

|date = {{Start date|2021|7|6|df=y}}

|time = 20:00

|team1 = Shkëndija {{fbaicon|MKD}}

|score = 0–1

|team2 = {{fbaicon|SVN}} Mura

|goals1 =

|goals2 =

• Bobičanec {{goal|28|pen.}}

|stadium = Toše Proeski Arena, Skopje{{refn|group=note|name=Shkëndija|Shkëndija played their home match at Toše Proeski Arena, Skopje, instead of their regular stadium Ecolog Arena, Tetovo, which did not meet UEFA requirements.}}

|attendance = 3,200{{UEFA match attendance|2032555|Shkëndija vs. Mura|date=6 July 2021|access-date=6 July 2021}}

|referee = António Nobre (Portugal)

|report = https://www.uefa.com/uefachampionsleague/match/2032555/

}}

{{Football box

|date = {{Start date|2021|7|13|df=y}}

|time = 20:00

|team1 = Mura {{fbaicon|SVN}}

|score = 5–0

|team2 = {{fbaicon|MKD}} Shkëndija

|goals1 =

• Bobičanec {{goal|25}}
• Kouter {{goal|45+1}}
• Klepač {{goal|55||87}}
• Kous {{goal|64}}

|goals2 =

|stadium = Fazanerija, Murska Sobota

|attendance = 3,100{{UEFA match attendance|2032571|Mura vs. Shkëndija|date=13 July 2021|access-date=13 July 2021}}

|referee = Marcel Birsan (Romania)

|report = https://www.uefa.com/uefachampionsleague/match/2032571/

}}

Mura won 6–0 on aggregate.

----

{{Football box

|date = {{Start date|2021|7|7|df=y}}

|time = 19:00

|team1 = Teuta {{fbaicon|ALB}}

|score = 0–4

|team2 = {{fbaicon|MDA}} Sheriff Tiraspol

|goals1 =

|goals2 =

• Luvannor {{goal|15||45+1}}
• Traoré {{goal|56}}
• Castañeda {{goal|89}}

|stadium = Niko Dovana Stadium, Durrës

|attendance = 500{{UEFA match attendance|2032556|Teuta vs. Sheriff Tiraspol|date=7 July 2021|access-date=7 July 2021}}

|referee = Amine Kourgheli (Belarus)

|report = https://www.uefa.com/uefachampionsleague/match/2032556/

}}

{{Football box

|date = {{Start date|2021|7|13|df=y}}

|time = 19:00 {{small|(20:00 UTC+3)}}

|team1 = Sheriff Tiraspol {{fbaicon|MDA}}

|score = 1–0

|team2 = {{fbaicon|ALB}} Teuta

|goals1 =

• Traoré {{goal|6}}

|goals2 =

|stadium = Malaya Sportivnaya Arena, Tiraspol

|attendance = 1,920{{UEFA match attendance|2032572|Sheriff Tiraspol vs. Teuta|date=13 July 2021|access-date=13 July 2021}}

|referee = Vladimir Moskalyov (Russia)

|report = https://www.uefa.com/uefachampionsleague/match/2032572/

}}

Sheriff Tiraspol won 5–0 on aggregate.

----

{{Football box

|date = {{Start date|2021|7|7|df=y}}

|time = 18:00 {{small|(20:00 UTC+4)}}

|team1 = Dinamo Tbilisi {{fbaicon|GEO}}

|score = 1–2

|team2 = {{fbaicon|AZE}} Neftçi

|goals1 =

• Marušić {{goal|36}}

|goals2 =

• Alaskarov {{goal|23}}
• Mahmudov {{goal|57|pen.}}

|stadium = Boris Paichadze Dinamo Arena, Tbilisi

|attendance = 5,890{{UEFA match attendance|2032557|Dinamo Tbilisi vs. Neftçi Baku|date=7 July 2021|access-date=7 July 2021}}

|referee = David Fuxman (Israel)

|report = https://www.uefa.com/uefachampionsleague/match/2032557/

}}

{{Football box

|date = {{Start date|2021|7|14|df=y}}

|time = 19:00 {{small|(21:00 UTC+4)}}

|team1 = Neftçi {{fbaicon|AZE}}

|score = 2–1

|team2 = {{fbaicon|GEO}} Dinamo Tbilisi

|goals1 =

• Mahmudov {{goal|58|pen.}}
• Alaskarov {{goal|68}}

|goals2 =

• Radin {{goal|51}}

|stadium = Bakcell Arena, Baku

|attendance = 3,218{{UEFA match attendance|2032573|Neftçi Baku vs. Dinamo Tbilisi|date=14 July 2021|access-date=14 July 2021}}

|referee = Dumitri Muntean (Moldova)

|report = https://www.uefa.com/uefachampionsleague/match/2032573/

}}

Neftçi won 4–2 on aggregate.

----

{{Football box

|date = {{Start date|2021|7|7|df=y}}

|time = 19:00 {{small|(20:00 UTC+3)}}

|team1 = Maccabi Haifa {{fbaicon|ISR}}

|score = 1–1

|team2 = {{fbaicon|KAZ}} Kairat

|goals1 =

• Atzili {{goal|45}}

|goals2 =

• Alip {{goal|76}}

|stadium = Sammy Ofer Stadium, Haifa

|attendance = 25,200{{UEFA match attendance|2032558|Maccabi Haifa vs. Kairat|date=7 July 2021|access-date=7 July 2021}}

|referee = Milovan Milačić (Montenegro)

|report = https://www.uefa.com/uefachampionsleague/match/2032558/

}}

{{Football box

|date = {{Start date|2021|7|14|df=y}}

|time = 16:00 {{small|(20:00 UTC+6)}}

|team1 = Kairat {{fbaicon|KAZ}}

|score = 2–0

|team2 = {{fbaicon|ISR}} Maccabi Haifa

|goals1 =

• Vágner Love {{goal|10}}
• Abiken {{goal|66}}

|goals2 =

|stadium = Almaty Central Stadium, Almaty

|attendance = 7,952{{UEFA match attendance|2032574|Kairat vs. Maccabi Haifa|date=14 July 2021|access-date=14 July 2021}}

|referee = Viktor Kopiievskyi (Ukraine)

|report = https://www.uefa.com/uefachampionsleague/match/2032574/

}}

Kairat won 3–1 on aggregate.

----

{{Football box

|date = {{Start date|2021|7|7|df=y}}

|time = 19:00 {{small|(20:00 UTC+3)}}

|team1 = Ludogorets Razgrad {{fbaicon|BUL}}

|score = 1–0

|team2 = {{fbaicon|BLR}} Shakhtyor Soligorsk

|goals1 =

• Cauly {{goal|90+2}}

|goals2 =

|stadium = Huvepharma Arena, Razgrad

|attendance = 4,762{{UEFA match attendance|2032559|Ludogorets Razgrad vs. Shakhtyor Soligorsk|date=7 July 2021|access-date=7 July 2021}}

|referee = Rohit Saggi (Norway)

|report = https://www.uefa.com/uefachampionsleague/match/2032559/

}}

{{Football box

|date = {{Start date|2021|7|13|df=y}}

|time = 21:30

|team1 = Shakhtyor Soligorsk {{fbaicon|BLR}}

|score = 0–1

|team2 = {{fbaicon|BUL}} Ludogorets Razgrad

|goals1 =

|goals2 =

• Despodov {{goal|71}}

|stadium = Čukarički Stadium, Belgrade, Serbia{{refn|group=note|name=Shakhtyor Soligorsk|Shakhtyor Soligorsk played their home match at Čukarički Stadium, Belgrade, Serbia, instead of their regular stadium Stroitel Stadium, Soligorsk, as in June 2021 UEFA suspended most matches to be played in Belarus, due to European Union sanctions in response to the Ryanair Flight 4978 incident which banned European Union airlines from flying over Belarusian airspace.{{cite web |url=https://bytribuna.global.ssl.fastly.net/football/1098237591-uefa-otkazalsya-provodit-v-belarusi-vse-meropriyatiya-pod-svoej-egidoj.html |title=УЕФА отказался проводить в Беларуси все мероприятия под своей эгидой |publisher=bytribuna.global.ssl.fastly.net/ |date=16 June 2021}}}}

|attendance = 0{{UEFA match attendance|2032575|Shakhtyor Soligorsk vs. Ludogorets Razgrad|date=13 July 2021|access-date=13 July 2021}}{{refn|group=note|name=Behind closed doors}}

|referee = Arda Kardeşler (Turkey)

|report = https://www.uefa.com/uefachampionsleague/match/2032575/

}}

Ludogorets Razgrad won 2–0 on aggregate.

----

{{Football box

|date = {{Start date|2021|7|6|df=y}}

|time = 18:00

|team1 = Ferencváros {{fbaicon|HUN}}

|score = 3–0

|team2 = {{fbaicon|KOS}} Prishtina

|goals1 =

• Nguen {{goal|71}}
• R. Mmaee {{goal|74}}
• Blažič {{goal|78}}

|goals2 =

|stadium = Ferencváros Stadion, Budapest

|attendance = 8,765{{UEFA match attendance|2032560|Ferencváros vs. Prishtina|date=6 July 2021|access-date=6 July 2021}}

|referee = David Munro (Scotland)

|report = https://www.uefa.com/uefachampionsleague/match/2032560/

}}

{{Football box

|date = {{Start date|2021|7|13|df=y}}

|time = 20:00

|team1 = Prishtina {{fbaicon|KOS}}

|score = 1–3

|team2 = {{fbaicon|HUN}} Ferencváros

|goals1 =

• Hoti {{goal|67}}

|goals2 =

• Uzuni {{goal|49||80||86}}

|stadium = Fadil Vokrri Stadium, Pristina

|attendance = 0{{UEFA match attendance|2032576|Prishtina vs. Ferencváros|date=13 July 2021|access-date=13 July 2021}}{{refn|group=note|name=Behind closed doors}}

|referee = Laurent Kopriwa (Luxembourg)

|report = https://www.uefa.com/uefachampionsleague/match/2032576/

}}

Ferencváros won 6–1 on aggregate.

----

{{Football box

|date = {{Start date|2021|7|6|df=y}}

|time = 19:00 {{small|(20:00 UTC+3)}}

|team1 = Žalgiris {{fbaicon|LTU}}

|score = 3–1

|team2 = {{fbaicon|NIR}} Linfield

|goals1 =

• Vidémont {{goal|38}}
• Kiš {{goal|45|pen.}}
• Sylvestr {{goal|67}}

|goals2 =

• Manzinga {{goal|54}}

|stadium = LFF Stadium, Vilnius

|attendance = 1,500{{UEFA match attendance|2032561|Žalgiris vs. Linfield|date=6 July 2021|access-date=6 July 2021}}

|referee = Alex Troleis (Faroe Islands)

|report = https://www.uefa.com/uefachampionsleague/match/2032561/

}}

{{Football box

|date = {{Start date|2021|7|13|df=y}}

|time = 20:45 {{small|(19:45 UTC+1)}}

|team1 = Linfield {{fbaicon|NIR}}

|score = 1–2

|team2 = {{fbaicon|LTU}} Žalgiris

|goals1 =

• Shields {{goal|66|pen.}}

|goals2 =

• Mikoliūnas {{goal|17}}
• Onazi {{goal|44}}

|stadium = Windsor Park, Belfast

|attendance = 888{{UEFA match attendance|2032577|Linfield vs. Žalgiris|date=13 July 2021|access-date=13 July 2021}}

|referee = Matthew De Gabriele (Malta)

|report = https://www.uefa.com/uefachampionsleague/match/2032577/

}}

Žalgiris won 5–2 on aggregate.

----

{{Football box

|date = {{Start date|2021|7|6|df=y}}

|time = 18:00 {{small|(19:00 UTC+3)}}

|team1 = Flora {{fbaicon|EST}}

|score = 2–0

|team2 = {{fbaicon|MLT}} Hibernians

|goals1 =

• Sappinen {{goal|75||89}}

|goals2 =

|stadium = Lilleküla Stadium, Tallinn

|attendance = 1,804{{UEFA match attendance|2032562|Flora vs. Hibernians|date=6 July 2021|access-date=6 July 2021}}

|referee = Lazar Lukić (Serbia)

|report = https://www.uefa.com/uefachampionsleague/match/2032562/

}}

{{Football box

|date = {{Start date|2021|7|13|df=y}}

|time = 18:00

|team1 = Hibernians {{fbaicon|MLT}}

|score = 0–3

|team2 = {{fbaicon|EST}} Flora

|goals1 =

|goals2 =

• Zenjov {{goal|25}}
• Sappinen {{goal|33}}
• Reinkort {{goal|87}}

|stadium = Centenary Stadium, Ta' Qali

|attendance = 155{{UEFA match attendance|2032578|Hibernians vs. Flora|date=13 July 2021|access-date=13 July 2021}}

|referee = Manfredas Lukjančukas (Lithuania)

|report = https://www.uefa.com/uefachampionsleague/match/2032578/

}}

Flora won 5–0 on aggregate.

----

{{Football box

|date = {{Start date|2021|7|7|df=y}}

|time = 20:00

|team1 = Dinamo Zagreb {{fbaicon|CRO}}

|score = 3–2

|team2 = {{fbaicon|ISL}} Valur

|goals1 =

• Ademi {{goal|8||72}}
• Majer {{goal|41|pen.}}

|goals2 =

• K. Sigurðsson {{goal|88}}
• Adolphsson {{goal|90}}

|stadium = Stadion Maksimir, Zagreb

|attendance = 987{{UEFA match attendance|2032563|Dinamo Zagreb vs. Valur|date=7 July 2021|access-date=7 July 2021}}

|referee = Genc Nuza (Kosovo)

|report = https://www.uefa.com/uefachampionsleague/match/2032563/

}}

{{Football box

|date = {{Start date|2021|7|13|df=y}}

|time = 22:00 {{small|(20:00 UTC+0)}}

|team1 = Valur {{fbaicon|ISL}}

|score = 0–2

|team2 = {{fbaicon|CRO}} Dinamo Zagreb

|goals1 =

|goals2 =

• Ivanušec {{goal|31}}
• Oršić {{goal|89}}

|stadium = Hlíðarendi, Reykjavík

|attendance = 800{{UEFA match attendance|2032579|Valur vs. Dinamo Zagreb|date=13 July 2021|access-date=13 July 2021}}

|referee = Zaven Hovhannisyan (Armenia)

|report = https://www.uefa.com/uefachampionsleague/match/2032579/

}}

Dinamo Zagreb won 5–2 on aggregate.

A total of 26 teams played in the second qualifying round. They were divided into two paths:

• Champions Path (20 teams): 4 teams which entered in this round, and 16 winners of the first qualifying round.
• League Path (6 teams): 6 teams which entered in this round.

Seeding of teams was based on their 2021 UEFA club coefficients. For the winners of the first qualifying round, whose identity was not known at the time of draw, the club coefficient of the highest-ranked remaining team in each tie was used. Prior to the draw, UEFA formed three groups in the Champions Path, two of three seeded teams and three unseeded teams, and one of four seeded teams and four unseeded teams, in accordance with the principles set by the Club Competitions Committee, while in the League Path there were three seeded teams and three unseeded teams. The first team drawn in each tie would be the home team of the first leg.

;Notes

{{Cnote2 Begin|liststyle=disc}}

{{Cnote2|†|n=0|group=Q2|^† Winner of the first qualifying round, whose identity was not known at the time of draw. Teams in italics defeated a team with a higher coefficient, thus effectively taking the coefficient of their opponent in the draw.}}

{{Cnote2 End}}

{{Football box

|date = {{Start date|2021|7|20|df=y}}

|time = 20:00

|team1 = Dinamo Zagreb {{fbaicon|CRO}}

|score = 2–0

|team2 = {{fbaicon|CYP}} Omonia

|goals1 =

• Majer {{goal|65}}
• Jakić {{goal|81}}

|goals2 =

|stadium = Stadion Maksimir, Zagreb

|attendance = 2,234{{UEFA match attendance|2032582|Dinamo Zagreb vs. Omonia|date=20 July 2021|access-date=20 July 2021}}

|referee = Paweł Gil (Poland)

|report = https://www.uefa.com/uefachampionsleague/match/2032582/

}}

{{Football box

|date = {{Start date|2021|7|27|df=y}}

|time = 17:00 {{small|(18:00 UTC+3)}}

|team1 = Omonia {{fbaicon|CYP}}

|score = 0–1

|team2 = {{fbaicon|CRO}} Dinamo Zagreb

|goals1 =

|goals2 =

• Menalo {{goal|79}}

|stadium = GSP Stadium, Strovolos

|attendance = 7,256{{UEFA match attendance|2032594|Omonia vs. Dinamo Zagreb|date=27 July 2021|access-date=27 July 2021}}

|referee = Glenn Nyberg (Sweden)

|report = https://www.uefa.com/uefachampionsleague/match/2032594/

}}

Dinamo Zagreb won 3–0 on aggregate.

----

{{Football box

|date = {{Start date|2021|7|21|df=y}}

|time = 20:30

|team1 = Slovan Bratislava {{fbaicon|SVK}}

|score = 0–0

|team2 = {{fbaicon|SUI}} Young Boys

|goals1 =

|goals2 =

|stadium = Tehelné pole, Bratislava

|attendance = 1,000{{UEFA match attendance|2032583|Slovan Bratislava vs. Young Boys|date=21 July 2021|access-date=21 July 2021}}

|referee = Chris Kavanagh (England)

|report = https://www.uefa.com/uefachampionsleague/match/2032583/

}}

{{Football box

|date = {{Start date|2021|7|28|df=y}}

|time = 20:15

|team1 = Young Boys {{fbaicon|SUI}}

|score = 3–2

|team2 = {{fbaicon|SVK}} Slovan Bratislava

|goals1 =

• Pefok {{goal|10|pen.}}
• Garcia {{goal|24}}
• Aebischer {{goal|49}}

|goals2 =

• Kanga {{goal|60|o.g.}}
• Henty {{goal|62}}

|stadium = Wankdorf Stadium, Bern

|attendance = 19,564{{UEFA match attendance|2032595|Young Boys vs. Slovan Bratislava|date=28 July 2021|access-date=28 July 2021}}

|referee = Irfan Peljto (Bosnia and Herzegovina)

|report = https://www.uefa.com/uefachampionsleague/match/2032595/

}}

Young Boys won 3–2 on aggregate.

----

{{Football box

|date = {{Start date|2021|7|21|df=y}}

|time = 21:00

|team1 = Legia Warsaw {{fbaicon|POL}}

|score = 2–1

|team2 = {{fbaicon|EST}} Flora

|goals1 =

• Kapustka {{goal|3}}
• Lopes {{goal|90+1}}

|goals2 =

• Sappinen {{goal|53}}

|stadium = Stadion Wojska Polskiego, Warsaw

|attendance = 16,721{{UEFA match attendance|2032584|Legia Warsaw vs. Flora|date=21 July 2021|access-date=21 July 2021}}

|referee = Vitali Meshkov (Russia)

|report = https://www.uefa.com/uefachampionsleague/match/2032584/

}}

{{Football box

|date = {{Start date|2021|7|27|df=y}}

|time = 18:00 {{small|(19:00 UTC+3)}}

|team1 = Flora {{fbaicon|EST}}

|score = 0–1

|team2 = {{fbaicon|POL}} Legia Warsaw

|goals1 =

|goals2 =

• Lopes {{goal|67}}

|stadium = Lilleküla Stadium, Tallinn

|attendance = 3,691{{UEFA match attendance|2032596|Flora vs. Legia Warsaw|date=27 July 2021|access-date=27 July 2021}}

|referee = Anastasios Papapetrou (Greece)

|report = https://www.uefa.com/uefachampionsleague/match/2032596/

}}

Legia Warsaw won 3–1 on aggregate.

----

{{Football box

|date = {{Start date|2021|7|20|df=y}}

|time = 17:00 {{small|(19:00 UTC+4)}}

|team1 = Alashkert {{fbaicon|ARM}}

|score = 0–1

|team2 = {{fbaicon|MDA}} Sheriff Tiraspol

|goals1 =

|goals2 =

• Luvannor {{goal|84}}

|stadium = Vazgen Sargsyan Republican Stadium, Yerevan{{refn|group=note|name=Alashkert}}

|attendance = 5,800{{UEFA match attendance|2032585|Alashkert vs. Sheriff Tiraspol|date=20 July 2021|access-date=20 July 2021}}

|referee = Rade Obrenovič (Slovenia)

|report = https://www.uefa.com/uefachampionsleague/match/2032585/

}}

{{Football box

|date = {{Start date|2021|7|28|df=y}}

|time = 19:00 {{small|(20:00 UTC+3)}}

|team1 = Sheriff Tiraspol {{fbaicon|MDA}}

|score = 3–1

|team2 = {{fbaicon|ARM}} Alashkert

|goals1 =

• Dulanto {{goal|15}}
• Luvannor {{goal|23}}
• Thill {{goal|87|pen.}}

|goals2 =

• Glišić {{goal|10}}

|stadium = Malaya Sportivnaya Arena, Tiraspol

|attendance = 2,046{{UEFA match attendance|2032597|Sheriff Tiraspol vs. Alashkert|date=28 July 2021|access-date=28 July 2021}}

|referee = Bojan Pandžić (Sweden)

|report = https://www.uefa.com/uefachampionsleague/match/2032597/

}}

Sheriff Tiraspol won 4–1 on aggregate.

----

{{Football box

|date = {{Start date|2021|7|21|df=y}}

|time = 21:00 {{small|(22:00 UTC+3)}}

|team1 = Olympiacos {{fbaicon|GRE}}

|score = 1–0

|team2 = {{fbaicon|AZE}} Neftçi

|goals1 =

• M. Camara {{goal|29}}

|goals2 =

|stadium = Karaiskakis Stadium, Piraeus

|attendance = 7,305{{UEFA match attendance|2032586|Olympiakos vs. Neftçi Baku|date=21 July 2021|access-date=21 July 2021}}

|referee = João Pinheiro (Portugal)

|report = https://www.uefa.com/uefachampionsleague/match/2032586/

}}

{{Football box

|date = {{Start date|2021|7|28|df=y}}

|time = 19:00 {{small|(21:00 UTC+4)}}

|team1 = Neftçi {{fbaicon|AZE}}

|score = 0–1

|team2 = {{fbaicon|GRE}} Olympiacos

|goals1 =

|goals2 =

• Gi. Masouras {{goal|15}}

|stadium = Eighth Kilometer District Stadium, Baku

|attendance = 5,500{{UEFA match attendance|2032598|Neftçi Baku vs. Olympiacos|date=28 July 2021|access-date=28 July 2021}}

|referee = Ricardo de Burgos (Spain)

|report = https://www.uefa.com/uefachampionsleague/match/2032598/

}}

Olympiacos won 2–0 on aggregate.

----

{{Football box

|date = {{Start date|2021|7|21|df=y}}

|time = 16:00 {{small|(20:00 UTC+6)}}

|team1 = Kairat {{fbaicon|KAZ}}

|score = 2–1

|team2 = {{fbaicon|SRB}} Red Star Belgrade

|goals1 =

• Kanté {{goal|24}}
• Bagnack {{goal|79}}

|goals2 =

• Mikanović {{goal|57|o.g.}}

|stadium = Almaty Central Stadium, Almaty

|attendance = 7,000{{UEFA match attendance|2032587|Kairat vs. Red Star Belgrade|date=21 July 2021|access-date=21 July 2021}}

|referee = Halil Umut Meler (Turkey)

|report = https://www.uefa.com/uefachampionsleague/match/2032587/

}}

{{Football box

|date = {{Start date|2021|7|28|df=y}}

|time = 20:30

|team1 = Red Star Belgrade {{fbaicon|SRB}}

|score = 5–0

|team2 = {{fbaicon|KAZ}} Kairat

|goals1 =

• Katai {{goal|9||42}}
• Diony {{goal|21}}
• Ivanić {{goal|49}}
• Falco {{goal|56}}

|goals2 =

|stadium = Red Star Stadium, Belgrade

|attendance = 0{{UEFA match attendance|2032599|Red Star Belgrade vs. Kairat|date=28 July 2021|access-date=28 July 2021}}{{refn|group=note|name=Behind closed doors}}

|referee = Andris Treimanis (Latvia)

|report = https://www.uefa.com/uefachampionsleague/match/2032599/

}}

Red Star Belgrade won 6–2 on aggregate.

----

{{Football box

|date = {{Start date|2021|7|20|df=y}}

|time = 18:00

|team1 = Lincoln Red Imps {{fbaicon|GIB}}

|score = 1–2

|team2 = {{fbaicon|ROU}} CFR Cluj

|goals1 =

• Rosa {{goal|45}}

|goals2 =

• Debeljuh {{goal|52||58}}

|stadium = Victoria Stadium, Gibraltar

|attendance = 1,039{{UEFA match attendance|2032588|Lincoln Red Imps vs. CFR Cluj|date=20 July 2021|access-date=20 July 2021}}

|referee = Willy Delajod (France)

|report = https://www.uefa.com/uefachampionsleague/match/2032588/

}}

{{Football box

|date = {{Start date|2021|7|28|df=y}}

|time = 19:30 {{small|(20:30 UTC+3)}}

|team1 = CFR Cluj {{fbaicon|ROU}}

|score = 2–0

|team2 = {{fbaicon|GIB}} Lincoln Red Imps

|goals1 =

• Cestor {{goal|18}}
• Sigurjónsson {{goal|58}}

|goals2 =

|stadium = Dr. Constantin Rădulescu, Cluj-Napoca

|attendance = 5,230{{UEFA match attendance|2032600|CFR Cluj vs. Lincoln Red Imps|date=28 July 2021|access-date=28 July 2021}}

|referee = Yigal Frid (Israel)

|report = https://www.uefa.com/uefachampionsleague/match/2032600/

}}

CFR Cluj won 4–1 on aggregate.

----

{{Football box

|date = {{Start date|2021|7|21|df=y}}

|time = 19:00

|team1 = Malmö FF {{fbaicon|SWE}}

|score = 2–1

|team2 = {{fbaicon|FIN}} HJK

|goals1 =

• Čolak {{goal|45+1}}
• Christiansen {{goal|74}}

|goals2 =

• Ro. Riski {{goal|68}}

|stadium = Stadion, Malmö

|attendance = 5,324{{UEFA match attendance|2032589|Malmö FF vs. HJK|date=21 July 2021|access-date=21 July 2021}}

|referee = Mykola Balakin (Ukraine)

|report = https://www.uefa.com/uefachampionsleague/match/2032589/

}}

{{Football box

|date = {{Start date|2021|7|27|df=y}}

|time = 18:00 {{small|(19:00 UTC+3)}}

|team1 = HJK {{fbaicon|FIN}}

|score = 2–2

|team2 = {{fbaicon|SWE}} Malmö FF

|goals1 =

• Tenho {{goal|1}}
• Ri. Riski {{goal|78}}

|goals2 =

• Christiansen {{goal|10}}
• Birmančević {{goal|76}}

|stadium = Bolt Arena, Helsinki

|attendance = 6,465{{UEFA match attendance|2032601|HJK vs. Malmö FF|date=27 July 2021|access-date=27 July 2021}}

|referee = Stuart Attwell (England)

|report = https://www.uefa.com/uefachampionsleague/match/2032601/

}}

Malmö FF won 4–3 on aggregate.

----

{{Football box

|date = {{Start date|2021|7|20|df=y}}

|time = 20:00

|team1 = Ferencváros {{fbaicon|HUN}}

|score = 2–0

|team2 = {{fbaicon|LTU}} Žalgiris

|goals1 =

• Uzuni {{goal|25}}
• Nguen {{goal|39}}

|goals2 =

|stadium = Ferencváros Stadion, Budapest

|attendance = 10,107{{UEFA match attendance|2032590|Ferencváros vs. Žalgiris|date=20 July 2021|access-date=20 July 2021}}

|referee = Giorgi Kruashvili (Georgia)

|report = https://www.uefa.com/uefachampionsleague/match/2032590/

}}

{{Football box

|date = {{Start date|2021|7|27|df=y}}

|time = 19:00 {{small|(20:00 UTC+3)}}

|team1 = Žalgiris {{fbaicon|LTU}}

|score = 1–3

|team2 = {{fbaicon|HUN}} Ferencváros

|goals1 =

• Diaw {{goal|90+3}}

|goals2 =

• R. Mmaee {{goal|44||72}}
• Mak {{goal|90+4}}

|stadium = LFF Stadium, Vilnius

|attendance = 2,032{{UEFA match attendance|2032602|Žalgiris vs. Ferencváros|date=27 July 2021|access-date=27 July 2021}}

|referee = Erik Lambrechts (Belgium)

|report = https://www.uefa.com/uefachampionsleague/match/2032602/

}}

Ferencváros won 5–1 on aggregate.

----

{{Football box

|date = {{Start date|2021|7|21|df=y}}

|time = 20:00

|team1 = Mura {{fbaicon|SVN}}

|score = 0–0

|team2 = {{fbaicon|BUL}} Ludogorets Razgrad

|goals1 =

|goals2 =

|stadium = Fazanerija, Murska Sobota

|attendance = 3,450{{UEFA match attendance|2032591|Mura vs. Ludogorets Razgrad|date=21 July 2021|access-date=21 July 2021}}

|referee = Harm Osmers (Germany)

|report = https://www.uefa.com/uefachampionsleague/match/2032591/

}}

{{Football box

|date = {{Start date|2021|7|28|df=y}}

|time = 20:00 {{small|(21:00 UTC+3)}}

|team1 = Ludogorets Razgrad {{fbaicon|BUL}}

|score = 3–1

|team2 = {{fbaicon|SVN}} Mura

|goals1 =

• Sotiriou {{goal|4}}
• Manu {{goal|82}}
• Cauly {{goal|90}}

|goals2 =

• Horvat {{goal|64}}

|stadium = Huvepharma Arena, Razgrad

|attendance = 5,008{{UEFA match attendance|2032603|Ludogorets Razgrad vs. Mura|date=28 July 2021|access-date=28 July 2021}}

|referee = Marco Di Bello (Italy)

|report = https://www.uefa.com/uefachampionsleague/match/2032603/

}}

Ludogorets Razgrad won 3–1 on aggregate.

{{Football box

|date = {{Start date|2021|7|20|df=y}}

|time = 20:30

|team1 = Rapid Wien {{fbaicon|AUT}}

|score = 2–1

|team2 = {{fbaicon|CZE}} Sparta Prague

|goals1 =

• Knasmüllner {{goal|63||71}}

|goals2 =

• Krejčí II {{goal|3}}

|stadium = Allianz Stadion, Vienna

|attendance = 19,500{{UEFA match attendance|2032592|Rapid Wien vs. Sparta Prague|date=20 July 2021|access-date=20 July 2021}}

|referee = Serdar Gözübüyük (Netherlands)

|report = https://www.uefa.com/uefachampionsleague/match/2032592/

}}

{{Football box

|date = {{Start date|2021|7|28|df=y}}

|time = 20:30

|team1 = Sparta Prague {{fbaicon|CZE}}

|score = 2–0

|team2 = {{fbaicon|AUT}} Rapid Wien

|goals1 =

• Karlsson {{goal|16|pen.}}
• Pešek {{goal|81}}

|goals2 =

|stadium = Stadion Letná, Prague

|attendance = 9,105{{UEFA match attendance|2032604|Sparta Prague vs. Rapid Wien|date=28 July 2021|access-date=28 July 2021}}

|referee = Bobby Madden (Scotland)

|report = https://www.uefa.com/uefachampionsleague/match/2032604/

}}

Sparta Prague won 3–2 on aggregate.

----

{{Football box

|date = {{Start date|2021|7|20|df=y}}

|time = 20:45 {{small|(19:45 UTC+1)}}

|team1 = Celtic {{fbaicon|SCO}}

|score = 1–1

|team2 = {{fbaicon|DEN}} Midtjylland

|goals1 =

• Abada {{goal|39}}

|goals2 =

• Evander {{goal|66}}

|stadium = Celtic Park, Glasgow

|attendance = 9,000{{UEFA match attendance|2032593|Celtic vs. Midtjylland|date=20 July 2021|access-date=20 July 2021}}

|referee = Sandro Schärer (Switzerland)

|report = https://www.uefa.com/uefachampionsleague/match/2032593/

}}

{{Football box

|date = {{Start date|2021|7|28|df=y}}

|time = 19:45

|team1 = Midtjylland {{fbaicon|DEN}}

|score = 2–1

|aet = yes

|team2 = {{fbaicon|SCO}} Celtic

|goals1 =

• Mabil {{goal|61}}
• Onyedika {{goal|94}}

|goals2 =

• McGregor {{goal|48}}

|stadium = MCH Arena, Herning

|attendance = 4,890{{UEFA match attendance|2032605|Midtjylland vs. Celtic|date=28 July 2021|access-date=28 July 2021}}

|referee = Bartosz Frankowski (Poland)

|report = https://www.uefa.com/uefachampionsleague/match/2032605/

}}

Midtjylland won 3–2 on aggregate.

----

{{Football box

|date = {{Start date|2021|7|21|df=y}}

|time = 21:00

|team1 = PSV Eindhoven {{fbaicon|NED}}

|score = 5–1

|team2 = {{fbaicon|TUR}} Galatasaray

|goals1 =

• Zahavi {{goal|2||35||84}}
• Götze {{goal|51||88}}

|goals2 =

• Kılınç {{goal|42}}

|stadium = Philips Stadion, Eindhoven

|attendance = 23,500{{UEFA match attendance|2032606|PSV Eindhoven vs. Galatasaray|date=21 July 2021|access-date=21 July 2021}}

|referee = Alejandro Hernández (Spain)

|report = https://www.uefa.com/uefachampionsleague/match/2032606/

}}

{{Football box

|date = {{Start date|2021|7|28|df=y}}

|time = 20:00 {{small|(21:00 UTC+3)}}

|team1 = Galatasaray {{fbaicon|TUR}}

|score = 1–2

|team2 = {{fbaicon|NED}} PSV Eindhoven

|goals1 =

• Diagne {{goal|84}}

|goals2 =

• Madueke {{goal|37}}
• Van Ginkel {{goal|59}}

|stadium = Başakşehir Fatih Terim Stadium, Istanbul{{refn|group=note|name=Galatasaray|Galatasaray played their home match at Başakşehir Fatih Terim Stadium in Istanbul, instead of their regular stadium Türk Telekom Stadium, also in Istanbul.}}

|attendance = 5,775{{UEFA match attendance|2032607|Galatasaray vs. PSV Eindhoven|date=28 July 2021|access-date=28 July 2021}}

|referee = Massimiliano Irrati (Italy)

|report = https://www.uefa.com/uefachampionsleague/match/2032607/

}}

PSV Eindhoven won 7–2 on aggregate.

A total of 20 teams played in the third qualifying round. They were divided into two paths:

• Champions Path (12 teams): 2 teams which entered in this round, and 10 winners of the second qualifying round (Champions Path).
• League Path (8 teams): 5 teams which entered in this round, and 3 winners of the second qualifying round (League Path).

Seeding of teams was based on their 2021 UEFA club coefficients. For the winners of the second qualifying round, whose identity was not known at the time of draw, the club coefficient of the highest-ranked remaining team in each tie was used. Prior to the draw, UEFA formed two groups in the Champions Path, of three seeded teams and three unseeded teams, in accordance with the principles set by the Club Competitions Committee, while in the League Path there were four seeded teams and four unseeded teams. Due to political reasons, teams from Ukraine and Russia in the League Path could not be drawn against each other, thus Shakhtar Donetsk and Spartak Moscow could not be drawn against each other. The first team drawn in each tie would be the home team of the first leg.

;Notes

{{Cnote2 Begin|liststyle=disc}}

{{Cnote2|†|n=0|group=Q3|^† Winner of the second qualifying round, whose identity was not known at the time of draw. Teams in italics defeated a team with a higher coefficient, thus effectively taking the coefficient of their opponent in the draw.}}

{{Cnote2 End}}

{{Football box

|date = {{Start date|2021|8|4|df=y}}

|time = 20:00

|team1 = Dinamo Zagreb {{fbaicon|CRO}}

|score = 1–1

|team2 = {{fbaicon|POL}} Legia Warsaw

|goals1 =

• Petković {{goal|60}}

|goals2 =

• Muçi {{goal|82}}

|stadium = Stadion Maksimir, Zagreb

|attendance = 4,597{{UEFA match attendance|2032608|Dinamo Zagreb vs. Legia Warsaw|date=4 August 2021|access-date=4 August 2021}}

|referee = Antonio Mateu Lahoz (Spain)

|report = https://www.uefa.com/uefachampionsleague/match/2032608/

}}

{{Football box

|date = {{Start date|2021|8|10|df=y}}

|time = 21:00

|team1 = Legia Warsaw {{fbaicon|POL}}

|score = 0–1

|team2 = {{fbaicon|CRO}} Dinamo Zagreb

|goals1 =

|goals2 =

• Franjić {{goal|20}}

|stadium = Stadion Wojska Polskiego, Warsaw

|attendance = 26,769{{UEFA match attendance|2032618|Legia Warsaw vs. Dinamo Zagreb|date=10 August 2021|access-date=10 August 2021}}

|referee = Benoît Bastien (France)

|report = https://www.uefa.com/uefachampionsleague/match/2032618/

}}

Dinamo Zagreb won 2–1 on aggregate.

----

{{Football box

|date = {{Start date|2021|8|3|df=y}}

|time = 20:00 {{small|(21:00 UTC+3)}}

|team1 = CFR Cluj {{fbaicon|ROU}}

|score = 1–1

|team2 = {{fbaicon|SUI}} Young Boys

|goals1 =

• Manea {{goal|4}}

|goals2 =

• Sierro {{goal|90+3}}

|stadium = Dr. Constantin Rădulescu, Cluj-Napoca

|attendance = 9,500{{UEFA match attendance|2032609|CFR Cluj vs. Young Boys|date=3 August 2021|access-date=3 August 2021}}

|referee = Danny Makkelie (Netherlands)

|report = https://www.uefa.com/uefachampionsleague/match/2032609/

}}

{{Football box

|date = {{Start date|2021|8|10|df=y}}

|time = 20:30

|team1 = Young Boys {{fbaicon|SUI}}

|score = 3–1

|team2 = {{fbaicon|ROU}} CFR Cluj

|goals1 =

• Pefok {{goal|23||42}}
• Ngamaleu {{goal|25}}

|goals2 =

• Omrani {{goal|4}}

|stadium = Wankdorf Stadium, Bern

|attendance = 21,145{{UEFA match attendance|2032619|Young Boys vs. CFR Cluj|date=10 August 2021|access-date=10 August 2021}}

|referee = Cüneyt Çakır (Turkey)

|report = https://www.uefa.com/uefachampionsleague/match/2032619/

}}

Young Boys won 4–2 on aggregate.

----

{{Football box

|date = {{Start date|2021|8|3|df=y}}

|time = 21:00 {{small|(22:00 UTC+3)}}

|team1 = Olympiacos {{fbaicon|GRE}}

|score = 1–1

|team2 = {{fbaicon|BUL}} Ludogorets Razgrad

|goals1 =

• A. Camara {{goal|87}}

|goals2 =

• Despodov {{goal|50}}

|stadium = Karaiskakis Stadium, Piraeus

|attendance = 9,212{{UEFA match attendance|2032610|Olympiacos vs. Ludogorets Razgrad|date=3 August 2021|access-date=3 August 2021}}

|referee = Bobby Madden (Scotland)

|report = https://www.uefa.com/uefachampionsleague/match/2032610/

}}

{{Football box

|date = {{Start date|2021|8|10|df=y}}

|time = 20:00 {{small|(21:00 UTC+3)}}

|team1 = Ludogorets Razgrad {{fbaicon|BUL}}

|score = 2–2

|aet = yes

|team2 = {{fbaicon|GRE}} Olympiacos

|goals1 =

• Semedo {{goal|49|o.g.}}
• Sotiriou {{goal|57|pen.}}

|goals2 =

• M'Vila {{goal|31}}
• El-Arabi {{goal|68|pen.}}

|stadium = Huvepharma Arena, Razgrad

|attendance = 5,118{{UEFA match attendance|2032620|Ludogorets Razgrad vs. Olympiacos|date=10 August 2021|access-date=10 August 2021}}

|referee = Orel Grinfeld (Israel)

|penalties1 =

• Sotiriou {{pengoal}}
• Santana {{pengoal}}
• Verdon {{pengoal}}
• Cicinho {{pengoal}}

|penaltyscore = 4–1

|penalties2 =

• {{penmiss}} Valbuena
• {{penmiss}} Hassan
• {{pengoal}} Lala

|report = https://www.uefa.com/uefachampionsleague/match/2032620/

}}

3–3 on aggregate; Ludogorets Razgrad won 4–1 on penalties.

----

{{Football box

|date = {{Start date|2021|8|3|df=y}}

|time = 21:00

|team1 = Red Star Belgrade {{fbaicon|SRB}}

|score = 1–1

|team2 = {{fbaicon|MDA}} Sheriff Tiraspol

|goals1 =

• Diony {{goal|45+1}}

|goals2 =

• Castañeda {{goal|33}}

|stadium = Red Star Stadium, Belgrade

|attendance = 24,433{{UEFA match attendance|2032611|Red Star Belgrade vs. Sheriff Tiraspol|date=3 August 2021|access-date=3 August 2021}}

|referee = Ovidiu Haţegan (Romania)

|report = https://www.uefa.com/uefachampionsleague/match/2032611/

}}

{{Football box

|date = {{Start date|2021|8|10|df=y}}

|time = 19:00 {{small|(20:00 UTC+3)}}

|team1 = Sheriff Tiraspol {{fbaicon|MDA}}

|score = 1–0

|team2 = {{fbaicon|SRB}} Red Star Belgrade

|goals1 =

• Arboleda {{goal|45+2}}

|goals2 =

|stadium = Sheriff Stadium, Tiraspol

|attendance = 4,950{{UEFA match attendance|2032621|Sheriff Tiraspol vs. Red Star Belgrade|date=10 August 2021|access-date=10 August 2021}}

|referee = Felix Zwayer (Germany)

|report = https://www.uefa.com/uefachampionsleague/match/2032621/

}}

Sheriff Tiraspol won 2–1 on aggregate.

----

{{Football box

|date = {{Start date|2021|8|3|df=y}}

|time = 19:00

|team1 = Malmö FF {{fbaicon|SWE}}

|score = 2–1

|team2 = {{fbaicon|SCO}} Rangers

|goals1 =

• Rieks {{goal|47}}
• Birmančević {{goal|49}}

|goals2 =

• Davis {{goal|90+5}}

|stadium = Stadion, Malmö

|attendance = 5,820{{UEFA match attendance|2032612|Malmö FF vs. Rangers|date=3 August 2021|access-date=3 August 2021}}

|referee = Szymon Marciniak (Poland)

|report = https://www.uefa.com/uefachampionsleague/match/2032612/

}}

{{Football box

|date = {{Start date|2021|8|10|df=y}}

|time = 21:00 {{small|(20:00 UTC+1)}}

|team1 = Rangers {{fbaicon|SCO}}

|score = 1–2

|team2 = {{fbaicon|SWE}} Malmö FF

|goals1 =

• Morelos {{goal|19}}

|goals2 =

• Čolak {{goal|53||58}}

|stadium = Ibrox Stadium, Glasgow

|attendance = 47,021{{UEFA match attendance|2032622|Rangers vs. Malmö FF|date=10 August 2021|access-date=10 August 2021}}

|referee = Slavko Vinčić (Slovenia)

|report = https://www.uefa.com/uefachampionsleague/match/2032622/

}}

Malmö FF won 4–2 on aggregate.

----

{{Football box

|date = {{Start date|2021|8|4|df=y}}

|time = 20:00

|team1 = Ferencváros {{fbaicon|HUN}}

|score = 2–0

|team2 = {{fbaicon|CZE}} Slavia Prague

|goals1 =

• Kacharaba {{goal|44|o.g.}}
• Kharatin {{goal|50|pen.}}

|goals2 =

|stadium = Ferencváros Stadion, Budapest

|attendance = 17,127{{UEFA match attendance|2032613|Ferencváros vs. Slavia Prague|date=4 August 2021|access-date=4 August 2021}}

|referee = Jesús Gil Manzano (Spain)

|report = https://www.uefa.com/uefachampionsleague/match/2032613/

}}

{{Football box

|date = {{Start date|2021|8|10|df=y}}

|time = 19:00

|team1 = Slavia Prague {{fbaicon|CZE}}

|score = 1–0

|team2 = {{fbaicon|HUN}} Ferencváros

|goals1 =

• Masopust {{goal|36}}

|goals2 =

|stadium = Sinobo Stadium, Prague

|attendance = 15,238{{UEFA match attendance|2032623|Slavia Prague vs. Ferencváros|date=10 August 2021|access-date=10 August 2021}}

|referee = Tobias Stieler (Germany)

|report = https://www.uefa.com/uefachampionsleague/match/2032623/

}}

Ferencváros won 2–1 on aggregate.

{{Football box

|date = {{Start date|2021|8|3|df=y}}

|time = 20:00

|team1 = PSV Eindhoven {{fbaicon|NED}}

|score = 3–0

|team2 = {{fbaicon|DEN}} Midtjylland

|goals1 =

• Madueke {{goal|19}}
• Götze {{goal|29}}
• Gakpo {{goal|32}}

|goals2 =

|stadium = Philips Stadion, Eindhoven

|attendance = 22,700{{UEFA match attendance|2032614|PSV Eindhoven vs. Midtjylland|date=3 August 2021|access-date=3 August 2021}}

|referee = Sergei Karasev (Russia)

|report = https://www.uefa.com/uefachampionsleague/match/2032614/

}}

{{Football box

|date = {{Start date|2021|8|10|df=y}}

|time = 20:00

|team1 = Midtjylland {{fbaicon|DEN}}

|score = 0–1

|team2 = {{fbaicon|NED}} PSV Eindhoven

|goals1 =

|goals2 =

• Bruma {{goal|90+3}}

|stadium = MCH Arena, Herning

|attendance = 6,288{{UEFA match attendance|2032624|Midtjylland vs. PSV Eindhoven|date=10 August 2021|access-date=10 August 2021}}

|referee = Clément Turpin (France)

|report = https://www.uefa.com/uefachampionsleague/match/2032624/

}}

PSV Eindhoven won 4–0 on aggregate.

----

{{Football box

|date = {{Start date|2021|8|4|df=y}}

|time = 19:00 {{small|(20:00 UTC+3)}}

|team1 = Spartak Moscow {{fbaicon|RUS}}

|score = 0–2

|team2 = {{fbaicon|POR}} Benfica

|goals1 =

|goals2 =

• Silva {{goal|51}}
• Gilberto {{goal|74}}

|stadium = Otkritie Arena, Moscow

|attendance = 2,933{{UEFA match attendance|2032615|Spartak Moscow vs. Benfica|date=4 August 2021|access-date=4 August 2021}}

|referee = Srđan Jovanović (Serbia)

|report = https://www.uefa.com/uefachampionsleague/match/2032615/

}}

{{Football box

|date = {{Start date|2021|8|10|df=y}}

|time = 21:00 {{small|(20:00 UTC+1)}}

|team1 = Benfica {{fbaicon|POR}}

|score = 2–0

|team2 = {{fbaicon|RUS}} Spartak Moscow

|goals1 =

• Mário {{goal|58}}
• Gigot {{goal|90+2|o.g.}}

|goals2 =

|stadium = Estádio da Luz, Lisbon

|attendance = 16,312{{UEFA match attendance|2032625|Benfica vs. Spartak Moscow|date=10 August 2021|access-date=10 August 2021}}

|referee = Anthony Taylor (England)

|report = https://www.uefa.com/uefachampionsleague/match/2032625/

}}

Benfica won 4–0 on aggregate.

----

{{Football box

|date = {{Start date|2021|8|3|df=y}}

|time = 20:00

|team1 = Genk {{fbaicon|BEL}}

|score = 1–2

|team2 = {{fbaicon|UKR}} Shakhtar Donetsk

|goals1 =

• Onuachu {{goal|39}}

|goals2 =

• Tetê {{goal|63|pen.}}
• Alan Patrick {{goal|81}}

|stadium = Luminus Arena, Genk

|attendance = 5,096{{UEFA match attendance|2032616|Genk vs. Shakhtar Donetsk|date=3 August 2021|access-date=3 August 2021}}

|referee = Anastasios Sidiropoulos (Greece)

|report = https://www.uefa.com/uefachampionsleague/match/2032616/

}}

{{Football box

|date = {{Start date|2021|8|10|df=y}}

|time = 19:30 {{small|(20:30 UTC+3)}}

|team1 = Shakhtar Donetsk {{fbaicon|UKR}}

|score = 2–1

|team2 = {{fbaicon|BEL}} Genk

|goals1 =

• Traoré {{goal|27}}
• Antônio {{goal|76}}

|goals2 =

• Dessers {{goal|90}}

|stadium = NSC Olimpiyskiy, Kyiv{{refn|group=note|name=Shakhtar|Shakhtar Donetsk played their third qualifying round home match at NSC Olimpiyskiy, Kyiv, instead of their regular stadium, the Donbas Arena in Donetsk, due to the war in Donbas.}}

|attendance = 20,594{{UEFA match attendance|2032626|Shakhtar Donetsk vs. Genk|date=10 August 2021|access-date=10 August 2021}}

|referee = István Kovács (Romania)

|report = https://www.uefa.com/uefachampionsleague/match/2032626/

}}

Shakhtar Donetsk won 4–2 on aggregate.

----

{{Football box

|date = {{Start date|2021|8|3|df=y}}

|time = 19:00

|team1 = Sparta Prague {{fbaicon|CZE}}

|score = 0–2

|team2 = {{fbaicon|FRA}} Monaco

|goals1 =

|goals2 =

• Tchouaméni {{goal|37}}
• Volland {{goal|59}}

|stadium = Stadion Letná, Prague

|attendance = 10,533{{UEFA match attendance|2032617|Sparta Prague vs. Monaco|date=3 August 2021|access-date=3 August 2021}}

|referee = Michael Oliver (England)

|report = https://www.uefa.com/uefachampionsleague/match/2032617/

}}

{{Football box

|date = {{Start date|2021|8|10|df=y}}

|time = 20:00

|team1 = Monaco {{fbaicon|FRA}}

|score = 3–1

|team2 = {{fbaicon|CZE}} Sparta Prague

|goals1 =

• Martins {{goal|50}}
• Golovin {{goal|56}}
• Diop {{goal|81}}

|goals2 =

• Karlsson {{goal|78}}

|stadium = Stade Louis II, Monaco

|attendance = 5,476{{UEFA match attendance|2032627|Monaco vs. Sparta Prague|date=10 August 2021|access-date=10 August 2021}}

|referee = Daniele Orsato (Italy)

|report = https://www.uefa.com/uefachampionsleague/match/2032627/

}}

Monaco won 5–1 on aggregate.

A total of 12 teams played in the play-off round. They were divided into two paths:

• Champions Path (8 teams): 2 teams which entered in this round, and 6 winners of the third qualifying round (Champions Path).
• League Path (4 teams): 4 winners of the third qualifying round (League Path).

Seeding of teams was based on their 2021 UEFA club coefficients. For the winners of the third qualifying round, whose identity was not known at the time of draw, the club coefficient of the highest-ranked remaining team in each tie was used. In the Champions Path there were four seeded teams and four unseeded teams, and in the League Path there were two seeded teams and two unseeded teams. The first team drawn in each tie would be the home team of the first leg.

;Notes

{{Cnote2 Begin|liststyle=disc}}

{{Cnote2|†|n=0|group=PO|^† Winners of the third qualifying round, whose identity was not known at the time of draw. Teams in italics defeated a team with a higher coefficient, thus effectively taking the coefficient of their opponent in the draw.}}

{{Cnote2 End}}

{{Football box

|date = {{Start date|2021|8|17|df=y}}

|time = 21:00

|team1 = Red Bull Salzburg {{fbaicon|AUT}}

|score = 2–1

|team2 = {{fbaicon|DEN}} Brøndby

|goals1 =

• Adeyemi {{goal|56}}
• Aaronson {{goal|90}}

|goals2 =

• Uhre {{goal|4}}

|stadium = Stadion Wals-Siezenheim, Wals-Siezenheim

|attendance = 17,538{{cite web |url=https://www.uefa.com/newsfiles/ucl/2022/2032628_fr.pdf |archive-url=https://web.archive.org/web/20210817210320/https://www.uefa.com/newsfiles/ucl/2022/2032628_fr.pdf |url-status=dead |archive-date=17 August 2021 |title=Full Time Summary Play-Offs 1st Leg – Red Bull Salzburg v Brøndby |work=UEFA |publisher=Union of European Football Associations |date=17 August 2021 |access-date=17 August 2021}}

|referee = Szymon Marciniak (Poland)

|report = https://www.uefa.com/uefachampionsleague/match/2032628/

}}

{{Football box

|date = {{Start date|2021|8|25|df=y}}

|time = 21:00

|team1 = Brøndby {{fbaicon|DEN}}

|score = 1–2

|team2 = {{fbaicon|AUT}} Red Bull Salzburg

|goals1 =

• Maxsø {{goal|62}}

|goals2 =

• Šeško {{goal|4}}
• Aaronson {{goal|10}}

|stadium = Brøndby Stadium, Brøndbyvester

|attendance = 22,397{{cite web |url=https://www.uefa.com/newsfiles/ucl/2022/2032634_fr.pdf |archive-url=https://web.archive.org/web/20210825205829/https://www.uefa.com/newsfiles/ucl/2022/2032634_fr.pdf |url-status=dead |archive-date=25 August 2021 |title=Full Time Summary Play-Offs 2nd Leg – Brøndby v Red Bull Salzburg |work=UEFA |publisher=Union of European Football Associations |date=25 August 2021 |access-date=25 August 2021}}

|referee = Carlos del Cerro Grande (Spain)

|report = https://www.uefa.com/uefachampionsleague/match/2032634/

}}

Red Bull Salzburg won 4–2 on aggregate.

----

{{Football box

|date = {{Start date|2021|8|18|df=y}}

|time = 21:00

|team1 = Young Boys {{fbaicon|SUI}}

|score = 3–2

|team2 = {{fbaicon|HUN}} Ferencváros

|goals1 =

• Elia {{goal|16}}
• Sierro {{goal|40}}
• Garcia {{goal|65}}

|goals2 =

• Boli {{goal|14||82}}

|stadium = Wankdorf Stadium, Bern

|attendance = 15,652{{cite web |url=https://www.uefa.com/newsfiles/ucl/2022/2032629_fr.pdf |archive-url=https://web.archive.org/web/20210823172944/https://www.uefa.com/newsfiles/ucl/2022/2032629_fr.pdf |url-status=dead |archive-date=23 August 2021 |title=Full Time Summary Play-Offs 1st Leg – Young Boys v Ferencváros |work=UEFA |publisher=Union of European Football Associations |date=18 August 2021 |access-date=18 August 2021}}

|referee = Willie Collum (Scotland)

|report = https://www.uefa.com/uefachampionsleague/match/2032629/

}}

{{Football box

|date = {{Start date|2021|8|24|df=y}}

|time = 21:00

|team1 = Ferencváros {{fbaicon|HUN}}

|score = 2–3

|team2 = {{fbaicon|SUI}} Young Boys

|goals1 =

• Wingo {{goal|18}}
• R. Mmaee {{goal|27}}

|goals2 =

• Zesiger {{goal|4}}
• Fassnacht {{goal|56}}
• Mambimbi {{goal|90+3}}

|stadium = Ferencváros Stadion, Budapest

|attendance = 20,667{{cite web |url=https://www.uefa.com/newsfiles/ucl/2022/2032635_fr.pdf |archive-url=https://web.archive.org/web/20210824210632/https://www.uefa.com/newsfiles/ucl/2022/2032635_fr.pdf |url-status=dead |archive-date=24 August 2021 |title=Full Time Summary Play-Offs 2nd Leg – Ferencváros v Young Boys |work=UEFA |publisher=Union of European Football Associations |date=24 August 2021 |access-date=24 August 2021}}

|referee = Sergei Karasev (Russia)

|report = https://www.uefa.com/uefachampionsleague/match/2032635/

}}

Young Boys won 6–4 on aggregate.

----

{{Football box

|date = {{Start date|2021|8|18|df=y}}

|time = 21:00

|team1 = Malmö FF {{fbaicon|SWE}}

|score = 2–0

|team2 = {{fbaicon|BUL}} Ludogorets Razgrad

|goals1 =

• Birmančević {{goal|26}}
• Berget {{goal|61}}

|goals2 =

|stadium = Stadion, Malmö

|attendance = 5,463{{cite web |url=https://www.uefa.com/newsfiles/ucl/2022/2032630_fr.pdf |archive-url=https://web.archive.org/web/20210823194538/https://www.uefa.com/newsfiles/ucl/2022/2032630_fr.pdf |url-status=dead |archive-date=23 August 2021 |title=Full Time Summary Play-Offs 1st Leg – Malmö FF v Ludogorets Razgrad |work=UEFA |publisher=Union of European Football Associations |date=18 August 2021 |access-date=18 August 2021}}

|referee = Antonio Mateu Lahoz (Spain)

|report = https://www.uefa.com/uefachampionsleague/match/2032630/

}}

{{Football box

|date = {{Start date|2021|8|24|df=y}}

|time = 21:00 {{small|(22:00 UTC+3)}}

|team1 = Ludogorets Razgrad {{fbaicon|BUL}}

|score = 2–1

|team2 = {{fbaicon|SWE}} Malmö FF

|goals1 =

• Nedyalkov {{goal|10}}
• Sotiriou {{goal|60|pen.}}

|goals2 =

• Birmančević {{goal|42}}

|stadium = Huvepharma Arena, Razgrad

|attendance = 5,130{{cite web |url=https://www.uefa.com/newsfiles/ucl/2022/2032636_fr.pdf |archive-url=https://web.archive.org/web/20210824210634/https://www.uefa.com/newsfiles/ucl/2022/2032636_fr.pdf |url-status=dead |archive-date=24 August 2021 |title=Full Time Summary Play-Offs 2nd Leg – Ludogorets Razgrad v Malmö FF |work=UEFA |publisher=Union of European Football Associations |date=24 August 2021 |access-date=24 August 2021}}

|referee = Clément Turpin (France)

|report = https://www.uefa.com/uefachampionsleague/match/2032636/

}}

Malmö FF won 3–2 on aggregate.

----

{{Football box

|date = {{Start date|2021|8|17|df=y}}

|time = 21:00 {{small|(22:00 UTC+3)}}

|team1 = Sheriff Tiraspol {{fbaicon|MDA}}

|score = 3–0

|team2 = {{fbaicon|CRO}} Dinamo Zagreb

|goals1 =

• Traoré {{goal|45||80}}
• Kolovos {{goal|54}}

|goals2 =

|stadium = Sheriff Stadium, Tiraspol

|attendance = 5,281{{cite web |url=https://www.uefa.com/newsfiles/ucl/2022/2032631_fr.pdf |archive-url=https://web.archive.org/web/20210817210319/https://www.uefa.com/newsfiles/ucl/2022/2032631_fr.pdf |url-status=dead |archive-date=17 August 2021 |title=Full Time Summary Play-Offs 1st Leg – Sheriff Tiraspol v Dinamo Zagreb |work=UEFA |publisher=Union of European Football Associations |date=17 August 2021 |access-date=17 August 2021}}

|referee = Cüneyt Çakır (Turkey)

|report = https://www.uefa.com/uefachampionsleague/match/2032631/

}}

{{Football box

|date = {{Start date|2021|8|25|df=y}}

|time = 21:00

|team1 = Dinamo Zagreb {{fbaicon|CRO}}

|score = 0–0

|team2 = {{fbaicon|MDA}} Sheriff Tiraspol

|goals1 =

|goals2 =

|stadium = Stadion Maksimir, Zagreb

|attendance = 8,015{{cite web |url=https://www.uefa.com/newsfiles/ucl/2022/2032637_fr.pdf |archive-url=https://web.archive.org/web/20210825205831/https://www.uefa.com/newsfiles/ucl/2022/2032637_fr.pdf |url-status=dead |archive-date=25 August 2021 |title=Full Time Summary Play-Offs 2nd Leg – Dinamo Zagreb v Sheriff Tiraspol |work=UEFA |publisher=Union of European Football Associations |date=25 August 2021 |access-date=25 August 2021}}

|referee = Daniele Orsato (Italy)

|report = https://www.uefa.com/uefachampionsleague/match/2032637/

}}

Sheriff Tiraspol won 3–0 on aggregate.

{{Football box

|date = {{Start date|2021|8|17|df=y}}

|time = 21:00

|team1 = Monaco {{fbaicon|FRA}}

|score = 0–1

|team2 = {{fbaicon|UKR}} Shakhtar Donetsk

|goals1 =

|goals2 =

• Pedrinho {{goal|19}}

|stadium = Stade Louis II, Monaco

|attendance = 5,700{{cite web |url=https://www.uefa.com/newsfiles/ucl/2022/2032632_fr.pdf |archive-url=https://web.archive.org/web/20210817210412/https://www.uefa.com/newsfiles/ucl/2022/2032632_fr.pdf |url-status=dead |archive-date=17 August 2021 |title=Full Time Summary Play-Offs 1st Leg – Monaco v Shakhtar Donetsk |work=UEFA |publisher=Union of European Football Associations |date=17 August 2021 |access-date=17 August 2021}}

|referee = Danny Makkelie (Netherlands)

|report = https://www.uefa.com/uefachampionsleague/match/2032632/

}}

{{Football box

|date = {{Start date|2021|8|25|df=y}}

|time = 21:00 {{small|(22:00 UTC+3)}}

|team1 = Shakhtar Donetsk {{fbaicon|UKR}}

|score = 2–2

|aet = yes

|team2 = {{fbaicon|FRA}} Monaco

|goals1 =

• Marlos {{goal|74}}
• Aguilar {{goal|114|o.g.}}

|goals2 =

• Ben Yedder {{goal|18||39}}

|stadium = Metalist OSC, Kharkiv{{refn|group=note|name=Shakhtar-2|Shakhtar Donetsk played their play-off round home match at Metalist OSC, Kharkiv, instead of their regular stadium, the Donbas Arena in Donetsk, due to the war in Donbas.}}

|attendance = 26,697{{cite web |url=https://www.uefa.com/newsfiles/ucl/2022/2032638_fr.pdf |archive-url=https://web.archive.org/web/20210825213927/https://www.uefa.com/newsfiles/ucl/2022/2032638_fr.pdf |url-status=dead |archive-date=25 August 2021 |title=Full Time Summary Play-Offs 2nd Leg – Shakhtar Donetsk v Monaco |work=UEFA |publisher=Union of European Football Associations |date=25 August 2021 |access-date=25 August 2021}}

|referee = Anthony Taylor (England)

|report = https://www.uefa.com/uefachampionsleague/match/2032638/

}}

Shakhtar Donetsk won 3–2 on aggregate.

----

{{Football box

|date = {{Start date|2021|8|18|df=y}}

|time = 21:00 {{small|(20:00 UTC+1)}}

|team1 = Benfica {{fbaicon|POR}}

|score = 2–1

|team2 = {{fbaicon|NED}} PSV Eindhoven

|goals1 =

• Silva {{goal|10}}
• Weigl {{goal|42}}

|goals2 =

• Gakpo {{goal|51}}

|stadium = Estádio da Luz, Lisbon

|attendance = 18,199{{cite web |url=https://www.uefa.com/newsfiles/ucl/2022/2032633_fr.pdf |archive-url=https://web.archive.org/web/20210823194539/https://www.uefa.com/newsfiles/ucl/2022/2032633_fr.pdf |url-status=dead |archive-date=23 August 2021 |title=Full Time Summary Play-Offs 1st Leg – Benfica v PSV Eindhoven |work=UEFA |publisher=Union of European Football Associations |date=18 August 2021 |access-date=18 August 2021}}

|referee = Felix Brych (Germany)

|report = https://www.uefa.com/uefachampionsleague/match/2032633/

}}

{{Football box

|date = {{Start date|2021|8|24|df=y}}

|time = 21:00

|team1 = PSV Eindhoven {{fbaicon|NED}}

|score = 0–0

|team2 = {{fbaicon|POR}} Benfica

|goals1 =

|goals2 =

|stadium = Philips Stadion, Eindhoven

|attendance = 21,855{{cite web |url=https://www.uefa.com/newsfiles/ucl/2022/2032639_fr.pdf |archive-url=https://web.archive.org/web/20210824210837/https://www.uefa.com/newsfiles/ucl/2022/2032639_fr.pdf |url-status=dead |archive-date=24 August 2021 |title=Full Time Summary Play-Offs 2nd Leg – PSV Eindhoven v Benfica |work=UEFA |publisher=Union of European Football Associations |date=24 August 2021 |access-date=24 August 2021}}

|referee = Slavko Vinčić (Slovenia)

|report = https://www.uefa.com/uefachampionsleague/match/2032639/

}}

Benfica won 2–1 on aggregate.

{{reflist|group=note}}

{{reflist}}

• {{Official website|https://www.uefa.com/uefachampionsleague/}}

{{UEFA Champions League phases}}

{{2021–22 in European football (UEFA)}}

{{DEFAULTSORT:Uefa Champions League qualifying phase and play-off round 2021-22}}

*1

2021-22

Category:June 2021 sports events in Europe

Category:July 2021 sports events in Europe

Category:August 2021 sports events in Europe